ライフサイエンスコーパス: enteroid

1 ian clock in 3D murine intestinal organoids (enteroids).

2 control mice, and established 3-dimensional enteroids.

3 inking the circadian clock and cell cycle in enteroids.

4 ition in undifferentiated and differentiated enteroids.

5 n Mtgr1(-/-) whole intestines and Mtgr1(-/-) enteroids.

6 In primary 3-dimensional enteroids, administration of excess Cu or Cu chelators i

7 eta-catenin target gene expression in murine enteroids and colonoid cultures and TNF-induced beta-cat

8 embryonic fibroblasts from mice, along with enteroids and human IEC lines, we found that induction o

9 on utilization of three-dimensional primary enteroids and organoids for mechanistic studies of intes

10 Using untransformed ex situ human intestinal enteroids and transformed Caco-2 cells, we report that E

11 milar in undifferentiated and differentiated enteroids, and was affected by known inhibitors, second

12 Human intestinal crypt-derived enteroids are a model of intestinal ion transport that r

13 ions, efficient phagocytosis, and stabilized enteroid barrier function revealed a coordinated respons

14 ndritic cells, B cells and stem-cell-derived enteroids can all support infection of certain norovirus

15 and characterized a primary human macrophage-enteroid co-culture model for in-depth studies of epithe

16 tablished the first primary human macrophage-enteroid co-culture system, defined conditions that allo

17 ated intestinal crypts or stem cells (termed enteroids/colonoids) and from inducible pluripotent stem

18 In mouse and human normal and tumor-derived enteroids/colonoids, those that expressed SPDEF for 3 da

19 We infected nontransformed human intestinal enteroid cultures from multiple individuals with human r

20 Enteroids derived from control and ATP7B-knockout mice w

21 Enteroids differentiated upon withdrawal of WNT3A, yield

22 However, in vitro, the knockout enteroids exhibit significantly weakened growth that can

23 pharmacological inhibition of CFTR abrogated enteroid fluid secretion, providing proof of concept for

24 In vitro IGF1 enhanced enteroid formation by Sox9-EGFP(High) facultative ISCs b

25 ocked fluid secretion in primary cultures of enteroids from human small intestine and anion current i

26 Here, we used stem cell-derived enteroids from human small intestines to study enterovir

27 The emphasis is on studies with human enteroids grown either as three-dimensional spheroids or

28 vitro, cultured ErbB4(-/-) ileal epithelial enteroids had reduced Paneth cell markers and were highl

29 Human intestinal enteroid (HIE) cultures contain multiple intestinal epit

30 also highlights the use of human intestinal enteroids in the study of enteric diseases.

31 e, we reveal that mouse and human intestinal enteroids in three-dimensional ex vivo cultures express

32 ntestinal crypts from C57BL/6 mice, cultured enteroids, incubated these with TNF (50 ng/mL, 24 hours)

33 ary to an immortalized intestinal cell line, enteroids induced antiviral and inflammatory signaling p

34 denosine monophosphate with forskolin caused enteroid intracellular acidification in HCO3(-)-free buf

35 Cyclic adenosine monophosphate-induced enteroid intracellular pH acidification as part of duode

36 ation quantified simultaneously in scores of enteroid lumens, recapitulating ETEC-induced intestinal

37 The duodenal enteroid model showed that electrogenic Na(+)/HCO3(-) co

38 ell-derived, nontransformed human intestinal enteroid monolayer cultures.

39 es enhanced barrier function and maturity of enteroid monolayers as indicated by increased transepith

40 Human intestinal stem cell-derived enteroid monolayers co-cultured with human monocyte-deri

41 m human small intestine and anion current in enteroid monolayers.

42 Intestinal enteroids offer a unique model, integrating the GUCY2C s

43 ke, and differentiated or villus-like, human enteroids represent distinct points along the crypt-vill

44 Enteroid secretion depended on canonical molecular signa

45 gfbeta signaling in cultured mouse and human enteroids supports further the in vivo data and reveals

46 We used human small intestinal enteroids to study neutral Na(+) absorption and stimulat

47 r intracellular pH and luminal dilatation in enteroids under basal and regulated conditions.

48 In vitro cleavage assays and studies of enteroids verified that HMGB1 protects beclin 1 and ATG5

49 knockdown gene and miRNA expression ex vivo enteroids, we demonstrate that we can knock down gene ex

50 Using transgenic mice and cultured enteroids, we now demonstrate that TLR4 induces ER stres

51 m tissues were collected from mice; IECs and enteroids were cultured and analyzed by histology, immun

52 Crypts were isolated, enteroids were propagated in culture, induced to undergo

53 We found that enteroids were susceptible to infection by diverse enter

54 mice with TNF or incubation of crypt-derived enteroids with TNF reduced their expression of DRA messe