ライフサイエンスコーパス: epiretinal

1 d patients have undergone implantation of an epiretinal 4 x 4 electrode array designed to directly st

2 d human subjects underwent implantation with epiretinal 4 x 4 electrode arrays designed to directly s

3 laucomatous eyes, pars plana vitrectomy with epiretinal and internal limiting membrane peel was ineff

4 rwent surgery with pars plana vitrectomy and epiretinal and internal limiting membrane peel.

5 anges treated with pars plana vitrectomy and epiretinal and internal limiting membrane peel.

6 lantation and electrical stimulation with an epiretinal array did not result in damage that could be

7 retinotopically corresponded to the site of epiretinal array implantation and stimulation.

8 age X-linked RP underwent implantation of an epiretinal array over the macula in the right eye and su

9 grasp performance of patients fitted with an epiretinal artifical retina device.

10 Epiretinal cell proliferation and vitreous collagen fibr

11 es on optical coherence tomography, we found epiretinal cells and vitreous collagen fibrils on the in

12 lasmin treatment, presence and topography of epiretinal cells and vitreous collagen remnants on the i

13 e using the same stimulating parameters with epiretinal electrode arrays.

14 f high-density arrays of small electrodes in epiretinal implants.

15 gularities or irregularity of each category (epiretinal, intraretinal, or RPE/choroidal irregularity)

16 gularities evaluated in the study (including epiretinal irregularities, abnormal retinal thickness, i

17 pectral-domain optical coherence tomography, epiretinal material of homogenous reflectivity without c

18 go surgery indipendently from the associated epiretinal material.

19 ommon complications were cataract (0.31/EY), epiretinal membrane (0.16/EY), and recurrent macular ede

20 roliferative diabetic retinopathy (PDR) (5), epiretinal membrane (4), vitreomacular traction syndrome

21 %), and all other baseline parameters except epiretinal membrane (84.3%), which was detected at a sig

22 (aHR, 1.43) and >/=2+ (aHR, 1.59) vs. none; epiretinal membrane (aHR, 1.25); peripheral anterior syn

23 e had a higher growth rate than eyes without epiretinal membrane (difference, 0.16; 95% CI, 0.03-0.30

24 Surgical indications included epiretinal membrane (ERM) (n = 121), vitreous floaters (

25 00 (Carl Zeiss Meditech, Jena, Germany) with epiretinal membrane (ERM) and internal retinal membrane

26 e the causes of diplopia in patients with an epiretinal membrane (ERM) and presenting diplopia.

27 selected among 369 patients examined for an epiretinal membrane (ERM) by Cirrus spectral-domain OCT

28 , or vehicle, and at appropriate time points epiretinal membrane (ERM) formation and retinal detachme

29 nal reattachment rate, final VA, and rate of epiretinal membrane (ERM) formation at month 6.

30 , the intraretinal glial response results in epiretinal membrane (ERM) formation, a proliferative and

31 More epiretinal membrane (ERM) formations occurred postoperat

32 e and clinical associations of patients with epiretinal membrane (ERM) who develop central-peripheral

33 (PPV): 6 for vitreous hemorrhage (VH), 1 for epiretinal membrane (ERM), and an additional 8 for tract

34 criteria included FTMH >400 mum, presence of epiretinal membrane (ERM), and aphakia in the study eye.

35 ndergoing pars plana vitrectomy to remove an epiretinal membrane (ERM), and test subjects (n = 7) wit

36 ickness macular hole (FTMH), and presence of epiretinal membrane (ERM).

37 epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM).

38 hment (RD), cystoid macular edema (CME), and epiretinal membrane (ERM).

39 .6 vs. 0.52); FTMH (kappa 0.9 vs. 0.78); and epiretinal membrane (kappa 0.65 vs. 0.45).

40 Surgical indications included epiretinal membrane (n = 26), diabetic tractional retina

41 fluid (n = 6), subretinal exudation (n = 6), epiretinal membrane (n = 3), retinal hemorrhage (n = 2),

42 cyclitic membrane (n = 18, 69%), neoplastic epiretinal membrane (n = 6, 23%), and persistent hyaloid

43 lusion (RR 12.9), macular hole (RR 7.7), and epiretinal membrane (RR 5.7).

44 al [CI], 1.57-4.34), a previous diagnosis of epiretinal membrane (RR, 5.60; 95% CI, 3.45-9.07), uveit

45 , and fibroblasts (the cell types crucial in epiretinal membrane [ERM] formation) under identical mic

46 Nine subjects (26%) had epiretinal membrane and 6 (17%) had MH (mean diameter 18

47 inner nuclear layer in eyes with concomitant epiretinal membrane and glaucomatous optic neuropathy.

48 l membrane, 338 +/- 23 mum; and eyes with an epiretinal membrane and surface wrinkling, 405 +/- 22 mu

49 IDIOPATHIC EPIRETINAL MEMBRANE AND VITREOMACULAR TRACTION PREFERRED

50 R) GUIDELINES: New evidence-based Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred

51 f small and medium FTMH, and in FTMH without epiretinal membrane at baseline.

52 and PDGF, both of which are associated with epiretinal membrane development.

53 Patients who had an epiretinal membrane for more than 18 months had signific

54 Optic disc edema and epiretinal membrane formation was found more frequently

55 cluding postoperative cystoid macular edema, epiretinal membrane formation, macular folds, and, ultim

56 Eyes with epiretinal membrane had a higher growth rate than eyes w

57 native internal limiting membrane in 2 eyes, epiretinal membrane in 1 eye, and remnant cortical vitre

58 8 eyes (29%) and 6 eyes (38%) (P = .34), and epiretinal membrane in 5 eyes (20.8%) and 4 eyes (25%) (

59 Epiretinal membrane is a common complication of uveitis

60 ptin receptor were detected in fibrovascular epiretinal membrane of patients with diabetes.

61 Seventy-two eyes of 59 patients had an epiretinal membrane on presentation.

62 naive wet AMD group (group 3, n = 10) and an epiretinal membrane or macular hole group (group 4, n =

63 ohorts with wet AMD and a control group with epiretinal membrane or macular hole.

64 patients in the single-peeling group had an epiretinal membrane remaining in the central fovea posto

65 ted internal limiting membrane specimens and epiretinal membrane specimens removed from 25 eyes of 25

66 r changes increased at advanced glaucoma and epiretinal membrane stages.

67 Epiretinal membrane was found in 7 eyes after endophthal

68 fects of "single peeling," in which only the epiretinal membrane was peeled, and "double peeling," in

69 ue to undergo PPV for either macular hole or epiretinal membrane were recruited.

70 Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a

71 l subfield thicknesses were: eyes without an epiretinal membrane, 338 +/- 23 mum; and eyes with an ep

72 , cataract, vitritis, cystoid macular edema, epiretinal membrane, and disc edema may occur in patient

73 lar edema, posterior capsular opacification, epiretinal membrane, and intraocular lens subluxation.

74 mia, foveal hemorrhage, vitreous hemorrhage, epiretinal membrane, and retinal detachment.

75 n younger patients (<65 years), eyes without epiretinal membrane, eyes with FTMH, phakic eyes, and ey

76 pathy, retinal vein occlusion, macular hole, epiretinal membrane, macular degeneration, retinal detac

77 e diabetic retinopathy, and the other 13 for epiretinal membrane, macular hole, vitreous opacities, o

78 3 months (20/94 vs 20/35 for eyes without an epiretinal membrane, P = .002) and at 6 months follow-up

79 llow-up (20/110 vs 20/36 for eyes without an epiretinal membrane, P = .02).

80 retinoschisis, myopic traction maculopathy, epiretinal membrane, vitreoretinal traction, optic or sc

81 etinal Defect Associated With High Myopia or Epiretinal Membrane," published online January 22, 2015,

82 , vitreomacular interface abnormalities, and epiretinal membrane.

83 nal detachment at macula while the other, an epiretinal membrane.

84 tractive properties were termed conventional epiretinal membrane.

85 for FTMH width, vitreomacular adhesion, and epiretinal membrane.

86 cular pseudohole presented with conventional epiretinal membrane.

87 s with ocular pathologic features such as an epiretinal membrane.

88 logic features, primarily the presence of an epiretinal membrane.

89 ntraocular pressure (IOP); (7) macula pucker/epiretinal membrane; (8) cataract; and (9) quality of li

90 er were diagnosed in 52 out of 264 eyes with epiretinal membranes (19.7%), of which 28 (55.0%) had co

91 ectopic inner foveal layers associated with epiretinal membranes (ERMs) and to present a new optical

92 The development of symptoms in patients with epiretinal membranes (ERMs) often corresponds with the a

93 Epiretinal membranes (ERMs) were present in 71% of eyes

94 ns of the central bouquet (CB) in idiopathic epiretinal membranes (ERMs).

95 ile of cells growing out of human idiopathic epiretinal membranes (iERMs) and testing their prolifera

96 Cells within epiretinal membranes and activated Muller cells were pre

97 HRPE cells in epiretinal membranes and in culture expressed c-Met.

98 In eyes with epiretinal membranes and retinal surface wrinkling, uvei

99 Eyes without epiretinal membranes and with epiretinal membranes witho

100 oid layer and was associated with tractional epiretinal membranes and/or vitreomacular traction.

101 Epiretinal membranes are associated with macular cysts,

102 Epiretinal membranes are commonly encountered in retinal

103 n of HGFR in human donor eyes and in several epiretinal membranes associated with proliferative vitre

104 n of HGFR in human donor eyes and in several epiretinal membranes associated with proliferative vitre

105 eadily detected in the cellular component of epiretinal membranes associated with PVR, whereas little

106 All six diabetic epiretinal membranes contained positively identified Mul

107 ces (ECM) is important in the development of epiretinal membranes found in proliferative vitreoretino

108 leptin and leptin receptor were localized in epiretinal membranes immunohistochemically.

109 We observed retinal hamartomas and/or epiretinal membranes in nine patients from five families

110 The development of epiretinal membranes may be associated with either vitre

111 he RPE monolayer in human donor eyes, and in epiretinal membranes obtained from patients with PVR.

112 eas myofibroblasts dominated in conventional epiretinal membranes of macular pseudoholes.

113 eptors (PDGFRs) are present and activated in epiretinal membranes of patient donors, and they are ess

114 Despite the absence of contractive epiretinal membranes on optical coherence tomography, we

115 Contractile epiretinal membranes on the inner retinal surface that c

116 epiretinal proliferation, whereas tractional epiretinal membranes presenting contractive properties w

117 ative vitreoretinopathy (PVR) and idiopathic epiretinal membranes was analyzed by immunohistochemistr

118 Epiretinal membranes were diagnosed when identified by 2

119 nsecutive patients diagnosed with idiopathic epiretinal membranes were reviewed and analyzed.

120 Sections of epiretinal membranes were stained immunohistochemically

121 Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not

122 opathy, ophthalmological lesions (cataracts, epiretinal membranes, and retinal hamartomas), and cutan

123 These factors include epiretinal membranes, edema, individual variation in fie

124 n of the retinal inner layers (DRIL), cysts, epiretinal membranes, microaneurysms, subretinal fluid,

125 These conditions include macular holes, epiretinal membranes, retinal detachments, and retinopat

126 er nuclear layer in patients with idiopathic epiretinal membranes, with and without glaucomatous opti

127 opathy, 7 had retinal detachments, and 9 had epiretinal membranes.

128 promoted the development of dense, fibrotic epiretinal membranes.

129 as little or no HGFR was found in idiopathic epiretinal membranes.

130 oliferative vitreoretinopathy and idiopathic epiretinal membranes.

131 on and decreased alpha-SMA expression in the epiretinal membranes.

132 active properties than cells of conventional epiretinal membranes.

133 Epiretinal neovascular membranes surgically removed from

134 Epiretinal pigment deposits were characterized clinicall

135 s) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal

136 It was often associated with nontractional epiretinal proliferation and a retinal "bump." Moreover,

137 Cells within lamellar hole-associated epiretinal proliferation appear to originate from vitreo

138 ructure showed that lamellar hole-associated epiretinal proliferation of lamellar macular holes mainl

139 ar holes presenting lamellar hole-associated epiretinal proliferation on the retinal surface.

140 Lamellar hole-associated epiretinal proliferation was seen in 73% of eyes with la

141 In lamellar hole-associated epiretinal proliferation, positive immunoreactivity for

142 was categorized as lamellar hole-associated epiretinal proliferation, whereas tractional epiretinal

143 ologic and ultrastructural analysis of these epiretinal proliferations peeled at the time of silicone

144 man subjects were implanted chronically with epiretinal prostheses consisting of two-dimensional elec

145 result of retinitis pigmentosa, who received epiretinal prostheses implanted monocularly as part of a

146 an effort to restore functional form vision, epiretinal prostheses that elicit percepts by directly s

147 light perception, and an implanted Argus II epiretinal prostheses used a touchscreen to trace white

148 f veridically reproducing such patterns with epiretinal prostheses.

149 The Argus I implant is the first-generation epiretinal prosthesis approved for an investigational cl

150 lanted blind human subjects with a prototype epiretinal prosthesis consisting of a 4 x 4 array of 16

151 with severe RP (implanted with a 16-channel epiretinal prosthesis in 2004) on nine individual electr

152 For an epiretinal prosthesis, short-duration current pulses may

153 ee categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal irregu

154 Implantation of an electrode array on the epiretinal side (i.e., side closest to the ganglion cell

155 e was misplaced into the choroid or into the epiretinal space on top of the host retina.

156 may be implanted either in the subretinal or epiretinal space.

157 Four hypotheses were tested: (1) epiretinal stimulation can be performed during acute exp

158 the KA/AMPA antagonist NBQX, suggesting that epiretinal stimulation evoked glutamate release from bip

159 Sustained currents were also evoked by epiretinal stimulation in bipolar cells.

160 effective activation of the inner retina by epiretinal stimulation.

161 re present 10 years after implantation of an epiretinal stimulator.

162 e visual pathway (ie, cortical, optic nerve, epiretinal, subretinal).

163 ation of dense, contractile membranes on the epiretinal surface and prevented development of traction

164 , and the response patterns were similar for epiretinal surface and subsurface applications.

165 Epiretinal surface application of glutamate was less lik

166 the contraction of fibrotic membranes on the epiretinal surface of the neurosensory retina, resulting

167 subsurface application (20 microm below the epiretinal surface).

168 microelectrode array then was tacked to the epiretinal surface.

169 l detachment and is present in fibrovascular epiretinal tissue.

170 ntified Muller cells are present in diabetic epiretinal tissues and appear to undergo the same progre

171 Cryosections of six diabetic epiretinal tissues were evaluated for the same antigens.

172 18 and was more strongly associated with the epiretinal vessels than with inner retinal vessels.

173 Use of an epiretinal visual prosthesis can allow RP patients with