ライフサイエンスコーパス: egress

1 very-low-density lipoprotein (VLDL) for its egress.

2 cretion of adhesins, motility, invasion, and egress.

3 not ubiquitinate eVP40 or enhance eVP40 VLP egress.

4 parasites, we resolve intermediate steps in egress.

5 nd to host cell plasma membrane lysis during egress.

6 arrow time window within the final stages of egress.

7 lieve its suppressive activity to potentiate egress.

8 cytoplasmic fenestrations for water and ion egress.

9 trols the maturation program required for BM egress.

10 teractor, ITCH, that regulates VP40-mediated egress.

11 ion but also in membrane disruption and cell egress.

12 ing regulators of cGMP metabolism to control egress.

13 the nuclear envelope, their site of nuclear egress.

14 cells, disrupts the S1P gradient, preventing egress.

15 V-1) remodels nuclear membranes during virus egress.

16 to rescue the phenotype of decreased thymic egress.

17 ges of infection through virion assembly and egress.

18 dentified small-molecule inhibitors of virus egress.

19 target for host-oriented inhibitors of EBOV egress.

20 quitination, and regulation of VP40-mediated egress.

21 odulate NE structure and promote EBV nuclear egress.

22 phosphate (S1P) receptors in human thymocyte egress.

23 is attributable to a defect in virus nuclear egress.

24 ight a new key chemokine for human thymocyte egress.

25 ntify DCs as metabolic gatekeepers of thymic egress.

26 ing LCAT show increased virulence and faster egress.

27 hrocytes for compounds that inhibit parasite egress.

28 ing additional roles for UL97 during nuclear egress.

29 host erythrocyte rupture to enable parasite egress.

30 tered nuclear morphology and increased viral egress.

31 as an alternative L-domain to promote virus egress.

32 ructural protein that is critical for virion egress.

33 s, including cellular attachment, entry, and egress.

34 by the parasite protease SUB1 just prior to egress.

35 cilitates reovirus T1L bloodstream entry and egress.

36 cells via a poorly understood process called egress.

37 lamina, which would otherwise impede nuclear egress.

38 ne-phosphate receptor required for thymocyte egress.

39 rions through vesicles during maturation and egress.

40 oth parasites and host simultaneously during egress.

41 phate (S1P) is a key regulator of lymphocyte egress.

42 derstanding of the mechanism of HCMV nuclear egress.

43 way for lateral substrate access and product egress.

44 aid in the detailed understanding of nuclear egress.

45 ation and was initiated prior to bone marrow egress.

46 nuclear envelope, the site of their nuclear egress.

47 te endocytic pathways in HCMV maturation and egress.

48 D103 expression, proteins that prevent cells egress.

49 replication complex vesicles cannot form or egress.

50 exhibited defects in lymph node entrance and egress.

51 ors and baculoviruses during viral entry and egress.

52 ucleocapsids in the perinuclear space during egress.

53 nvelopment of the cytoplasmic virion and its egress.

54 orafenib, was found to be important for RVFV egress.

55 se that ubiquitinates VP40 and regulates VLP egress.

56 important for malaria parasite invasion and egress.

57 sue dissemination and host cell invasion and egress.

58 gumentation, secondary envelopment, and then egress.

59 nclosing erythrocyte membrane shortly before egress.

60 in increased vascular permeability and HSPC egress.

61 exhibits increased local disorder, and water egresses.

62 s in the gene Suppressor of Ca(2+)-dependent Egress 1 (SCE1).

63 alpha-Toc directly inhibited neutrophil egress across epithelial cell monolayers in vitro in res

64 rial cGMP-dependent protein kinase, triggers egress, activating malarial proteases and other effector

65 c antagonism also prevented splenic monocyte egress after acute stress.

66 toplasm in an unusual process termed nuclear egress, an attractive target for antiviral therapy.

67 previous view of PKG-triggered initiation of egress and a gradual dismantling of the host erythrocyte

68 glia are removed by a dual mechanism of cell egress and apoptosis to re-establish the stable microgli

69 teins participate in motility, invasion, and egress and are subjected to proteolytic maturation prior

70 udded virus (BV) into the host cell and (ii) egress and budding of nucleocapsids newly produced from

71 may be involved in baculovirus nucleocapsid egress and BV formation.

72 erts PA and DAG, and whose depletion impairs egress and causes parasite death.

73 f Francisella spp. and facilitating cellular egress and cell-to-cell spread in the case of Brucella s

74 intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understo

75 r, we find that a TCR is required for thymic egress and development of peripheral murine tumours, yet

76 sufficient to significantly inhibit parasite egress and dispersion.

77 The series targets both merozoite egress and erythrocyte invasion, but crucially, also blo

78 leocapsid-associated protein required for BV egress and has previously been shown to be associated wi

79 One of these enhancers blocks parasite egress and invasion and shows strong antiparasitic activ

80 and recombinantly active PMIX and PMX cleave egress and invasion factors in a 49c-sensitive manner.

81 In contrast, PMX is essential for both egress and invasion, controlling maturation of the subti

82 ng in malaria parasites, including host cell egress and invasion, protein secretion, motility and cel

83 rocesses that regulate dendritic cell tissue egress and migration across the lymphatic endothelium ar

84 nd respond to cell contact to polarize viral egress and promote cell-cell spread.

85 ile suppressing genes associated with tissue egress and recirculation.

86 unity for a new strategy to inhibit parasite egress and replication.

87 ted protein 1 (TRP1) is important for oocyst egress and salivary gland invasion, and hence for the tr

88 -oocyst motility and subsequently sporozoite egress and salivary gland invasion.

89 nt, our findings identify an initial step in egress and show that host cell cytoskeleton breakdown is

90 sequently, HMGB1-release induced bone marrow egress and splenic proliferation of bone marrow-derived

91 Alix) that are important for efficient virus egress and spread.

92 n the required contents of this envelope for egress and subsequent attachment and entry.

93 tein-protein interaction involved in nuclear egress and suggest that NEC subunit interactions can be

94 e Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.

95 f intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense agains

96 expression of CD69 that regulates lymphocyte egress and the ability to produce IL-2 and to survive.

97 ening is hypothesized to facilitate parasite egress and the consequent dissemination of released mero

98 ine 1-phosphate receptor 1 (S1PR1) in T cell egress and the regulation of S1P gradients between lymph

99 wing, in real time, Ca(2+) signals preceding egress and their direct link with motility, an essential

100 1P-Rs) play a role in mature human thymocyte egress and to identify the thymocyte population or popul

101 heckpoint in spermatogenesis, determines the egress and tolerogenicity of MGCA.

102 eVP40 and a subsequent increase in eVP40 VLP egress, and (iii) an enzymatically inactive mutant of WW

103 l CDPKs play a role in controlling invasion, egress, and cell division in T. gondii, the roles of mos

104 it remained throughout maturation, merozoite egress, and host cell invasion.

105 ficiently processed MSP1 mutant show delayed egress, and merozoites lacking surface-bound MSP1 displa

106 omplex (NEC), which is essential for nuclear egress, and we obtained evidence that this phosphorylati

107 isms involved in virus particle assembly and egress are still elusive.

108 n at effector sites, revealing T cell tissue egress as a novel control point of inflammation.

109 Following thymic maturation, T cells egress as recent thymic emigrants to peripheral lymphoid

110 in 3 (NS3) plays a key role in mediating BTV egress as well as in impeding the in vitro synthesis of

111 s to ensure efficient entry, maturation, and egress as well as the avoidance of antiviral defenses th

112 They egressed as cargo in residual bodies and maintained Treg

113 apicomplexan gliding motility, invasion, and egress by connecting the micronemal adhesins with the ac

114 Heparin blocks egress by interacting with both the surface of intra-ery

115 that sorafenib causes a disruption in viral egress by targeting VCP and the secretory pathway, resul

116 sviruses assemble capsids in the nucleus and egress by unconventional vesicle-mediated trafficking th

117 to form daughter cells that eventually exit (egress) by sequential rupture of the vacuole and erythro

118 The harvested scaffold egress can also be expanded and differentiated to the re

119 te this CD31(-)CD45RA(-) subpopulation, most egress-capable mature CD45RA(+) CD4 SP thymocytes expres

120 To examine only egress, cells were transfected with the double-stranded

121 l budding process is mediated by the nuclear egress complex (NEC) composed of two conserved viral pro

122 , we discovered that the herpesvirus nuclear egress complex (NEC) could bud synthetic membranes in vi

123 Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocaps

124 pUL53 heterodimerize and form a core nuclear egress complex (NEC), which is anchored to the inner nuc

125 d that UL97 phosphorylates the viral nuclear egress complex (NEC), which is essential for nuclear egr

126 d by two viral proteins, forming the nuclear egress complex (NEC).

127 While the nuclear egress complex mediates capsid transit across the nuclea

128 nteractions may suggest the formation of an "egress complex" involved in the nuclear release or trans

129 opose that these viral proteins may form an "egress complex" that is involved in recruiting ESCRT-III

130 lular p32, protein kinase C, and the nuclear egress complex.

131 rulence factor of HSV-1, facilitates nuclear egress cooperatively with cellular p32, protein kinase C

132 lacking surface-bound MSP1 display a severe egress defect.

133 Despite the thymic and lymph node egress defects, sphingosine-1-phosphate signaling was no

134 to isolate gain-of-function mutants from an egress-deficient cdpk3 knockout strain.

135 ow reduced burst expansion, rapid peripheral egress, delayed antigen clearance and continuous activat

136 , presumably by facilitating replication and egress depending on the developmental stage of the paras

137 This untimely egress depends on host cell acidification.

138 n recruiting ESCRT-III components to a virus egress domain on the nuclear membrane.IMPORTANCE The ESC

139 nent and suppressor of Ca(2+)-dependent cell egress during Toxoplasma lytic growth.

140 not explain the observed virus-like particle egress enhancement.

141 nger distances, thereby facilitating nuclear egress for a larger fraction of capsids.

142 tact to support polarized viral assembly and egress for efficient cell-cell spread.

143 f aquaporin-4 plays a critical role in water egress from brain; and 3) hypertonic saline attenuates b

144 Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary for the

145 anchor-truncated form, inhibited HBV virion egress from HepAD38 cells.

146 hemical inhibition of PKG decreases parasite egress from hepatocytes by inhibiting either the formati

147 suggests that IFN-alpha inhibits HBV virion egress from hepatocytes through the induction of tetheri

148 covered mutants that regained the ability to egress from host cells that harbored mutations in the ge

149 igration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced path

150 virulence in animals, and exhibit delays in egress from host cells.

151 s are necessary for events like motility and egress from host cells.

152 ty between cells, as well as invasion of and egress from host cells.

153 es not bind cAMP triggers premature parasite egress from infected cells followed by serial invasion a

154 site mutants did not adversely affect virion egress from infected cells.

155 erstanding of how these viruses assemble and egress from infected cells.

156 ified disparate effects on infectious virion egress from infected cells.

157 omotes inflammation by preventing macrophage egress from inflamed sites and is required for osteoclas

158 Thus, in addition to promoting egress from its human host, RpoS may also prime this pat

159 that expanded Vgamma4(+) gammadeltaT17 cells egress from LNs in a fingolimod (FTY720)-sensitive manne

160 oattractant receptors also control leukocyte egress from lymphoid organs and peripheral tissues.

161 this study, we show that ACKR4 also aids APC egress from mouse skin under steady-state and inflammato

162 phate (S1P) receptors that enable homing and egress from secondary lymphoid organs (SLO).

163 hate receptor 1) agonists prevent lymphocyte egress from secondary lymphoid organs and cause a reduct

164 ammation when it facilitates Langerhans cell egress from skin and enables the accumulation of dermal

165 r cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking

166 -EPCR-PAR1 signaling reduces progenitor cell egress from the bone marrow, increases retention of bone

167 knockout mice exhibit an accelerated B cell egress from the bone marrow, resulting in the accumulati

168 L-33 plays a critical role in promoting ILC2 egress from the bone marrow.

169 step in morphogenesis of vaccinia virus and egress from the cell.

170 ulate the complex process of effector T-cell egress from the dLN after infection are poorly understoo

171 Viral clearance requires effector T-cell egress from the draining lymph node (dLN).

172 itis induction, and we found that Th17 cells egress from the gut in a S1P-receptor-1-dependent fashio

173 ced liver:lymph S1P gradient and limited HSC egress from the liver.

174 rnica multiple nucleopolyhedrovirus (AcMNPV) egress from the nucleus to the plasma membrane, leading

175 e an effective intraretinal barrier to fluid egress from the optic disc cavitation.

176 Deficiency of alphaMbeta2 suppressed Mvarphi egress from the peritoneal cavity, decreased the product

177 s the chemokine receptor CCR7, which directs egress from the skin via dermal lymphatic vessels and ex

178 T cell egress from the thymus is essential for adaptive immunit

179 able for thymocyte survival and development, egress from the thymus, and survival of recent thymic em

180 s binding to the coreceptors promotes T cell egress from these tissues.

181 l proteins, ultimately effecting cholesterol egress from this compartment.

182 le is known about factors that affect T cell egress from tissues.

183 oteases of the plasmepsin family in parasite egress from, and invasion into, RBCs.

184 Nonsequestered MCGA (NS-MGCA) egressed from normal tubules, as evidenced by their abil

185 When Toxoplasma gondii egresses from the host cell, glyceraldehyde-3-phosphate

186 governs the types of reactive oxygen species egressing from the organelle to affect cellular signalli

187 occur in the cytosol of the parasite during egress, gliding, and invasion, which are critical steps

188 he endosome to cause membrane fusion; during egress, HA contributes to virus assembly and morphology.

189 During nuclear egress, herpesvirus capsids bud at the inner nuclear mem

190 viruses, M proteins drive viral assembly and egress; however, some paramyxoviral glycoproteins have b

191 ous WWP1 resulted in inhibition of eVP40 VLP egress, (ii) coexpression of WWP1 and eVP40 resulted in

192 nation, and regulation of EBOV VP40-mediated egress.IMPORTANCE Ebola virus (EBOV) is a high-priority,

193 onducive to productive viral replication and egress.IMPORTANCE HPV genome amplification and capsid fo

194 ion is essential for motility, invasion, and egress in apicomplexan parasites.

195 marizes our current understanding of nuclear egress in herpesviruses, examines the experimental evide

196 stalk between PKA and PKG pathways to govern egress in T. gondii.

197 also decreased virus production and nuclear egress in the absence of maribavir.

198 es multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and parti

199 ved progressive stages of virus assembly and egress, including flower-like flat Gag lattice assemblie

200 cGMP-dependent protein kinase G (PKG) blocks egress induced by PKAc1 inactivation or environmental ac

201 Prior to entering the brain, iMOs must egress into the blood from the bone marrow through a mec

202 ting inflammatory and mesenchymal progenitor egress into the zone of injury.

203 the steps of virion assembly, transport, and egress involved in axonal spread.

204 ts support an exosome-like mechanism of eHAV egress involving endosomal budding of HAV capsids into m

205 HSV nuclear egress is a key step that determines the outcome of vira

206 amine actin tail formation, one of the viral egress mechanisms for cell-to-cell dissemination, and re

207 ame Syk kinase inhibitors suppress merozoite egress near the end of the parasite's intraerythrocytic

208 is a host restriction factor that blocks the egress of a variety of enveloped viruses through tetheri

209 iral transmembrane protein that inhibits the egress of a variety of enveloped viruses, was highly ind

210 y, these mutants were also unable to promote egress of accumulated intracellular cholesterol from npc

211 fCcl19 Thus, ACKR4 on stromal cells aids the egress of APCs from mouse skin, and, during inflammation

212 hinery, is necessary for efficient entry and egress of Autographa californica multiple nucleopolyhedr

213 is required for efficient entry and nuclear egress of budded virions of AcMNPV.IMPORTANCE Little is

214 ese results suggest their involvement in the egress of BV.

215 little has been known about how budding and egress of Ebola virus are mediated at the plasma membran

216 ESCRT) machinery is required for the nuclear egress of EBV.

217 We find that egress of Gna13 mutant GC B cells from lymph nodes in th

218 ystemic disease by driving the induction and egress of gut Tfh cells.

219 hrough signals that enhance the retention or egress of hematopoietic stem cells (HSCs) from bone marr

220 ear envelope dynamics as well as the nuclear egress of herpes simplex virus 1 (HSV-1).

221 cule with the unique ability to restrict the egress of human immunodeficiency virus (HIV) and other e

222 epeated injections of FTY720, which prevents egress of IgA-secreting cells from Peyer's patches.

223 l ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow.

224 Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the

225 during La Crosse Virus-induced encephalitis, egress of iMOs was surprisingly independent of CCR2, wit

226 culture progresses, whilst also facilitating egress of increasingly differentiated cells.

227 gh-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils.

228 s are key players in the endosomal/lysosomal egress of low-density lipoprotein-derived cholesterol.

229 xiety-like behavior that was associated with egress of Ly6C(hi) monocytes from the spleen.

230 IL-10 promoted lymphangiogenesis and faster egress of macrophages from inflamed corneas.

231 The mechanisms that govern the egress of mature thymocytes from the human thymus to the

232 ia-mediated CCR1 upregulation in driving the egress of multiple myeloma PCs from the bone marrow.

233 enter the activated/memory pool, continuous egress of new T lymphocytes from thymus is essential for

234 ned that SFB, by driving differentiation and egress of PP Tfh cells into systemic sites, boosted syst

235 or this trafficking, we investigated nuclear egress of progeny herpesvirus capsids where capsid envel

236 quired for efficient entry of BV and nuclear egress of progeny nucleocapsids of baculoviruses.

237 -I) are also necessary for efficient nuclear egress of progeny nucleocapsids.

238 mponents) are required for efficient nuclear egress of progeny nucleocapsids.

239 ted in a discernible effect on the entry and egress of progeny Sendai virus.

240 tion at the effector site reduced the tissue egress of proinflammatory Th1 cells in a mouse model of

241 e in rate constants for both the ingress and egress of substrate.

242 binding of the metal ion occludes access or egress of substrates.

243 ion with air tamponade was done resulting in egress of supra-descemet's fluid and DM appeared apposed

244 sphate receptor 1 (S1P1) is critical for the egress of T and B cells out of lymphoid organs.

245 The egress of the genome from SBPV virions is associated wit

246 ch abnormal lamina organization prevents the egress of these RNAs via NE budding.

247 dy revealed that S1P1 not only regulated the egress of Treg cells out of lymphoid organs and subseque

248 ering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.

249 ng of phagocytosed material, replication and egress of viral particles, and regulation of inflammator

250 ely cell-associated herpesvirus with limited egress of viral particles.

251 pression of VP40 leads to the production and egress of virus-like particles (VLPs) that accurately mi

252 hat ubiquitination of eVP40 by WWP1 enhances egress of VLPs and concomitantly decreases cellular leve

253 40, leading to enhanced ubiquitinylation and egress of VP40.

254 els in mammalian cells inhibits assembly and egress of VP40.

255 ng as a mechanism that restricts viral entry/egress or transports RABV particles through axons.IMPORT

256 lying the organ provides cues for neutrophil egress out of the bloodstream in a manner dependent upon

257 egulator for NK cell terminal maturation and egress out of the BM and that immature NK cells present

258 sfer of peripheral wild-type DCs rescued the egress phenotype of DC-specific SPL knockout mice.

259 duces effects that biologically resemble the egress phenotype taken on by CLL cells treated with idel

260 n assembly, and E2_G209 shows us a new viral egress phenotype.

261 This showed that the egress population is comprised of haematopoietic progeni

262 rove our understanding of the viral assembly/egress process and point to potential interactions with

263 tilize host cytoplasmic resources, elaborate egress processes have evolved to minimize the time betwe

264 mic dynein and kinesin during entry, whereas egressing progeny particles are exclusively transported

265 of two essential and conserved viral nuclear egress proteins, pUL50 and pUL53, is pivotal.

266 etrograde trafficking was required for virus egress rather than entry.

267 In this study, we showed that the egress receptor, sphingosine-1-phosphate (S1P) receptor

268 s between these proteins during assembly and egress remain to be fully understood.

269 cGMP-phosphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisation.

270 Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects o

271 tify putative substrate entrance and product egress routes within the enzyme, which are discussed in

272 he corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are

273 rectionally by kinesin motors towards distal egress sites.

274 s play a central role in virion assembly and egress, such that independent expression of VP40 leads t

275 failed to migrate within oocysts and did not egress, suggesting that TRP1 is a vital component of the

276 eractions are essential for normal thymocyte egress, T cell trafficking, and homeostasis.

277 hypoxia, protein deposition and immune cell egress that allows the development of a CNS-specific imm

278 invasion, parasite replication, and eventual egress that constitute the lytic cycle, as well as the w

279 During viral assembly and egress, the late domain within the p12 N terminus functi

280 1P1 receptor agonists to suppress lymphocyte egress, they have great potential as therapeutic agents

281 o investigate how Ca(2+) signaling activates egress through CDPKs, we performed a forward genetic scr

282 with endothelial cells in directing monocyte egress to bloodstream in response to infections.

283 tion in the fetal intestine and subsequently egress to the AF.

284 emonstrate that the CCR2 requirement for iMO egress to the blood is not universal for all viruses.

285 nyon virus also induced CCR2-independent iMO egress to the blood.

286 lls that have completed thymic selection and egress to the lymphoid periphery.

287 nstrating that S1P is required for thymocyte egress to the periphery, our data highlight a new key ch

288 key to inflammation, the relevance of T cell egress to this process is unknown.

289 In this Article, we report the egress transfer of aryl diazonium cation across the liqu

290 arin surprisingly inhibited malaria parasite egress, trapping merozoites within infected erythrocytes

291 During its egress, vaccinia virus transiently recruits AP-2 and cla

292 rving replication, virion assembly, or virus egress via budding out of infected cells.

293 the sympathetic nervous system regulate HSC egress via its niche, but how the brain communicates wit

294 alymphoid tissues by entering from blood and egressing via afferent lymph.

295 During entry and egress, viral capsids depend on microtubule-based molecu

296 ccumulated at efferent lymphatic vessels for egress, whereas high affinity-stimulated CD8(+) T cells

297 ds to T cell activation shortly after thymic egress, which is accompanied by a chronic inflammatory p

298 packaged with HPbetaCD, improved cholesterol egress, while Pluronic block copolymers capable of micel

299 lls were efficiently selected in the thymus, egressed with a naive phenotype, and could be exploited

300 ells exhibit a remarkable reproducibility of egress, with an increased output when directly compared