ライフサイエンスコーパス: endonuclease

1 ndency of Cas9 to develop a XNA-programmable endonuclease.

2 e-specific chromosomal DSB induced by I-SceI endonuclease.

3 remodeling, and act as a structure-specific endonuclease.

4 DD is a guanosine-specific, single-stranded endonuclease.

5 hereof were found to be potent inhibitors of endonuclease.

6 of cross-linked chromatin with a restriction endonuclease.

7 toward identifying novel inhibitors of pUL89 endonuclease.

8 d by EJ between two DSBs induced by the Cas9 endonuclease.

9 against foreign nucleic acids via RNA-guided endonucleases.

10 milar to the RuvC family of the RNase H-like endonucleases.

11 riction and yet point to diversity among the endonucleases.

12 of AgeI is novel among Type IIP restriction endonucleases.

13 s a member of the XPG/Rad2 family of 5'-flap endonucleases.

14 nding of newly discovered single-protein Cas endonucleases.

15 ge of structured precursor by RNase III-like endonucleases.

16 s generated in cells lacking the abasic site endonucleases.

17 cleavage preference in this family of homing endonucleases.

18 adruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but inefficiently cleaves,

19 drogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major oxidized DNA repair enz

20 downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be tested simultaneously, at

21 ication proteins, including the enzymes flap endonuclease 1 (FEN-1) and DNA ligase I that complete th

22 Human flap endonuclease 1 (FEN1) and related structure-specific 5'n

23 DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and

24 Flap endonuclease 1 (FEN1) phosphorylation is proposed to reg

25 Flap endonuclease 1 (FEN1) plays a crucial role in both DNA r

26 in the maturation of Okazaki fragments, flap endonuclease 1 (FEN1) removes the 5'-flap and maintains

27 strate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via

28 int to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

29 underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear.

30 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome

31 donuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221

32 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interactomes and prot

33 of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstra

34 mbinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 from human cell extracts

35 Flap endonuclease-1 (FEN1) belongs to the Rad2 family of stru

36 Flap endonuclease-1 (FEN1) is a multifunctional, structure-sp

37 Human flap endonuclease-1 (hFEN1) catalyzes the essential removal o

38 Inositol-requiring transmembrane kinase/endonuclease 1alpha (IRE1alpha), an ER stress sensor, is

39 e Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'-5' nucleolyt

40 ed modifications of CRISPR/CRISPR-associated endonuclease 9 (Cas9) technology to interrogate the func

41 In addition, the RNAP-GreA endonuclease accelerated transcription kinetics from oth

42 Structure-specific endonucleases act to repair potentially toxic structures

43 PabI-mediated restriction was promoted by AP endonuclease action in vivo or in vitro.

44 a is an endoplasmic reticulum (ER) localized endonuclease activated by misfolded proteins in the ER.

45 These mutations mapped to the endonuclease active site where they can directly impact

46 tory effects of WH on FEN1's flap versus gap endonuclease activities are consistent with the proposed

47 sive 5'-3' exonuclease and secondary 5'-flap endonuclease activities participate in various DNA repai

48 ing to diagnostic tools based on various Cas endonuclease activities.

49 des of action: the canonical guide-dependent endonuclease activity and a non-guided DNA endonuclease

50 lation at seDSBs, acting downstream of MRE11 endonuclease activity and in parallel with MRE11 exonucl

51 os that are consistent with the data: either endonuclease activity and subsequent error-prone repair

52 acterial genome before the toxic restriction endonuclease activity appears.

53 while ATP hydrolysis is essential for Mre11 endonuclease activity at blocked DNA ends.

54 unodeficiency virus RNase H, inhibited pUL89 endonuclease activity at low-micromolar concentrations.

55 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key fact

56 Additionally, Mre11 endonuclease activity is dispensable for resection in G1

57 We hypothesize that the pUL89 endonuclease activity is inhibited by known RNase H inhi

58 ational change; this in turn enhances the AP endonuclease activity of APE1.

59 We also show that endonuclease activity of apurinic/apyrimidinic endonucle

60 3' overhangs, but this DNA-PKcs-independent endonuclease activity of Artemis awaited confirmation.

61 been shown to play a role in activating the endonuclease activity of Cas9.

62 show increased motility is dependent on the endonuclease activity of hPMR1, and cells expressing act

63 The endonuclease activity of INT is mediated by its subunit

64 ocytogene prophages, were shown to block the endonuclease activity of type II-A Streptococcus pyogene

65 and human Utp24 proteins exhibited in vitro endonuclease activity on an RNA substrate containing yea

66 otein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure.

67 fied and characterized an inhibitor of pUL89 endonuclease activity that also inhibits human cytomegal

68 mismatch repair complex acting as the major endonuclease activity that resolves dHJs into crossovers

69 These dHJs are resolved by endonuclease activity to form exclusively crossovers, wh

70 n other betabetaalpha-Me members, suppresses endonuclease activity, but confers on hEXOG a strong 5'-

71 s double-flap endonuclease and gap-dependent endonuclease activity, but lacks exonuclease activity.

72 Sae2 has intrinsic endonuclease activity, but the role of this activity has

73 t endonuclease activity and a non-guided DNA endonuclease activity.

74 n DNASE2, associated with a loss of DNase II endonuclease activity.

75 PCNA are critical for the stimulation of the endonuclease activity.

76 stalled replication forks and stimulates its endonuclease activity.

77 nd the MR complex coordinate the melting and endonuclease activity.

78 Type IIP restriction endonuclease AgeI recognizes a palindromic sequence 5-A/

79 inhibitors of wild type and resistant mutant endonucleases along with their high-resolution co-crysta

80 We expressed and purified the BisI endonuclease and 34 BisI homologs identified in bacteria

81 The Mre11-Rad50-Nbs1 (MRN) endonuclease and Ctp1 (CtIP and Sae2 ortholog) are requi

82 Both endonuclease and exonuclease activities of MRE11 were re

83 first demonstration of a non-RNA-guided Cas9 endonuclease and first step towards eliminating the ribo

84 is an FEN1 homologue that shows double-flap endonuclease and gap-dependent endonuclease activity, bu

85 pUL89 is a viral ATPase and endonuclease and is an attractive target for anti-human

86 restriction-modification system in which the endonuclease and methyltransferase are encoded by a sing

87 t, DNA repair activities of DNA ligase, flap endonuclease and RNase H2 were monitored.

88 lusive presence of the KREN1, KREN2 or KREN3 endonuclease and their associated partner proteins.

89 thylation events using methylation-sensitive endonucleases and molecular beacon technology.

90 erminus (PIN) domain proteins are frequently endonucleases and the PIN domain protein Utp24 is essent

91 iniscent of the type IIE and IIF restriction endonucleases and the two systems may share mechanistic

92 itosome proteins, but interactions among the endonucleases and their partner proteins, and their inte

93 e the response of supercoiled DNA to nicking endonucleases and topoisomerases.

94 were transduced with CRISPR guide RNAs, Cas9 endonuclease, and a donor homology template.

95 fite treatment, (ii) cleavage by restriction endonucleases, and (iii) immuno/affinity reaction were d

96 mvent the normal essentiality of the editing endonucleases, and created cell lines in which both alle

97 noparticles were highly resistant to DNase I endonucleases, and degradation was carried out exclusive

98 r of PARP1 in the absence and presence of AP endonuclease (APE1) on AP DNA damage arrays.

99 epairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base ex

100 Homing endonucleases are sequence-tolerant DNA endonucleases th

101 RNA-guided CRISPR-Cas9 endonucleases are widely used for genome engineering, bu

102 The endonuclease Artemis improves joining efficiency by func

103 ydrazones in an enzymatic assay with PA-Nter endonuclease, as well as in cell-based influenza vRNP re

104 contain or lack polymerization barriers and endonuclease assays performed with varying ratios of end

105 Biophysical and cap-dependent endonuclease assays show that in solution the polymerase

106 h3 does not behave like a structure-specific endonuclease but forms polymers required to generate nic

107 and requires caspase-9, caspase-3/7 and the endonuclease CAD/DFF40.

108 The RNA-guided Cas9 endonuclease can be introduced into cells as a purified

109 The Cas9 endonuclease can be targeted to genomic sequences by pro

110 hort palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9)

111 reaks (DSBs) generated by the RNA-guided DNA endonuclease Cas9 determine how gene function is altered

112 to reveal the conformational dynamics of the endonuclease Cas9 during its activation toward catalysis

113 The CRISPR-associated endonuclease Cas9 from Streptococcus pyogenes (spCas9) a

114 Recently, the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered r

115 The RNA-guided endonuclease Cas9 generates a double-strand break at DNA

116 In this system, the endonuclease Cas9 generates double strand breaks in DNA

117 The RNA-guided DNA endonuclease Cas9 has emerged as a powerful tool for gen

118 The RNA-guided endonuclease Cas9 is a versatile genome-editing tool wit

119 stem, a single guide RNA (sgRNA) directs the endonuclease Cas9 to a targeted DNA sequence for site-sp

120 PR/Cas system, short RNA sequences guide the endonuclease Cas9 to any location in the genome, causing

121 (Cas) systems employ the dual RNA-guided DNA endonuclease Cas9 to defend against invading phages and

122 As an RNA-guided DNA endonuclease, Cas9 can be easily programmed to target ne

123 activity of two CRISPR-associated RNA-guided endonucleases, Cas9 and Cpf1, observing that Cpf1 has hi

124 Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis wi

125 Surprisingly, the MutLgamma (Mlh1/Mlh3) endonuclease caused R-loop-dependent CAG fragility, defi

126 The restriction endonuclease CglI from Corynebacterium glutamicum recogn

127 Ku, RPA, and nucleosomes, stimulate MRX-Sae2 endonuclease cleavage in vitro.

128 Because endonuclease cleavage is a likely point of regulation fo

129 ate the polymerization extension and nicking endonuclease cleavage reaction.

130 same sites protecting them from restriction endonuclease cleavage.

131 ndromic repeats (CRISPR)-associated 9 (Cas9) endonuclease cleaves double-stranded DNA sequences speci

132 The MUS81-EME1 endonuclease cleaves late replication intermediates at c

133 An endonuclease cleaves these into monomers, and a ligase s

134 which encodes a subunit of the tRNA splicing endonuclease complex.

135 systems - are sequence-specific RNA-directed endonuclease complexes that bind and cleave nucleic acid

136 We describe CRISPR-Cas9 endonuclease constructs that function as gene drive syst

137 we present an innovative approach exploiting endonuclease-controlled aggregation of plasmonic gold na

138 ing genome transplantation and tandem repeat endonuclease coupled cleavage (TREC) with yeast as an in

139 aced short palindromic repeats (CRISPR)-Cas9 endonucleases coupled with paired guide RNAs flanking th

140 The RNA-guided endonuclease Cpf1 is a promising tool for genome editing

141 lyadenylated histone mRNAs by recruiting the endonuclease CPSF-73 to histone pre-mRNA.

142 set of polyadenylation factors including the endonuclease CPSF73.

143 The RNA-guided endonuclease CRISPR-associated protein 9 (Cas9), in part

144 The revolutionary RNA-guided endonuclease CRISPR/Cas9 system has proven to be a power

145 comprises somatic deletions generated by L1 endonuclease cutting activity.

146 ease assays performed with varying ratios of endonuclease-deficient and endonuclease-proficient Mlh1-

147 he development of inhibitors of influenza PA endonuclease derived from lead compounds identified from

148 The novel endonuclease, designated as Endonulcease Q (EndoQ), reco

149 Using Sanger sequencing and endonuclease digestion, we identified and validated aden

150 to digest chromatin, instead relying on the endonuclease DNase I.

151 The endonuclease DNase1L2 and the exonuclease Trex2 are expr

152 he structure of the ZRANB3 HNH (His-Asn-His) endonuclease domain and provide a detailed analysis of i

153 ends on PCNA interaction with the C-terminal endonuclease domain of the MutLalpha PMS2 subunit.

154 iated virus (AAV) combines a DNA binding and endonuclease domain with a helicase-ATPase domain, which

155 anslocates approximately 90 A to bind to the endonuclease domain.

156 The auxiliary PB2 cap-binding and the PA endonuclease domains are both involved in cap snatching,

157 omoter-bound polymerase, the cap-binding and endonuclease domains are configured for cap snatching, w

158 o covalently link proteins and DNA using HUH-endonuclease domains as fusion partners (HUH-tags).

159 Using the isolated wild-type and mutant endonuclease domains, we used kinetics, inhibitor bindin

160 Two proteins with PIN endonuclease domains, yUtp24(Fcf1)/hUTP24 and yUtp23/hUT

161 ght on a conserved function of Vpr in a host endonuclease down-regulation.

162 enhanced with the use of the highly specific endonuclease dsDNase for an enzymatic amplification step

163 DNA double-strand breaks (DSBs) by the Spo11 endonuclease early in prophase I, at discrete regions in

164 structurally similar 'PD-D/ExK' restriction endonucleases (EcoRV and HincII) that also generate blun

165 Here we show that the 5'-endonuclease EEPD1 cleaves replication forks at the junc

166 This protein contains endonuclease (EN) and reverse transcriptase (RT) domains

167 nuclease family that includes the apoptotic endonuclease EndoG.

168 duced at Igkappa loci by the Rag1/Rag2 (RAG) endonuclease engage this DDR to modulate transcription o

169 ng claw that is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic cor

170 ined activities of polymerase B (PolB), flap endonuclease (Fen1), and DNA ligase are required to comp

171 cific DNA sequence for cleavage and the Cas9 endonuclease for introducing breaks in the double-strand

172 superfamily and is a paralog of CPSF-73, the endonuclease for pre-mRNA 3'-end processing.

173 rget gene expression and to recruit the Cas3 endonuclease for target degradation.

174 XD2, and Exo1 execute resection, and Artemis endonuclease functions to complete the process.

175 Furthermore, we show that endonuclease G, an apoptotic nuclease downstream of Casp

176 CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial facto

177 ein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities of FEN1 but retains DNA-bi

178 omologs of the resolvase (structure-specific endonuclease): GEN1/Yen1.

179 BRCA1, although dispensable for resection of endonuclease-generated DSB ends, is required for resecti

180 Cells lacking multiple endonucleases had altered editosome sedimentation on gly

181 The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances

182 Influenza virus PA endonuclease has recently emerged as an attractive targe

183 Although several candidate endonucleases have been implicated in cleavage of stalle

184 Many inteins contain a homing endonuclease (HEN) domain and rely on its activity for h

185 Some inteins contain a homing endonuclease (HEN) responsible for their propagation.

186 We find that ErrASE and T7 Endonuclease I are the most effective at decreasing aver

187 tially corrects C/G transversions whereas T7 Endonuclease I preferentially corrects A/T transversions

188 and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxida

189 Both heatshock-inducible endonuclease I-CreI expression and X-ray irradiation can

190 ates the ability of two DNA repair proteins, Endonuclease III and DinG, to bind preferentially to DNA

191 vascular endothelial growth factor (VEGF) or endonuclease III-like protein 1 (NTHL1) genes.

192 mediated by RECQ1 DNA helicase and ERCC1-XPF endonuclease in cooperation with PARP1 poly(ADP-ribose)

193 og 1 (Mlh1)-postmeiotic segregation 1 (Pms1) endonuclease in the presence of a mispair and a nick 3'

194 etic variation impacts target choice for Cas endonucleases in the context of therapeutic genome editi

195 led that recombination-activating gene (RAG) endonuclease-induced DNA double-strand breaks (DSBs) tra

196 ers demonstrated that expression of the Cas9 endonuclease induces a gene-independent response that co

197 er characterization revealed that this pUL89 endonuclease inhibitor blocked human cytomegalovirus rep

198 Compound L-742,001 is a prototypical endonuclease inhibitor, and we found that repeated passa

199 ed potential for the development of clinical endonuclease inhibitor-resistant influenza strains.

200 The tRNA splicing endonuclease is a highly evolutionarily conserved protei

201 owever, the mechanism by which the Mlh1-Mlh3 endonuclease is activated is unknown.

202 The influenza endonuclease is an essential subdomain of the viral RNA

203 The yeast HO endonuclease is expressed in late G1 in haploid mother c

204 The yUtp24/hUTP24 PIN endonuclease is proposed to cleave at sites A1/1 and A2/

205 The Fan1 endonuclease is required for repair of DNA interstrand c

206 The nucleolytic activity of MUS81 endonuclease is required for replication fork restart un

207 strand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is required for the incisions that release,

208 lease shows a striking similarity to E. coli endonuclease IV, which provides clues regarding the mech

209 of BTR) are resolved by structure-selective endonucleases known as HJ resolvases.

210 LAGLIDADG homing endonucleases (LHEs) are a class of rare-cleaving nuclea

211 al functions, including apurnic-apyrimidinic endonuclease-like activity suggested to be important dur

212 comprises a standalone apurnic-apyrimidinic endonuclease-like domain.

213 on endonuclease (REase), protein kinase, HNH endonuclease, LK-nuclease (a RNase) and multiple distinc

214 LAGLIDADG homing endonucleases ("meganucleases") are highly specific DNA

215 Among all fields, the T7 endonuclease mismatch cleavage assay, or Surveyor assay,

216 on confounds the target sites of certain Cas endonucleases more than others, and we provide a compend

217 However, combined absence of the endonucleases MUS81 and SEND1 results in severe developm

218 apping activities of the structure-selective endonucleases Mus81-Mms4, Slx1-Slx4, and Yen1.

219 e absence of Srs2 rely on structure-specific endonucleases, Mus81 and Yen1, that resolve toxic joint-

220 -function mutations in the gene encoding the endonuclease Nei endonuclease VIII-like 3 (NEIL3), which

221 Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been

222 tation frequencies in yeast deficient in BER endonucleases or DNA damage tolerance proteins.

223 -13 nucleotides downstream of the cap by the endonuclease PA subunit.

224 d to a structurally distinct enzyme (the HNH endonuclease PacI) that also recognizes an 8-bp target s

225 Class 2 CRISPR-Cas systems use single Cas endonucleases paired with guide RNAs to cleave complemen

226 ll as PCNA-dependent activation of MutLalpha endonuclease, PCNA- and DNA-dependent activation of MutL

227 The isolated recombinant exonuclease-endonuclease-phosphatase domain of OsCCR4a and OsCCR4b e

228 varying ratios of endonuclease-deficient and endonuclease-proficient Mlh1-Mlh3.

229 RNA-guided Cas9 endonucleases protect bacteria from viral infection and

230 ethyltransferase (M) and cognate restriction endonuclease (R).

231 lI is composed of two different proteins: an endonuclease (R.CglI) and a DEAD-family helicase-like AT

232 hereas mutation of another potential site 2a endonuclease, RCL1, did not affect 18S production.

233 The methylation-dependent restriction endonuclease (REase) BisI (G(m5)C downward arrow NGC) is

234 tion and Restriction), a Type IV restriction endonuclease (REase), as instigator for this enigmatic H

235 erse C-terminal domains, such as restriction endonuclease (REase), protein kinase, HNH endonuclease,

236 Restriction endonucleases (REases) of the recipient bacteria fail to

237 DNA sensitivity to >200 Type II restriction endonucleases (REases).

238 ic behaviors that play a significant role in endonuclease recognition and cleavage.

239 together as the T4 PNK, DNA polymerase, and endonuclease recognition probe, and thus avoid the deman

240 with sequence variations flanking an I-SceI endonuclease recognition site into I-SceI expressing Dro

241 R.SwaI, a Type IIP restriction endonuclease, recognizes a palindromic eight base pair (

242 ermit end resection, the identity of such an endonuclease remains elusive.

243 XPG is a structure-specific endonuclease required for nucleotide excision repair, an

244 53/Sp1-dependent downregulation of APE1, the endonuclease responsible for the DNA incision during BER

245 on four human genomic DNAs treated with four endonuclease restriction enzymes using both chamber and

246 EndoG, which encodes a mitochondria-targeted endonuclease, retarded elimination [8].

247 RNA-guided endonucleases (RGENs) have invigorated the field of site

248 Their turnover requires the housekeeping endonuclease RNase E and is activated by the presence of

249 te the important role of the low-specificity endonuclease RNase E in shaping the transcriptome of a b

250 C2c2 protein functions as an RNA-guided RNA endonuclease (RNase).

251 t is built around the major decay-initiating endonuclease, RNase Y, and there is ample evidence for a

252 taining three DNA repair structure-selective endonucleases: SLX1-SLX4, MUS81-EME1, and XPF-ERCC1.

253 Thus, endonuclease specificities in vivo are distinct but with

254 of regulation for RNA editing, we elucidated endonuclease specificity in vivo.

255 ctivity of the DNA repair structure-specific endonuclease subunit (SLX4) complex and to promote cell

256 directly demonstrate a delay in restriction endonuclease synthesis after transformation of Escherich

257 The CRISPR-Cas9 RNA-guided endonuclease system allows precise and efficient modific

258 c repeats (CRISPR)/CRISPR-associated9 (Cas9) endonuclease system is a powerful RNA-guided genome edit

259 The recently discovered CRISPR/Cas9 endonuclease system, comprised of a guide RNA for the re

260 Like many AGO proteins, AGO4 is an endonuclease that can 'slice' RNAs.

261 ification (R-M) systems encode a restriction endonuclease that cleaves DNA at specific sites, and a m

262 I) is a conserved, gene-regulatory bacterial endonuclease that cleaves double-helical structures in d

263 ATPase) that powers DNA translocation and an endonuclease that cleaves the concatemeric genome at bot

264 nto the host chromosome, casposons employ an endonuclease that is homologous to the Cas1 protein invo

265 (Exo1) is a 5'-->3' exonuclease and 5'-flap endonuclease that plays a critical role in multiple euka

266 n early steps of mismatch repair as a latent endonuclease that requires a mismatch, MutSalpha/beta, a

267 ified guide RNA-mediated type V-B CRISPR-Cas endonuclease that site-specifically targets and cleaves

268 hrough the activity of a naturally-occurring endonuclease that targets a repetitive rDNA sequence hig

269 The EcMutH endonuclease that targets mismatch repair excision only

270 ming endonucleases are sequence-tolerant DNA endonucleases that act as mobile genetic elements.

271 rget sites, often assisted by intron-encoded endonucleases that initiate the homing process.

272 RNase E and RNase G are homologous endonucleases that play important roles in RNA processin

273 VapC toxins are PIN domain endonucleases that, in enterobacteria, inhibit translati

274 ively retargeted variants of a single homing endonuclease, that have been shown to function efficient

275 pUL89 endonuclease, therefore, should be explored as a potenti

276 eration of their function from a transposase/endonuclease to a heterochromatin protein, designed to s

277 n RDE-4 initiates silencing by recruiting an endonuclease to process long dsRNA into short dsRNA.

278 d oligonucleotides were cut by a restriction endonuclease to provide small strands and enable positio

279 Amp exploits the ability of some restriction endonucleases to cleave substrates containing nicks with

280 The ability of homing endonucleases to cleave substrates with multiple nucleot

281 systems utilize sequence-specific RNA-guided endonucleases to defend against infection by viruses, ba

282 al miRNAs are degraded in human cells by the endonuclease Tudor-SN (TSN).

283 Using the sequence-specific VMA1-derived endonuclease (VDE) to initiate recombination in meiosis,

284 homologous HIV integrase (IN) and influenza endonuclease via metal chelation.

285 ns in the gene encoding the endonuclease Nei endonuclease VIII-like 3 (NEIL3), which has not been pre

286 Endonuclease VIII-like protein 1 (NEIL1) is a DNA glycos

287 sing reporter mice that express an inducible endonuclease, we find that HDR is particularly robust in

288 both alleles of one, two or all three of the endonucleases were deleted.

289 We recently discovered a novel endonuclease, which cleaves the 5' side of deoxyinosine,

290 lly toxic structures requires the MUS81-EME1 endonuclease, which is activated at prometaphase by form

291 y target the active site of the PA influenza endonuclease, which we report here.

292 Dna2, a flap endonuclease with 5'-3' helicase activity, is involved i

293 obacterium smegmatis NucS/EndoMS, a putative endonuclease with no structural homology to known MMR fa

294 sly) is an RNase H1-type magnesium-dependent endonuclease with stringent specificity for RNA:DNA hybr

295 Streptococcus pyogenes is an RNA-guided DNA endonuclease with widespread utility for genome modifica

296 CRISPR-Cas systems comprise diverse effector endonucleases with different targeting ranges, specifici

297 are typified by mutually exclusive RNase III endonucleases with distinct cleavage specificities and u

298 Human GEN1 and yeast Yen1 are endonucleases with the ability to cleave Holliday juncti

299 Cpf1 is a novel class of CRISPR-Cas DNA endonucleases, with a wide range of activity across diff

300 ication stress response is the ATP-dependent endonuclease ZRANB3.

301 iated by piRNA-guided Slicer cleavage or the endonuclease Zucchini (Zuc).