ライフサイエンスコーパス: focal adhesion kinase

1 line using mass spectrometry, including FAK (focal adhesion kinase).

2 GAP, GRAF1 (GTPase Regulator Associated with Focal Adhesion Kinase).

3 tent and showed increased phosphorylation of focal adhesion kinase.

4 of PI3K signaling mediated by integrins and focal adhesion kinase.

5 integrin-linked kinase but is independent of focal adhesion kinase.

6 rylation of N-WASP at the Tyr-256 residue by focal adhesion kinase.

7 cytoskeleton and reduced phosphorylation of focal adhesion kinase.

8 olipase C, or the gamma-Pcdh binding partner focal adhesion kinase.

9 sions, and attenuated autophosphorylation of focal adhesion kinase.

10 oteolysis of the adhesion proteins talin and focal adhesion kinase.

11 otransduction in primary hepatocytes through focal adhesion kinase.

12 ously expressed non-receptor tyrosine kinase focal adhesion kinase.

13 llin independently of upstream regulation by focal adhesion kinase.

14 the MAP/microtubule affinity regulating and focal adhesion kinases.

15 nt change in mass but a 3-fold increase in P-focal adhesion kinase, 1.5-fold increase in P-Akt, and 5

16 ellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-depe

17 previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor

18 eptor (CXCR) 1, and the intracellular kinase focal adhesion kinase-1.

19 consists of the integrin subunit betanu and focal adhesion kinase 56 (Fak56), both of which are requ

20 e of RhoH the distribution of phosphorylated focal adhesion kinase, a protein known to coordinate act

21 Focal adhesion kinase activation and satellite cell numb

22 es several oncogenic pathways, such as early focal adhesion kinase activation upstream of PI3K-mTOR,

23 Additionally, integrin beta1d expression and focal adhesion kinase activation were increased in this

24 SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension b

25 actin concomitant with a decrease in Rho and focal adhesion kinase activity.

26 Furthermore, Ten-4 positively regulated focal adhesion kinase, an essential signaling molecule f

27 teractions led to impaired activation of the focal adhesion kinase, an integrin-mediated regulator of

28 beta3 and the concomitant phosphorylation of focal adhesion kinase and AKT in podocytes.

29 ion of integrin-beta3 and phosphorylation of focal adhesion kinase and AKT, known mediators of integr

30 rite extension in vitro by signaling through focal adhesion kinase and Akt.

31 f angiogenic factors and mechanotransducers (focal adhesion kinase and beta1-integrin) ex vivo A 3-we

32 In humans, focal adhesion kinase and Cas phosphorylation - markers

33 omes that could be reversed by knocking down focal adhesion kinase and depleting it from the MVs or b

34 cones and forms a multiprotein complex with focal adhesion kinase and ERK.

35 igh-affinity conformation and an increase in focal adhesion kinase and ERK1/2 activation.

36 A induced cytoskeletal changes and activated focal adhesion kinase and ERKs 1/2, and decreased Src ki

37 lated c-MET, total c-MET, and phosphorylated focal adhesion kinase and increased terminal deoxynucleo

38 f transcription 3-mediated activation of the focal adhesion kinase and its associated focal adhesion

39 evealed that integrin beta5 mediates the Src-focal adhesion kinase and MEK-extracellular signal-regul

40 t in SHP-2 exhibited decreased activation of focal adhesion kinase and mitogen-activated protein kina

41 intracellular signaling cascades, including focal adhesion kinase and mitogen-activated protein kina

42 1 integrin, which subsequently regulates Src/focal adhesion kinase and paxillin and prevents anoikis.

43 ion formation and reduced phosphorylation of focal adhesion kinase and paxillin, which could be resto

44 ibitor protein 1, and the phosphorylation of focal adhesion kinase and paxillin, while enhancing E-ca

45 sly identified PTP-zeta downstream effectors focal adhesion kinase and paxillin.

46 3a were dependent on TGF-beta1 activation of focal adhesion kinase and PI3K/Akt.

47 process required integrin signaling through focal adhesion kinase and relied on an intact microtubul

48 eta3 integrin surface expression, activating focal adhesion kinase and Src kinases, and promoting cel

49 ls, TNFalpha-treated cells exhibited reduced focal adhesion kinase and subsequent plasma membrane per

50 egrin-linked kinase and endothelial-specific focal adhesion kinase and talin-1 ablation.

51 ICOS-Fc downmodulated the phosphorylation of focal adhesion kinase and the expression of beta-Pix in

52 ate that integrin-mediated signaling through focal adhesion kinase and the p38 mitogen-activated prot

53 on integrin beta-3 signals that activate the focal-adhesion kinase and c-Src kinase and their downstr

54 ain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin-linked kinase, enhan

55 he migratory proteins rho-associated kinase, focal adhesion kinase, and matrix metalloproteinases.

56 raction and the following activation of Src, focal adhesion kinase, and p38 MAPK.

57 SCs increase phosphorylation of ErbB2, ERK, focal adhesion kinase, and paxillin in response to NRG1,

58 mpaired by inhibitors of NADPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase

59 lving vasodilator-stimulated phosphoprotein, focal adhesion kinase, and protein-disulfide isomerase i

60 he focal adhesion complex signaling pathway, focal adhesion kinase, and rac1.

61 as phosphorylation of cortactin, activity of focal adhesion kinase, and small GTPases.

62 dynamic competitive interactions between E6, focal adhesion kinase, and the GIT1 ARF-GAP protein for

63 n Shp2 depends on hyperactivation of Akt and focal adhesion kinase as well as mammalian target of rap

64 volves stimulation of Src-family kinases and focal adhesion kinase, as well as the localized accumula

65 on of beta1-integrins and phosphorylation of focal adhesion kinase at synaptic sites, and were preven

66 ell cell interface and by phosphorylation of focal adhesion kinase at Tyr(407).

67 decreased VEGF-dependent phosphorylation of focal adhesion kinase at Tyr407, but had little effect o

68 amily kinases (SFKs), and phosphorylation of focal adhesion kinase at Y397 (pFAK(Y397)), the latter b

69 The putative focal adhesion kinase autophosphorylation site Tyr(397)

70 tein phosphatase 2A (PP2A) and inhibition of focal adhesion kinase by MEK/ERK to allow the binding be

71 lecularly supported by the regulation of the focal adhesion kinase by p38delta in the human breast ce

72 to adopt a structure similar to that of the focal adhesion kinase C-terminal focal adhesion-targetin

73 ent of vinculin and the formation of a novel focal adhesion kinase complex in response to ErbB2 activ

74 n of ACF7, whose phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin

75 alpain 1, the primary enzyme responsible for focal adhesion kinase degradation, which becomes induced

76 The intricate interplay of this "MEK/ERK-focal adhesion kinase-DLC1-PP2A" quartet provides a nove

77 molecular changes, such as reduced levels of focal adhesion kinase expression and a misbalance in foc

78 We have found that focal adhesion kinase expression is downregulated under

79 th at baseline and after hemodynamic stress; focal adhesion kinase expression was reduced after stres

80 ion in both cell motility and phosphorylated focal adhesion kinase expression, suggesting a defect in

81 rrent FA assembly and Src activation leading focal adhesion kinase (FAK) activation by 42.6 +/- 12.6

82 In addition, vinculin is necessary for Focal Adhesion Kinase (FAK) activation in 3D as vinculin

83 ase in cell adhesion, as well as in integrin/focal adhesion kinase (FAK) activation, and exhibit an e

84 cular mechanism, whereby adiponectin targets focal adhesion kinase (FAK) activity and disrupts key fe

85 We identified hyperactivated focal adhesion kinase (FAK) activity in neoplastic PDAC

86 nctly control force transmission to regulate focal adhesion kinase (FAK) activity, a crucial molecula

87 type I receptor (AT1R) signaling and abated focal adhesion kinase (FAK) activity.

88 Focal adhesion kinase (FAK) acts as an adaptor at the fo

89 However, some of these kinases like focal adhesion kinase (FAK) also possess scaffolding fun

90 with increased activating phosphorylation of focal adhesion kinase (FAK) and breast cancer anti-estro

91 sion, axon attraction and phosphorylation of focal adhesion kinase (FAK) and Crk-associated substrate

92 lating the phosphorylation and activation of focal adhesion kinase (FAK) and cytoskeletal reorganizat

93 on and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading.

94 se actions, which prevents the activation of focal adhesion kinase (FAK) and extracellular signal-reg

95 Sorafenib dephosphorylated focal adhesion kinase (FAK) and extracellular signal-reg

96 illin at the centrosome that is dependent on focal adhesion kinase (FAK) and identify an important co

97 siRNA knockdown to block phosphorylation of focal adhesion kinase (FAK) and increase the size of foc

98 ar mediators of integrin alpha5/Fn1 activity focal adhesion kinase (FAK) and integrin-linked kinase (

99 GIV interacts with focal adhesion kinase (FAK) and ligand-activated beta1 i

100 the interdependence of the tyrosine kinases focal adhesion kinase (FAK) and Mer tyrosine kinase (Mer

101 he Gas6/Axl signalling pathway recruits Src, focal adhesion kinase (FAK) and NFkappaB.

102 ainst LD2 and LD4 that are binding sites for focal adhesion kinase (FAK) and other proteins.

103 A decreased expression of integrin-recruited focal adhesion kinase (FAK) and p-FAK, while increasing

104 emporal relationship between the dynamics of focal adhesion kinase (FAK) and paxillin at FAs in the p

105 Specifically, the disruption of focal adhesion kinase (FAK) and paxillin interactions us

106 a1 integrin and decreased phosphorylation of focal adhesion kinase (FAK) and paxillin resulting in FA

107 ed the glucose-responsive co-localization of focal adhesion kinase (FAK) and paxillin with integrin b

108 and PTP-PEST, with consequent activation of focal adhesion kinase (FAK) and paxillin.

109 ntracellular signaling pathways that include focal adhesion kinase (FAK) and phosphoinositide 3-kinas

110 We demonstrate that Lyn association with focal adhesion kinase (FAK) and phosphorylation of FAK a

111 , we demonstrate that VEGF and NRP2 activate focal adhesion kinase (FAK) and promote FAK-dependent br

112 by a decrease in the phosphorylation of both focal adhesion kinase (Fak) and protein kinase B (Akt).

113 Pharmacological inhibition of both focal adhesion kinase (FAK) and Raf also induced regress

114 ibition results in altered signaling through focal adhesion kinase (FAK) and RhoA GTPase and a transf

115 Focal adhesion kinase (FAK) and Src family kinases (SFK)

116 urbation of the key IAC signaling components focal adhesion kinase (FAK) and Src.

117 Integrins recruit focal adhesion kinase (FAK) and the cytoskeletal protein

118 creases tyrosine phosphorylation of p130Cas, focal adhesion kinase (FAK) and the downstream adaptor p

119 deletion of gH prevented phosphorylation of focal adhesion kinase (FAK) and the transport of viral c

120 e cell through a pathway including paxillin, focal adhesion kinase (FAK) and vinculin.

121 hanges in subcellular distribution of active focal adhesion kinase (FAK) are associated with the fusi

122 Tumor necrosis factor-alpha (TNF-alpha) and focal adhesion kinase (FAK) are key regulators of inflam

123 beta4 integrin and focal adhesion kinase (FAK) are often associated with a

124 We identified focal adhesion kinase (FAK) as a VHR-interacting molecul

125 We previously identified focal adhesion kinase (FAK) as an important regulator of

126 we identify the adhesion proteins talin and focal adhesion kinase (FAK) as proteolytic targets of ca

127 STRADalpha have increased phosphorylation of focal adhesion kinase (FAK) at Tyr(397)/Tyr(861) and enh

128 C family kinase-dependent phosphorylation of focal adhesion kinase (FAK) at tyrosine 925, FAK associa

129 nhibited alpha3beta1 signaling downstream of focal adhesion kinase (FAK) autoactivation at the point

130 TrxR linkage to sF-actin requires focal adhesion kinase (FAK) based on immunoprecipitation

131 ue to the reduced expression and activity of focal adhesion kinase (FAK) by this cell type.

132 yperoxia were abrogated in cells depleted of focal adhesion kinase (FAK) by treatment with small inhi

133 imulate FN matrix assembly and activation of focal adhesion kinase (FAK) compared with the level of a

134 pathways regulated by keratinocyte-specific focal adhesion kinase (FAK) control dermal remodeling vi

135 tly developed breast cancer mouse model with focal adhesion kinase (FAK) deletion in mammary tumor ce

136 NF1 functions downstream of the Drosophila focal adhesion kinase (FAK) Fak56 and physically interac

137 investigate the proposal that integrins and focal adhesion kinase (FAK) form a complex that has stru

138 mics, and release the cell motility effector focal adhesion kinase (FAK) from inhibition by the autop

139 Focal adhesion kinase (FAK) has an important role in neu

140 A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to

141 n and a ligand resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C depend

142 5beta1 integrin and downstream signalling to focal adhesion kinase (FAK) in an endoglin-dependent man

143 ation of membrane-associated adaptor protein focal adhesion kinase (FAK) in Caco-2 monolayers.

144 Here, we show that conditional deletion of focal adhesion kinase (FAK) in embryonic mammary epithel

145 Focal adhesion kinase (FAK) in platelets regulated their

146 Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor gr

147 Focal Adhesion Kinase (FAK) inhibitor can bypass extrusi

148 Addition of a focal adhesion kinase (FAK) inhibitor reduces disassembl

149 Focal adhesion kinase (FAK) is a critical regulator of s

150 Focal adhesion kinase (FAK) is a cytoplasmic tyrosine ki

151 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

152 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

153 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

154 Nuclear focal adhesion kinase (FAK) is a potentially important r

155 Focal adhesion kinase (FAK) is considered as an attracti

156 Focal Adhesion Kinase (FAK) is essential for cell migrat

157 suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulat

158 Focal adhesion kinase (FAK) is overexpressed in many HCC

159 d dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tum

160 rrelates with the number of bound integrins, focal adhesion kinase (FAK) phosphorylation correlates w

161 6-stimulated migration, whereas knockdown of focal adhesion kinase (FAK) preferentially inhibited EGF

162 Focal adhesion kinase (FAK) promotes anti-tumor immune e

163 Both Pyk2 and the closely related focal adhesion kinase (FAK) regulate tumor cell invasion

164 Focal adhesion kinase (FAK) regulates different cellular

165 Inhibition of focal adhesion kinase (FAK) rescued SERT function in syn

166 directly bind paxillin, which in turn bound focal adhesion kinase (FAK) resulting in FAK activation

167 ced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576).

168 was invasion, which was mediated by both Src-focal adhesion kinase (FAK) signaling and Forkhead box p

169 ssays revealed that S100A4 activates Src and focal adhesion kinase (FAK) signaling events, and inhibi

170 ficantly dysregulated expression of genes in focal adhesion kinase (FAK) signaling, a key pathway reg

171 RhoA also activates focal adhesion kinase (FAK) signaling.

172 tor (uPAR), and beta1-integrin, which affect focal adhesion kinase (FAK) signaling.

173 tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase (FAK) subfamily of cytoplasmic tyr

174 we report that Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway

175 Activated integrins recruit focal adhesion kinase (FAK) that mediates metastatic dow

176 orylation and downstream signals of Akt, and focal adhesion kinase (FAK) thus induced were down-regul

177 Activation of the tyrosine kinase focal adhesion kinase (FAK) upon cell stimulation by the

178 Mechanistically, dephosphorylation of focal adhesion kinase (FAK) upon inhibition of beta(1) i

179 Inhibition of focal adhesion kinase (FAK) using pharmacological inhibi

180 nteractions, as did inhibiting intracellular focal adhesion kinase (FAK) using Y15.

181 The gamma-Pcdhs bind to and inhibit focal adhesion kinase (FAK) via a constant C-terminal cy

182 Signaling from focal adhesion kinase (FAK) was blocked using FAK inhibi

183 The non-receptor tyrosine kinase focal adhesion kinase (FAK) was found to be co-associate

184 We demonstrate that the host cell focal adhesion kinase (FAK) was necessary for the invasi

185 Mechanistically, VEGF-A induced binding of focal adhesion kinase (FAK) with paxillin.

186 We examined interactions of the focal adhesion kinase (FAK) with protein-tyrosine phosph

187 ed, we examined the phosphorylation state of focal adhesion kinase (Fak)(Ser732), a known target of C

188 Here we show that focal adhesion kinase (FAK), a focal adhesion localized

189 We now report that focal adhesion kinase (FAK), a key regulator of focal ad

190 Focal adhesion kinase (FAK), a key transmitter of growth

191 We demonstrate that focal adhesion kinase (FAK), a major component of integr

192 and subsequently to partial inactivation of focal adhesion kinase (FAK), a major effector kinase of

193 nger isoforms exhibited increased binding to focal adhesion kinase (FAK), a molecule important for mi

194 Focal adhesion kinase (FAK), a nonreceptor protein tyros

195 Furthermore, focal adhesion kinase (FAK), a nonreceptor tyrosine kina

196 e is similar to that produced by deletion of focal adhesion kinase (FAK), a signaling partner of paxi

197 t has been shown to regulate the activity of focal adhesion kinase (FAK), a tyrosine kinase activated

198 hat COUP-TFII also reduces the activation of focal adhesion kinase (FAK), an integrin downstream regu

199 Cells without focal adhesion kinase (FAK), an integrin-activated tyros

200 ecrease in invasion, less phosphorylation of focal adhesion kinase (FAK), and an approximately 2-fold

201 A and invadopodia-associated proteins talin, focal adhesion kinase (FAK), and cortactin and reduced c

202 evated mRNA and protein expression levels of focal adhesion kinase (FAK), and increased FAK and Src a

203 Without Focal Adhesion Kinase (FAK), developing murine Schwann c

204 microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP.

205 Cryptococcus also induces phosphorylation of focal adhesion kinase (FAK), ezrin, and protein kinase C

206 in beta1-integrin activation with vinculin, focal adhesion kinase (FAK), FAK(PY397), F actin, and pa

207 MUCL1 silencing abrogated phospho-focal adhesion kinase (FAK), Jun NH2-terminal kinase (JN

208 Net1A interacts with focal adhesion kinase (FAK), localizes to focal adhesion

209 er, mifepristone inhibited the expression of focal adhesion kinase (FAK), paxillin, and the formation

210 -mediated protease-independent function; and focal adhesion kinase (FAK), Rac-1, and NF-kappaB were i

211 egrin-associated signaling molecules such as focal adhesion kinase (FAK), Src, c-Cbl, phosphoinositid

212 we show that a signaling axis consisting of focal adhesion kinase (FAK), Src, phosphatidylinositol 3

213 Vbeta5), and EphrinA2 (EphA2), and activates focal adhesion kinase (FAK), Src, phosphoinositol 3-kina

214 ways, leading to tyrosine phosphorylation of focal adhesion kinase (FAK), the tyrosine kinase Src, an

215 both RACK1 and vimentin have been linked to focal adhesion kinase (FAK), we investigated whether thi

216 tivation, such as phosphorylation of ERK and focal adhesion kinase (FAK), were increased after knockd

217 ve conformations of the kinase domain of the focal adhesion kinase (FAK), which are distinguished by

218 how that fibronectin adhesion stimulation of focal adhesion kinase (FAK)-Src signaling is another ups

219 ied by down-regulation of phosphorylated (p)-focal adhesion kinase (FAK)-Tyr(397) and retention of ne

220 We reported previously that the CXCL12-focal adhesion kinase (FAK)-VLA4 pathway plays an import

221 reen revealed that RABV P interacts with the focal adhesion kinase (FAK).

222 dentified another cellular partner of P, the focal adhesion kinase (FAK).

223 elial growth factor receptor 2 (VEGF-R2) and focal adhesion kinase (FAK).

224 this residue blocks PKD2's interaction with Focal Adhesion Kinase (FAK).

225 s, a reaction that is partially dependent on focal adhesion kinase (FAK).

226 ignal-regulated kinases 1/2 to phosphorylate focal adhesion kinase (FAK).

227 bling the focal adhesion targeting region of focal adhesion kinase (FAK).

228 PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK).

229 late the PMCA directly but instead activated focal adhesion kinase (FAK).

230 orylation, which is known to be regulated by focal adhesion kinase (FAK).

231 including CRK-like proto-oncogene (CRKL) and focal adhesion kinase (FAK).

232 cessary for promoting autophosphorylation of focal adhesion kinase (FAK).

233 lso led to the incorporation of activity for focal adhesion kinase (FAK).

234 y and tumor progression via interaction with focal adhesion kinase (FAK).

235 We also found that IL-33 activated focal adhesion kinase (FAK).

236 epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK)/protein kinase B (AKT) signa

237 We have demonstrated previously that focal adhesion kinase (FAK)/RhoA alteration by the aryl-

238 le activated tyrosine kinases, we identified focal adhesion kinase (FAK, PTK2) as a candidate target

239 We establish that specific targeting of focal adhesion kinase (FAK; also known as PTK2) in endot

240 ed kinase (ERK1/2; by approximately 44%) and focal adhesion kinase (FAK; by approximately 46%) as wel

241 The latter co-localizes with focal adhesion kinases (FAK) at dynamic focal adhesions

242 IGFBP-1 acts via beta1-integrin and focal-adhesion-kinase (FAK), which are strongly overexpr

243 ne receptor 4 (CXCR4) and PTK2 (encoding for focal adhesion kinase [FAK]).

244 tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family and is highly expressed in

245 cell motility itself, which instead utilizes focal adhesion kinase-fibronectin signalling.

246 serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signali

247 n, fibronectin, and impaired accumulation of focal adhesion kinase, indicating that the GPR56-TG2 int

248 ease in intracellular phosphorylated Src and focal adhesion kinase, integrin-dependent cell signaling

249 Focal adhesion kinase is an intracellular protein kinase

250 l-regulated kinase 1 and 2, Elk-1, p38, Akt, focal adhesion kinase, mechanistic target of rapamycin,

251 invadopodia formation through PDGFRalpha and focal adhesion kinase-mediated (FAK-mediated) activation

252 -2 (Has2) are also enhanced upon PN/INTEGRIN/focal adhesion kinase-mediated activation of PI3K and/or

253 hibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of I

254 w that LKB1 kinase activity is essential for focal adhesion kinase-mediated cell adhesion and subsequ

255 t calpain-mediated proteolysis of talin1 and focal adhesion kinase mediates adhesion disassembly in m

256 -WASP via activation of small Rho GTPase and focal adhesion kinase mediates TGF-beta1-induced paracel

257 luding transforming growth factor-beta/SMAD, focal adhesion kinase, MRTFs, Wnt/beta-catenin and YAP/T

258 pha resulted in increased phosphorylation of focal adhesion kinase on Tyr-407, which induced the recr

259 otein tyrosine kinase 2 (ptk2, also known as focal adhesion kinase or FAK), is reduced in the neuromu

260 ation experiments revealed that Yes bound to focal adhesion kinase or p130Cas more strongly in GD3+ c

261 simultaneous depletion of alpha-catenin and focal adhesion kinase or p21-activated kinase eliminates

262 However, modulation of focal adhesion kinase or Src, the major downstream compo

263 gration away from the lipid raft-independent focal adhesion kinase pathway and toward a lipid raft-de

264 ocal adhesion turnover via a PKCbeta-Calpain-focal adhesion kinase pathway.

265 ses showed that P15-1 blocks RHAMM-regulated focal adhesion kinase pathways in fibroblasts.

266 e prominent tyrosine-phosphorylated proteins focal adhesion kinase, paxillin, and cortactin were iden

267 Shc, phospholipase Cgamma, protein kinase C, focal adhesion kinase, paxillin, and mitogen-activated p

268 hosphorylation and/or dampened activation of focal adhesion kinase, paxillin, Rac1, and Erk1/2 during

269 dingly, BA caused an increase in the size of focal-adhesion-kinase/paxillin-positive peripheral adhes

270 initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin an

271 msk mutants fail to localize phosphorylated focal adhesion kinase (pFAK) to the sites of muscle-tend

272 Perlecan augments the reduction in phospho-focal adhesion kinase (phospho-FAK) levels that result f

273 Focal adhesion kinase phosphorylation indicated that CCL

274 T lymphocytes, which induces ATP secretion, focal adhesion kinase phosphorylation, cell polarization

275 However, all peptides increased focal adhesion kinase phosphorylation, OSE2 transcriptio

276 hesion kinase expression and a misbalance in focal adhesion kinase phosphorylation, which may lead to

277 ractions, in part dependent on activation of focal adhesion kinases, promote delivery of basophil-der

278 s and myosin phosphatase activity, including focal adhesion kinase, protein tyrosine kinase-2, Janus

279 the present study show the importance of the focal adhesion kinase Pyk2 downstream of G-protein-coupl

280 yze the contribution of the Ca(2+)-dependent focal adhesion kinase Pyk2 in platelet activation and th

281 Herein, we show that focal adhesion kinase-related nonkinase (FRNK) plays a k

282 ein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wisko

283 Focal adhesion kinase's (FAK) role in regulating cell mi

284 s proliferation of CPCs via beta(1)-integrin-focal adhesion kinase-signal transducer and activator of

285 can bind to INTEGRINs and activate INTEGRIN/focal adhesion kinase signaling pathways and downstream

286 of extracellular signal-regulated kinase and focal adhesion kinase signaling pathways that are critic

287 regulation of integrin alpha(V)beta(3)-FAK (focal adhesion kinase) signaling pathway.

288 matrix stiffness and activation of the FAK (focal adhesion kinase)/SRC-signaling pathway, with a sti

289 Importantly LAMB1 stimulated ITG-dependent focal adhesion kinase/Src proto-oncogene non-receptor ty

290 ing Exo(fib+), two major events are induced: focal adhesion kinase/Src-dependent signaling pathways a

291 terference (RNAi) depletion of myosin II and focal adhesion kinase, suggesting that this behavior req

292 mTOR mutations that clustered in focal adhesion kinase targeting domain (FAT) and kinase

293 lving vasodilator-stimulated phosphoprotein, focal adhesion kinase, the H(+)/K(+) ATPase beta (flippa

294 uding vasodilator-stimulated phosphoprotein, focal adhesion kinase, the membrane phospholipid translo

295 l-ECM adhesion nor cell-ECM adhesion-induced focal adhesion kinase Tyr-397 phosphorylation.

296 rombin treatment led to increases in phospho-focal adhesion kinase (tyrosine 397), ERK1/2 phosphoryla

297 sin light chain kinase or phosphorylation of focal adhesion kinase was ineffective.

298 rgets, epidermal growth factor receptors and focal adhesion kinase, were significantly reduced in c-C

299 eral application, here we apply the model to focal adhesion kinase, which initiates the chemical sign

300 nd activate the non-receptor tyrosine kinase focal adhesion kinase, which plays a key role in signali