ライフサイエンスコーパス: gastrula

1 d within the first 48 h of development (late gastrula).

2 ic endodermal expression in the blastula and gastrula.

3 for both D/V and A/P patterning of the early gastrula.

4 nd signaling mechanisms patterning the human gastrula.

5 eron-inducible transmembrane proteins in the gastrula.

6 naling centers that pattern the blastula and gastrula.

7 stributed mesodermal fields within the early gastrula.

8 ed out by redundant enzymes in the zebrafish gastrula.

9 mesodermal extension exists in the zebrafish gastrula.

10 anging from the mid-blastula through the mid-gastrula.

11 convergent extension movements in zebrafish gastrula.

12 ein activity specifies cell fates within the gastrula.

13 ed in a loss of Sox17alpha expression in the gastrula.

14 sue and regulates somite size in the Xenopus gastrula.

15 he prospective notochord region of the early gastrula.

16 osteriorization of neuroectoderm in the late gastrula.

17 sed in the presumptive mesoderm of the early gastrula.

18 rostral to the primitive streak in the early gastrula.

19 astula, and to the posterior mesoderm by mid-gastrula.

20 ed throughout the nonaxial region of the spt gastrula.

21 de variety of posterior tissues of the mouse gastrula.

22 ted by the dorsal and ventral centers of the gastrula.

23 ntributes to defective cell movements in the gastrula.

24 mes exclusively in bottle cells in the early gastrula.

25 albeit incomplete, is already evident in the gastrula.

26 nt in a broad, crescent-shaped region of the gastrula.

27 in patterning the A/P axis of the amphioxus gastrula.

28 m during gut endoderm formation in the mouse gastrula.

29 ifically in the dorsolateral mesoderm of the gastrula, a domain that is established by the interactio

30 tends all the way to the ventral side of the gastrula, a long way from the organiser.

31 In the late gastrula, a single field of odd-paired-like-expressing c

32 ricted domains along the A-P axis during the gastrula and early neurula stage.

33 ttern is almost identical to that of Xbra at gastrula and early neurula stages.

34 us endoderm patterning such that during late gastrula and early somite stages of embryogenesis, Wnt a

35 We show that in gastrula and early-somite stage Xenopus embryos, Wnt/bet

36 x is called "Brachet's cleft" in the Xenopus gastrula and is present in all vertebrate embryos.

37 ongest in the presumptive neural ectoderm at gastrula and neural plate stages, but there is minor par

38 A series of treatments at the gastrula and neurula stages that block the calcium trans

39 Loss of NRH1 function is followed, during gastrula and neurula stages, by a dramatic increase in a

40 ion is a long process that continues through gastrula and neurula stages.

41 e 24 generates late endodermal expression at gastrula and pluteus stages.

42 e 24 led to ubiquitous GFP expression in the gastrula and pluteus.

43 of mesoderm induction are conserved between gastrula and post-gastrula stages of development.

44 d behavior but not cell specification during gastrula and segmentation stages of development.

45 -catenin is present in endoderm cells of the gastrula, and depletion of beta-catenin from embryos res

46 extent of mesoderm formation in the Xenopus gastrula, and point to related roles for Xenopus HNF3bet

47 a BMP antagonist in the context of the frog gastrula, and that it acts cooperatively with chordin to

48 We find that explants of late gastrula anterior lateral endoderm plus mesoderm, which

49 evel the observation that cells of the early gastrula are less committed to one germ layer than are c

50 lino concentrations specifically cause a pre-gastrula arrest of cell division and morphogenesis, and

51 x is expressed in the foregut region of late gastrula avian and mammalian embryos in a pattern that o

52 h dorsal and ventral mesoderm across the pre-gastrula axis historically called the dorsal-ventral axi

53 ses, STELLA was immunolocalized to the mouse gastrula between Early Streak (ES) and 12-somite pair (-

54 In contrast, on the ventral gastrula, blood progenitors are multipotential cells wit

55 On the dorsal gastrula, blood progenitors are unipotential cells that

56 are essential in generating the presumptive gastrula BMP activity gradient that patterns the dorsal-

57 nction, we find that larvae with reduced mid-gastrula Bmp signaling cannot properly excrete waste.

58 Thus, a gastrula Bmp2b/Swirl and Bmp7/Snailhouse-dependent activ

59 in and zic2, weakly represses sox11 at early gastrula but later (st12) induces it; weakly represses s

60 ed early in development, in the blastula and gastrula, but not at later stages when a putative chemos

61 The cells of the Drosophila gastrula can also delay metaphase-anaphase transition in

62 s a cross-species functional screen of mouse gastrula cDNA libraries for components of endoderm and m

63 Pools of 96 cDNAs from arrayed mouse gastrula cDNA libraries were transcribed into mRNA and i

64 otype embryonic arrays contain 864 sequenced gastrula cDNA.

65 he ventral and dorsal tail bud, whereas post-gastrula Chordin activity patterns the derivatives of th

66 tween the Xbra- and Xnr2-expressing cells at gastrula corresponds to a future tissue boundary.

67 ue territories are specified, early and late gastrula, during which important morphogenetic events oc

68 , FGF, and other signaling molecules in late gastrula-early neurula stage embryos generate the border

69 teral blastoderm isolates (LBIs) at the late gastrula/early neurula stage (i.e., stage 3d/4) that lac

70 tero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting

71 tly enhanced and is no longer limited to pre-gastrula ectoderm.

72 ibition of epidermal inducing signals in the gastrula ectoderm.

73 ned the effects of BMP-4 on MAPK activity in gastrula ectoderm.

74 led to a reduction in MAPK activity in early gastrula ectoderm.

75 ellular levels of Sizzled and Chordin in the gastrula embryo and enzyme reaction constants were all i

76 Patterning of the pre-gastrula embryo and subsequent neural induction post-gas

77 lusively within the organizer of the Xenopus gastrula embryo and therefore are predicted to act as bo

78 the neural ectoderm in the late blastula to gastrula embryo in zebrafish.

79 st steps in germ layer patterning of the pre-gastrula embryo to tissue healing, regeneration and home

80 ly restricted to the ventral mesoderm of the gastrula embryo under the signaling control of bone morp

81 These included systems both in vivo (gastrula embryo, embryo and adult liver) and in vitro (c

82 to one germ layer than are cells of the late gastrula embryo.

83 tes dorsal-to-ventral (DV) patterning of the gastrula embryo.

84 sing the central role of this pathway in the gastrula embryo.

85 c dorsal/ventral (back-to-belly) axis in pre-gastrula embryos and allowed the assignment of the rostr

86 ted by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity

87 onset of neural-specific expression in early gastrula embryos is transcriptionally regulated.

88 an4 (a Wnt co-receptor) and frizzled7 mutant gastrula embryos with disrupted non-canonical Wnt signal

89 r lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and h

90 derm in individual cells from early and late gastrula embryos, by both in situ hybridization and sing

91 nly Xenopus EGF-CFC factor expressed in post-gastrula embryos, in embryogenesis.

92 y and Cdc2 tyrosine phosphorylation in early gastrula embryos.

93 al and ventral mesoderm dissected from early gastrula embryos.

94 sed in the endoderm of mouse pregastrula and gastrula embryos.

95 le1a decreases fibronectin protein levels in gastrula embryos.

96 s in the induction of cardiac field genes in gastrula embryos.

97 ntified over 300 transcripts enriched in the gastrula endoderm, including most of the known endoderm

98 t originate from specific regions of the pre-gastrula epiblast, but the plasticity of cells within th

99 y due to widespread FGF/MAPK activity in the gastrula epiblast.

100 optic vesicles and an expansion of the post-gastrula expression domains of six3 and rx3.

101 We demonstrate that in the zebrafish gastrula, Fmi1 proteins function in concert with each ot

102 In the gastrula, FoxD3 functions as a transcriptional repressor

103 ntire antero-posterior axis of the zebrafish gastrula including prechordal plate and ventral dienceph

104 mammalian cells, and cells of the Drosophila gastrula inhibit Cdk1 to delay the entry into mitosis.

105 The organizer of the vertebrate gastrula is an important signalling centre that induces

106 al4-UAS-mediated fezl overexpression in late gastrula is capable of expanding the prethalamus telence

107 dherens junctions in Drosophila melanogaster gastrula is delayed until mesoderm is internalized, desp

108 We report that FoxD3 function in the Xenopus gastrula is essential for dorsal mesodermal development

109 Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shie

110 and extraembryonic regions of the mammalian gastrula is poorly understood.

111 in the yolk cell and hypoblast in the early gastrula, just preceding the appearance of the bib mesod

112 show that BMP signaling is nearly absent in gastrula lacking both maternal and zygotic Laf/Alk8 acti

113 Inhibition of Bmp signaling in the early gastrula leads to increased beta-cell numbers and partia

114 expression domains of Xnr-2 and Xbra in the gastrula marginal zone appear to mark presumptive blood

115 Patterning of the Xenopus gastrula marginal zone in the axis running equatorially

116 le, and in the embryo it is expressed in the gastrula marginal zone, neural plate, and cranial and tr

117 initiated prior to the establishment of the gastrula mesodermal organizer.

118 al (trunk and tail) regions of the zebrafish gastrula, neural specification is initiated at all DV po

119 At gastrula, neurula, and tailbud stages, Axdazl RNA is wid

120 for paraxial mesoderm (PM) induction in post-gastrula NMPs.

121 Here we show that the gastrula of the cephalochordate amphioxus expresses dors

122 During vertebrate development the dorsal gastrula or Spemann-Mangold organizer orchestrates axis

123 sly in the ventral-most vegetal cells of the gastrula or their derivatives.

124 eta-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarc

125 es for prdm1 in limiting the function of the gastrula organizer and regulating cell fate specificatio

126 boz and Nodal signaling largely cooperate in gastrula organizer formation, they have opposing roles i

127 In the activation step, the Spemann gastrula organizer induces neuroectoderm with anterior c

128 protein (BMP) antagonism emanating from the gastrula organizer is key.

129 In this model, the gastrula organizer of the mouse embryo inhibits BMP sign

130 The dorsal gastrula organizer plays a fundamental role in establish

131 een shown to be a determinant at the Xenopus gastrula organizer region and a segment-polarity determi

132 Based on these results, we propose that gastrula organizer specification requires the Nieuwkoop

133 ryos originate within the Spemann-Mangold or gastrula organizer.

134 nog1, which is specifically expressed in the gastrula organizer.

135 tion factors regulate hhex expression in the gastrula organizer.

136 lled to the opposite cell edges in zebrafish gastrula parallels their distribution in fly, and sugges

137 At the end of the gastrula period, prdm1 morphant embryos have enlarged an

138 se results we conclude that in the amphioxus gastrula RA signaling primarily acts via regulation of H

139 linker region localizes to a ventral vegetal gastrula region that could coordinate DV patterning with

140 We hypothesize that the gastrula role of Chordin in tail patterning is to genera

141 ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that i

142 the injected quadrant, while at mid- to late-gastrula stage and beyond, more PMCs are found outside t

143 fic GFP reporter DNA construct were grown to gastrula stage and their fluorescence recorded as a seri

144 retina regions are not determined by the mid-gastrula stage but are by the neural plate stage.

145 Injected embryos were examined at gastrula stage by in situ hybridization with endoderm or

146 ned along the dorsal-ventral axis during the gastrula stage by opposing gradients of Bmps and Bmp inh

147 expressed in the primitive streak region of gastrula stage chicken embryos.

148 different steps: first, an induction at the gastrula stage dependent on signals arising from the dor

149 non-axial mesoderm occurs across the classic gastrula stage DV axis while DV patterning aligns along

150 plate precursor cells in the epiblast of the gastrula stage embryo, and does not share a lineage with

151 should be highest on the dorsal side of the gastrula stage embryo, we have found that while Smad2 ph

152 , or about 15% of the mRNAs expressed by the gastrula stage embryo.

153 strate that HBX2 specifically interacts with gastrula stage embryonic extracts and that in vitro tran

154 trulation, we manipulated Notch signaling in gastrula stage embryos and examined gene expression in r

155 al mesendoderm (Spemann organizer tissue) of gastrula stage embryos and that its expression is regula

156 However, our analysis of these pathways in gastrula stage embryos indicates that the MAP kinase pat

157 The TERT mRNA from gastrula stage embryos was found to be 4497 bp in length

158 Smurf1 is enriched on the dorsal side of gastrula stage embryos, and blocking Smurf1 disturbs neu

159 vation of the Notch pathway, specifically in gastrula stage embryos, results in a dramatic decrease i

160 to define signaling centers in blastula and gastrula stage embryos.

161 m, respectively, and the prechordal plate of gastrula stage embryos.

162 zes with Lim1 in the anterior mesendoderm of gastrula stage embryos.

163 esendoderm of single wild-type and Lim1-null gastrula stage embryos.

164 fate restriction events taking place in the gastrula stage epiblast.

165 ntral halves of axin-depleted embryos at the gastrula stage have dramatically increased levels of cho

166 m, transcripts first being detectable at the gastrula stage in a ring of mesendoderm just inside the

167 eural ectoderm during late blastula to early gastrula stage in zebrafish.

168 ters containing more than 72000 cDNAs from a gastrula stage library were hybridized with differential

169 Thus, the anterior mesendoderm of gastrula stage mouse embryos should express Lim1-regulat

170 pts are detected in the visceral endoderm of gastrula stage mouse embryos, suggesting a signaling rol

171 n of the Xenopus ABCE1 arrests growth at the gastrula stage of development, consistent with a block i

172 rly as 7 hours postfertilization, during the gastrula stage of development.

173 ssential function of Chk1 at the blastula-to-gastrula stage of development.

174 is generally thought to occur around the mid-gastrula stage of embryogenesis.

175 stays constitutively active until the early gastrula stage of embryogenesis.

176 riant, blimp1/krox1a, is expressed only from gastrula stage onward.

177 etal cells of Xenopus embryos from the early gastrula stage onwards, when these cells become committe

178 s derived from an enriched population of mid-gastrula stage PMCs.

179 own that retinoic acid (RA) signaling at the gastrula stage strongly influences anterior-posterior (A

180 gly, we find that Bmp signaling from the mid-gastrula stage through early somitogenesis is important

181 gnaling acts from early cleavage through the gastrula stage to specify and maintain dorsal/anterior d

182 have undertaken a transcriptomic analysis on gastrula stage Xenopus embryos in which MyoD has been kn

183 estricted to lateral and ventral mesoderm in gastrula stage Xenopus embryos, leading us to investigat

184 bra in the presumptive trunk and tail at the gastrula stage, and find that they fate to presumptive s

185 xtends across to the ventral side by the mid-gastrula stage, and is then turned off in the dorsal ect

186 degradation beginning precisely at the early gastrula stage, and represses translation of transcripts

187 ior development while, starting at the early gastrula stage, BMP signaling promotes ventral/posterior

188 in embryos from fertilization to the initial gastrula stage, but that a tremendous increase in retino

189 axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not

190 tral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding

191 ssed in the S. purpuratus embryo, up to late gastrula stage, by means of high-resolution custom tilin

192 amming onset was first observed at the early gastrula stage, even if the cells to be replaced were re

193 However, by the late gastrula stage, individual cells express markers that ar

194 Beginning at mid- to late-gastrula stage, PMCs utilize oral-aboral cues from the e

195 igate the targets of RA signaling during the gastrula stage, we used the basal chordate amphioxus, in

196 g in the basal chordate amphioxus during the gastrula stage, which is the RA-sensitive period for ant

197 mesoderm and endoderm cells up to the early gastrula stage, while module 24 generates late endoderma

198 expressed at significant levels by the late gastrula stage.

199 f Xnr3 and chordin in organizer cells at the gastrula stage.

200 emisphere of the Xenopus embryo at the early gastrula stage.

201 e set up between the late blastula and early gastrula stage.

202 ker gene expression beginning at mid to late gastrula stage.

203 vivo during a short period at the end of the gastrula stage.

204 s first detected in the yolk sac at the late gastrula stage.

205 a dorsal domain in transgenic Xenopus at the gastrula stage.

206 cibly reduced the expression of 247 mRNAs at gastrula stage.

207 cription and developmental patterning at the gastrula stage.

208 ox3 and HNF3-1) are direct RA targets at the gastrula stage.

209 rd precursors in the axial mesoderm at early gastrula stage.

210 f the EVL, and rupture of the embryo at late gastrula stage.

211 lateral edges of the neural plate at the mid-gastrula stage; in contrast to its mouse and chick ortho

212 d by Smad7 using a Xenopus laevis 5000-clone gastrula-stage cDNA microarray.

213 n patterns of these markers in blastula- and gastrula-stage chick embryos, using whole-mount in situ

214 hronic transplantation to the node region of gastrula-stage chicken embryos.

215 a critical window of development in the late gastrula-stage embryo when vitamin A is essential for no

216 tides results in normal development of early gastrula-stage embryos but abnormal, asymmetric larvae.

217 mal mouse development when transplanted into gastrula-stage embryos, providing in vivo functional val

218 have identified a molecular pathway linking gastrula-stage endoderm patterning to organ specificatio

219 Late gastrula-stage FoxH1 morphants exhibit delayed mesoderm

220 xpression of the homeobox gene Pitx2 links a gastrula-stage intercellular signalling cascade to the l

221 s previously suggested, is excluded from the gastrula-stage mesoderm.

222 animal cap explants, although expression of gastrula-stage mesodermal markers was very weak and subs

223 orting from disaggregated late blastula- and gastrula-stage sea urchin embryos according to the regul

224 l of neural transformation in which a planar gastrula-stage Wnt8 signal, promoted by Nodal signaling

225 Here, using gastrula-stage Xenopus laevis embryos as a model system,

226 h control is exerted during the early to mid-gastrula stages (i.e., stages 2-3a), prior to formation

227 at is expressed ubiquitously at blastula and gastrula stages and is enriched in neural tissues and th

228 with nlz1 in a broad posterior domain during gastrula stages as well as at the midbrain-hindbrain bou

229 ion of plakoglobin protein during the egg to gastrula stages caused collapse of embryonic architectur

230 ly asymmetric cell divisions at blastula and gastrula stages give rise to the superficial (apical) an

231 urprise, levels of Xbra are elevated at late gastrula stages in such embryos, and over-expression of

232 s from a layer of cells which emerges during gastrula stages in the vertebrate embryo.

233 ors ectopically accumulate in the PS at late gastrula stages in Wnt5a(-/-); Wnt11(-/-) embryos and th

234 th, while cell death during the blastula and gastrula stages is random and predominantly caspase-medi

235 tion are conserved between gastrula and post-gastrula stages of development.

236 During blastula and gastrula stages of Xenopus development, cells become pro

237 d dynamic pattern in the nervous system from gastrula stages onward, with lesser expression in mesode

238 expressed in the paraxial mesoderm from mid-gastrula stages onwards.

239 on of Smad2 signaling in the neural plate at gastrula stages results in inhibition of neural markers,

240 ct in the regulation of Cdx genes and during gastrula stages the normal expression of the Cdx genes r

241 lation, but becomes insensitive during early gastrula stages when Hairy2a/Dlx5 requires an inhibition

242 1/FRL1 and XCR3, which are both expressed at gastrula stages when Nodal signalling is active.

243 rmal and non-neural ectodermal fates even at gastrula stages, after the conventionally assigned end o

244 sumptive rhombomere (r) 3/r4 boundary during gastrula stages, and its expression progressively expand

245 erm expresses lvnumb during the blastula and gastrula stages, and that the protein is localized to th

246 opus ALDH1 was not expressed at blastula and gastrula stages, but was expressed at the neurula stage.

247 At pre-gastrula stages, cells of the AVE are initially located

248 At mid-gastrula stages, GATA5 is restricted to the sub-blastopo

249 At late mesenchyme blastula and early gastrula stages, greater than 90% of GFP-expressing PMCs

250 h the NP is sensitive to BMP levels at early gastrula stages, Hairy2a/Dlx5 expression is unaffected.

251 By gastrula stages, Hoxb1b binds together with TALE factors

252 We show that at early gastrula stages, individual cells in the same region may

253 ucts of an FGF induction at the blastula and gastrula stages, initially express neural plate-specific

254 signaling plays an essential role during the gastrula stages, it has not been possible with mutants o

255 During the blastula and gastrula stages, mutant cells are more cohesive and migr

256 al skeleton first occurs around mid- to late-gastrula stages, when some PMCs from an aboral quadrant

257 pus embryos are large, and during the egg to gastrula stages, when there is little extracellular matr

258 gression and an early lysis phenotype during gastrula stages.

259 ons of BMPs differ during the early and late gastrula stages.

260 ntrasting Tld's requirement only during post-gastrula stages.

261 sion of all three amphibian Cdx genes during gastrula stages.

262 ity of BMP antagonists from blastula through gastrula stages.

263 g eliminates neural marker expression during gastrula stages.

264 uclear DNA and subsequent apoptosis at early gastrula stages.

265 ly strongly associates with these regions at gastrula stages.

266 and in mesoderm and ectoderm at blastula and gastrula stages.

267 requires a BMP signal during blastoderm and gastrula stages.

268 ulatory processes between early cleavage and gastrula stages.

269 endants during mesenchyme blastula and early gastrula stages.

270 ential cell cycle regulation in cleavage and gastrula stages.

271 ssion in dorsal mesoderm and ectoderm at mid-gastrula stages.

272 Noggin, can inhibit Bmp4 expression at early gastrula stages.

273 ortant for the switch from NPB to NC at late gastrula stages.

274 ing the endogenous expression of Ci-Dll-B at gastrula stages.

275 reduction of a subset of mesodermal genes at gastrula stages.

276 t USP12 regulates Xenopus development during gastrula stages.

277 , does not begin until much later during mid-gastrula stages.

278 expressed as early as 30% epiboly and during gastrula stages: in the germ ring, shield, prechordal pl

279 of the blastoderm and for rare cells of the gastrula that involute into the hypoblast, motility appe

280 the entire vegetal half was removed at early gastrula, the animal caps reprogrammed and replaced the

281 le many of these proteins are expressed post-gastrula, their later roles have typically remained uncl

282 last of pre-streak embryos, and in the early gastrula they are located in the mid-primitive streak, f

283 ple lineages in individual border cells from gastrula through neurula stages.

284 ange in BMP necessity from BMP inhibition at gastrula to BMP activation at neurula stages is further

285 We have used the zebrafish gastrula to carry out structure/function studies on Chor

286 relates with the BMP4 expression domain from gastrula to neurula stages.

287 mesoderm were dissected from embryos of mid-gastrula to swimming tadpole stages.

288 at an embryonic checkpoint called the early gastrula transition (EGT).

289 scription is gradually acquired at the early gastrula transition.

290 ive screen of gene expression in the Xenopus gastrula using cDNA macroarrays.

291 ling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesod

292 These mutant embryos lack almost all gastrula ventral cell fates, with a concomitant expansio

293 The neuroectoderm of the vertebrate gastrula was proposed by Nieuwkoop to be regionalized in

294 The dorsal ectoderm of the vertebrate gastrula was proposed by Nieuwkoop to be specified towar

295 fate maps of the zebrafish late blastula and gastrula, we demonstrate that individual cells can give

296 be expressed in the mesoendoderm of Xenopus gastrula were characterized according to their modes of

297 The dorsal/anterior endoderm of the Xenopus gastrula, which expresses Hex and the putative head-indu

298 -cripto, which begins in the epiblast of the gastrula, with a pattern similar to EGF-CFC genes of oth

299 lasmic interphase extract isolated from post-gastrula Xenopus embryos.

300 to the vegetal and marginal zones of the pre-gastrula Xenopus laevis embryo.