ライフサイエンスコーパス: gastrulation

1 Mesoderm induction begins during gastrulation.

2 ity and cell blebbing, eventually abrogating gastrulation.

3 niche, and germ line commitment occurs after gastrulation.

4 rocess of apical constriction during Xenopus gastrulation.

5 in convergent extension movements in Xenopus gastrulation.

6 blastopore closure throughout the course of gastrulation.

7 ndent epiblast populations, specified before gastrulation.

8 constriction during Drosophila melanogaster gastrulation.

9 ession of individual cells start well before gastrulation.

10 y modulation and tissue morphogenesis during gastrulation.

11 (YSL) secretes a ventralizing signal during gastrulation.

12 stic and can form multiple individuals until gastrulation.

13 er emerging from the primitive streak during gastrulation.

14 rs of endoderm, mesoderm and ectoderm during gastrulation.

15 TGFbeta) signal expressed posteriorly before gastrulation.

16 s required for Wnt5b/Vangl2 signaling during gastrulation.

17 ment of mesendodermal cells during zebrafish gastrulation.

18 d more recently in cell intercalation during gastrulation.

19 tical role in C&E movements during zebrafish gastrulation.

20 ts, specified in the primitive streak during gastrulation.

21 organization of germ layers during mammalian gastrulation.

22 ed cell migration and cell morphology during gastrulation.

23 nt5b/Vangl2/Ror2 signaling during vertebrate gastrulation.

24 properties of the cellular blastoderm during gastrulation.

25 tructural stiffness of the blastopore during gastrulation.

26 particularly during the early stages before gastrulation.

27 formation dynamics diverge near the onset of gastrulation.

28 rning of DV tissues along the AP axis during gastrulation.

29 of approximately 1,000 mesoderm cells during gastrulation.

30 tion of a three-dimensional body plan during gastrulation.

31 of the ectoderm persists throughout much of gastrulation.

32 ts, and the Wnt antagonist iCRT14, following gastrulation.

33 the dynamic cellular events occurring during gastrulation.

34 onvergent and extension cell movement during gastrulation.

35 and protein are expressed from oogenesis to gastrulation.

36 to during the formation of mesoderm layer in gastrulation.

37 ipotent states, before lineage commitment at gastrulation.

38 ocytes, and to a developmental arrest during gastrulation.

39 this process, but is known to act only after gastrulation.

40 tion on expression levels of 205 genes up to gastrulation.

41 rvive through implantation but fail prior to gastrulation.

42 an inhibitor of Rho-kinase activity, prevent gastrulation.

43 eral displacement of Bazooka still occurs by gastrulation.

44 oposterior axis but fail to progress through gastrulation.

45 ed, basolateral displacement still occurs by gastrulation.

46 g convergent extension during Xenopus laevis gastrulation.

47 and mesodermal cell behaviors during Xenopus gastrulation.

48 cell movements and lineage induction during gastrulation.

49 tory genes during early frog development and gastrulation.

50 points to a simplified model for Drosophila gastrulation.

51 to the formation of the primitive streak and gastrulation.

52 r axial elongation of the mouse embryo after gastrulation.

53 against being caught up in the movements of gastrulation.

54 the embryo is severely altered during early gastrulation.

55 ryos null for Rala and Ralb do not live past gastrulation.

56 sults in embryonic lethality with failure of gastrulation.

57 ess than half of the genomes needed to reach gastrulation.

58 invagination of the mesoderm at the onset of gastrulation.

59 tes mesendoderm development during zebrafish gastrulation.

60 h post-fertilization, immediately following gastrulation.

61 of early mesoderm formation during mammalian gastrulation.

62 postpone EMT during Drosophila melanogaster gastrulation.

63 iated with pattern formation at the onset of gastrulation.

64 or Wnt signaling activation during embryonic gastrulation.

65 non-canonical Wnt pathways during vertebrate gastrulation.

66 d evolution of similar transitions in animal gastrulation.

67 hogenesis and papc expression during Xenopus gastrulation.

68 pluripotency protein Ventx2 at the onset of gastrulation.

69 arise from basal posterior progenitors after gastrulation.

70 spatiotemporal pattern starting during late gastrulation.

71 that drive initial cell shape changes during gastrulation.

72 the conditions for successful pregnancy and gastrulation.

73 internalization of the ventral furrow during gastrulation.

74 l, whose function is required for vertebrate gastrulation.

75 in pigment cells, and its inhibition impairs gastrulation.

76 during germ layer formation at the onset of gastrulation.

77 several aspects of embryogenesis, including gastrulation.

78 enous strain during a critical period around gastrulation.

79 f Smad2/3 binding and gene expression during gastrulation.

80 vergence and extension cell behaviors during gastrulation.

81 ibits the repression of lambda-olt 2-1 after gastrulation.

82 to a diploblastic epithelial body plan after gastrulation [2, 3].

83 ene regulatory network (GRN) at the onset of gastrulation (24 h postfertilization) in N. vectensis Su

84 individual regulatory genes each hour up to gastrulation (30 h) in four different spatial domains of

85 During vertebrate gastrulation, a complex set of mass cellular rearrangeme

86 During Drosophila gastrulation, a higher number of cells undergo invaginat

87 utant embryos that fail to form cells before gastrulation ('acellular' embryos), such that the global

88 ation and t48, which in the evolution of fly gastrulation acted as a likely switch from an ingression

89 During Drosophila gastrulation, actomyosin contraction in ventral cells ge

90 of dorsal transverse folds during Drosophila gastrulation, adherens junctions shift basally in the in

91 ry mesenchyme cells (PMCs) during sea urchin gastrulation, although the relative contributions of the

92 out how changes in cell behavior might drive gastrulation among arthropods.

93 tors resulted in developmental arrest before gastrulation and a failure to activate >75% of zygotic g

94 fically in the epiblast are able to initiate gastrulation and advance to late primitive streak stages

95 mit CM number in zebrafish embryos: prior to gastrulation and after the initial wave of CM differenti

96 ed cell movements are crucial for vertebrate gastrulation and are controlled by multiple signals.

97 Basic body plans are organized by the end of gastrulation and are refined as limbs, organs, and nervo

98 In zebrafish, ZGA is required for gastrulation and clearance of maternal messenger RNAs, w

99 remain receptive to extracellular cues after gastrulation and continue to make basic germ layer decis

100 by morpholino injection causes arrest before gastrulation and early embryonic death.

101 ot required for force production during late gastrulation and early neurulation.

102 During gastrulation and immediately after, Xtgfbi is expressed

103 s TRPM6 (XTRPM6) is elevated at the onset of gastrulation and is concentrated in the lateral mesoderm

104 the prospective neural crest epiblast during gastrulation and is unlikely to operate through mesoderm

105 yury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates.

106 The gastrulation and mitotic phenotypes can be rescued by ei

107 Loss of XTRPM6 produced gastrulation and neural tube closure defects.

108 at drives key morphogenetic events including gastrulation and neural tube formation.

109 phic imaging with a typical duration of 2 h (gastrulation and neurulation stages), intricacies of ima

110 pathway in endomesoderm specification during gastrulation and overall animal-vegetal patterning at ea

111 pp-a, one of the two paralogs, begins during gastrulation and persists throughout the first week of d

112 al or cellular defects, including failure of gastrulation and problems with placement and function of

113 of inductive interactions that begins before gastrulation and progressively divide embryonic ectoderm

114 Both changes set the stage for gastrulation and require downregulation of Cdc25 phospha

115 ol of cell adhesion and morphogenesis during gastrulation and segmentation stages.

116 and in vivo imaging of SHG nanoprobes during gastrulation and segmentation.

117 roles played by growth factors in sea urchin gastrulation and skeletogenesis.

118 Here we identify two genes, folded gastrulation and t48, which in the evolution of fly gast

119 in ventral-posterior germ layer patterning, gastrulation and tadpole morphology.

120 he formation of the three germ layers during gastrulation and the differentiation of adult stem cells

121 delamination of mesendodermal precursors at gastrulation and the proper specification of the neural

122 epression of endogenous Bmp signaling during gastrulation and this enables mesodermal progenitors to

123 ers epithelial cell shape changes that drive gastrulation and tissue folding and is one of the most e

124 They are activated during gastrulation and undergo a dynamic shift from a transcri

125 However, this strong coupling diminished at gastrulation and was absent in non-embryonic samples, in

126 derm-endoderm boundary is established before gastrulation, and ectodermal cells at the boundary are t

127 ion of the transcription factor Gata2 during gastrulation, and Gata2 is required in both ectodermal a

128 sed cell rearrangements in processes such as gastrulation, and has also been implicated in regulation

129 PTU is teratogenic during late blastula, gastrulation, and neurulation; whereas MMI is not.

130 are expressed in a localized fashion by mid-gastrulation, and which thus provide spatial regulatory

131 r in many developmental processes, including gastrulation, anterior-posterior axis specification, org

132 different progenitor cell populations during gastrulation are poorly understood.

133 a signaling pathway active during Drosophila gastrulation as a model system to study Ric-8/Galpha int

134 Knockout embryos did not undergo gastrulation, as demonstrated by the absence of mesoderm

135 time is highest immediately before and after gastrulation, as well early in the segmentation period.

136 emerge as the cell cycle slows just prior to gastrulation at a major embryonic transition known as th

137 NC cells arise during gastrulation at the neural plate border (NPB), which is

138 During vertebrate gastrulation, axial mesendoderm migrates in a group, the

139 itially arises in the developing skin during gastrulation, based on the appearance of polarized apica

140 Treatment with SB43 during gastrulation blocks anterior PMC positioning and the for

141 quires an inhibition of Wnt signals prior to gastrulation, but becomes insensitive during early gastr

142 tively along a fibronectin (FN) substrate at gastrulation, but how the adhesive and mechanical forces

143 epithelial-mesenchymal transition (EMT) and gastrulation, but its role in self-renewal, pluripotency

144 tinuing roles in Bazooka localization during gastrulation, but other polarity cues partially restore

145 els in cell aggregates and during vertebrate gastrulation, but the role of differential Cdh activity

146 ansfated from notochord to somite fate after gastrulation by ectopic expression of msgn1, a master re

147 cells and the elongating archenteron during gastrulation; Cadherin (G form) has an important role in

148 Shortly after gastrulation, canonical Wnts promote the recruitment of

149 Zebrafish gastrulation cell movements occur in the context of dyna

150 fects on ECM organization underlying PCP and gastrulation cell movements.

151 oderm undergo morphogenetic movements during gastrulation, cells in both germ layers read their posit

152 During mouse gastrulation, cells in the primitive streak undergo epit

153 ctions with the extracellular proteins Short gastrulation/Chordin (Chd) and Twisted gastrulation (Tsg

154 xes, is required for normal morphogenesis at gastrulation, closure of the anterior neural tube, axial

155 Zic3 demonstrates an early role for Zic3 in gastrulation, CNS, cardiac and left-right axial developm

156 nt of left-right (LR) asymmetry occurs after gastrulation commences and utilizes a conserved cascade

157 anterior and visceral mesoderm precursors as gastrulation commences, and find that both Cytochalasin

158 three populations acts independently during gastrulation, confirming previous hypotheses that cell b

159 Gastrulation constitutes a fundamental yet diverse morph

160 ing, required for hypochord induction during gastrulation, continues to act in the tailbud to specify

161 As the primary driving forces of gastrulation, convergence and extension (C&E) movements

162 During vertebrate gastrulation, convergence and extension movements elonga

163 tion events occurring prior to completion of gastrulation coordinate the morphogenetic movements unde

164 cipates in noncanonical Wnt signaling during gastrulation, Daam2 function remains completely uncharac

165 s embryos was sufficient to fully rescue the gastrulation defect caused by loss of hepatocystin.

166 Gastrulation Defective (GD) cleaves and activates Snake

167 Gastrulation defects are not rescued by a Kif2a mutated

168 ltaN) mice were not viable, and several post-gastrulation defects revealed the first in vivo function

169 Ric-8 mutants exhibit similar gastrulation defects to Cta mutants.

170 man heterotaxy phenotype but also have early gastrulation defects, axial patterning defects and neura

171 -1; miR-9a double mutant revealed defects in gastrulation, demonstrating the importance of co-activat

172 n and monkey in vitro models simulating peri-gastrulation development to show the conserved principle

173 inhibition of jagn just before the start of gastrulation disrupts this asymmetric division of the ER

174 he resultant directed fluid flow during late gastrulation/early neurulation.

175 m-like properties of the epiblast of the pre-gastrulation embryo and for cellular and physiological h

176 After the initiation of gastrulation, embryos that lack Pten in the epiblast sho

177 During zebrafish gastrulation, endodermal cells sequentially exhibit firs

178 During gastrulation, epiblast cells are pluripotent and their f

179 c processes, including the cell movements of gastrulation, epiboly and dorsal convergence.

180 disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchymal transition (EMT).

181 rate a critical role for Cripto during mouse gastrulation, especially in mesoderm and endoderm format

182 fish tailbud is not a simple continuation of gastrulation events.

183 y to trigger actomyosin contractility during gastrulation events.

184 s a model, we show that regulation of folded gastrulation expression by the Fork head transcription f

185 eractive Nodal signalling contributes to the gastrulation failure of Tet mutants.

186 sh ybx1 lead to deregulated Nodal signaling, gastrulation failure, and embryonic lethality.

187 Loss of Zfp568, which causes gastrulation failure, or mutation of the ZFP568-binding

188 ssion in dorsal posterior cells during early gastrulation, focusing Wnt1 signaling to the posterior-v

189 three signaling pathways are required during gastrulation for the proper expression of pax3a and zic3

190 vely regulate each other's expression during gastrulation, forming a self-sustaining network that ope

191 Altogether, our data establish that during gastrulation, FOXF1 marks all posterior primitive streak

192 Gastrulation generates three layers of cells (ectoderm,

193 Historically, the position of the site of gastrulation has been used to understand the development

194 stically reducing the level of FGF8 later in gastrulation has no apparent effect on somitogenesis or

195 nd spreading of the animal hemisphere during gastrulation, here we provide evidence that radial inter

196 PZR was required for zebrafish gastrulation in a manner dependent upon PZR tyrosyl phos

197 mplex epithelium in planula stages following gastrulation in addition to previously described roles f

198 ing critical morphogenetic events, including gastrulation in diverse organisms and neural tube closur

199 Around the time of gastrulation in higher vertebrate embryos, inductive int

200 This protocol describes how to observe gastrulation in living mouse embryos by using light-shee

201 vide essential cues to mesoderm cells during gastrulation in many metazoans.

202 static and developmental contexts, including gastrulation in many organisms and neural tube formation

203 ates that mesoderm induction continues after gastrulation in neuromesodermal progenitors (NMPs) withi

204 progression from preimplantation epiblast to gastrulation in rodents.

205 ions that form two aggregations during early gastrulation in the crustacean Parhyale hawaiensis.

206 with the elongation of the notochord during gastrulation in the rapidly developing species.

207 f a reprogramming capability occurs at early gastrulation in the sea urchin embryo and requires activ

208 rs systemically must be established prior to gastrulation in the very early embryo and, because it is

209 rotocol for applying this technique to study gastrulation in Xenopus laevis (African clawed frog) emb

210 rax transcription is initiated at the end of gastrulation in Xenopus, and is a key part of the regula

211 e that Uhrf1 phosphorylation is required for gastrulation in zebrafish.

212 ulates CE, and Wnts regulate many aspects of gastrulation including CE and EMT.

213 imelines and summarizes key stages following gastrulation, including endoderm patterning, organ speci

214 igration away from the primitive streak when gastrulation initiates, but previous studies have shown

215 At gastrulation, interactions between the pair-rule genes l

216 Germ-layer formation during gastrulation is both a fundamental step of development a

217 enetically proving that Tcf3 function during gastrulation is independent of beta-catenin interaction.

218 ism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear cleava

219 a demonstrate that Alk4/5/7 signaling during gastrulation is required to direct PMCs to the oral hood

220 and ECM assembly/remodeling during zebrafish gastrulation is unclear.

221 d that cell organization in the embryo until gastrulation is well described by a purely mechanical mo

222 Isolated skin explanted before gastrulation lacks strain and fails to acquire a global

223 Conditional inactivation of Cripto during gastrulation leads to varied defects in mesoderm and end

224 als its abnormal development at the onset of gastrulation, many hours before changes are obvious to t

225 te the position of the head and the onset of gastrulation, marked by T/Brachyury (T/Bra) at the poste

226 During Drosophila gastrulation, mitosis is associated with the transcripti

227 s, demonstrating that in the early stages of gastrulation most subapical clusters in mesoderm not onl

228 While gastrulation movements offer mechanistic paradigms for h

229 Gastrulation movements place endodermal precursors, meso

230 he source of this extrinsic force, we mapped gastrulation movements temporally using light sheet micr

231 he cytoplasmic tyrosine kinase Arg modulates gastrulation movements through control of actin remodeli

232 r of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a seri

233 nimal caps are not compliant enough to allow gastrulation movements.

234 and body plan evolution despite variation in gastrulation movements.

235 d convergence and extension movements during gastrulation, neurulation and epidermis defects and enha

236 We conclude that perturbed gastrulation not only explains the neurulation defects,

237 Gastrulation of the Drosophila embryo is one of the most

238 lls gained the ability to reprogram early in gastrulation only after extended contact with the vegeta

239 in mice, required for embryonic growth from gastrulation onward.

240 layers that provide the structural basis for gastrulation or subsequent developmental events [1].

241 The Drosophila Folded gastrulation pathway triggers epithelial cell shape chan

242 rations provide only weak rescue of an early gastrulation phenotype induced by Megf8 knockdown.

243 eletion of Igf2 can completely rescue Zfp568 gastrulation phenotypes through late gestation.

244 tion of all three Tet genes in mice leads to gastrulation phenotypes, including primitive streak patt

245 During amphibian gastrulation, presumptive endoderm is internalised as pa

246 It has been considered a gastrulation process unique to amphibians, but we show t

247 rk recapitulates these variable and bistable gastrulation profiles and emphasizes the importance of t

248 Modes of gastrulation range from stochastic translocation of indi

249 hich is distinct from PCP signaling or other gastrulation regulators, including BMP and Nodals.

250 ypotheses that cell behavior during Parhyale gastrulation relies on intrinsic signals instead of an i

251 regulated switch to late replication during gastrulation, reminiscent of mammalian X Chromosome inac

252 ergent extension movements during vertebrate gastrulation require a balanced activity of non-canonica

253 t and its conditional ablation, beginning at gastrulation, results in increased apoptosis, growth ret

254 bition renders the concentration of dNTPs at gastrulation robust, with respect to large variations in

255 To assess the post-gastrulation role of YY1, a conditional knock-out (cKO)

256 ulate cell polarity and intercalation during gastrulation, signaling molecules acting in other pathwa

257 , using enhancers of brinker (brk) and short gastrulation (sog), both of which are directly activated

258 Later, during gastrulation, Sox32 restricts Pou5f3-Nanog complexes to

259 Strikingly, mouse EpiSCs express gastrulation stage regional markers in self-renewing con

260 t1 in mouse embryos causes death at the post-gastrulation stage; however, the functions of Dnmt1 and

261 PTU exposure during gastrulation (stage 8-12.5) was identified as the critic

262 d mesodermal cells during cleavage and early gastrulation stages.

263 , suggesting that they might use alternative gastrulation strategies.

264 ntration caused changes in cell movements at gastrulation that also altered the tissue fates of these

265 nase MRCK-1 as a key regulator of C. elegans gastrulation that integrates spatial and developmental p

266 te embryos undergo dramatic shape changes at gastrulation that require locally produced and anisotrop

267 ed population of cells emerges at the end of gastrulation that, under the influence of Wnt and FGF si

268 By gastrulation the ectodermal territories of the sea urchi

269 During gastrulation, the animal and marginal regions dissociate

270 Immediately after gastrulation, the CB consists of four separate regulator

271 At the start of gastrulation, the ER divides asymmetrically into a popul

272 Around late gastrulation, the PPE forms at the border surrounding th

273 During gastrulation, the primary morphogenetic event of early d

274 During Drosophila gastrulation, the ventral mesodermal cells constrict the

275 d CaN signaling opposes BMP signaling during gastrulation, thereby promoting neural induction and the

276 we examined whether C5a could be involved in gastrulation through cAMP transport.

277 ng is required for mesoderm induction during gastrulation through positive transcriptional regulation

278 els in the embryo blocks force generation at gastrulation through two distinct mechanisms: destabiliz

279 entiation to mimic lineage commitment during gastrulation to ectoderm (early switch) or mesoderm/endo

280 ailbud that make a germ layer decision after gastrulation to form spinal cord and mesoderm.

281 r of left-right (L-R) information from early gastrulation to morphogenesis.

282 F-beta-receptor signaling is required during gastrulation to pattern the anterior skeleton.

283 Short gastrulation/Chordin (Chd) and Twisted gastrulation (Tsg).

284 Twisted gastrulation (TWSG1) is a secreted BMP binding protein t

285 Gastrulation was arguably the key evolutionary innovatio

286 n and random motility exhibited during early gastrulation were dependent on both Nodal and Rac1 signa

287 In the sea urchin embryo, cells at gastrulation were found to reprogram and replace missing

288 milar in both species until the beginning of gastrulation, when BMP signaling broadens and intensifie

289 of the three major germ layers occurs during gastrulation, when cells ingressing through the primitiv

290 ter is expressed throughout the embryo until gastrulation, when it becomes specifically expressed in

291 ipts differentially expressed by PMCs during gastrulation, when these cells undergo a striking sequen

292 These progenitors are specified during gastrulation, when they transiently express Foxa2, a gen

293 h changes broadly regulate translation until gastrulation, when this coupling disappears.

294 t activation induces the neural crest during gastrulation, whereas activation of both pathways mainta

295 genes is also upregulated in males prior to gastrulation; whether it results in functional dosage co

296 Dynamic local methylation was evident during gastrulation, which enabled the identification of putati

297 ) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the pri

298 mits the developmental rate beginning during gastrulation without affecting the normal patterning of

299 ation (Tcf3(DeltaN/DeltaN)) progress through gastrulation without apparent defects, thus genetically

300 During vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling o