ライフサイエンスコーパス: fetal liver

1 in the dorsal aorta and fail to colonize the fetal liver.

2 or cells (EPCs) in human bone marrow and the fetal liver.

3 highly reminiscent of erythropoiesis in the fetal liver.

4 progenitor and hematopoietic stem cells from fetal liver.

5 is in the yolk sac and its transition to the fetal liver.

6 that primitive RBCs in mice enucleate in the fetal liver.

7 rrelating with erythropoiesis defects in the fetal liver.

8 omal cells that support HSC expansion in the fetal liver.

9 sential for definitive erythropoiesis in the fetal liver.

10 tion day E18 human beta-YAC transgenic mouse fetal liver.

11 maturing erythroblast populations within the fetal liver.

12 This structure appears conserved in mouse fetal liver.

13 defects in definitive erythropoiesis in the fetal liver.

14 is sufficient to induce expansion of MEPs in fetal livers.

15 forkhead box class O (FOXO)1 in CON and IUGR fetal livers.

16 livers and that derive from ductal plates in fetal livers.

17 weeks of gestation were found for the human fetal livers.

18 pressed in the cytoplasm of human and rodent fetal livers.

19 s there was no significant difference in the fetal liver (2.72 msec vs 3.18 msec; P = .47).

20 ated with hematopoietic abnormalities in the fetal liver, a preleukemic condition termed transient my

21 ur fate-mapping experiments identify, in the fetal liver, a sequence of yolk sac EMP-derived and HSC-

22 In the fetal liver, a subset of common lymphoid progenitors (CL

23 uantitatively compare the proteomes of human fetal liver, adult hepatocytes, and the HepG2 cell line.

24 ion of 11beta-HSD1 and reductase activity in fetal liver and adipose tissues.

25 so regulates GATA-2 expression in definitive fetal liver and adult BM HSCs, and that GATA-2 function

26 Mouse B cell precursors from fetal liver and adult bone marrow (BM) generate distinct

27 Fetal liver and adult bone marrow hematopoietic stem cel

28 novel subset of lymphoid precursors in mouse fetal liver and adult bone marrow that transiently expre

29 CD45R(low/-)CD19(+) progenitor found both in fetal liver and adult bone marrow.

30 s important roles in normal hematopoiesis in fetal liver and adult bone marrow.

31 Cited2 is an essential regulator in fetal liver and adult hematopoiesis.

32 functional consequence of ARNT deficiency on fetal liver and adult hematopoiesis.

33 erythropoiesis occurs in the murine spleen, fetal liver and adult liver.

34 in embryonic day 13.5 and embryonic day 18.5 fetal liver and adult spleen and bone marrow cells, resp

35 genes such as Fgf21 remain repressed in the fetal liver and become PPARalpha responsive after birth

36 Using fetal liver and BM congenic transplantations and deletin

37 Fetal liver and BM-derived CD34(+)ACE(+) cells, but not

38 l antibody support ex vivo expansion of both fetal liver and bone marrow hematopoietic stem cells (HS

39 how regulation of different progenitors from fetal liver and bone marrow may play a role in the age-r

40 BI formation is regulated differently in the fetal liver and bone marrow.

41 h the hematopoietic stem cell compartment of fetal liver and bone marrow.

42 ean placental TTP negatively correlated with fetal liver and brain volumes at the time of MRI as well

43 phoid tissue inducer cell progenitors in the fetal liver and common lymphoid progenitors in the bone

44 was used to reseed the scaffolds with human fetal liver and endothelial cells.

45 of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known.

46 etic stem/progenitor cell compartment in the fetal liver and for essential vascular processes.

47 tally immature B cells recovered from murine fetal liver and from human immature/transitional 1 B cel

48 ed exclusively during pregnancy by the human fetal liver and initially considered as a weak estrogen.

49 increases steatosis and oxidative stress in fetal liver and is associated with lifetime disease risk

50 natural killer (NK) cells arise in the mouse fetal liver and persist in the adult liver.

51 fetal protein that is expressed in the human fetal liver and silenced in the adult liver, but it is r

52 - and Mrtf-deleted animals, hematopoiesis in fetal liver and spleen is intact but does not become est

53 Here we show that HSCs in murine fetal liver and the bone marrow are of two types that ca

54 ors among common lymphoid progenitors in the fetal liver and the bone marrow.

55 is is reconstituted by implantation of human fetal liver and thymus tissue (Thy/Liv) plus intravenous

56 is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or

57 me 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peri

58 most entirely eliminated pro-B cells in both fetal livers and adult bone marrow, resulting in a sever

59 yolk sac, aorta-gonad-mesonephros, placenta, fetal liver, and bone marrow with that of HSCs derived f

60 hyperoxygenation for live FPUs in placenta, fetal liver, and brain.

61 educed erythroid colony forming cells in the fetal liver, and low Bag1 expression impairs erythroid d

62 regions of interest of the entire placenta, fetal liver, and maternal liver.

63 ed in the embryonic yolk sac, but not in the fetal liver; and wild-type beta-globin was co-expressed

64 ata2 mutant embryos involved HSC loss in the fetal liver, as demonstrated by in vitro colony-forming

65 ., the aorta-gonad-mesonephros (AGM) and the fetal liver at 10.5-11.5 dpc, and found that only a rare

66 c progenitor cells available for seeding the fetal liver at E11.

67 the bloodstream of E10.5 embryos and in the fetal liver at E11.5 to E13.5.

68 recursors (Ter119pos population) in Gpr48-/- fetal liver at E13.5 was confirmed by histological analy

69 5(-) NK-cell progenitor (NKP) emerges in the fetal liver at E13.5.

70 In situ hybridization of fetal liver at embryonic day 17.5 of gestation revealed

71 The change in the fetal liver AUC ratio served as a reporter of placental

72 type 3, whereas murine HNF6 participates in fetal liver B lymphopoiesis.

73 mble and wt mice displayed similar levels of fetal liver B-1 progenitors and splenic neonatal transit

74 ay (E) 8.5, migrate and colonize the nascent fetal liver before E10.5, and give rise to fetal erythro

75 re red blood cells in cultures of both mouse fetal liver BFU-Es and mobilized human adult CD34(+) per

76 sis of progenitor cells from bone marrow and fetal liver both in vitro and in vivo revealed that UCP2

77 H3K14ac and DBC1-SIRT1 complex formation in fetal livers, both of which were abrogated with diet rev

78 tal phenotype with beneficial effects in the fetal liver but an unexplained and concerning alteration

79 HSCs emerge and successfully migrate to the fetal liver but are decreased in frequency by embryonic

80 endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown.

81 hese abnormalities overlap with those of T21 fetal livers, but also reflect important differences.

82 that IRF2-occupied genes identified in human fetal liver CD34(+) HSPCs are actively transcribed in hu

83 ing following HCV infection of primary human fetal liver cell (HFLC) cultures from 18 different donor

84 globin gene expression in primary erythroid fetal liver cells (eFLCs) after 72 hours in culture, fro

85 ture hepatocytes in adult liver (adult HCs), fetal liver cells (FLCs), induced hepatic stem cells (iH

86 e demonstrate that primary cultures of human fetal liver cells (HFLC) reliably support infection with

87 an inflammatory cytokine expressed by human fetal liver cells (HFLCs) after infection with cell cult

88 ed expression of HAI-1 and -2 transcripts in fetal liver cells and this induction could be antagonize

89 oviral complementation of STAT5ab(null/null) fetal liver cells and transplantation, persistently acti

90 Lack of STAT5 in fetal liver cells caused rapid differentiation and loss

91 id differentiation assay from primary murine fetal liver cells demonstrated that Elf-1 downregulation

92 Fetal liver cells derived from low-density-lipoprotein r

93 All mice transplanted with fetal liver cells ectopically expressing miR-125b showed

94 leukemic pathology in mice transplanted with fetal liver cells expressing translocated in liposarcoma

95 genitor cells, because Vav-iCre Ripk1(fl/fl) fetal liver cells failed to reconstitute hematopoiesis i

96 Fetal liver cells from Cited2 null embryos give rise to

97 Fetal liver cells from Dusp16tp/tp embryos efficiently r

98 Neither adult bone marrow-derived cells nor fetal liver cells from wild-type or Rag1-/- mice were ab

99 ion of human fetal thymic tissue and CD34(+) fetal liver cells in nonobese diabetic (NOD)/severe comb

100 topoietic reconstitution with Mafb-deficient fetal liver cells in recipient LDL receptor-deficient hy

101 oprecipitates with GATA-1 and EKLF in murine fetal liver cells in vivo and is recruited to the far-up

102 Transplantation of Bv8 null fetal liver cells into lethally irradiated hosts also re

103 e present study, we transplanted necdin-null fetal liver cells into lethally irradiated recipients.

104 n fetal thymus and liver tissues and CD34(+) fetal liver cells into nonobese diabetic/severe combined

105 Previously we showed that the ~2% of fetal liver cells reactive with an anti-CD3epsilon monoc

106 sed embryonic lethality, and Srsf2-deficient fetal liver cells showed significantly enhanced apoptosi

107 They are also the principal fetal liver cells that express CXCL12, a factor required

108 These are the principal fetal liver cells that express not only angiopoietin-lik

109 Bone marrow transplantation of SENP1 KO fetal liver cells to irradiated adult recipients confers

110 Bone marrow cells and, alternatively, fetal liver cells were cultured in media containing M-CS

111 When murine fetal liver cells were transduced with either of the hum

112 Fetal liver cells were transplanted from DPPIV(+) F344 r

113 macrophage-specific markers CD 11b, F4/80 in fetal liver cells, and bone marrow-derived macrophages w

114 In EBF- or EBF/Pax5-deficient fetal liver cells, both EBF and Pax5 were required for e

115 rsist when Runx1 is conditionally deleted in fetal liver cells, demonstrating that the requirement fo

116 Furthermore, we observe that in PU.1(-/-) fetal liver cells, low levels of the IE GATA-1 isoform i

117 r hematopoietic abnormalities in Klotho(-/-) fetal liver cells, suggesting that the effects of klotho

118 were 275-fold higher, compared with unsorted fetal liver cells, when 3 reprogramming factors were tra

119 oth murine erythroleukemia cells, as well as fetal liver cells, whereas an increase in PIAS3 levels i

120 between the three-dimensional liver bud and fetal liver cells.

121 angiopathies by exploring their functions in fetal liver cells.

122 enes genome-wide in embryonic stem cells and fetal liver cells.

123 munodeficient mice in the presence of scurfy fetal liver cells.

124 most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anoge

125 amoxifen-induced depletion or by Bcl11b(-/-) fetal liver chimera reconstitution, demonstrates that IL

126 KI/KI) mice die neonatally, but Orai1(KI/KI) fetal liver chimeric mice are viable and show normal lym

127 Irradiated fetal liver chimeric mice reconstituted with Gimap5-defi

128 d HSCs, and whether that transition requires fetal liver colonization, we performed conditional, time

129 least a subset of HSCs that does not require fetal liver colonization.

130 are largely methylated at CpG residues among fetal liver common lymphoid progenitor cells.

131 Fetal liver concentration of Cbl reflects nutritional st

132 Human T21 fetal livers contain expanded erythro-megakaryocytic pre

133 Fetal liver contained large numbers of distinct oligopot

134 These data show that the fetal liver contains two populations of erythroid progen

135 ristic differences between HSCs derived from fetal liver, cord blood, bone marrow, and peripheral blo

136 plication was not observed in primary equine fetal liver cultures or after electroporation of selecta

137 Intra-hepatic transfer of human fetal liver derived hematopoietic stem and progenitor ce

138 vered a potent shRNA against CCR5 into human fetal liver-derived CD34(+) hematopoietic progenitor/ste

139 ded by the simultaneous presence of EryP and fetal liver-derived definitive erythroid (EryD) cells in

140 vivo due to defective endocytic pathway, and fetal liver-derived Dnm2-null MKs formed proplatelets po

141 ression in terminally differentiating murine fetal liver-derived erythroid cells to identify regulato

142 long-term outgrowth of B-lymphoid cells from fetal liver-derived hematopoietic progenitor cells.

143 mod3 regulates F-actin organization in mouse fetal liver-derived MKs, thereby controlling MK cytoplas

144 Finally, in wild-type mature murine fetal liver-derived MKs, Wnt3a potently induced proplate

145 By taking advantage of two fetal liver-derived stromal lines with widely differing

146 at mouse iPS cells retain full potential for fetal liver development and describe a procedure that fa

147 y, we examine the localization of YAP during fetal liver development and show that higher levels of Y

148 thylation and demethylation, whereas in vivo fetal liver development is characterized predominantly b

149 Conversely, fetal liver did not exhibit this regulation.

150 P-gp was completely inhibited, the brain and fetal liver distribution clearance (K1) approximated tis

151 CsA increased maternal brain and fetal liver distribution of (11)C radioactivity by 276%

152 model best explained the observed brain and fetal liver distribution of (11)C-radioactivity.

153 c enhancer (-10E) that displayed activity in fetal liver, dorsal aorta, vitelline vessels, yolk sac,

154 LT accumulation in fetal liver resulted in a fetal liver dose of 53 microGy/MBq.

155 These early fetal liver erythroblasts express predominantly adult be

156 Knockdown of Xpo7 in primary mouse fetal liver erythroblasts resulted in severe inhibition

157 Flow cytometry of fetal liver erythroblasts shows that late-stage populati

158 Tmod1 leads to enucleation defects in mouse fetal liver erythroblasts, and in CD34(+) hematopoietic

159 4 is important for the maturation of primary fetal liver erythroid cells.

160 n alone plays a significant role in terminal fetal liver erythroid differentiation.

161 Fetal liver erythroid precursors of Ccbe1 null mice exhi

162 Knockdown of Mbnl1 in cultured murine fetal liver erythroid progenitors resulted in a strong b

163 d during ex vivo differentiation of Hri(-/-) fetal liver erythroid progenitors.

164 cy resulted in porphyrin accumulation in the fetal liver, erythroid maturation arrest, and embryonic

165 titution studies suggest that CCBE1 promotes fetal liver erythropoiesis cell nonautonomously.

166 In contrast to the profound effects on fetal liver erythropoiesis, postnatal deletion of Ccbe1

167 ipk2 are highly induced during primary mouse fetal liver erythropoiesis.

168 GEF2(cko/cko)ER(cre) mice leads to defective fetal liver erythropoiesis.

169 E1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that

170 The mutant bone marrow and fetal liver exhibited severe deficiency in HSCs and hema

171 Gata4 knockout fetal livers exhibited reduced size, advanced fibrosis,

172 cell progenitors emerging in the E13.5 mouse fetal liver express the colony-stimulating factor-1 rece

173 esis, we examined the number and function of fetal liver (FL) and bone marrow cells.

174 UHCT would mobilize endogenous HSCs from the fetal liver (FL) and result in preferential FL homing of

175 ematopoietic progenitor cells migrate to the fetal liver (FL) between gestational days (E) 9.5 and 10

176 enitor (MkP) hyperproliferation during early fetal liver (FL) hematopoiesis, but not during postnatal

177 rategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis.

178 d with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and mega

179 that of native LKS cells isolated from mouse fetal liver (FL) or bone marrow (BM).

180 Macrophages and erythroid cells in the fetal liver (FL) were also decreased after midgestation

181 HSCs first migrate to the fetal liver (FL), where they expand, before they seed th

182 Before birth, B cells develop in the fetal liver (FL).

183 (AGM) and mature as they transit through the fetal liver (FL).

184 poietic stem cells (HSCs) accumulated in the fetal liver following geminin ablation, while committed

185 bryonic day 11.5 (E11.5) Zfp36l2 KO mice and fetal livers from E14.5 KO mice gave rise to markedly re

186 r with androgen excess, affects maternal and fetal liver function as demonstrated by increased trigly

187 les characterized by increased expression of fetal liver genes including alpha-fetoprotein.

188 f a maternal HF diet on molecular markers of fetal liver gluconeogenesis.

189 uely present in a narrow window of embryonic fetal liver hematopoiesis and do not persist in adult bo

190 expression decreased with the termination of fetal liver hematopoiesis, and this decrease correlated

191 lved in various biologic processes including fetal liver hematopoiesis.

192 itors that seed the skin before the onset of fetal liver hematopoiesis.

193 mal mitochondrial respiration) caused lethal fetal liver hematopoietic defects and hematopoietic stem

194 Chimeric mice generated with Gata3-deficient fetal liver hematopoietic precursors lack all intestinal

195 requires cell-intrinsic Gata3 expression in fetal liver hematopoietic precursors.

196 c expression and KD of miR-486-5p in primary fetal liver hematopoietic progenitors demonstrated that

197 Flt3Cre+ KrasG12D fetal liver hematopoietic progenitors give rise to a mye

198 tative deficiencies in the murine Fancc(-/-) fetal liver hematopoietic stem and progenitor cell pool.

199 Fancc(-/-) fetal liver hematopoietic stem and progenitor cells reve

200 chimeric mice generated with Gata3-deficient fetal liver hematopoietic stem cells fail to develop sys

201 ion experiments demonstrated that Zfp36l2 KO fetal liver hematopoietic stem cells were unable to adeq

202 tein GPI-80 defines a subpopulation of human fetal liver hematopoietic stem/progenitor cells (HSPCs)

203 and primary erythroblasts (ERY) from murine fetal liver hematopoietic stem/progenitor cells.

204 primordial gallbladder epithelia but not in fetal liver hepatoblasts.

205 lk1-Gtl2 locus are predominantly enriched in fetal liver HSCs and the adult LT-HSC population and sus

206 ow hematopoietic stem cells (HSCs), although fetal liver HSCs are produced in normal numbers.

207 We show that ex vivo-matured and fetal liver HSCs express programmed death ligand 1 (PD-L

208 In addition, TAD-deficient fetal liver HSCs fail to compete with wild-type HSCs in

209 Ex vivo matured HSCs more closely resemble fetal liver HSCs than pre-HSCs, but are not their molecu

210 4) describe a novel surface marker for human fetal liver HSCs, glycosylphosphatidylinositol-anchored

211 of a Gata2 cis-element (+9.5) that depletes fetal liver HSCs, is lethal at E13-14 of embryogenesis,

212 tomes of pre-HSCs, HSCs matured ex vivo, and fetal liver HSCs.

213 uencies of 17% and 26%, respectively, and in fetal liver HSPCs at 19% and 43%, respectively.

214 ng to intrauterine fetal growth restriction, fetal liver hypocellularity, and demise.

215 nery are transcribed in the nonhuman primate fetal liver in an intact phase-antiphase fashion and tha

216 cells (HSCs) located in adult bone marrow or fetal liver in mammals produce all cells from the blood

217 Fetal liver injury in NH cases is associated with a seve

218 notypic expression of gestational alloimmune fetal liver injury.

219 of the tyrosine kinase activity of VEGFR-2 (fetal liver kinase 1, kinase insert domain-containing re

220 nism, requires paracrine VEGF stimulation of fetal liver kinase 1-Notch signaling, and adult collater

221 lial growth factor receptor-2, also known as fetal liver kinase-1 (FLK1).

222 cantly reduced CNS vascular permeability and fetal liver kinase-1 activation, and preserved levels of

223 Phosphorylation of fetal liver kinase-1 is significantly increased early in

224 Lm-listeriolysin-O-fetal liver kinase-1 was able to eradicate some establis

225 dothelial growth factor receptor 2 molecule (fetal liver kinase-1) to the microbial adjuvant, listeri

226 Repopulation of LC-deficient mice using fetal liver LC-precursors restores DMBA-induced tumor su

227 entiation conditions favoring development of fetal liver-like, gamma-globin expressing, definitive he

228 Comparison of adult bone marrow to fetal liver lysates demonstrated developmental silencing

229 with RUNX-1, and dominantly inhibits primary fetal liver megakaryocyte differentiation in vitro.

230 irculation, suggesting increased maternal or fetal liver metabolism of vitamin E.

231 topoietic stem cells (HSCs) expanding in the fetal liver migrate to the developing bone marrow (BM) t

232 quently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribu

233 erived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis.

234 lation changes can be detected in trisomy 21 fetal liver mononuclear cells, prior to the acquisition

235 PLCSCs were directly compared to fetal liver MSCs (flMSCs).

236 ow has been characterized, the nature of the fetal liver niche is not yet elucidated.

237 (E10.5 and E11.5) AGM or derived from E13.5 fetal liver not only differentiate into hematopoietic co

238 tudies revealed a severely dilated ER in the fetal liver of mutant embryos, indicative of alteration

239 GATA1-dependent genes are down-regulated in fetal liver of SENP1 KO mice.

240 pmentally mature, definitive HSCs from E14.5 fetal liver or adult bone marrow (BM) more robustly engr

241 -10 production, or differences between their fetal liver or adult bone marrow progenitor cell origins

242 macrophages and NK cells derived from human fetal liver or adult CD34(+) progenitor cells injected i

243 Stem/progenitor cells derived from fetal livers or mature hepatocytes from DPPIV(+) F344 ra

244 While it has been well established that the fetal liver originates from foregut endoderm, the identi

245 We determined MNR effects on fetal liver phosphoenolpyruvate carboxykinase 1 (protein

246 In this study, we report identification of a fetal liver population characterized phenotypically as L

247 cells derived from the Lin(-)CD45R(-)CD19(-) fetal liver population produce natural Ab that binds pne

248 DHT exposure, regardless of diet, decreased fetal liver Pparg mRNA expression and increased placenta

249 0 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common pr

250 enhancer factor 2 C (Mef2C) from Scl(fl/fl) fetal liver progenitor cell lines.

251 the identification of a unique population of fetal liver progenitor cells in mice that can serve as a

252 Here, we show that human fetal liver progenitor cells self-assembled inside acell

253 tion of flt3l severely reduced the number of fetal liver progenitors and lymphoid tissue inducer cell

254 Mutant fetal liver progenitors generated B cells in situ but no

255 ) and periphery in chimeras established with fetal liver progenitors lacking Akt1 and/or Akt2.

256 from yolk sac erythromyeloid progenitors and fetal liver progenitors that seed tissues during embryog

257 Here we show that the differentiation of fetal liver progenitors to adult hepatocytes involves a

258 kdown and Gata1s knockin, but not wild-type, fetal liver progenitors.

259 n FLI-1 in wild-type and Gata1 mutant murine fetal liver progenitors.

260 Fetal liver reconstitution experiments demonstrated that

261 olyadenylated RNA from differentiating mouse fetal liver red blood cells and identified 655 lncRNA ge

262 Dynamic (11)C-verapamil brain or fetal liver (reporter of placental P-gp function) activi

263 aorta, vitelline and umbilical arteries, and fetal liver require or express Gata2.

264 . (2016) provide justification for transient fetal liver residence, where select bile acid compositio

265 nificant long-term (18)F-FLT accumulation in fetal liver resulted in a fetal liver dose of 53 microGy

266 xamination of extruded erythroid nuclei from fetal liver revealed a striking depletion of most nuclea

267 (18)F-FLT trapping in the fetal liver should be considered in the risk-benefit ana

268 Bright(-/-) embryonic day 12.5 (E12.5) fetal livers showed an increase in the expression of imm

269 e myeloid hematopoiesis in trisomy 21 at the fetal liver stage.

270 RNAs during hepatocytic differentiation of a fetal liver stem cell line, HBC-3, promoted expression o

271 uman interleukin (IL)-10 gene into the total fetal liver stem cells (hIL-10-TFLs) of mice protects ag

272 Highly proliferative fetal liver stem/progenitor cells (FLSPCs) repopulate li

273 (111)In labeling of human fetal liver stem/progenitor cells and adult hepatocytes

274 We found that adult hepatocytes and fetal liver stem/progenitor cells incorporated (111)In b

275 es wherein adult human hepatocytes and human fetal liver stem/progenitor cells were labeled with indi

276 Transplanted adult hepatocytes or fetal liver stem/progenitor cells were targeted to the l

277 Compared with fetal liver stem/progenitor cells, fewer adult hepatocyt

278 rosis/cirrhosis, but to a lesser extent than fetal liver stem/progenitor cells.

279 poietic stem and progenitor cells from mouse fetal liver, suggesting that enhancer activity is highly

280 e hematopoietic changes are also detected in fetal livers, suggesting that they are not the result of

281 Analysis of human fetal livers suggests that similar progenitors are prese

282 B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, w

283 arent P50 values were significantly lower in fetal liver than in maternal liver for both gestation st

284 rsor cells arise in the adult bone marrow or fetal liver, they migrate to the thymus where they rearr

285 l aorta and subsequently switch niche to the fetal liver through unknown mechanisms.

286 l is prepared by co-transplantation of human fetal liver, thymus and HSC.

287 n primary sequence, were negligible in human fetal liver tissues or in the differentiating hESCs, and

288 lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the form

289 tion of PIT1 in the hematopoietic system and fetal liver transplantation experiments demonstrated tha

290 ematopoietic cell TFPI that was generated by fetal liver transplantation.

291 In mixed chimeras with Scurfy fetal liver, Tregs derived from IFNAR KO bone marrow wer

292 AID expression in human fetal liver was also robust, approaching that of human t

293 frequency of hematopoietic stem cells in the fetal liver were observed on APAP treatment.

294 Subsequently 55 human fetal livers were analyzed.

295 Cells isolated from 12- to 14-d fetal livers were used to reconstitute irradiated recipi

296 mbryonic development, pHSCs migrate into the fetal liver, where they develop and mature to B cells in

297 ages (Max Planck Institute cells) from mouse fetal liver, which reflect the innate immune characteris

298 matopoietic stem and progenitor cells to the fetal liver, while it hampers hematopoiesis in wild-type

299 mbers are moderately increased in Tmod3(-/-) fetal livers, with only a slight increase in the 8N popu

300 island formation was impaired in Tmod3(-/-) fetal livers, with Tmod3 required in both erythroblasts