ライフサイエンスコーパス: eukaryotic initiation factor

1 s composed of 13 subunits and is the largest eukaryotic initiation factor.

2 heterogeneous protein complexes such as the eukaryotic initiation factors.

3 complex (TC) with eIF2-GTP, is stimulated by eukaryotic initiation factor 1 (eIF1), eIF1A, eIF3, and

4 that can phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) and inhibit

5 ke ER kinase (PERK) and the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha), as well as

6 During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary co

7 Eukaryotic initiation factor 2 (eIF2) is a key integrato

8 Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important me

9 ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

10 repression of the p53 protein by the CUGBP1-eukaryotic initiation factor 2 (eIF2) repressor complex.

11 Protein translation through eukaryotic initiation factor 2 (EIF2) signaling, a pathw

12 rotein kinase R (PKR), which inactivates the eukaryotic initiation factor 2 (eIF2) translation initia

13 Activated GCN2 phosphorylates eukaryotic initiation factor 2 (eIF2), altering gene-spe

14 ludes an early initiation complex containing eukaryotic initiation factor 2 (eIF2), GTP, and methioni

15 an Obg-family GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translati

16 ough phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

17 tion of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).

18 nitiation is regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2-P) that causes decr

19 phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits

20 the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in MEFs in an

21 the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) translation i

22 ated phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

23 t on phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

24 tion initiation factor, the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

25 anslation initiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

26 responses (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to incre

27 t the hepatic heme-regulated inhibitor (HRI)-eukaryotic initiation factor 2 alpha (eIF2 alpha) kinase

28 spond to cellular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2alpha) or othe

29 PKR's pro-apoptotic role through eukaryotic initiation factor 2 alpha (eIF2alpha) phospho

30 d by attenuating protein translation through eukaryotic initiation factor 2 alpha (eIF2alpha) phospho

31 both with capsid-induced phosphorylation of eukaryotic initiation factor 2 alpha and with capsid-med

32 In 2014, scientists discovered mutations in eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4)

33 ation with polysomes likewise depends on the eukaryotic initiation factor 2 alpha kinase 4, which ass

34 which can be repressed by phosphorylation of eukaryotic initiation factor 2 alpha-subunit (eIF2alpha)

35 eatic ER kinase, and its downstream effector eukaryotic initiation factor 2 in human leukemia (HL60)

36 Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 on serine 51 was not dete

37 orylation of both protein kinase R (PKR) and eukaryotic initiation factor 2 on the alpha-subunit in s

38 ts, independent of source of infection, with eukaryotic initiation factor 2 signaling being the most

39 (ER) cisternae, increased phosphorylation of eukaryotic initiation factor 2 subunit alpha (P-eIF2alph

40 nslational arrest through phosphorylation of eukaryotic initiation factor 2 subunit alpha.

41 m activates the eIF-2alpha (alpha subunit of eukaryotic initiation factor 2) kinase PERK to transient

42 hosphorylation of the alpha-subunit of eIF2 (eukaryotic initiation factor 2), which inhibits its guan

43 -like ER kinase)-eIF2alpha (alpha subunit of eukaryotic initiation factor 2)-dependent pathway by Sub

44 bits the translation initiation factor eIF2 (eukaryotic initiation factor 2).

45 trol nonderepressible 2), phosphorylation of eukaryotic initiation factor 2, and increased synthesis

46 sphorylation of PKR and the alpha subunit of eukaryotic initiation factor 2, indicating that K1L and

47 ither protein kinase R, which phosphorylates eukaryotic initiation factor 2, nor oligoadenylate synth

48 e in phosphorylation of the alpha subunit of eukaryotic initiation factor 2, requiring PKR-like endop

49 ated PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2, thereby inhibiting prote

50 ated PKR phosphorylates the alpha-subunit of eukaryotic initiation factor 2, thereby inhibiting prote

51 translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in l

52 suppresses protein synthesis by inactivating eukaryotic initiation factor 2-alpha (eIF2-alpha), to ex

53 st-in-class, small molecule inhibitor of the eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3)

54 Eukaryotic initiation factor 2-associated glycoprotein,

55 w "privileged" translation despite inhibited eukaryotic initiation factor 2-guanosine triphosphate-in

56 vent phosphorylation of the alpha-subunit of eukaryotic initiation factor 2.

57 sphorylation of PKR and the alpha subunit of eukaryotic initiation factor 2.

58 the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2.

59 mulate and activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general am

60 ly of protein kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in transl

61 t environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces pr

62 site (IRES) whose activity is suppressed by eukaryotic initiation factor 2A (eIF2A; YGR054W).

63 (i)(Met)) pathway but required expression of eukaryotic initiation factor 2A.

64 mal inhibitors enhanced GADD34 stability and eukaryotic initiation factor 2alpha (eIF-2alpha) dephosp

65 to amino acid deficiency, phosphorylation of eukaryotic initiation factor 2alpha (eIF2 approximately

66 kinase 1/2 (ERK1/2 Tyr202/204; +65% +/- 9%), eukaryotic initiation factor 2alpha (eIF2alpha Ser51; -2

67 ed through the translation initiation factor eukaryotic initiation factor 2alpha (eIF2alpha) and the

68 Phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) controls

69 associated with increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) in the l

70 und in solid tumours, activated the upstream eukaryotic initiation factor 2alpha (eIF2alpha) kinase G

71 R kinase (EIF2AK3)], the ER stress-activated eukaryotic initiation factor 2alpha (eIF2alpha) kinase.

72 mbryonic fibroblasts depleted for individual eukaryotic initiation factor 2alpha (eIF2alpha) kinases,

73 In metazoans phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) on Ser(5

74 nt study, we investigated whether increasing eukaryotic initiation factor 2alpha (eIF2alpha) phosphor

75 endoplasmic reticulum (ER) kinase-dependent eukaryotic initiation factor 2alpha (eIF2alpha) phosphor

76 ein induction, PKR-like ER kinase (PERK) and eukaryotic initiation factor 2alpha (eIF2alpha) phosphor

77 e previously reported that activation of the eukaryotic initiation factor 2alpha (eIF2alpha) stress p

78 a rudimentary amino acid starvation-sensing eukaryotic initiation factor 2alpha (eIF2alpha) stress r

79 e of several kinases that phosphorylates the eukaryotic initiation factor 2alpha (eIF2alpha) to inhib

80 SNCEE, we found the translational regulator eukaryotic initiation factor 2alpha (eIF2alpha) was hype

81 f the PERK arm stimulates phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), resulti

82 nretinide and bortezomib are mediated by the eukaryotic initiation factor 2alpha (eIF2alpha)-ATF4 sig

83 KR)-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2alpha (eIF2alpha)-dependen

84 nize SAMD9 to prevent granule formation in a eukaryotic initiation factor 2alpha (eIF2alpha)-independ

85 sis, as well as increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

86 nase domain, and subsequently phosphorylates eukaryotic initiation factor 2alpha (eIF2alpha).

87 ein synthesis by inducing phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

88 sponse accompanied by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

89 dings in this investigation was that PKR and eukaryotic initiation factor 2alpha are phosphorylated u

90 ent of its canonical induction downstream of eukaryotic initiation factor 2alpha eIF2alpha phosphoryl

91 ed ATF6 translocation and phosphorylation of eukaryotic initiation factor 2alpha in mouse cortical ne

92 The phosphorylation of eukaryotic initiation factor 2alpha increased only at 18

93 general control nonderepressible 2-dependent eukaryotic initiation factor 2alpha phosphorylation and

94 BP1 and G3BP2 cannot form SGs in response to eukaryotic initiation factor 2alpha phosphorylation or e

95 Thus far, a unifying principle of eukaryotic initiation factor 2alpha phosphorylation prio

96 indicative of proliferation such as reduced eukaryotic initiation factor 2alpha phosphorylation, inc

97 ely depleted within a few days, resulting in eukaryotic initiation factor 2alpha phosphorylation, TCR

98 tol-requiring enzyme 1alpha (IRE1alpha), and eukaryotic initiation factor 2alpha phosphorylation.

99 acentas, providing a potential mechanism for eukaryotic initiation factor 2alpha phosphorylation.

100 Increased phosphorylation of eukaryotic initiation factor 2alpha suggests suppression

101 r protein kinase R, which phosphorylates the eukaryotic initiation factor 2alpha to inhibit global pr

102 the translation initiation factor eIF2alpha (eukaryotic initiation factor 2alpha), and, through subse

103 t to phosphorylate its substrate, eIF2alpha (eukaryotic initiation factor 2alpha), halting cellular t

104 PKR phosphorylates eukaryotic initiation factor 2alpha, a translation initi

105 ulate translation via phosphorylation of the eukaryotic initiation factor 2alpha, and transcription v

106 h enables it to phosphorylate its substrate, eukaryotic initiation factor 2alpha, leading to translat

107 in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and t

108 ylation of the translation initiation factor eukaryotic initiation factor 2alpha, suggesting a novel

109 In addition, increased phosphorylation of eukaryotic initiation factor 2alpha, the translation fac

110 PKR then phosphorylates eukaryotic initiation factor 2alpha, thus inhibiting pro

111 le stress pathways is the phosphorylation of eukaryotic initiation factor 2alpha, which is phosphoryl

112 (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor 2alpha.

113 NASH (n = 21) were associated with increased eukaryotic initiation factor-2alpha (eIF-2alpha) phospho

114 anded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF-2alpha) was det

115 yzed the effects of NTZ on the regulation of eukaryotic initiation factor-2alpha (eIF2alpha) and its

116 latency is an active process controlled by a eukaryotic initiation factor-2alpha (eIF2alpha) kinase (

117 t results in phosphorylation of the parasite eukaryotic initiation factor-2alpha (eIF2alpha), leading

118 anded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).

119 sly shown that phosphorylation of Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is a co

120 We report that Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is phos

121 hPNPase(old-35) precedes phosphorylation of eukaryotic initiation factor-2alpha and induction of gro

122 ess marker proteins including phosphorylated eukaryotic initiation factor-2alpha, activating transcri

123 Eukaryotic initiation factor 2B (eIF2B) is the guanine n

124 Eukaryotic initiation factor 2B (eIF2B) plays a key role

125 Eukaryotic initiation factor 2B (eIF2B), a five-subunit

126 Cyclin D1 and the eukaryotic initiation factor 2B epsilon subunit were als

127 (T421/S424)-p70S6K phosphorylation and total eukaryotic initiation factor 2Bepsilon (eIF2Bepsilon) pr

128 n 80S ribosomes and diminishes dependence on eukaryotic initiation factor 3 (eIF3) of reinitiation by

129 in some of the bona fide SG markers, such as eukaryotic initiation factor 3 (eIF3) or eIF4A, or the p

130 The 13-subunit, 800-kilodalton eukaryotic initiation factor 3 (eIF3) organizes initiati

131 A single 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficie

132 binding to the tumor suppressor eIF3e/Int6 (eukaryotic initiation factor 3 subunit e).

133 ntified the N-terminal 91 amino acids of the eukaryotic initiation factor 3 subunit f (N91-eIF3f) as

134 pression encoded the N-terminal 91 aa of the eukaryotic initiation factor 3 subunit f (N91-eIF3f).

135 Eukaryotic initiation factor-3a (eIF3a), a putative subu

136 ith, and relieves the inhibitory function of eukaryotic initiation factor 3f, a repressive component

137 then applied to quantify phosphorylations on eukaryotic initiation factor 3H (eIF3H), a protein integ

138 carrying a T-DNA insertion in one of the two eukaryotic initiation factor 4A (eIF4A) genes present in

139 anslation initiation by strongly stimulating eukaryotic initiation factor 4A (eIF4A) helicase activit

140 The eukaryotic initiation factor 4A (eIF4A) is a DEAD box he

141 unwind G4 substrates, reminiscent of that of eukaryotic initiation factor 4A (eIF4A) on double-strand

142 This process is powered by the eukaryotic initiation factor 4A (eIF4A), a DEAD-box heli

143 Here we identify the catalytic activity of eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

144 RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

145 l Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit transla

146 n our design, the RNA-binding protein is the eukaryotic initiation factor 4A (eIF4A).

147 Although the eukaryotic initiation factors 4A/4B/4G can mediate scann

148 PRMT1 methylated the eukaryotic initiation factor 4A1 (eIF4A1) protein, which

149 Here we demonstrate that eukaryotic initiation factor 4a3 (eIF4a3) is involved in

150 ted that knockdown of the EJC core component Eukaryotic initiation factor 4a3 (Eif4a3) results in ful

151 of MET by regulating the phosphorylation of eukaryotic initiation factor 4B (eIF4B) on S406.

152 y brain cytoplasmic (BC) RNAs cooperate with eukaryotic initiation factor 4B (eIF4B) to control trans

153 of translation/initiation factors, including eukaryotic initiation factor 4B in a stoichiometric mann

154 TOR and the downstream targets S6 kinase and eukaryotic initiation factor 4B.

155 (eIF2alpha Ser51; -20 +/- 5%, P < 0.05) and eukaryotic initiation factor 4E (eIF4E Ser209; +33 +/- 1

156 This step is initiated by eukaryotic initiation factor 4E (eIF4E) (the m7GTP cap-b

157 a mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein

158 hosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein

159 ing pathways enhanced polysome occupancy and eukaryotic initiation factor 4E (eIF4E) binding to the 5

160 Surprisingly, Shh promoted eukaryotic initiation factor 4E (eIF4E) expression, but

161 Eukaryotic initiation factor 4E (eIF4E) has long been kn

162 Elevated levels of phosphorylated eukaryotic initiation factor 4E (eIF4E) have been implic

163 The m(7)G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiti

164 Elevated eukaryotic initiation factor 4E (eIF4E) levels frequentl

165 h, in turn, regulates phosphorylation of the eukaryotic initiation factor 4E (eIF4E) on Ser-209.

166 Thus, AR suppressed eukaryotic initiation factor 4E (eIF4E) phosphorylation,

167 The eukaryotic initiation factor 4E (eIF4E) plays a central

168 Hypoxic cells switch from eukaryotic initiation factor 4E (eIF4E) to eIF4E2 cap-de

169 In vitro, the overexpression of eukaryotic initiation factor 4E (eIF4E) up-regulates the

170 te the phosphorylation and activation of the eukaryotic initiation factor 4E (eIF4E), a protein that

171 h biotin and an orthosteric inhibitor of the eukaryotic initiation factor 4E (eIF4E), an enzyme invol

172 of Pea enation mosaic virus (PEMV) binds to eukaryotic initiation factor 4E (eIF4E), but how this af

173 machinery, SFV reduces levels of translation eukaryotic initiation factor 4E (eIF4E), diminishes phos

174 importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly

175 n of 4E-BP1, a repressor binding protein for eukaryotic initiation factor 4E (eIF4E), that was depend

176 mTORC1 phosphorylates eukaryotic initiation factor 4E (eIF4E)-binding protein

177 ression of constitutively hypophosphorylated eukaryotic initiation factor 4E (eIF4E)-binding protein

178 (CDK1/CYCB1) to directly hyperphosphorylate eukaryotic initiation factor 4E (eIF4E)-binding protein

179 Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein

180 /3 (4EBP), which inhibits the translation of eukaryotic initiation factor 4E (eiF4E)-bound mRNAs.

181 ian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S c

182 NFAT, and translation factors, specifically eukaryotic initiation factor 4E (elf4E) and S6 ribosomal

183 irways have increased phosphorylation of the eukaryotic initiation factor 4E and its partner the 4E-b

184 egulation and dephosphorylation of STAT5 and eukaryotic initiation factor 4E as wild-type cells.

185 regulates downstream phosphorylation of the eukaryotic initiation factor 4E at Ser-209.

186 ly depends on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP)

187 tion of p70 ribosomal S6 kinase (p70s6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1

188 Thr-308 and Ser-473), S6 kinase 1 (Thr-389), eukaryotic initiation factor 4E binding protein 1 (Thr-3

189 p70 ribosomal protein S6 kinase 1 [S6K1] and eukaryotic initiation factor 4E binding protein 1) and c

190 protein synthesis by inhibition of eIF4EBPs (eukaryotic Initiation Factor 4E Binding Proteins), regul

191 p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding (eIF4E-binding)

192 C1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosp

193 mTORC1 signaling through p70S6Ks (S6K1/2) or eukaryotic initiation factor 4E-binding protein (4E-BP1/

194 , and mLST8, is activated and phosphorylates eukaryotic initiation factor 4E-binding protein (4EBP) a

195 ence of amino acids increased the binding of eukaryotic initiation factor 4E-binding protein (4EBP1)

196 active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP

197 ever, adult HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP

198 Here we show that deletion of the eukaryotic initiation factor 4E-binding protein 1 (4E-BP

199 athways of p70 ribosomal S6 kinase (p70S6K), eukaryotic initiation factor 4E-binding protein 1 (4EBP1

200 rEC showed selective increased expression of eukaryotic initiation factor 4E-binding protein 1 (4EBP1

201 d completely suppressed Akt, GSK3beta, mTOR, eukaryotic initiation factor 4E-binding protein 1, and S

202 n of the ribosomal protein S6 kinase and the eukaryotic initiation factor 4E-binding protein 1, two d

203 ng to the phosphorylation of S6 kinase 1 and eukaryotic initiation factor 4E-binding protein 1, which

204 ng protein interacting protein 2 (Paip2) and eukaryotic initiation factor 4E-binding protein 2 (4E-BP

205 egulator of mRNA translation initiation, the eukaryotic initiation factor 4E-binding protein 2, leads

206 ncrease in ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E-binding protein-1 (4E-BP

207 The eukaryotic initiation factor 4E-binding protein-2 (4E-BP

208 ned the expression and distribution of mTOR, eukaryotic initiation factor 4E-binding protein1/2 (4E-B

209 is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs

210 phorylation of translation initiation factor eukaryotic initiation factor 4E.

211 3 kinase or blocking the interaction between eukaryotic initiation factors 4E (eIF4E) and 4G (eIF4G)

212 n, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and indu

213 ion initiation in eukaryotes begins with the Eukaryotic Initiation Factor 4F (eIF4F) complex, made up

214 The eukaryotic initiation factor 4F (eIF4F) is thought to be

215 nce of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulat

216 an replace the cellular cap-binding complex, eukaryotic initiation factor 4F (eIF4F), to mediate tran

217 on of 4E-BP1 and increasing the formation of eukaryotic initiation factor 4F (eIF4F), which promote c

218 it enhanced imatinib-mediated inhibition of eukaryotic initiation factor 4F induction, and second, i

219 Translation initiation factor eIF4F (eukaryotic initiation factor 4F), composed of eIF4E, eIF

220 In mammals, the direct interaction between eukaryotic initiation factor 4G (eIF4G) and eIF3 is thou

221 ings, we show that the eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an

222 ty to activate translation and interact with eukaryotic initiation factor 4G (eIF4G) were required to

223 This mechanism requires eukaryotic initiation factor 4G (eIF4G), subunit of hete

224 rotein kinase B (PKB) and phosphorylation of eukaryotic initiation factor 4G preceded the rise of MPS

225 Binding of the eukaryotic initiation factor 4G to Ded1p interferes with

226 on (UTR) of several mRNA transcripts and the eukaryotic initiation factor 4G.

227 sGAP SH3-domain binding protein 1 (G3BP) and eukaryotic initiation factor 4G.

228 initiation scaffold and "ribosome adaptor," eukaryotic initiation factor 4G1 (eIF4G1) in interphase

229 els of translation initiation factor eIF4G1 (eukaryotic initiation factor 4gamma1).

230 Eukaryotic initiation factor 4GI (eIF4GI) was cleaved ra

231 st cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI).

232 oliovirus (PV) 2A protease (2A(Pro)) cleaves eukaryotic initiation factors 4GI and 4GII (eIF4GI and e

233 Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as

234 large decrease in the amount of hypusinated eukaryotic initiation factor 5A (eIF5A) (1/20 of normal)

235 The eukaryotic initiation factor 5A (eIF5A), which is highly

236 tor P (EF-P) is the ortholog of archaeal and eukaryotic initiation factor 5A (eIF5A).

237 eIF5A (eukaryotic initiation factor 5A) is the only known prote

238 -dependent posttranslational modification of eukaryotic initiation factor 5A.

239 d in the posttranslational activation of the eukaryotic initiation factor 5A.

240 usine modification of the translation factor eukaryotic initiation factor 5A.

241 ) in prokaryotes and a related protein named eukaryotic initiation factor 5B (eIF5B) in eukaryotes.

242 ing the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S

243 Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase tr

244 some synthesis by promoting the recycling of eukaryotic initiation factor 6 (eIF6) in a GTP-dependent

245 Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for la

246 Eukaryotic initiation factor 6 (eIF6), a highly conserve

247 Eukaryotic initiation factor 6 (eIF6), an essential prot

248 ightly controlled system that is composed of eukaryotic initiation factors, and which controls the re

249 ion of downstream signaling pathways S6K and eukaryotic initiation factor binding protein 1 (4E-BP1).

250 ied targets of mTORC1 in translation are the eukaryotic initiation factor-binding protein 1 (4E-BP1)

251 and 4E-binding protein; and (4) formation of eukaryotic initiation factor complex 4F, a critical firs

252 ms, their disruption via knockdown of RCK or eukaryotic initiation factor E transporter (eIF4E-T) inc

253 Eukaryotic initiation factor (eIF) 1 is a small protein

254 nslation initiation factors to occur, namely eukaryotic initiation factor (eIF) 2 and eIF3.

255 or methionine transfer RNA (Met-tRNAi(Met)), eukaryotic initiation factor (eIF) 2, and guanosine trip

256 ly, AMPK activation increased stress-induced eukaryotic initiation factor (eIF) 2alpha phosphorylatio

257 es, consisting of the 40S ribosomal subunit, eukaryotic initiation factor (eIF) 3 and the eIF2/GTP/Me

258 serve to recruit the ribosomal 40S subunit, eukaryotic initiation factor (eIF) 3 and the ternary eIF

259 Eukaryotic initiation factor (eIF) 3j is a subunit of eI

260 Eukaryotic initiation factor (eIF) 4A is a DEAD-box heli

261 Eukaryotic initiation factor (eIF) 4B is known to intera

262 e PI3K/mammalian target of rapamycin and MYC-eukaryotic initiation factor (eIF) 4E pathways, are pred

263 ownstream kinase, MNK1, which phosphorylates eukaryotic initiation factor (eIF) 4E.

264 Eukaryotic initiation factor (eIF) 4F binding to mRNA is

265 onents of the translation apparatus, such as eukaryotic initiation factor (eIF) 4G (type 2), 40S ribo

266 gh physical and functional interactions with eukaryotic initiation factor (eIF) 4G and eIF4B.

267 fect was not due to MNK's known functions as eukaryotic initiation factor (eIF) 4G binding partner or

268 ESs is their ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the e

269 ranslation; and (iv) LARP1 competes with the eukaryotic initiation factor (eIF) 4G for TOP mRNA bindi

270 zation of the mRNA typically provided by the eukaryotic initiation factor (eIF) 4G/PABP/poly(A) tail

271 on in sensory neurons by converging onto the eukaryotic initiation factor (eIF) eIF4F complex.

272 The universally conserved eukaryotic initiation factor (eIF), eIF1A, plays multipl

273 ty to phosphorylate the alpha subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting

274 et-tRNAi(Met) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA l

275 nslation involves specific interactions with eukaryotic initiation factor (eIF)4A and eIF4G, which ar

276 ease translation of IRE-mRNA in vitro; (iii) eukaryotic initiation factor (eIF)4F binds specifically

277 KAR results in enhanced interaction with the eukaryotic initiation factor (eIF)4G and recruitment of

278 The resulting framework reveals that eukaryotic initiation factor (eIF)5B actually accelerate

279 selectively disrupts the interaction between eukaryotic initiation factors (eIF) 4E and 4G, attenuate

280 Two eukaryotic initiation factors, eIF1 and eIF1A, are key a

281 cylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2.

282 interact with the alpha and beta subunits of eukaryotic initiation factor eIF2.

283 SGs despite an increased phosphorylation of eukaryotic initiation factor eIF2alpha, a hallmark of st

284 se stresses, different kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the tra

285 iciency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to

286 which allowed for release and activation of eukaryotic initiation factor eIF4E and subsequent OPN tr

287 pathways and mediate phosphorylation of the eukaryotic initiation factor (eIF4E), a protein that pla

288 , which are known to show high levels of the eukaryotic initiation factor, eIF4E, a potent oncogene.

289 CaMKI-mediated phosphorylation of Ser1156 in eukaryotic initiation factor eIF4GII (4GII).

290 Type I IRESs, 48S complex formation requires eukaryotic initiation factors (eIFs) 1, 1A, 2, 3, 4A, 4B

291 C), consisting of the 40S ribosomal subunit, eukaryotic initiation factors (eIFs) and initiator tRNA

292 translation, requiring only a subset of the eukaryotic initiation factors (eIFs) needed for canonica

293 ng the availability and function of specific eukaryotic initiation factors (eIFs).

294 of protein synthesis that involves multiple eukaryotic initiation factors (eIFs).

295 anced CVB3-induced cleavage of the host cell eukaryotic initiation factor of translation eIF4G in car

296 enzyme system increasing phosphorylation of eukaryotic initiation factor (P-eIF2alpha), which blocks

297 f Plasmodium falciparum eIF2alpha factor, an eukaryotic initiation factor phosphorylated by eIF2alpha

298 omotes dosage-dependent dephosphorylation of eukaryotic initiation factor, potentially inhibiting tra

299 g multiple translation components, including eukaryotic initiation factors, ribosomal large and small

300 r inactivation of the translational molecule eukaryotic initiation factor subunit 2alpha by way of th