ライフサイエンスコーパス: dorsal horn

1 hresholds by gating mechanical inputs in the dorsal horn.

2 gene-related peptide (CGRP) staining in the dorsal horn.

3 ndogenous adenosine tone is increased in the dorsal horn.

4 citatory synaptic transmission in the spinal dorsal horn.

5 markedly elevated in the ipsilateral spinal dorsal horn.

6 n gene-related peptide-labeled fibers in the dorsal horn.

7 lements in pain signaling in the spinal cord dorsal horn.

8 proteins, including neuronal NOS (nNOS), in dorsal horn.

9 nal terminals in the superficial spinal cord dorsal horn.

10 matergic transmission within the superficial dorsal horn.

11 regulated by inhibitory interneurons in the dorsal horn.

12 between these two populations in the medial dorsal horn.

13 injection exhibited CASP6 activation in the dorsal horn.

14 vities in postsynaptic neurons in the spinal dorsal horn.

15 eus caudalis (Vc), the homolog of the spinal dorsal horn.

16 nctive clusters in the ventral horn and deep dorsal horn.

17 labeled laminae I and II of the spinal cord dorsal horn.

18 % of nonaffected neurons were located in the dorsal horn.

19 pressed on glial cells in superficial spinal dorsal horn.

20 Ascl1-independent subpopulation of the deep dorsal horn.

21 vities in postsynaptic neurons in the spinal dorsal horn.

22 y non-overlapping expression patterns in the dorsal horn.

23 e for rostrocaudal "processing units" in the dorsal horn.

24 -dependent subpopulations of the superficial dorsal horn.

25 tic changes that converge at the spinal cord dorsal horn.

26 iceptive processing, such as the superficial dorsal horn.

27 e, but absence of glial activation in spinal dorsal horn.

28 matter, but it is particularly dense in the dorsal horn.

29 myelinated, and peptidergic afferents in the dorsal horn.

30 cule-1-positive microglial reactivity in the dorsal horn.

31 nterneurons in the superficial layers of the dorsal horn.

32 ndent synaptic strengthening in the immature dorsal horn.

33 ses of these cells in the superficial spinal dorsal horn.

34 c plasma membranes (SPMs) of the ipsilateral dorsal horn.

35 creased CaV2.2 expression in the SPMs of the dorsal horn.

36 ojection neurons in the spinal and medullary dorsal horn.

37 idence of double labeling in the superficial dorsal horn.

38 M1alpha-facilitated CaV2.2 expression in the dorsal horn.

39 h reconsolidation-like effects in the spinal dorsal horn.

40 ced pain behaviors and BIP expression in the dorsal horn.

41 ibers and both labels were quantified in the dorsal horns.

42 activity in the ipsilateral L4/5 superficial dorsal horn 1 day after CFA injection.

43 ons via descending projections to the spinal dorsal horn [1].

44 na I and II neurons within the rodent spinal dorsal horn, a principal site of action for opiate analg

45 In the newborn spinal dorsal horn, activity is dominated by inputs from low th

46 1R sensitivity at excitatory synapses in the dorsal horn after nerve injury suggest that new generati

47 ble in neurons (not glia) of the superficial dorsal horn after noxious heat stimuli.

48 ) is present in lamina II of the superficial dorsal horn, an area involved in nociception.

49 hysiological evidence of reconnection to the dorsal horn and behavioral recovery in mechanical pressu

50 eurons in laminae I and V of the spinal cord dorsal horn and caudal spinal trigeminal nucleus and in

51 l afferents, which terminate medially in the dorsal horn and dorsolaterally in nTTD, terminate in spe

52 The TrkA(+) afferents remain outside the dorsal horn and fail to extend into the spinal cord, whi

53 n second-order neurons, disinhibition in the dorsal horn and glia cell activation.

54 sphorylated p38 MAPK immunoreactivity in the dorsal horn and Iba1 and cluster of differentiation 45 e

55 processing of nociceptive information in the dorsal horn and in the generation of central sensitizati

56 n parvalbumin-expressing interneurons in the dorsal horn and represents a pharmacological target to m

57 s-synaptic tracing of genetically identified dorsal horn and RVM neurons to uncover an RVM-spinal cor

58 (<0.1 Hz) frequency oscillations within the dorsal horn and somatosensory thalamus.

59 own by c-Fos expression in lamina III of the dorsal horn and the expression of ChR2-EYFP in a subpopu

60 other laminar populations in the superficial dorsal horn, and that suggest a critical role in interla

61 tra cell settling pattern in the medial deep dorsal horn, and, most importantly, they project axons c

62 segmental correlations in the ventral horns, dorsal horns, and central spinal cord gray matter.

63 at GRP-expressing neurons of the superficial dorsal horn are predominantly interneurons, that a small

64 g interleukin-1beta (IL-1beta) in the spinal dorsal horn, are key mechanisms underlying the developme

65 ion of synaptic strength at the level of the dorsal horn as an underlying mechanism.

66 glutamate transporter, GLT1, in superficial dorsal horn astrocytes are associated with both excitabi

67 Within the dorsal horn, besides KChIP3 in the inner lamina II and l

68 y excitatory interneurons in the superficial dorsal horn but preservation of primary afferents and sp

69 al funiculi and in the dorsal surface of the dorsal horn, but A6 axons take predominantly the dorsal

70 lates cytokine expression in the spinal cord dorsal horn by activating Wnt5a signaling.

71 microglia and reduced CGRP expression in the dorsal horn caudal to the lesion.

72 nset neuropathic pain behavior and increased dorsal horn cell sensitivity to cutaneous mechanical and

73 Our data suggest that this newly identified dorsal horn cholinergic system in monkeys is the source

74 ntification of key components of the elusive dorsal horn circuit for mechanical allodynia.

75 iew highlights the complexity of superficial dorsal horn circuitry and addresses the question whether

76 ressing MGE-derived neuronal precursors into dorsal horn circuitry in intact, adult mice with short-

77 to the presence of cell type specificity in dorsal horn circuitry, and show how the study of connect

78 expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal

79 By examining the dorsal horn circuits that underlie the transmission of "

80 tonin system in rostral ventromedial medulla-dorsal horn circuits.

81 functional glycinergic inhibition in newborn dorsal horn circuits: Dorsal horn receptive fields and a

82 us of processes in superficial layers of the dorsal horn, commissural neurons in the intermediate are

83 YAP and TAZ distribution in the spinal cord dorsal horn consistent with their distinctive associatio

84 and mu-opioid receptors (MOR) in the spinal dorsal horn constitutively repress the expression of syn

85 The superficial spinal dorsal horn contains a heterogeneous population of neuro

86 ology and number of cells in the spinal cord dorsal horn could change following peripheral nerve inju

87 ble of enhancing glycinergic tone within the dorsal horn could obtund nociceptor signaling to the bra

88 ing protein expression within neurons of the dorsal horn despite continued up-regulation of the chara

89 atergic dorsal horn neurons and critical for dorsal horn development, is expressed in nociceptive dor

90 signaling and the descending control of the dorsal horn (DH) by brain regions such as the periaquedu

91 ns antagonize each other through spinal cord dorsal horn (DH) gating neurons.

92 onic afferent central terminals (CACTs), the dorsal horn (DH) neurons activated by colonic stimuli in

93 ABSTRACT: The dorsal horn (DH) of the spinal cord is an important site

94 (T-channels) in synaptic transmission in the dorsal horn (DH) of the spinal cord using patch-clamp re

95 involves changes in sensory circuits of the dorsal horn (DH) where nociceptive inputs integrate for

96 ociated regions of the CNS, including in the dorsal horn (DH), its contribution to pain remains undef

97 cated in Clarke's column (ccDSCT) and in the dorsal horn (dhDSCT) and ventral spinocerebellar tract (

98 , we show that multiple microcircuits in the dorsal horn encode this form of pain.

99 ons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic interneurons.

100 while pregabalin significantly reduced deep dorsal horn evoked neuronal responses in animals treated

101 We conclude that different subsets of dorsal horn excitatory interneurons contribute to tissue

102 In addition, Y2 antagonism increased dorsal horn expression of Fos and phosphorylated form of

103 pect of the superficial medullary and spinal dorsal horn from the trigeminal subnucleus caudalis to C

104 hological pain likely via modulation of deep dorsal horn GABAergic neurons.SIGNIFICANCE STATEMENT Pai

105 ibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is essential in

106 on in dorsal root ganglion neurons, enhanced dorsal horn glutamate release from primary afferents, en

107 cord TRPV1-immunoreactive terminals, altered dorsal horn GRP immunoreactivity.

108 calization of these receptor subtypes in the dorsal horn has not been fully resolved.

109 in the inner part of lamina II (IIi ) of the dorsal horn, has been implicated in the expression of ta

110 Excitatory interneurons in the dorsal horn have been shown to possess I(A) currents, wh

111 ivity for D1 in synaptic compartment (P3) in dorsal horn homogenates and presynaptic met-enkephalin-c

112 eased immunoreactivity for met-enkephalin in dorsal horn homogenates, which was dose-dependently atte

113 ctivations in the middle part of ipsilateral dorsal horn (iDH), along with significantly weaker activ

114 reach adolescence (postnatal day 25-30), the dorsal horn immune profile switches from an anti-inflamm

115 DA) receptor and PKCgamma in the spinal cord dorsal horn (immunohistochemistry; Western blot) was upr

116 teral pathway, a region of the sacral spinal dorsal horn important for the relay of pelvic visceral a

117 s and also within neurons of the spinal cord dorsal horn in a pattern complementing, yet distinct fro

118 ange (WDR) neurons within lamina IV-V of the dorsal horn in diabetes.

119 amina II but not lamina I of the spinal cord dorsal horn in nerve-injured versus control animals, sug

120 matergic synaptic transmission in the spinal dorsal horn in rats with neuropathic pain induced by lig

121 ay was activated in astrocytes of the spinal dorsal horn in the SNL model.

122 n the superficial laminae of the spinal cord dorsal horn in TOW mice, specifically in GABAergic inhib

123 ssion at C-fiber synapses in rat spinal cord dorsal horn in vivo.

124 nto DRGs, and microglia activation in spinal dorsal horns in wild-type mice, but all these changes we

125 roinflammatory immune response in the spinal dorsal horn, infant nerve injury triggers an anti-inflam

126 afferent input influences the maturation of dorsal horn inhibition is not known.

127 lectively in presynaptic Abeta-LTMRs removes dorsal horn inhibition that otherwise prevents Abeta-LTM

128 new genetic markers for specific subsets of dorsal horn inhibitory interneurons.

129 These results indicate that dorsal horn inhibitory synapses follow different rules o

130 s integration underlies normalization of the dorsal horn inhibitory tone after injury and may be resp

131 "closes" the gate by engaging a superficial dorsal horn interneuron that inhibits the firing of proj

132 To what extent dorsal horn interneurons contribute to the modality spec

133 d "itch" circuits via excitatory superficial dorsal horn interneurons that express GRP and that likel

134 in both the dorsal root ganglion and spinal dorsal horn ipsilateral to the injury site in neuropathi

135 aberrant terminal label was observed in the dorsal horn ipsilateral to the lesion, indicating sprout

136 Lamina I of the spinal dorsal horn is a major site of integration and transmiss

137 The deep dorsal horn is a poorly characterized spinal cord region

138 whether their exclusion from the superficial dorsal horn is an important aspect of neural circuitry.

139 ore generally, local connectivity within the dorsal horn is governed by rules relating the position o

140 odels suggests that neuronal loss within the dorsal horn is involved in the development and/or mainte

141 a discrete population of neurons in the deep dorsal horn is required for mechanical pain and that act

142 -95-pNR2B coprecipitation in the ipsilateral dorsal horn (L4-L5).

143 h of R-profiles within the Vc/C2 superficial dorsal horn (lamina I) 3 weeks post-CCI-ION.

144 (sites that give local synaptic inputs) for dorsal horn laminae III-IV neurons, in parasagittal and

145 bserved in central terminals innervating all dorsal horn laminae.

146 ing neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LT

147 In the dorsal horn, most NECAB1/2 neurons are glutamatergic.

148 n lateral lamina I and in lamina IV/V of the dorsal horn (n = 5).

149 By dissecting the cellular composition of dorsal-horn networks, studies are beginning to elucidate

150 We found that when dorsal horn neurokinin 1 receptor-positive neurons or de

151 receptors (GlyRs) play a role in control of dorsal horn neuron excitability, their relative contribu

152 ons preferentially target certain classes of dorsal horn neuron.

153 chanical and thermal hypersensitivity of rat dorsal horn neurones and enhanced perceptual responses o

154 measured as augmented evoked activity of rat dorsal horn neurones and increased perceptual responses

155 nist, ketanserin, on the evoked responses of dorsal horn neurones to electrical, mechanical and therm

156 Here we show that in spinal dorsal horn neurons >80% of mGluR5 is intracellular, of

157 ranscriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the develop

158 ein translation, was activated in rat spinal dorsal horn neurons after repeated intrathecal morphine

159 stribution in primary afferent terminals and dorsal horn neurons allows for multiple, circuit-specifi

160 ously shown to be expressed in glutamatergic dorsal horn neurons and critical for dorsal horn develop

161 We investigated the role of spinal dorsal horn neurons and descending circuitry in plastici

162 reveal that a novel SOC signal is present in dorsal horn neurons and may play an important role in pa

163 orn development, is expressed in nociceptive dorsal horn neurons and that its deletion results in the

164 ly sufficient for noxious heat activation of dorsal horn neurons and that, despite their polymodal pr

165 m-chloride cotransporter KCC2 in spinal cord dorsal horn neurons are a major contributor to the centr

166 that cholinergic boutons are presynaptic to dorsal horn neurons as well as to the terminals of senso

167 n results in the specific loss of excitatory dorsal horn neurons by apoptosis, without any effect on

168 ion of hyperexcitability of nociceptive deep dorsal horn neurons by TNF-alpha largely depends on the

169 Importantly, wide dynamic-range dorsal horn neurons continued to faithfully encode A-noc

170 of evoked NMDAR-EPSCs and NMDAR currents of dorsal horn neurons elicited by puff NMDA application.

171 To characterize the subtypes of dorsal horn neurons engaged by dopamine signaling in the

172 excitatory postsynaptic currents (EPSCs) of dorsal horn neurons evoked by dorsal root stimulation in

173 excitatory postsynaptic currents (EPSCs) of dorsal horn neurons evoked by dorsal root stimulation.

174 c excitatory postsynaptic currents of spinal dorsal horn neurons evoked from the dorsal root.

175 iation of glycine-activated current in mouse dorsal horn neurons from spinal cord slices.

176 tivation of non-NMDA receptors in the spinal dorsal horn neurons in neuropathic pain conditions.

177 ary sensory neurons and nociceptive input to dorsal horn neurons in neuropathic pain.

178 tsynaptic currents (EPSCs) were performed on dorsal horn neurons in rat spinal cord slices.

179 significantly potentiate glycine currents in dorsal horn neurons in rat spinal cord slices.

180 thresholds of lamina IV-V wide dynamic-range dorsal horn neurons in response to both A- and C-nocicep

181 synaptic excitatory postsynaptic currents of dorsal horn neurons in SNL rats.

182 pain transmission by measuring activation of dorsal horn neurons in the spinal cord in response to no

183 n processed in individual wide dynamic-range dorsal horn neurons is modulated by prostanergic descend

184 s of normal function in parvalbumin positive dorsal horn neurons may result in the development of tac

185 PSCs and the frequency of miniature EPSCs in dorsal horn neurons of FK506-treated rats.

186 ular recordings from mechanonociceptive deep dorsal horn neurons of normal rats in vivo, we found tha

187 rents (EPSCs) were recorded from superficial dorsal horn neurons of spinal slices taken from young ad

188 we made extracellular recordings from lumbar dorsal horn neurons of the mouse in response to graded t

189 d, as nothing is known about how superficial dorsal horn neurons process sensory input from muscle ve

190 of the serotonin receptor 2A (5-HT(2A)R) in dorsal horn neurons promotes spinal hyperexcitation and

191 lecular identity and function in spinal cord dorsal horn neurons remain elusive.

192 Since many PPD-expressing dorsal horn neurons respond to noxious stimulation, this

193 iniature excitatory postsynaptic currents in dorsal horn neurons that could be blocked by gabapentin.

194 e activity of second-order trigeminovascular dorsal horn neurons that receive peripheral input from t

195 her ablation procedure reduced the number of dorsal horn neurons that responded to noxious cold.

196 excitatory and inhibitory synaptic inputs to dorsal horn neurons using whole-cell recordings in rat s

197 urrents elicited by puff NMDA application to dorsal horn neurons was also significantly greater in FK

198 y of spontaneous and miniature EPSCs in most dorsal horn neurons was profoundly increased in FK506-tr

199 Dorsal horn neurons with stronger C-nociceptor input wer

200 afferent terminals vs inhibitory synapses on dorsal horn neurons).

201 w a loss of a subpopulation of glutamatergic dorsal horn neurons, abnormal sensory afferent innervati

202 at ATP induces ROS production in spinal cord dorsal horn neurons, an effect eliminated by ROS scaveng

203 g in the primary sensory neurons, the spinal dorsal horn neurons, and astrocytes.

204 us stimuli activate overlapping ensembles of dorsal horn neurons, and that stimulus type and intensit

205 hreshold neurons, but not wide dynamic-range dorsal horn neurons, and why it may not be effective in

206 mouse has abundant expression in superficial dorsal horn neurons, but not in the DRG.

207 abeled only about 5% of the normal number of dorsal horn neurons, mainly in lamina IV, below the leve

208 to enhance the frequency of EPSCs in spinal dorsal horn neurons, suggesting an increased excitatory

209 in vivo potentiates glycinergic synapses on dorsal horn neurons, suggesting that GlyR LTP is trigger

210 ory synaptic inputs to mouse lamina I spinal dorsal horn neurons, using laser scanning photostimulati

211 the spinal cord and oxidative DNA damage in dorsal horn neurons.

212 larizing shift in GABA reversal potential of dorsal horn neurons.

213 Ca(2+) release-activated Ca(2+) channels in dorsal horn neurons.

214 e, we demonstrate that SOCs are expressed in dorsal horn neurons.

215 ion of SOCs produced an excitatory action in dorsal horn neurons.

216 lutamatergic input from primary afferents to dorsal horn neurons.

217 stent hyperexcitability of these superficial dorsal horn neurons.

218 activity-dependent Fos expression in spinal dorsal horn neurons.

219 mbined with markers of primary afferents and dorsal horn neurons.

220 be coexpressed in postsynaptic densities in dorsal horn neurons.

221 ine-mediated currents (E(glycine)) in spinal dorsal horn neurons.

222 signal-regulated kinase (ERK) in superficial dorsal horn neurons.

223 egulating central excitability within spinal dorsal horn nociceptive circuitry.

224 heat, but reduced the firing of superficial dorsal horn nociceptive-specific neurons in response to

225 that were significantly downregulated in the dorsal horn of Ptf1a(-/-) mice.

226 ured spinal cord neurons and the superficial dorsal horn of rat spinal cord slices.

227 area synapse on second-order neurons in the dorsal horn of subnucleus caudalis and cervical C1/C2 sp

228 Large numbers of neurons in the dorsal horn of the cervical spinal cord were labeled, es

229 cholinergic fibers in laminae II-III of the dorsal horn of the macaque monkey.

230 Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following infla

231 eased activation of astrocytes in the lumbar dorsal horn of the spinal cord due to SNI.

232 ibitory neurotransmission in the superficial dorsal horn of the spinal cord is thought to contribute

233 munoreactive varicosities in the superficial dorsal horn of the spinal cord was 15-30% lower, ipsilat

234 ceptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically invol

235 Here we report that in the superficial dorsal horn of the spinal cord, glycinergic synapses on

236 ial early enhancement of pain signals in the dorsal horn of the spinal cord, we combined a nocebo hea

237 ond-order nociceptive neurons located in the dorsal horn of the spinal cord.

238 n of cholinergic interneurons located in the dorsal horn of the spinal cord.

239 ced pain-related activity in the ipsilateral dorsal horn of the spinal cord.

240 by c-Fos labeling in laminae I and II of the dorsal horn of the spinal cord.

241 uli at the primary synaptic afferents in the dorsal horn of the spinal cord.

242 gulation of sensory information entering the dorsal horn of the spinal cord.

243 to modulate incoming noxious stimuli in the dorsal horn of the spinal cord.

244 are initially integrated in the superficial dorsal horn of the spinal cord.

245 thers, but also in the intermediate zone and dorsal horn of the spinal gray matter.

246 The dorsal horn of the thoracic spinal cords of rats with CP

247 Each type was counted within the superficial dorsal horn of the Vc/C2 and the means from each rat wer

248 d host sensory axons only in the spinal cord dorsal horn of treated animals.

249 er of excitatory synapses in the superficial dorsal horn of Vc/C2 could lead to enhanced activation o

250 d genome-wide expression profiling of spinal dorsal horns of wild-type mice and of two strains of tra

251 tral nucleus of the amygdala and spinal cord dorsal horn only in mice with ongoing allodynia.

252 n active, constitutive immune suppression of dorsal horn pain activity.

253 Inhibitory interneurons of the spinal dorsal horn play critical roles in the processing of nox

254 hydrobromide (TCB-2) enhanced C-fiber-evoked dorsal horn potentials after SNL, which was prevented by

255 In the spinal cord dorsal horn, presynaptic GABA(A) receptors (GABA(A)Rs) i

256 peripheral afferent arbor morphologies, and dorsal horn projections; and (3) the consequences for th

257 inhibition in newborn dorsal horn circuits: Dorsal horn receptive fields and afferent-evoked excitat

258 and its upstream pathway in the spinal cord dorsal horn (SCDH).

259 ins in postmortem tissues of the spinal cord dorsal horn (SDH) from HIV-1/acquired immunodeficiency s

260 re the glial reaction profiles in the spinal dorsal horn (SDH) from three cohorts of sex- and age-mat

261 duced hyperesthesia, locomotor deficits, and dorsal horn (SDH) glial changes after SCI, similar to tr

262 at activation of ERK signaling in the spinal dorsal horn (SDH) is required selectively for histamine-

263 citability of neurons within the superficial dorsal horn (SDH) of the spinal cord is thought to under

264 Neurons in the superficial dorsal horn (SDH) of the spinal cord play an important r

265 tivity within the developing rat superficial dorsal horn (SDH).

266 ciceptors and their terminals in superficial dorsal horn (SDH; laminae I-II) constitute two separate

267 upon the maturation of C-fiber inputs to the dorsal horn: selective block of afferent C fibers in pos

268 lanced excitation and inhibition achieved in dorsal horn sensory circuits.

269 tors, and prevented Homer1a up-regulation in dorsal horn sensory neurons.

270 tsynaptic density fractions from spinal cord dorsal horns showed an increase in GluA4 expression and

271 n neuropathic pain, central sensitization of dorsal horn spinothalamic tract (STT) neurons is a major

272 rostral, as in other species, into cervical dorsal horn, subnucleus caudalis, subnucleus interpolari

273 ural circuits related to pain and SCS in the dorsal horn, supraspinal structures, and the Pain Matrix

274 th and regulate glutamate release at the DRG-dorsal horn synapse.

275 d modulation of glutamate release at the DRG-dorsal horn synapse.

276 neurotransmission at spinal cord superficial dorsal horn synapses in a rat partial nerve-injury model

277 A preferential ability of the dorsal horn synaptic network to amplify nociceptive inpu

278 , A fibers projected to deeper layers of the dorsal horn than did C fibers.

279 tion of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuou

280 rimary afferent terminals in the superficial dorsal horn that co-expressed the neuropeptide CGRP.

281 ubset of neurons in lamina III and IV of the dorsal horn that coexpress PAX2, a transcription factor

282 ith ceramide and S1P formation in the spinal dorsal horn that corresponded with the engagement of S1P

283 remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and struct

284 ns (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxiou

285 ontribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated di

286 branches move from medial to lateral in the dorsal horn to dorsomedial to ventrolateral in nTTD, whe

287 ed mechanosensory columns of the spinal cord dorsal horn underlies the nervous system's enormous capa

288 ile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT3 receptors (5-

289 ptors depresses synaptic input to the spinal dorsal horn, via the inhibition of voltage-gated calcium

290 creased Cavalpha2delta1 in Vc/C2 superficial dorsal horn was associated with increased excitatory syn

291 For example, in sagittal sections the dorsal horn was significantly stiffer than the ventral h

292 This differs from GABAA receptors in the dorsal horn, where different receptor stoichiometries un

293 marily innervated layers I, II, and V of the dorsal horn, where pain-sensory afferents terminate.

294 n channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduc

295 interneurons in lamina IIi of the medullary dorsal horn, where they constitute 1/3 of total neurons.

296 mice lack all inhibitory interneurons in the dorsal horn, whereas only the late-born inhibitory inter

297 n of excitatory synaptic transmission in the dorsal horn, which contributes to pain hypersensitivity

298 ced in vivo electrophysiological response of dorsal horn wide dynamic range neurons.

299 the effect of inhibition of VL-PAG COX-1 on dorsal horn wide dynamic-range neurons evoked by C- vs.

300 lated by Hippo signaling, in the spinal cord dorsal horn would be altered by chronic constriction sci