ライフサイエンスコーパス: dorsal column

1 T) axons descends in the ventral part of the dorsal column.

2 t collaterals in Lissauer's tract and in the dorsal column.

3 ch express TRPV1 in Lissauer's tract and the dorsal column.

4 3 compared with the contralateral unlesioned dorsal column.

5 3b after complete or partial lesions of the dorsal columns.

6 axonal loss in the corticospinal tracts and dorsal columns.

7 be explained by conduction delays within the dorsal columns.

8 neurons in the corticospinal tracts and the dorsal columns.

9 more similar to peripheral nerve than intact dorsal columns.

10 gray matter rather than in the degenerating dorsal columns.

11 illimeters rostral to a severe lesion of the dorsal columns.

12 ollowing the onset of anoxia in demyelinated dorsal columns.

13 ses in immunostaining in the gray matter and dorsal columns.

14 llum, brainstem, spinocerebellar tracts, and dorsal columns.

15 ining was also prominent along the ascending dorsal columns.

16 cal injections of S-AMPA or NMDA into lumbar dorsal columns.

17 infused with vehicle for two weeks into the dorsal column, 3 mm rostral to the nerve graft, essentia

18 Following a partial section, the remaining dorsal column afferents continue to activate neurons wit

19 Here, we unilaterally sectioned dorsal column afferents in the cervical spinal cord (C4-

20 er large but incomplete lesions of ascending dorsal column afferents in the cervical spinal cord, the

21 It has long been thought that dorsal column afferents of the spinal cord represent the

22 ion-induced enhanced regeneration of injured dorsal column afferents.

23 macrophages in axonal retraction within the dorsal columns after spinal cord injury in vivo and foun

24 ter near the crush site and in the ascending dorsal column also exhibited increased Mac1 staining tha

25 spinal segments in Lissauer's tract and the dorsal column and regulate motor activity.

26 ion, including somatosensory inputs from the dorsal column and spinal trigeminal nuclei.

27 eptive fields of spinocervical, postsynaptic dorsal column and spinothalamic tract neurons was used t

28 nkeys with chronic unilateral lesions of the dorsal columns and expanded chin representation, connect

29 he injury, HO-1 was primarily induced in the dorsal columns and occasionally in the lateral white mat

30 lso severely affected, with shrinkage of the dorsal columns and reduction in the number of neurones i

31 f the main dorsal corticospinal tract in the dorsal columns and some damage to the adjacent medial pa

32 expressed in the synaptic terminations from dorsal columns and trigeminal brainstem nuclei, the effe

33 In 6 experiments, dorsal columns and ventrolateral funiculi were sequentia

34 rocesses were seen along fiber tracts in the dorsal columns and, after intracerebral injection, subja

35 important relays for indirect, postsynaptic dorsal column, and direct ascending pathways, respective

36 ns fail to cross the midline to the opposite dorsal column as normal.

37 ted into the superficial dorsal horn and the dorsal columns, as well as across the dorsal commissure.

38 lcium transients within Lissauer's tract and dorsal column at L5 segments when compared to the calciu

39 ipolar ball electrode was placed on the left dorsal column at lumbar spinal cord segments 2-3 in sodi

40 We found that stimulating the dorsal column at the L2 spinal segment at 0.6 mA at eith

41 ed to the calcium transients only within the dorsal column at the lumbar 2 (L2) segments, which were

42 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal cord segments (L2

43 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal cord segments (L2

44 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal segments in rats.

45 Lesions of the dorsal columns at a mid-cervical level render the hand r

46 dorsal hemisection promotes regeneration of dorsal column axons across and beyond the lesion site in

47 This same compound promotes regeneration of dorsal column axons after acute lesions and potentiates

48 hwann cell-mediated remyelination of central dorsal column axons and whether Nrg1 ablation influences

49 lted in the total failure in regeneration of dorsal column axons consequent on the lack of GAP43 upre

50 h wild-type DRG neurons, and regeneration of dorsal column axons does not occur after a conditioning

51 Furthermore, regeneration of dorsal column axons does not occur after a conditioning

52 ditioning lesion of the peripheral branch of dorsal column axons is a well-known paradigm enabling th

53 ing cells, suggesting that the retraction of dorsal column axons is not a secondary effect of increas

54 db-cAMP results in extensive regeneration of dorsal column axons lesioned 1 week later.

55 Dorsal column axons of the rat spinal cord are partially

56 sal column crush resulted in regeneration of dorsal column axons up to and beyond the injury site int

57 utcomes of previous studies, regeneration of dorsal column axons was compared following transplants o

58 leus of rats partially denervated of forepaw dorsal column axons was examined.

59 n and the electrophysiological properties of dorsal column axons were characterized after transplanta

60 cal doses, both in vivo and in vitro, to rat dorsal column axons which had been experimentally demyel

61 he spinal cord and profound demyelination of dorsal column axons.

62 romote regeneration of subsequently lesioned dorsal column axons.

63 and functional remyelination of demyelinated dorsal column axons.

64 yelinated central axons, particularly in the dorsal columns, become associated with peripheral myelin

65 thin 12 min of the onset of anoxia in normal dorsal columns, but was not abolished until 50 min follo

66 ating lesions were induced in the rat spinal dorsal column by microinjection of lipopolysaccharide, a

67 focal demyelination in the mouse spinal cord dorsal column by microinjection of lysophosphatidylcholi

68 We found that the dorsal column cerebrospinal-fluid-normalized magnetizati

69 12.2% of control amplitude) in demyelinated dorsal columns compared to controls (30.8 +/- 5.3%) foll

70 Attenuation of dorsal column compound action potentials was ameliorated

71 Our in vivo analysis of dorsal column crush lesions confirms the close associati

72 el of axonal dieback as well as an adult rat dorsal column crush model of spinal cord injury, we foun

73 Using either spinal cord dorsal column crush or contusion injury models, miR-155

74 to the sciatic nerve 1 week before bilateral dorsal column crush resulted in regeneration of dorsal c

75 In addition, a minor dorsal column CST projection was identified.

76 or spinal cord corticospinal tract (CST) and dorsal column (DC) axons in both monophasic (C57/BL6 mic

77 mation (MRF) neurons after acute and chronic dorsal column (DC) lesions of the T8 spinal cord and los

78 a visceral pain pathway that ascends in the dorsal column (DC) of the spinal cord.

79 ctal distension (CRD), whereas lesion in the dorsal column (DC) reverses this neuronal sensitization,

80 y by forming neuronal relays between injured dorsal column (DC) sensory axons and the denervated dors

81 Here, we show that the dorsal column (DC) somatosensory pathway contains projec

82 collaterals of dorsal root axons within the dorsal column (DC) was studied after neonatal spinal ove

83 The dorsal column (DC) white matter, for example, is the spi

84 atter (VGM), ventral white matter (VWM), and dorsal columns (DC) at levels ranging 15 mm rostral and

85 sneuronal atrophy occurred in neurons of the dorsal column (DCN) and ventral posterior lateral thalam

86 that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epile

87 Selective lesions of the spinal dorsal columns did not affect either of these types of r

88 In NG2 knock-out mice, sensory axons in the dorsal columns dieback further than their control counte

89 The transplanted dorsal columns displayed improved conduction velocity an

90 set blindness, cerebellar ataxia, nystagmus, dorsal column dysfuction, and spasticity with upper moto

91 er spinal pathways do not substitute for the dorsal columns even after injury.

92 my, DTI revealed a lesion in the ipsilateral dorsal column extending from the lumbar to the cervical

93 However, tracing of ascending dorsal column fibres showed that few regenerated beyond

94 ere used to record field potentials from the dorsal columns following distal local surface stimulatio

95 hich the main contingent of CST axons in the dorsal column had been transected.

96 and behavioural consequences of cutting the dorsal column have been reported to range from mild and

97 l cord of adult rats or the injury site in a dorsal column hemisection model of spinal cord injury, a

98 ithin weeks after a unilateral lesion of the dorsal column in squirrel monkeys.

99 on reduced immunostaining of the ipsilateral dorsal columns in segments rostral to the lesion and in

100 Injections of BMP4 or BMP7 into the dorsal columns in the absence of demyelination led to in

101 ave re-examined this issue by sectioning the dorsal columns in the cervical region and recording the

102 that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in

103 ripheral nerve graft bridging the transected dorsal columns in the thoracic spinal cord resulted in a

104 d axons, we studied axonal conduction in rat dorsal columns in vitro following a 60-min period of ano

105 o examine the spinal cord in rats with focal dorsal column inflammatory or demyelinating lesions to d

106 what extent this brain reorganization due to dorsal column injuries is related to axonal sprouting is

107 ndergo severe atrophy 4 weeks after thoracic dorsal column injury and that ChABC is neuroprotective f

108 onditioning lesion 1 or 2 weeks prior to the dorsal column injury results in growth into the spinal c

109 l pattern of callosal connections depends on dorsal column input and not on normal interhemsipheric i

110 sal root lesion (DRL), (2) or a combined DRL/dorsal column lesion (DRL/DCL), or (3) a DRL/DCL where t

111 , the relationship between the extent of the dorsal column lesion and the amount of cortical reactiva

112 luation of total soluble CSPGs 2 weeks after dorsal column lesion in the rat demonstrated that NG2 is

113 on across the monkeys shows that even if the dorsal column lesion is partial, preserving most of the

114 omoted by olfactory cell transplants after a dorsal column lesion.

115 ort bridging of corticospinal axons beyond a dorsal column lesion.

116 gracilis was blocked by dorsal rhizotomy or dorsal column lesion.

117 lls results in functional remyelination of a dorsal column lesion.

118 g and grasping function following a cervical dorsal column lesion.

119 to spontaneously regenerate in vivo after a dorsal column lesion.

120 ry cortex confirmed the effectiveness of the dorsal column lesion.

121 cortex were more widespread after incomplete dorsal column lesions (DCLs) than after a complete DCL.

122 ntly higher acutely than those of LINGO-1 in dorsal column lesions and reduced in models of dorsal ro

123 eorganization of digit representations after dorsal column lesions and reveals differences between fu

124 Dorsal column lesions at a high cervical level deprive t

125 mus are affected by long standing unilateral dorsal column lesions at cervical levels in macaque monk

126 cuneate nucleus that survives high cervical dorsal column lesions by traveling in the lateral funicu

127 itory protein, CD59 (hCD59), into transected dorsal column lesions of the spinal cord of the immunosu

128 the near-completeness of the more extensive dorsal column lesions we studied, we suggest that altern

129 Dorsal column lesions were placed at a spinal cord level

130 In three other squirrel monkeys, unilateral dorsal column lesions were placed at the cervical segmen

131 After dorsal column lesions, all fibers stop at the injury sit

132 nucleus through pathways that circumvent the dorsal column lesions, contributing to cortical reactiva

133 on and ethidium bromide-induced demyelinated dorsal column lesions, with or without co-transplantatio

134 ith dorsal hemisection lesions as opposed to dorsal column lesions.

135 ected in the larger size of both primary and dorsal column lesions.

136 f the brain reorganization immediately after dorsal column lesions.

137 ronal system with dendrites that embrace the dorsal columns like palisades is observed.

138 the few spared primary axon afferents in the dorsal columns, likely have a major role in the reactiva

139 tly different at each of these levels of the dorsal column-medial lemniscal pathway.

140 are found: 1) ascending ipsilaterally in the dorsal column near the dorsal intermediate septum or the

141 that distinguish ventral, intermediate, and dorsal column neuroectoderm and neuroblasts, and a cell

142 nts have a transformation of intermediate to dorsal column neuroectoderm fate, and only 10% of the in

143 m dorsal root ganglions to a small number of dorsal column neurons, a caudal extension of nucleus gra

144 Following a complete section of the dorsal columns, neurons in area 3b become immediately an

145 The mammalian dorsal column nuclei (DCN) are principally composed of t

146 Tactile receptive fields (RFs) of brainstem dorsal column nuclei (DCN) neurons rapidly enlarge when

147 ance P receptor binding was localized in the dorsal column nuclei (DCN) of the rat, cat, monkey, and

148 sizes and plasticity of RFs in the brainstem dorsal column nuclei (DCN) when peripheral inputs were n

149 column (DC) sensory axons and the denervated dorsal column nuclei (DCN).

150 cluding excitatory projection neurons of the dorsal column nuclei and for vital components of the int

151 The dorsal column nuclei are large and distinct.

152 These results suggest that the dorsal column nuclei can participate in persistent pain

153 Lesions of the dorsal column nuclei did not affect the climbing fibre r

154 on of labeled neurons in the spinal cord and dorsal column nuclei following injections of Fluoro-Gold

155 Based on their anatomical connections, the dorsal column nuclei may contribute to thalamic changes

156 luded the effects of TEA and 4-AP in NTS and dorsal column nuclei neurones, but not in dorsal vagal n

157 or circular immunostained structures in the dorsal column nuclei of old cats.

158 axonal accumulation of neurofilaments in the dorsal column nuclei of the cat by using immunohistochem

159 Although the dorsal column nuclei receive both primary afferent input

160 t in mammals, involving projections from the dorsal column nuclei to the thalamus, and thence to soma

161 ed with somatosensory function, although the dorsal column nuclei were also labelled above control.

162 ory inputs from the somatosensory cortex and dorsal column nuclei were found to terminate almost excl

163 About half the neurons in the rat dorsal column nuclei were immunopositive for glycine or

164 ory pathways originating in the dorsal horn, dorsal column nuclei, and trigeminal nuclei, and the oth

165 in segments rostral to the lesion and in the dorsal column nuclei, presumably from the loss of ascend

166 uded neurons in sensory pathways such as the dorsal column nuclei, the area postrema, the spinal trig

167 ponses were not exclusively mediated via the dorsal column nuclei.

168 imary afferents that project directly to the dorsal column nuclei.

169 ine is an inhibitory neurotransmitter in the dorsal column nuclei.

170 r crest, in the solitary nucleus, and in the dorsal column nuclei.

171 terminate within discrete subdomains of the dorsal column nuclei.

172 n to examine the physiological properties of dorsal column nucleus neurons during persistent pain.

173 cord send long ascending projections to the dorsal column nucleus that are important in the transmis

174 bulbs, optic tectum, octavolateral area, and dorsal column nucleus, and it innervates, apart from the

175 and medial nuclei of the octavolateral area, dorsal column nucleus, solitary tract nucleus, motoneuro

176 (SpVi) and subnuclei caudalis (SpVc) and the dorsal column nucleus-based lemniscal and cortical pathw

177 tion potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating

178 progressive loss of myelin in the brain and dorsal column of the spinal cord associated with increas

179 vagus nerve, and in the motor neurons of the dorsal column of the spinal cord.

180 vented degeneration of sensory fibers in the dorsal column of the spinal cord.

181 igalacto-cerebroside, are implanted into the dorsal columns of 4-8 d rat spinal cord, some of the mye

182 ult CNS, ES cells were transplanted into the dorsal columns of adult rat spinal cord 3 days after che

183 Dorsal columns of adult rat spinal cords were demyelinat

184 The dorsal columns of adult rats were injected with lysoleci

185 d chondroitinase ABC (ChABC) to the lesioned dorsal columns of adult rats.

186 in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous ge

187 d severely impaired axonal conduction in the dorsal columns of global Nrg1 mutants (where Schwann cel

188 the X-irradiation/ethidium bromide lesioned dorsal columns of immunosuppressed Wistar rat.

189 marker of axonal injury, in the spinal cord dorsal columns of mice with EAE.

190 are expressed in ventral, intermediate, and dorsal columns of neuroectoderm, respectively.

191 ound demyelinating phenotype observed in the dorsal columns of Nrg1 mutant mice is related to conduct

192 ins of adult monkeys with chronic lesions of dorsal columns of spinal cord at cervical levels undergo

193 To examine this issue, the dorsal columns of the adult rat spinal cord were demyeli

194 omatosensory afferents as they ascend in the dorsal columns of the cervical spinal cord.

195 cells were transplanted into the transected dorsal columns of the rat spinal cord to induce axonal r

196 the ascending afferents from the hand in the dorsal columns of the spinal cord in monkeys is followed

197 ucleus in adult monkeys after lesions of the dorsal columns of the spinal cord or therapeutic amputat

198 To address this possibility, the dorsal columns of the spinal cord were sectioned between

199 but the central branch, which courses in the dorsal columns of the spinal cord, does not.

200 after section of ascending afferents in the dorsal columns of the spinal cord, it reorganizes to ove

201 imb in monkeys because of transection of the dorsal columns of the spinal cord, therapeutic amputatio

202 educed, number of corticospinal axons in the dorsal columns of the spinal cord.

203 Lesions of dorsal column or lateral habenula (LHb) prevented the in

204 ty is achieved by ipsilateral lesions of the dorsal columns or lidocaine microinjection into the nucl

205 Rats with incomplete lesions that spared the dorsal column pathway on the left side but not the right

206 own that the gracile nucleus in postsynaptic dorsal column pathway plays an important role in conveyi

207 ns were normal along both the trigeminal and dorsal column pathways.

208 s achieved through a boosted growth state of dorsal column projecting sensory neurons.

209 Postsynaptic dorsal column (PSDC) neurons transmit noxious visceral i

210 Bilateral lesions of the dorsal columns reduced the size of the brainstem nuclei

211 neurons, but not their central axons in the dorsal columns, regenerate after injury.

212 on of long axons in corticospinal tracts and dorsal columns, resulting in spasticity and difficulty w

213 axons in mice with selective lesions of the dorsal column revealed that DLCST axons arborize extensi

214 sh motor output longitudinally after a C3/C4 dorsal column SCI that bilaterally ablated the dorsal co

215 After dorsal column SCI, miR-155 KO mouse spinal cord has redu

216 after severely disrupting afferent inputs by dorsal column section.

217 Previous studies have shown that injured dorsal column sensory axons extend across a spinal cord

218 infusions through a lumbar puncture rescued dorsal column sensory axons innervating the nucleus grac

219 s underwent C3 lesions to transect ascending dorsal column sensory axons, and autologous bone marrow

220 By in vivo two-photon imaging of spinal dorsal column sensory axons, we systematically examined

221 eration of several spinal systems, including dorsal column sensory, regionally projecting propriospin

222 etrated control fibroblast grafts, including dorsal column sensory, rubrospinal, and nociceptive axon

223 One to 3 months later, long-projecting dorsal-column sensory axons regenerated into and beyond

224 stepwise multiple regression showed that the dorsal column signal and diagnosis subtype alone explain

225 A complete unilateral lesion of the dorsal column somatosensory pathway in the upper cervica

226 Adult rats underwent bilateral dorsal column spinal cord lesions that remove the dorsal

227 dorsal half, Ia fibers entering through the dorsal columns still grew ventrally within the host dors

228 atest changes in cutaneous blood flow during dorsal column stimulation (DCS).

229 We propose that dorsal column stimulation might become an efficient and

230 In contrast, dorsal column subcortical paw representation areas that

231 sted in neurology to assess the state of the dorsal column system.

232 spinal cord lesion, even when <1% of labeled dorsal column terminations in the cuneate nucleus remain

233 he central branch of the same neurons in the dorsal column, these central axons will regenerate and,

234 A dorsal column transection between the C6-C7 dorsal root

235 al tract axons into spinal gray matter after dorsal column transection SCI.

236 s of axon injury and regeneration, including dorsal column transection, dorsal root rhizotomy and per

237 epicenter in spinal cord after a concomitant dorsal column transection.

238 ory-evoked potentials that disappeared after dorsal column transection.

239 c organization of the gracile nucleus of the dorsal column-trigeminal complex, neuroanatomical tracer

240 ascin-C-rich dorsal root entry zone into the dorsal column up to C1 level and above (>25 mm axon leng

241 jury from both sides including epicenter and dorsal column was microdissected and used for further st

242 ion, inflammatory cell infiltration into the dorsal columns was reduced in phenytoin-treated mice wit

243 border, preferentially including the ventral dorsal column watershed.

244 The dorsal columns were removed and maintained in an in vitr

245 The dorsal columns were removed and maintained in an in vitr

246 phosphorylated NFs of the small axons in the dorsal columns were widely spaced, suggesting that phosp

247 ndary lesion extending rostrocaudally in the dorsal columns (where long ascending and descending fibe

248 of the graft had grown up to 0.5 mm into the dorsal column white matter, 30+/-2% up to 1 mm, 19+/-3%

249 d injury, sensory neurons that course in the dorsal columns will regenerate, presumably because their