ライフサイエンスコーパス: gene product

1 xnIP promoter, controlling expression of its gene product.

2 tions in at least 1 PI3K pathway gene and/or gene product.

3 ementation lines when attributing roles to a gene product.

4 terwoven into networks, rather than a single gene product.

5 differential expression of the small Ad E1B gene product.

6 ferentially modified proteoforms of the same gene product.

7 rily conserved Cys residue for an Arg in the gene product.

8 thways via a single evolutionarily conserved gene product.

9 omplexity otherwise inaccessible to a single gene product.

10 ange in the redox state of the corresponding gene product.

11 erk1/2) and is restrained by a JAK-dependent gene product.

12 ombicola, and the functional activity of its gene product.

13 many Archaea form homohexamers from a single gene product.

14 n in tsv causes premature termination of the gene product.

15 molecular identification of the Sm1 and Sm2 gene products.

16 of the predicted protein interactions of the gene products.

17 ratus have been identified, most as deafness gene products.

18 d increased expression of many of these same gene products.

19 lipid homeostasis in concert with their host gene products.

20 ed in subfunctionalization of the respective gene products.

21 andards for accurate representation of these gene products.

22 tification of 14,213 phosphosites from 4,499 gene products.

23 od of the Human Papillomavirus (HPV) encoded gene products.

24 rally regulate late expression of structural gene products.

25 up-regulate the expression of Nrf2-dependent gene products.

26 contribute to the heterogeneity observed in gene products.

27 nt form that does not actively express HIV-1 gene products.

28 ing behind the more abundant HLA-A and HLA-B gene products.

29 ing RNA had no effect on expression of these gene products.

30 ure models are available for the majority of gene products.

31 oolkit will prove useful for the analysis of gene products.

32 o a gain or loss of conserved domains in the gene products.

33 HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products.

34 used resource to describe the attributes for gene products.

35 of MERS-CoV and human interferon-stimulated gene product 15 (hISG15) was probed with isothermal calo

36 moval of ubiquitin and interferon-stimulated gene product 15 (ISG15) from target proteins.

37 uitin (Ub) and Ub-like interferon-stimulated gene product 15 (ISG15) to stabilize, or activate, a var

38 teins by ubiquitin and interferon-stimulated gene product 15 (ISG15), subsequently facilitating downr

39 quitin (Ub) or Ub-like interferon-stimulated gene product 15 (ISG15).

40 ure of the bacteriophage T4 portal assembly, gene product 20 (gp20), determined by cryo-electron micr

41 s mutations that disrupt function of the MMR gene product: 31 in MLH1 (61%), 11 in MSH2 (21%), 3 in M

42 The ssDNA binding protein [gene product 32 (gp32)] of the T4 bacteriophage is a cen

43 m (un)folding intermediate state of T4 phage gene product 45 (gp45, also known as DNA polymerase proc

44 ervation was stained with 2 markers: protein gene product 9.5 (PGP 9.5), a general neuronal marker, a

45 was used with antibodies specific to protein gene product 9.5 (PGP9.5) and, for the first time in hum

46 zation showed increased TUBB3(+) and protein gene product 9.5(+) Merkel cells during in vivo repair,

47 ation of the maize insect resistance1 (mir1) gene product, a cysteine (Cys) proteinase that is a key

48 We have studied the UL116 gene product, a putative open reading frame identified b

49 We report that the gamma134.5 gene product, a virulence factor of HSV-1, facilitates n

50 To identify more gene products able to regulate EC1 expression together w

51 We categorize known ASD-associated gene products according to their roles in such feedback

52 a functional core proteome consisting of 356 gene products, accounting for 44% of the Escherichia col

53 roject integrates data about the function of gene products across a diverse range of organisms, allow

54 ite the selective pressure to keep terminase gene products active and localized in the nucleus.

55 To determine whether the truncated gene product acts as a dominant negative allele and if R

56 An early, IE1-regulated viral gene product acts on a necroptosis step that follows MLK

57 30 cancer-related genes was used to identify gene products affected by JQ1.

58 interaction could preserve ERV/host chimeric gene products affecting female fertility.

59 l genomes suggests that extensive sharing of gene products among symbiont cells must occur.

60 a multienzyme complex that includes the mcrC gene product, an Fe-protein homolog, an iron-sulfur flav

61 is the annotation, an association between a gene product and a term from one of the three ontologies

62 leles, suggesting a link between the gene or gene product and disease development.

63 lack of a strong, dominant function for each gene product and the ability of many viruses to interfer

64 tags are fundamental tools used to visualize gene products and analyze their dynamics in vivo.

65 enome (rP18tri), which encodes all four PICV gene products and as many as two foreign genes.

66 e single csoS2 gene yields expression of two gene products and both display an apparent molecular wei

67 -binding adaptor shared by APAF-1, certain R gene products and CED-4) and NACHT (named for NAIP, CIIA

68 typic networks were associated with distinct gene products and clinical syndromes (i.e., the schizoph

69 eptide generation at the level of individual gene products and create a predictive algorithm for dise

70 anscriptome, revealing previously undetected gene products and isoform-specific protein expression.

71 (citations, nomenclature, genomic location, gene products and their attributes, phenotypes, sequence

72 part of the currently undruggable genes and gene products and to generate entirely new therapeutic p

73 adipocytes produced striking increases in P2 gene-products and dramatic falls in P1-transcribed mRNA,

74 ion about interactions between chemicals and gene products, and their relationships to diseases.

75 representing essentially all canonical human gene products, and we exemplify the utility of these dat

76 olecular screens reveal functionally related gene products; and advanced proteomic methods can determ

77 as well as an increase in both the number of gene product annotations and their granularity, thus imp

78 rmediate Physcomitrella patens, a moss, both gene products are active.

79 A2*05 gene is present in abundance, and its gene products are characterized by low cell-surface expr

80 of the T9SS are co-transcribed and that the gene products are distributed in the cell envelope.

81 c evidence suggesting that the sufU and sufB gene products are essential.

82 Their gene products are functional receptors for Yersinia pest

83 However, cyanophage-encoded gene products are hypothesized to maintain or even suppl

84 ently in certain tissues, indicating that LR gene products are important.

85 Both gene products are involved in key pathways regulating in

86 iated with mutations in NPC1 and NPC2, whose gene products are key players in the endosomal/lysosomal

87 It has been shown that both gene products are necessary for tubular myelin formation

88 In the noisy cellular environment, gene products are subject to inherent random fluctuation

89 f HSCR genes and haploinsufficiency of their gene products are the primary pathogenic mechanisms for

90 The gene product, ArsI, is an Fe(II)-dependent extradiol dio

91 expression and correct trafficking of target gene products as assessed by immunofluorescence assays a

92 Further, we focused on IFN-induced gene products associated to promyelocytic leukemia (PML)

93 belliferone directly and selectively blocked gene products associated with the pro-catabolic metaboli

94 We have shown that Borrelia burgdorferi gene product BB0323 is essential for cell fission and pa

95 The BLM gene product, BLM, is a RECQ helicase that is involved i

96 required the breast and ovarian susceptible gene product BRCA1, highlighting important roles of the

97 ls are not controlled by Mbl or the Laccase2 gene product but rather by multiple hnRNP (heterogeneous

98 ll as posttranscriptional regulation of MCMV gene products by pIE611.

99 We demonstrate here that the FADS2 gene product can directly Delta4-desaturate 22:5n-3-->22

100 logy in mouse models and that the HTT exon 1 gene product can self-assemble into amyloid structures.

101 and biochemical properties of CAPN14 and its gene product CAPN14, and its emerging role in patients w

102 4, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA and DMA

103 Epstein-Barr virus (EBV) latent gene products cause human cancers and transform B lympho

104 ings identify that the asthma susceptibility gene product CDHR3 mediates RV-C entry into host cells,

105 binds to a conserved region of that same MHC gene product (class II or I, respectively).

106 tenance in wild-type mice, PKCiota/lambda, a gene-product closely related to PKMzeta, persistently in

107 Interestingly, transient expression of SPFMV gene products coagroinfiltrated with a reporter gene in

108 ty of Leptospira interrogans strain Lai colA gene product (ColA) to hydrolyze different collagenic su

109 Because the corresponding gene products compete with factor H in the regulation of

110 TSV genome revealed a potential three-domain gene product containing an N-terminal leucine-rich repea

111 n order to infer the properties of genes and gene products containing little or no experimental annot

112 The csaA gene product contains a predicted glycosyltransferase do

113 vel synaptogenic mechanism in which a single gene product coordinates the nuclear transcription and p

114 Based on our findings, we designate the gene product corresponding to ct694-ctl0063translocated

115 , implying that the THIAMIN REQUIRING2 (TH2) gene product could be a dedicated ThMP phosphatase.

116 nonical defense pathways and how herpesvirus gene products counter them, highlighting the contributio

117 oaches are required to study the function of gene products critical for growth and erythrocyte invasi

118 o control the copies and residence time of a gene product delivered in host human cells but also sele

119 espite acting in a common pathway, each PCLD gene product demonstrated distinct effects on polycystin

120 r burden of NsM generates novel epitopes and gene products, detected by the immune system as foreign.

121 The two gene products differ in their expression level, subcellu

122 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are imp

123 the peptidase domain of the Synpcc7942_1133 gene product (dubbed PteB for peptidase transporter esse

124 t that potential exposure to DsRed2 and tTAV gene products (e.g. mRNA and encoded proteins) would hav

125 BE3A gene and aberrant overexpression of the gene product E6AP protein is a common cause of autism sp

126 ing of avirulence genes PWT3 and PWT4, whose gene products elicit defense in wheat cultivars containi

127 petence regulation and stress tolerance by a gene product encoded within the comX gene that appears u

128 it the longstanding concept that some of the gene products encoded by ERVs and other endogenous viral

129 rotein triggering each of the two resistance gene products; epidemiology of RB isolates is discussed

130 Antiviral agents can target viral or host gene products essential for viral replication.

131 Many mitochondrial gene products exhibit extraordinary levels of divergence

132 Our studies revealed that BoHV-1 gene products expressed during latency stabilize express

133 ochrome bd oxidase as an essential bacterial gene product for mosquito growth.

134 Colocation of gene and gene product for redox regulation of gene expression (Co

135 ystematically screened all human phosphatase gene products for a regulatory role in the SMN complex.

136 ry mechanism ensures optimal output of these gene products for proper physiological function of the a

137 ent quantities of embryos depleted of single gene products for proteomics.

138 we examined the relative roles of two viral gene products for the ability to promote loss of the ant

139 und that vesicles containing the PKHD1/Pkhd1 gene product, FPC, also contain the NEDD4 ubiquitin liga

140 the FMR1 gene leading to the absence of its gene product, fragile X mental retardation protein (FMRP

141 We characterize here the MJ1541 gene product from Methanocaldococcus jannaschii, an enzy

142 Expression of gene products from both the spliced and unspliced RNAs i

143 cadian pacemaker gene frequency (frq), whose gene product, FRQ, as a part of the FRQ-FRH complex (FFC

144 nk the presence of an SNP to altered in vivo gene product function and hence contribute to disease ri

145 Gene and gene product function was reviewed on OMIM and from publ

146 ordinated interactions between diverse human gene products functioning within various pathways underl

147 Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyr

148 The gene products hamartin and tuberin form the TSC complex

149 nhibition of apoptotic activity by the Diap1 gene product has been decreased.

150 an 70 distinct loci and more than 50 mutated gene products have been identified in patients with here

151 pH, this resulting in a grand total of 1151 gene products identified after the capture.

152 ressed proteins, including podocyte-specific gene products, identified in an unbiased tandem mass spe

153 Three viral gene products-IE1, pp71, and UL26-were shown to inhibit

154 the expression of the interferon-stimulated gene product IFIT2 than the parent virus.

155 the expression of the interferon-stimulated gene product IFIT2 than the parent virus.

156 The ATP7A interactome concentrated gene products implicated in neurodegeneration and neurod

157 ppressor TP53 is the most frequently mutated gene product in human cancer.

158 These results support a role for this gene product in protein secretion as well as in pili for

159 Guanylin is the most commonly lost gene product in sporadic colorectal cancer, and its univ

160 nt with this finding, examination of Slc52a3 gene products in adult tissues revealed expression in th

161 re used to investigate the role of three fra gene products in channel formation.

162 GFP enables localization and quantitation of gene products in otherwise unmanipulated live cells or o

163 nt differences exist in the role of specific gene products in regulating analogous steps in the gener

164 Translation of mitochondrial gene products in Saccharomyces cerevisiae depends on mRN

165 Roles for the gene products in WTA galactosylation are proposed.

166 ein resulting from fusion of MIA2 and cTAGE5 gene products, in the export of pre-chylomicrons and pre

167 RNAi-mediated ablation of these gene products inhibited cancer cell migration and cell i

168 complex inheritance and potentially complex gene product interactions during development, contributi

169 bined 651 gene expression datasets with 1.4M gene product interactions to predict the inclusion of 40

170 erms of biomedical concepts (e.g., genes and gene products, interactions and processes) rather than f

171 ly transform the sequence of disease-causing gene products into lead modalities.

172 RTA is an essential viral gene product involved in the initiation of gammaherpesvi

173 synthesis using a high throughput screen for gene products involved in capsular alpha-glucan producti

174 t: 1) OmpR regulates mostly membrane-located gene products involved in diverse fundamental biological

175 ges aiming at the unbiased identification of gene products involved in Nlrp3 inflammasome activation.

176 However, key gene products involved in tRNA biogenesis and subcellula

177 ocus TNIP1, also referred to as ABIN1, whose gene product is a negative regulator of various inflamma

178 ures, non-optimal codon use, and those whose gene product is cotranslationally translocated into the

179 etion analysis indicated that only the cel3B gene product is essential for efficient cellodextrin uti

180 sarcoma-associated herpesvirus (KSHV) ORF57 gene product is essential for lytic KSHV replication and

181 Here, we show that the UL116 gene product is expressed in infected cells and forms a

182 egulates plant architecture whereas the Ant1 gene product is involved in anthocyanin biosynthesis.

183 nding how expression of this essential viral gene product is regulated may identify new strategies fo

184 are needed to determine, for example, which gene product is responsible for catalyzing each step in

185 hermore, the results suggest that sharing of gene products is limited, and thus there is incomplete b

186 well established that neurofibromin, the NF1 gene product, is an antioncogene that down-regulates the

187 genome-which encodes potentially inhibitory gene products-is still allowed to enter the cell.

188 Here, we establish that the ISG15 gene product itself directly regulates HCMV replication

189 ribe the manual annotation of a selection of gene products known to be associated with autism and/or

190 tion of ubiquitinated SLiPs to the autophagy gene product LC3.

191 activity classifications based on changes in gene product level are mechanistically uninformative, we

192 All of the gene products localize in and around the primary cilium,

193 a SCZ genome-wide association studies and in gene products localized to mitochondria and cytoplasm.

194 The suspected role for the MAN1B1 gene product MAN1B1, also known as ER mannosidase I, is

195 nce that these modules and their constituent gene products may play central roles in metabolic inflam

196 Networks of interacting genes and gene products mediate most cellular and developmental pr

197 eractor of the X-linked Opitz G/BBB syndrome gene product Mid1.

198 dingly, any potential drug targeting of this gene product must be strictly assessed for safety.

199 ations in the beta-myosin heavy chain (MYH7) gene product (Myosin-7).

200 Five different gene products (NCKX1-5) have been identified in humans,

201 munotoxin sensitivity, indicating that these gene products normally contribute to inefficiencies in t

202 Since most NPH gene products (NPHP) function at the primary cilium, NPH

203 t RNA polymerase from the Hepatitis C Virus (gene product NS5B) is a validated drug target because of

204 hin nuclear-encoded genes with mitochondrial gene products (odds ratio, 1.075; 95% CI, 1.018-1.135; P

205 Here we report that the gamma134.5 gene product of HSV-1 facilitates nucleocapsid release t

206 rt that mutant huntingtin (Htt), a causative gene product of Huntington's diseases (HD) selectively i

207 independent growth, which is mediated by the gene product of its target gene HMGA1, encoding a multip

208 The K1 gene product of Kaposi's sarcoma-associated herpesvirus

209 mox organism Kuenenia stuttgartiensis as the gene product of kustc0694 and determined some of its cat

210 Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cau

211 The gene product of this ORF localizes to promyelocytic leuk

212 Here, we show that the gene products of Alr1 and Alr2 (Alr1 and Alr2) are self-

213 Gene products of bovine and poultry were produced two di

214 has been growing interest in the homodimeric gene products of CISD1 (mitoNEET) and CISD2 (NAF-1), the

215 of PSAT by annotating the predicted peptide gene products of Herbaspirillum sp. strain RV1423, impor

216 We further found that viral gene products of IE1, pp71, and UL26 play roles in inhib

217 ular structure data for one or more genes or gene products of interest.

218 Furthermore, we found that the gene products of PA4330 and PA4331, located in a predict

219 Gene products of potyviruses include P1, HCPro, P3, 6K1,

220 Here we show that the gene products of two cbbX genes encoded by the nuclear a

221 Individual binding sites of select KSHV gene products on PAN RNA were also identified in in vitr

222 ine the synergistic effects of the various P gene products on pathogenesis in animal models.

223 s were cholinergic, colocalized with protein gene product (PGP)9.5, the vesicular ACh transporter, an

224 e R (PKR), a classical interferon-stimulated gene product, phosphorylates the eukaryotic translation

225 s associated with a combined deficiency of 2 genes products, PI3-kinase p110delta and SKAP, both of w

226 ated the dispensability of the canonical ie3 gene product pIE611 for viral replication and delineated

227 ated the dispensability of the canonical ie3 gene product pIE611 for viral replication.

228 The NPHS2 gene product podocin is a key component of the slit diap

229 l dominant polycystic kidney disease (ADPKD) gene products polycystin-1 and polycystin-2 localize to

230 teome-based assay revealed that the NAALADL1 gene product possesses previously unrecognized aminopept

231 Its gene product (pRB) regulates transcription and is a nega

232 Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to onco

233 kinase II, and the Alzheimer's disease risk gene product protein tyrosine kinase 2 beta.

234 erent data types including sequences, genes, gene products, proteins, protein domains, protein famili

235 ude nucleotide and protein sequences, genes, gene products, proteins, protein domains, protein famili

236 The Epstein-Barr virus (EBV) BNLF2a gene product provides immune evasion properties to infec

237 The VHL gene product, pVHL, is the substrate recognition unit of

238 nd downstream phosphorylation of the AD risk gene product Pyk2, and of NR2B Glu receptors in brain sl

239 sis with cellulosic substrates, seven of the gene products (Ra0185, Ra0259, Ra0325, Ra0903, Ra1831, R

240 The recombination-activating gene products, RAG1 and RAG2, initiate V(D)J recombinati

241 of mutant plants it is known that the Ert-m gene product regulates plant architecture whereas the An

242 izophrenia, alterations in the expression of gene products regulating these properties could disrupt

243 the functions and mechanisms of several clb gene products remain poorly understood.

244 f herpes simplex virus 1 (HSV-1) is an alpha gene product required for viral replication at low multi

245 structurally and functionally replaces four gene products required for carboxysome formation.

246 In this work, we identify two viral gene products required for postentry tropism in endothel

247 Transposon mutagenesis identified several gene products required for symplasmata formation, includ

248 ered with optical reporters and tumouricidal gene products retain the capacity to differentiate and i

249 n together, our data imply that the NAALADL1 gene product's primary physiological function is associa

250 control of another unknown RpoS-independent gene product(s) associated with borrelial replication.

251 of lytic transcripts, and a late lytic KSHV gene product(s) targets IFI16 for degradation during lyt

252 The gene product serves an essential function in vivo, as bb

253 of intense miRNA innovation and that mature gene products show a very different tempo and mode of se

254 MV utilizes the traditionally IFN-associated gene product, STAT1, to promote these changes.

255 Additional gene products, such as chromatin modification enzymes, h

256 oisomerase-induced DNA breaks and the RecBCD gene products, suggesting a new co-antibacterial strateg

257 ia burgdorferi notably encodes a single HtrA gene product, termed BbHtrA.

258 structure and molecular function of ClbS, a gene product that confers resistance to colibactin toxic

259 ndividual baboons, the identity of the viral gene product that is the major target of cellular immune

260 d for a total genome-wide screen to identify gene products that affected aggregate formation.

261 significantly reduces expression of over 600 gene products that are targets of the DREAM complex, whi

262 There are a paucity of data concerning gene products that could contribute to the ability of Mo

263 Pathogenic viruses encode gene products that enable evasion of host immune surveil

264 12 previously known Saccharomyces cerevisiae gene products that function in tRNA processing, turnover

265 t feature of HCMV is the wide range of viral gene products that it encodes which function to modulate

266 udies in schizophrenia reveal alterations in gene products that regulate the release and extracellula

267 Our work defines the pollen tube gene products that respond to the pistil and are require

268 Many publications describe sets of genes or gene products that share a common biology.

269 ssociated with an up-regulation of the ALOX5 gene product, the 5Lipoxygenase (5LO), herein we investi

270 no acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins.

271 Despite biochemical studies on individual gene products, the composition and cofactor requirement

272 Among the influenza viral gene products, the hemagglutinin (HA) glycoprotein plays

273 Although these screens affect thousands of gene products, the typical readout is based on low compl

274 New experimental discoveries about gene products, their function and regulation, new metabo

275 asic activation of a traditionally antiviral gene product through an EGFR- and integrin-dependent pat

276 that tolerance can be modulated by microRNA gene products through the control of opposing activities

277 ir targets impart rhythmic functions to many gene products through transcriptional, posttranscription

278 ne Interaction Database search identified 47 gene products to be affected by coxibs.

279 e analysis of the contribution of microbiome gene products to community assembly, host physiology, an

280 tein-protein interactions among at least six gene products to form a metabolic core, around which the

281 ks to implement stochastic switches that map gene products to phenotypes, and investigate the impact

282 our understanding of how drugs interact with gene products to produce physiological responses (phenot

283 elopment is passed from exclusively maternal gene products to those encoded by the embryonic genome i

284 Although Nef is the viral gene product used by most simian immunodeficiency viruse

285 r immune molecules and enabling detection of gene products usually not detected on arrays.

286 ry function is to regulate the expression of gene products via hybridization to mRNA transcripts, res

287 , we report that human herpesvirus 8 (HHV-8) gene product viral interferon regulatory factor 1 (vIRF-

288 rary for deficiency in acetylation, the yvoF gene product was identified to be the acetyltransferase.

289 Expression of 50 mRNA gene products was measured by quantitative polymerase ch

290 sease and establish that the Wiskott-Aldrich gene product (WASP) serves an essential role in T regula

291 ling of all annotated and predicted secreted gene products, we find that NF-kappaB activity is requir

292 were expressed in E. coli and the resulting gene products were characterized in vitro.

293 93 cells and the expression and functions of gene products were compared.

294 racted attention about a decade ago when CMV gene products were found in glioma tissue but not in nor

295 ex, or BMI, and transcripts for inflammatory gene products were noted in fetal beta-cells.

296 t assays further verified that the virulence gene products were produced and that the T3SS effector E

297 The clusters correspond to small sets of gene products, which can be processed quickly to give ca

298 st time that hydin, a hydrocephalus-inducing gene product whose mutation impairs ciliary motility, an

299 ghly conserved ortholog of the DrosophilaEcd gene product whose mutations impair the synthesis of Ecd

300 probably a result of heterotetramers of Kir2 gene products, with this regulating resting potentials a