ライフサイエンスコーパス: guanine nucleotide

1 change the 6-TGDP adducted on Rac1 with free guanine nucleotide.

2 ar binding affinities for GDP, GTP and other guanine nucleotides.

3 h is the pivotal step in the biosynthesis of guanine nucleotides.

4 tive of the presence or absence of competing guanine nucleotides.

5 matically accelerated in the presence of its guanine nucleotide-activating protein (GAP), Sec23-Sec24

6 Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers

7 ferred resistance to oligomer disassembly by guanine nucleotides and high ionic strength solutions.

8 reveals that these integrations are rich in guanine nucleotides and the integrated bacterial DNA may

9 signal transfer from receptor to G-protein, guanine nucleotide binding and hydrolysis, G protein sub

10 out mice and short hairpin RNA to knock down guanine nucleotide binding protein (GNB) isoforms (GNB1,

11 entricular and right atrial beta2-AR and Gi (guanine nucleotide binding protein inhibitory regulatory

12 levels of left ventricular beta1-AR and Gs (guanine nucleotide binding protein stimulatory) were red

13 chanism critically depends on Rab23, a small guanine nucleotide binding protein that has important ef

14 Septins comprise a conserved family of guanine nucleotide binding proteins that polymerize in t

15 on between the receptor binding site and the guanine nucleotide binding site, which are separated by

16 we report a kinetic analysis of fluorescent guanine nucleotides binding to EFL1 alone and in the pre

17 G-proteins, Rad and Rem contain a conserved guanine-nucleotide binding domain (G-domain).

18 ate that irreversible targeting of the K-Ras guanine-nucleotide binding site is potentially a viable

19 We previously showed that guanine nucleotide-binding (G) protein alpha subunit (Ga

20 the C-terminal alpha5-helix of Galpha to the guanine nucleotide-binding pocket.

21 GPR56 encodes a heterotrimeric guanine nucleotide-binding protein (G protein)-coupled r

22 Immunostaining with guanine nucleotide-binding protein beta 3 (GNB3) and cel

23 subunit of protein kinase A (PRKACA) or the guanine nucleotide-binding protein subunit alpha (GNAS)

24 Here we show by microarray and RNAi that guanine nucleotide-binding protein subunit alpha13 (Galp

25 in a sub-region of GNB1, a gene encoding the guanine nucleotide-binding protein subunit beta-1, Gbeta

26 h CSNB identified biallelic mutations in the guanine nucleotide-binding protein subunit beta-3 gene (

27 De novo mutations in the guanine nucleotide-binding protein, beta 1 (GNB1) gene,

28 The guanine nucleotide-binding proteins beta-3 subunit (GNB3

29 itutive and agonist-stimulated CB1R-mediated guanine nucleotide-binding regulatory protein (G-protein

30 of the Galpha Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the in

31 Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-protei

32 ites because it catalyzes a critical step in guanine nucleotide biosynthesis.

33 The guanine nucleotide biosynthetic enzyme inosine monophosp

34 dynamics are thought to be regulated by the guanine nucleotide cycle of Rab7.

35 However, the mechanism by which guanine nucleotide depletion suppresses T-cell activatio

36 onal modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galp

37 In Saccharomyces cerevisiae, the guanine nucleotide dissociation inhibitor (GDI) Rdi1 rec

38 t to require dynamic Cdc42 recycling through Guanine nucleotide Dissociation Inhibitor (GDI)-mediated

39 show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), c

40 membrane/cytosol cycle regulated by the Rho guanine nucleotide dissociation inhibitor alpha (RhoGDIa

41 metazoan-specific SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RA

42 nding partner [GPCRs, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (GDIs), GTPas

43 GDP-bound conformation of Galphai, acting as guanine nucleotide dissociation inhibitors.

44 ence of the SBDS protein irrespective of the guanine nucleotide evaluated.

45 kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward hetero

46 Importantly, the guanine nucleotide exchange activity of SOS1 is not requ

47 erexpression inhibits amino-acid-induced Rag guanine nucleotide exchange and mTORC1 translocation to

48 reen utilizing two complementary fluorescent guanine nucleotide exchange assays to identify small mol

49 Surprisingly, unlike in eEF1A and EF-Tu, the guanine nucleotide exchange does not cause a major confo

50 how considerably lower intrinsic activity in guanine nucleotide exchange experiments at D2R and conse

51 ways mediated by the ADP ribosylation factor guanine nucleotide exchange factor (ARF-GEF) GNOM.

52 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

53 ta1, Ggamma2, and/or Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), a

54 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

55 ibiting ARF1 activation by knocking down its guanine nucleotide exchange factor (Gartenzwerg) or over

56 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

57 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

58 GIV (a.k.a. Girdin) is the first for which a guanine nucleotide exchange factor (GEF) activity has be

59 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

60 A missense mutation that disrupts DOCK8 guanine nucleotide exchange factor (GEF) activity while

61 or embryonic development that acts as both a guanine nucleotide exchange factor (GEF) and a chaperone

62 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

63 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

64 risingly, this occurred independently of the guanine nucleotide exchange factor (GEF) catalytic activ

65 cted with the major activator of Cdc42p, the guanine nucleotide exchange factor (GEF) Cdc24p, which w

66 ell-cell contacts, mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicato

67 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

68 ino-terminal portion of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.

69 The guanine nucleotide exchange factor (GEF) epithelial cell

70 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

71 sed in epithelial cells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small G

72 Thus, SBDS acts as a guanine nucleotide exchange factor (GEF) for EFL1 promot

73 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

74 dent phosphorylation of Dock180, a bipartite guanine nucleotide exchange factor (GEF) for Rac1.

75 zed that the ability of PLC to function as a guanine nucleotide exchange factor (GEF) for Rap1 suppor

76 PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-rel

77 rimeric G protein Galphai by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known

78 1, a PI3K- and G protein betagamma-regulated guanine nucleotide exchange factor (GEF) of the Rac smal

79 We find that the guanine nucleotide exchange factor (GEF) of Ypt7 (the Mo

80 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

81 Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

82 Guanine nucleotide exchange factor (GEF) proteins activa

83 ECT-2, the guanine nucleotide exchange factor (GEF) required for Rh

84 The guanine nucleotide exchange factor (GEF) Son of Sevenles

85 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

86 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

87 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

88 The Rac1 guanine nucleotide exchange factor (GEF) Trio is essenti

89 NC-73, the C. elegans ortholog of Trio, as a guanine nucleotide exchange factor (GEF) upstream of bot

90 However, the guanine nucleotide exchange factor (GEF) which activates

91 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

92 co-Lbc protein is a hyperactive Rho-specific guanine nucleotide exchange factor (GEF), but its struct

93 acking GEF-H1 (GEF-H1(-/-)), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limi

94 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

95 ntly impairs Rab8A activation by its cognate guanine nucleotide exchange factor (GEF), Rabin8 (by usi

96 We identified the guanine nucleotide exchange factor (GEF), VAV2, as havin

97 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

98 oma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).

99 DP-ribosylated Ras loses the ability to bind guanine nucleotide exchange factor (GEF).

100 that the Rab3GAP complex is a specific Rab18 guanine nucleotide exchange factor (GEF).

101 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

102 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

103 have identified that leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as

104 hat phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) by polo-like

105 viously that nonmuscle myosin II-interacting guanine nucleotide exchange factor (MyoGEF) plays an imp

106 Pix is a conserved Rho-type guanine nucleotide exchange factor (Rho-GEF) homologous

107 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

108 notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1) and JAK1, as

109 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell div

110 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

111 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

112 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

113 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

114 The Rab exchange depends on the guanine nucleotide exchange factor activity of the Mon1-

115 nd proinflammatory gene expression is OGG1's guanine nucleotide exchange factor activity, acquired af

116 tide exchange factor Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac reg

117 oma homology domain of Cb, which carries the guanine nucleotide exchange factor activity, leads to ep

118 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

119 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

120 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

121 c GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA an

122 ly, beta-arrestin2 can interact with the ARF guanine nucleotide exchange factor ARNO, although the C-

123 interaction with the b isoform of Rac/Cdc42 guanine nucleotide exchange factor beta-PIX, regulates t

124 ed that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion

125 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

126 critically dependent upon the brain-specific guanine nucleotide exchange factor Collybistin (Cb).

127 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

128 that DCs from Nlrp10 knockout mice lack the guanine nucleotide exchange factor DOCK8 (dedicator of c

129 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

130 Here, we show that the Cdc42-guanine nucleotide exchange factor FGD6 coordinates thes

131 It functions as a guanine nucleotide exchange factor for Galphai, Galphaq,

132 ntify the DENN domain protein DENND2B as the guanine nucleotide exchange factor for Rab13 and develop

133 dynein-dependent transport) and Sprint (the guanine nucleotide exchange factor for Rab5), suggesting

134 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

135 t, behaviour to show that VAV-1, a conserved guanine nucleotide exchange factor for Rho-family GTPase

136 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

137 Epac, a guanine nucleotide exchange factor for the low molecular

138 tokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTP

139 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

140 an inhibitor of the cellular protein GBF1, a guanine nucleotide exchange factor for the small cellula

141 More specifically, alphaPIX, a known guanine nucleotide exchange factor for the small GTPases

142 FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the small GTPases

143 filin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimu

144 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

145 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

146 ow that this common pathway involves Trio, a guanine nucleotide exchange factor known to promote cyto

147 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

148 ves the activation of the Rac pathway by the guanine nucleotide exchange factor Myoblast City and its

149 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

150 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

151 e targets, the SF3B2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.

152 we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11)

153 Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is ra

154 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

155 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

156 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

157 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

158 The guanine nucleotide exchange factor Rgnef (also known as

159 synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at t

160 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

161 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

162 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

163 t Abl has been reported to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its R

164 GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1.

165 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates hetero

166 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

167 Sec2p is a guanine nucleotide exchange factor that activates Sec4p,

168 lyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the sm

169 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

170 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

171 nterfering RNA screen, we identify Dbl3 as a guanine nucleotide exchange factor that is recruited by

172 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

173 ell lymphoma invasion and metastasis 1) is a guanine nucleotide exchange factor that specifically con

174 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

175 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

176 ified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key componen

177 by the repulsive receptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance

178 wth by regulating the levels of the Rho-type guanine nucleotide exchange factor Trio, a transcription

179 ry cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 recept

180 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

181 the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is a

182 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

183 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

184 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

185 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

186 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

187 tudy, we explored the role of the epithelial guanine nucleotide exchange factor, GEF-H1, in complemen

188 sis revealed that microtubule-associated Rho guanine nucleotide exchange factor, GEF-H1, participates

189 otein (also known as Tuba), a Cdc42-specific guanine nucleotide exchange factor, in ciliogenesis and

190 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

191 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

192 ent membrane recruitment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115

193 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

194 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

195 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

196 As N-Ras is activated by Sos, a guanine nucleotide exchange factor, we modeled the N-Ras

197 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai

198 on impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide

199 ng proteins, such as RIN3, a RAB5-activating guanine nucleotide exchange factor.

200 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

201 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

202 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

203 TR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regu

204 Guanine nucleotide exchange factors (GEFs) activate and

205 Guanine nucleotide exchange factors (GEFs) activate ARF6

206 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

207 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

208 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

209 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

210 Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomy

211 Ric-8 proteins also act as Galpha-subunit guanine nucleotide exchange factors (GEFs) in vitro.

212 We find that suppression of the RhoA guanine nucleotide exchange factors (GEFs) LARG and GEF-

213 haromyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9

214 in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio a

215 Rho GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserve

216 Rho GTPases, activated by guanine nucleotide exchange factors (GEFs), are essentia

217 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

218 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

219 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF a

220 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

221 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

222 ess is known, however, about the function of guanine nucleotide exchange factors (GEFs), which activa

223 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

224 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

225 alyzed by a special class of enzymes, termed guanine nucleotide exchange factors (GEFs).

226 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

227 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

228 anger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate

229 tor of G protein signaling homology (RH) Rho guanine nucleotide exchange factors (RhoGEFs) (p115RhoGE

230 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

231 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

232 ted expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs).

233 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

234 Guanine nucleotide exchange factors control many aspects

235 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

236 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

237 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

238 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

239 roteins directly activated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects

240 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

241 These guanine nucleotide exchange factors regulate the spatiot

242 RasGRPs are guanine nucleotide exchange factors that are specific fo

243 to a selective inhibitor of the Rac-specific guanine nucleotide exchange factors Tiam1 and Trio (NSC2

244 We found decreased transcription of the Rac guanine nucleotide exchange factors Tiam1 and Vav1 in un

245 ptor proteins that interact with Dock family guanine nucleotide exchange factors to promote activatio

246 main-bearing proteins that function as GEFs (guanine nucleotide exchange factors) for the small GTPas

247 thereby Afp18(G) inhibits RhoA activation by guanine nucleotide exchange factors, and blocks RhoA, bu

248 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

249 uiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in

250 Arf1 is activated by guanine nucleotide exchange factors, but essential roles

251 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

252 Thus, Rho guanine nucleotide exchange factors, the activators of t

253 g via direct interactions with RhoA-specific guanine nucleotide exchange factors.

254 focal adhesion-associated proteins, and Rho guanine nucleotide exchange factors.

255 G proteins, most prominently, G12/13, to Rho guanine nucleotide exchange factors.

256 coupled receptors through receptor-catalyzed guanine nucleotide exchange on Galphabetagamma heterotri

257 ociation, thereby preventing agonist-induced guanine nucleotide exchange.

258 ing heterotrimeric G protein Galphai subunit guanine nucleotide exchange.

259 omotes PAK1 binding to beta-PAK1-interacting guanine-nucleotide exchange factor (betaPIX) and G prote

260 hil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) activators seem

261 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

262 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

263 a bona fide metastasis-related protein and a guanine-nucleotide exchange factor (GEF) for Galphai, to

264 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

265 eracting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates

266 d in the Golgi by GIV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).

267 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

268 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

269 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

270 bed an early decrease of Kalirin-7 (Kal7), a guanine-nucleotide exchange factor for Rho-like small GT

271 Further, EphB2 can interact with Zizimin1, a guanine-nucleotide exchange factor that activates Cdc42

272 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

273 The 2 EPAC isoforms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTP

274 act downstream of integrin signaling as Rac guanine-nucleotide exchange factors.

275 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

276 Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize

277 Kalirin-7 is a guanine nucleotide-exchange factor for the small GTPase

278 ion of BIG1 and/or BIG2 or overexpression of guanine nucleotide-exchange factor inactive mutant, but

279 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

280 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

281 Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases

282 The extruded cytosine and last guanine nucleotides form water-mediated hydrogen bonds,

283 ion, and the central domain, involved in the guanine nucleotide (GTP) binding.

284 riants, two point mutants predicted to alter guanine nucleotide handling, one that disrupts cilia loc

285 e Rnt1p dsRNA-binding domain (dsRBD) and the guanine nucleotide in the second position of the loop.

286 n autism caused by the insertion of a single guanine nucleotide into exon 21 (Shank3(G)).

287 e pathway mutants, some in which adenine and guanine nucleotide metabolism is uncoupled.

288 The co-purification of guanine nucleotide on the beta-tubulin in the trimer is

289 in bloodstream parasites led to depletion of guanine nucleotide pools and was lethal.

290 regulated expression of Ras protein-specific guanine nucleotide releasing factor 1 (RasGrf1), a Ras a

291 and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and relat

292 Ablation of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1), a neur

293 f CARD9 to complex with Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), leading

294 al 2) and RASGRF2 gene (Ras protein-specific guanine nucleotide-releasing factor 2) with all clinical

295 by overexpression of the RasGEF RasGRP1 (Ras guanine nucleotide-releasing protein 1), was recently im

296 Addition of guanine nucleotides resulted in changes in the solvent a

297 a unique 'G-loop' element that accounts for guanine nucleotide specificity.

298 te mofetil are highly specific inhibitors of guanine nucleotide synthesis and of T-cell activation.

299 demonstrate that the binding of adenine and guanine nucleotides to the canonical nucleotide binding

300 r SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase act