ライフサイエンスコーパス: genomic imprinting

1 tance of the placenta as a target tissue for genomic imprinting.

2 hat supports the parental conflict theory of genomic imprinting.

3 coadaptation can also favor the evolution of genomic imprinting.

4 site alleles suggest that sRNAs may regulate genomic imprinting.

5 critical function of Tet1 in the erasure of genomic imprinting.

6 y, phenotypes commonly observed in defective genomic imprinting.

7 ong mammalian placentas and to mechanisms of genomic imprinting.

8 pression, genomic stability, DNA repair, and genomic imprinting.

9 ion is subject to both maternal and paternal genomic imprinting.

10 nonequivalence of parental genomes caused by genomic imprinting.

11 me (PWS) are neurodevelopmental disorders of genomic imprinting.

12 re exceptions, notably in regions subject to genomic imprinting.

13 Approximately 100 genes undergo genomic imprinting.

14 c and genetic features of regions regulating genomic imprinting.

15 future studies of phenotypic plasticity and genomic imprinting.

16 cleolar (sno)RNA species that are subject to genomic imprinting.

17 he previously reported instances of apparent genomic imprinting.

18 in patterns that mimic those expected under genomic imprinting.

19 native model for investigating mechanisms of genomic imprinting.

20 sual mode of sex determination that involves genomic imprinting.

21 icking those expected under various modes of genomic imprinting.

22 cal point of the selective forces leading to genomic imprinting.

23 eles and illuminate epigenetic mechanisms of genomic imprinting.

24 olecular bases of Rett syndrome, autism, and genomic imprinting.

25 en syndrome to defective DNA methylation and genomic imprinting.

26 sophila melanogaster are not attributable to genomic imprinting.

27 for understanding the evolution of mammalian genomic imprinting.

28 use chromosome 7C region, that is subject to genomic imprinting.

29 ests a significant role for YY1 in mammalian genomic imprinting.

30 eins that act in trans to induce or maintain genomic imprinting.

31 expression of alleles at a locus results in genomic imprinting.

32 ng, such as in X-chromosome inactivation and genomic imprinting.

33 e effects of different mutant backgrounds on genomic imprinting.

34 encies in multiple genes that are subject to genomic imprinting.

35 perinatal lethality in C57BL/6J mice due to genomic imprinting.

36 mmetry of expression is breached by allowing genomic imprinting.

37 Expression at this locus is mediated by genomic imprinting.

38 a greater proportion of parameter sets with genomic imprinting.

39 igenetic modifications that are critical for genomic imprinting.

40 exual reproduction through the phenomenon of genomic imprinting.

41 ic variation in the level of expression, and genomic imprinting.

42 f this highly conserved protein in mammalian genomic imprinting.

43 insight into the mechanisms and evolution of genomic imprinting.

44 transcript (WT1-AS) that is consistent with genomic imprinting.

45 ggest that DMDs have a determinative role in genomic imprinting.

46 hylation-dependent chromatin insulation, and genomic imprinting.

47 paternal or maternal imprints, which lead to genomic imprinting.

48 ders, and ZFP57, a trans-acting regulator of genomic imprinting.

49 ctive fitness, early zygotic development and genomic imprinting.

50 adaptation rather than the kinship theory of genomic imprinting.

51 for understanding the biochemical aspects of genomic imprinting.

52 oped to explain the epigenetic phenomenon of genomic imprinting.

53 be more plausible evolutionary outcomes than genomic imprinting.

54 he primary explanations for the evolution of genomic imprinting.

55 t Tet1 has a critical role in the erasure of genomic imprinting.

56 downstream factors, e.g. Pheres1 (PHE1), by genomic imprinting.

57 in-dependent gene expression associated with genomic imprinting.

58 resulting from X-chromosome inactivation and genomic imprinting, a large-scale analysis of allelic ge

59 There is increasing evidence that genomic imprinting, a process by which certain genes are

60 We conclude that genomic imprinting affecting gene expression is a genera

61 Genomic imprinting affects a subset of genes in mammals,

62 y embryo culture and embryo transfer, affect genomic imprinting after implantation in the mouse.

63 tiple equilibria exist both with and without genomic imprinting, although they occurred in a greater

64 gene regulation, including the emergence of genomic imprinting, an epigenetic regulation leading to

65 ent roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to

66 Genomic imprinting, an inherently epigenetic phenomenon

67 This success has depended on genomic imprinting and a biased role of the matriline.

68 at MeCP2 plays no role in the maintenance of genomic imprinting and add PEG3 and PEG10 to the list of

69 Here, we review the mechanisms of plant genomic imprinting and discuss theories of imprinting ev

70 enomes in placental mammals is essential for genomic imprinting and embryogenesis.

71 ted in germ cells is essential to understand genomic imprinting and epigenetic reprogramming.

72 rther roles for ZFP57-mediated regulation of genomic imprinting and identifies a novel mechanism for

73 In summary, despite genomic imprinting and its consequences on development t

74 cations -- for example, when one is modeling genomic imprinting and must keep track of the parental o

75 The lack of genomic imprinting and parent-of-origin differentially m

76 fitness effects can lead to the evolution of genomic imprinting and place recent theoretical advances

77 rovide the first evidence for a link between genomic imprinting and RNA silencing in plants.

78 howed that the Mcts2/H13 locus is subject to genomic imprinting and that alternative polyadenylation

79 s, which should improve our understanding of genomic imprinting and the role of genomic imprinting in

80 play crucial roles in embryonic development, genomic imprinting and transcriptional silencing.

81 e expression (ASE) have long been studied in genomic imprinting and X chromosome inactivation.

82 sion, DNA methylation, chromatin remodeling, genomic imprinting and X chromosome inactivation.

83 ing of retrotransposons and genes subject to genomic imprinting and X chromosome inactivation.

84 romosomes, a well-known mechanism leading to genomic imprinting and X-chromosome inactivation, is wid

85 n has key roles in several processes such as genomic imprinting and X-chromosome inactivation, the fu

86 ally regulated sequences, including sites of genomic imprinting, and at the X-inactivation centre, su

87 plasticity in somatic cell nuclear transfer, genomic imprinting, and cancer.

88 Demethylation by DME is necessary for genomic imprinting, and demethylation by a related prote

89 f alphaCGRP in adulthood did not result from genomic imprinting, and differences between B6 and cJ mi

90 e for studying transposition, recombination, genomic imprinting, and paramutation.

91 ce in unilineal and bilineal relatives under genomic imprinting, and some generalized linear function

92 plays an important role in gene expression, genomic imprinting, and suppression of transposable elem

93 activation, transposable element repression, genomic imprinting, and tissue-specific gene expression.

94 lian development, retrotransposon silencing, genomic imprinting, and X-chromosome inactivation.

95 Variation in imprinted loci and control of genomic imprinting appear to underlie the hybrid effects

96 eptions of the 'parental conflict' theory of genomic imprinting are addressed.

97 X chromosome inactivation and genomic imprinting are classic epigenetic processes that

98 The effects on genomic imprinting are consistent with the maternal-zygo

99 of DNMT3L and Dnmt3a in DNA methylation and genomic imprinting are discussed.

100 Random X inactivation and genomic imprinting are epigenetic allelic effects that a

101 analysis suggests that maternal and paternal genomic imprinting are equally rare events in Arabidopsi

102 n epigenetic phenomena of X inactivation and genomic imprinting are incompletely understood.

103 The evolutionary advantages of genomic imprinting are puzzling.

104 Our results show that the effects of genomic imprinting are relatively small, with reciprocal

105 Genomic imprinting arises from allele-specific epigeneti

106 aternal-offspring coadaptation theories view genomic imprinting as a mechanism to modify the resembla

107 hese findings highlight dosage regulation by genomic imprinting as being critical for maintaining a b

108 le Strategy) conditions for the evolution of genomic imprinting at an X-linked locus.

109 dback network between free methyl groups and genomic imprinting at birth.-Tserga, A., Binder, A.

110 Genomic imprinting at the Delta-like 1 (Dlk1)-Maternally

111 w members of epigenetic complexes regulating genomic imprinting at the PWS/AS domain.

112 Selection favors genomic imprinting because it coordinates the coexpressi

113 nalyses maternal effects are confounded with genomic imprinting because they can produce the same pat

114 Genomic imprinting begins during gametogenesis with the

115 Genomic imprinting brings about allele-specific silencin

116 e "conflict hypothesis" for the evolution of genomic imprinting but do not clearly demonstrate common

117 lation in gametes is not entirely related to genomic imprinting but is a strong factor in determining

118 entially involved not only in the origins of genomic imprinting, but also in its maintenance in human

119 r with described roles in X inactivation and genomic imprinting, but Smchd1 is also critically involv

120 as been well characterized as a paradigm for genomic imprinting, but the H19 RNA's biological functio

121 s the dominant evolutionary explanation for "genomic imprinting." But a new study in PLOS Biology pro

122 stigates the potential roles of macroH2A1 in genomic imprinting by lowering the cellular levels of th

123 able to construct an in vitro mouse model of genomic imprinting, by generating EG cells from 8.5-day

124 Genomic imprinting, by which maternal and paternal allel

125 ave been primarily studied in the context of genomic imprinting, cancer, and cell differentiation, ar

126 Genomic imprinting causes genes to be expressed or repre

127 Genomic imprinting causes parental origin-specific gene

128 center, and is regulated by a combination of genomic imprinting, cell lineage-dependent erasure of im

129 Placental development and genomic imprinting coevolved with parental conflict over

130 defective lineage specification and loss of genomic imprinting, compromising normal development.

131 Angelman syndrome gene, UBE3A, is subject to genomic imprinting controlled by mechanisms that are onl

132 In the context of genomic imprinting, CTCF and/or cohesin bind to a majori

133 tenance of genome stability, gene silencing, genomic imprinting, development, and disease.

134 Genomic imprinting directs the allele-specific marking a

135 evealed an increased incidence of growth and genomic imprinting disorders in children conceived using

136 These iPSC models of genomic imprinting disorders will facilitate investigati

137 e predictions of models for the evolution of genomic imprinting (e.g., conflict models), but other ge

138 hromatin modifications, DNA methylation, and genomic imprinting, each of which is altered in cancer c

139 The proposed approach models genomic imprinting effect as a probability measure with

140 o these mammalian evolutionary developments, genomic imprinting emerged as a monoallelic gene dosage

141 ng of several biological processes including genomic imprinting, epigenetic reprogramming and the est

142 Whether genomic imprinting exists in chickens remains debatable,

143 Genomic imprinting functionally distinguishes the parent

144 Genomic imprinting governs allele-specific gene expressi

145 tion imprint, suggesting that the memory for genomic imprinting had been lost or altered in Zfp57-nul

146 We concluded that genomic imprinting has a negligible effect on these spec

147 Genomic imprinting has been identified in therian (euthe

148 Albeit no genomic imprinting has been reported in the chicken embr

149 Genomic imprinting has been theorized as the main determ

150 In mammals, genomic imprinting has evolved as a dosage-controlling m

151 The epigenetic phenomenon of genomic imprinting has motivated the development of nume

152 These results indicate that genomic imprinting has small, but detectable, effects on

153 To test whether regions undergoing genomic imprinting have unique genomic characteristics,

154 ch highlights the role of CpG methylation in genomic imprinting, histone and chromatin modification,

155 t3b are responsible for the establishment of genomic imprinting, how the methylation mark is erased d

156 l for understanding the relationship between genomic imprinting, human development, and cancer.

157 There was no evidence detected of genomic imprinting in 12-day-old embryonic brain and liv

158 The modulation of genomic imprinting in a stem-cell environment adds a new

159 r >8,000 covered genes, suggesting a lack of genomic imprinting in adult Nasonia.

160 xcise 5-methylcytosine from DNA and regulate genomic imprinting in Arabidopsis.

161 imb, indicating that UBE3A is not subject to genomic imprinting in chicken.

162 etic considerations assessing the absence of genomic imprinting in chicken.

163 tion provides insight into the regulation of genomic imprinting in hESCs and the corresponding peri-i

164 A benefit of our and other recent studies of genomic imprinting in hESCs was the identification of im

165 anding of genomic imprinting and the role of genomic imprinting in human diseases.

166 les of imprinted genes that are required for genomic imprinting in maize endosperm.

167 At the heart of genomic imprinting in mammals are imprinting control reg

168 Genes that are subject to genomic imprinting in mammals are preferentially express

169 Genomic imprinting in mammals is thought to be the produ

170 Genomic imprinting in mammals marks the parental alleles

171 Genomic imprinting in mammals marks the two parental all

172 A methylation states from gametes determines genomic imprinting in mammals.

173 ion of the molecular mechanisms that control genomic imprinting in mammals.

174 as a major driving force in the evolution of genomic imprinting in mammals.

175 e of the driving forces for the evolution of genomic imprinting in mammals.

176 heds light on the causes and consequences of genomic imprinting in mammals.

177 m a useful tool to dissect the regulation of genomic imprinting in normal development and disease.

178 n the tammar wallaby confirm the presence of genomic imprinting in nutrient-regulatory genes in the a

179 mic imprinting while supporting the study of genomic imprinting in placenta for the determination of

180 able that tie the fetal growth trajectory to genomic imprinting in response to environmental stimuli,

181 we interrogated the existence or absence of genomic imprinting in the 12-day-old chicken embryonic b

182 Here we investigate genomic imprinting in the cerebellum using a newly devel

183 ation, so there may be greater selection for genomic imprinting in the mammary gland than in the shor

184 better understanding of the significance of genomic imprinting in the normal and pathological brain

185 In studies of genomic imprinting in the Prader-Willi/Angelman domain,

186 lve CSD, but it is consistent with a form of genomic imprinting in which activation of the female dev

187 ta demonstrate that epiallelic variation and genomic imprinting intersect to produce novel gene expre

188 Loss of genomic imprinting is a common epigenetic event in cance

189 Genomic imprinting is a conserved epigenetic phenomenon

190 Genomic imprinting is a critical developmental process c

191 Genomic imprinting is a developmentally important mechan

192 Genomic imprinting is a mechanism in which gene expressi

193 Genomic imprinting is a mechanism in which only one of t

194 Genomic imprinting is a phenomenon by which the expressi

195 ly imprinted in both species, revealing that genomic imprinting is a rapidly evolving phenomenon in p

196 The molecular basis of genomic imprinting is allele-specific DNA methylation.

197 Genomic imprinting is an allele-specific gene expression

198 Genomic imprinting is an allelic gene expression phenome

199 Genomic imprinting is an epigenetic inheritance system c

200 Genomic imprinting is an epigenetic mechanism by which a

201 Genomic imprinting is an epigenetic mechanism controllin

202 Genomic imprinting is an epigenetic mechanism resulting

203 Genomic imprinting is an epigenetic modification that re

204 Genomic imprinting is an epigenetic phenomenon causing p

205 Genomic imprinting is an epigenetic phenomenon in which

206 Genomic imprinting is an epigenetic phenomenon occurring

207 Genomic imprinting is an epigenetic phenomenon that resu

208 Genomic imprinting is an epigenetic process that restric

209 Genomic imprinting is an epigenetically-driven phenomeno

210 Genomic imprinting is an important regulatory mechanism

211 Genomic imprinting is an intriguing type of ASE in which

212 Although genomic imprinting is conserved in mammals, ICRs are gen

213 Together these studies provide evidence that genomic imprinting is critical for regulating growth and

214 Genomic imprinting is highly prevalent in the brain, yet

215 Genomic imprinting is implicated in the control of gene

216 Recent studies have indicated that genomic imprinting is less conserved in human placenta a

217 Genomic imprinting is limited to a subset of genes that

218 Genomic imprinting is manifested as differential allelic

219 This indicates that the ability to undergo genomic imprinting is not an inherent property of all me

220 Genomic imprinting is often associated with allele-speci

221 Genomic imprinting is predicted to influence behaviors t

222 Genomic imprinting is regulated by differential methylat

223 Mammalian genomic imprinting is regulated by imprinting control re

224 ific; an important trans-acting regulator of genomic imprinting is regulated by this phenomenon; and

225 Genomic imprinting is the differential expression of an

226 Genomic imprinting is the phenomenon where the expressio

227 e of its strict parent-of-origin dependence, genomic imprinting is thought to contribute to the aberr

228 Genomic imprinting is well known as a regulatory propert

229 Prader-Willi syndrome (PWS), a disorder of genomic imprinting, is characterized by neonatal hypoton

230 ve distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal hetero

231 Disruption of genomic imprinting leads to biallelic expression which m

232 Loss of genomic imprinting (LOI) of insulin-like growth factor I

233 ectively, the evidence suggests that XCI and genomic imprinting may have a common origin.

234 Genomic imprinting may have evolved not only to regulate

235 These observations could suggest that genomic imprinting may occur in chicken.

236 o the general life environment, the study of genomic imprinting may reveal critical information on al

237 parent-of-origin effects, perhaps including genomic imprinting, may play a role in human obesity.

238 for female sexual development and suggest a genomic imprinting mechanism involving an imprinted gene

239 ions driven by specific KRAB-ZFPs, including genomic imprinting, meiotic recombination hotspot choice

240 ion embryos, among other anomalies including genomic imprinting, mitochondrial and cytoplasmic hetero

241 a new, independent line of evidence for the genomic imprinting model of Nasonia sex determination.

242 The genomic imprinting model predicts that a loss-of-functio

243 act of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.

244 Loss of genomic imprinting of insulin-like growth factor II (IGF

245 cific to embryonic X inactivation as neither genomic imprinting of multiple genes nor imprinted X ina

246 Genomic imprinting of the PWS/AS domain is regulated thr

247 s genre are necessary for the full impact of genomic imprinting on mammalian gene expression and phen

248 However, little is known about the effect of genomic imprinting on relative growth.

249 ted regions (DMRs) associated primarily with genomic imprinting or DNA sequence variation acting in c

250 Genomic imprinting (parent-of-origin-dependent gene regu

251 In genomic imprinting, parental marks determine which of th

252 Genomic imprinting plays an important role in both norma

253 The study of genomic imprinting profiles in placentas from birth coho

254 The kinship theory of genomic imprinting proposes that parent-specific gene ex

255 We hypothesize (1) that genomic imprinting provides a previously suggested haplo

256 The epigenetic phenomenon of genomic imprinting provides an additional level of gene

257 Recent work has shown that genomic imprinting reaches beyond the basic significance

258 Genomic imprinting refers to a specialized form of epige

259 Genomic imprinting refers to an epigenetic mark that dis

260 Genomic imprinting refers to the pattern of monoallelic

261 Thus, genomic imprinting regulates multiple pathways to contro

262 Genomic imprinting relies on establishing and maintainin

263 e the problem of gene dosage, the purpose of genomic imprinting remains controversial.

264 Genomic imprinting represents a mechanism through which

265 verall, the functional connection of Rex1 to genomic imprinting represents another case where newly m

266 Genomic imprinting restricts gene expression to a patern

267 Genomic imprinting results in allele-specific silencing

268 Genomic imprinting results in monoallelic gene transcrip

269 Genomic imprinting results in preferential expression of

270 Genomic imprinting results in preferential gene expressi

271 Genomic imprinting results in the differential expressio

272 Genomic imprinting results in the monoallelic expression

273 hypermethylation; and (ii) for mechanisms of genomic imprinting since point mutations of CTCF binding

274 However, although the kinship theory of genomic imprinting suggests that parent-of-origin-specif

275 type is uncertain due to the consequences of genomic imprinting that in mammalian uniparental tissues

276 response to environmental stimuli, making of genomic imprinting the driving force of the fetal growth

277 The regulation of genomic imprinting, the allele-specific expression of an

278 f DNA methylation and H3K27me3 in regulating genomic imprinting, the contributions of allele-specific

279 Genomic imprinting, the differential expression of autos

280 A current model concerning the evolution of genomic imprinting, the parental conflict hypothesis, po

281 ents have been suggested to be important for genomic imprinting, the requirement of a G-rich repetiti

282 However, genomic imprinting theory predicts that the individual's

283 The discovery of genomic imprinting through studies of manipulated mouse

284 neral framework for statistical inference of genomic imprinting underlying allometry scaling in anima

285 Genomic imprinting underlying growth and development tra

286 f two epigenetic systems--X inactivation and genomic imprinting--using the genes Atp7a and Igf2, resp

287 n insights into these essential processes in genomic imprinting, we examined how ZFP57 maintains geno

288 Genomic imprinting, whereby certain genes are expressed

289 Approximately 100 mouse genes undergo genomic imprinting, whereby one of the two parental alle

290 Genomic imprinting, which has an active role in mammalia

291 Principle among these effects is genomic imprinting, which has generally been examined in

292 bject to X chromosome inactivation (XCI) and genomic imprinting, which were not corrected during dire

293 describing the transgenerational meaning of genomic imprinting while supporting the study of genomic

294 ent deluge of data, future investigations of genomic imprinting will require integrating evolutionary

295 findings reveal the remarkable complexity of genomic imprinting, with important implications for unde

296 , computational prediction, and evolution of genomic imprinting would be better addressed by having a

297 a role in diverse biologic processes such as genomic imprinting, X chromosome inactivation, and silen

298 ding of a wide range of phenomena, including genomic imprinting, X-chromosome inactivation, and cis-r

299 g embryonic development, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ

300 l cases of monoallelic expression, including genomic imprinting, X-inactivation, and random monoallel