ライフサイエンスコーパス: homophilic

1 other (heterophilic) but not to themselves (homophilic).

2 hism level tend to be positively correlated (homophilic).

3 gage in trans interactions that are strictly homophilic.

4 be used to establish specificity, including homophilic adhesion and synaptic refinement, but the ran

5 Neither the mechanism of homophilic adhesion by PCDH19, nor the biochemical effec

6 propose that Fas2-mediated intermicrovillar homophilic adhesion complexes help stabilize the brush b

7 Vascular endothelial (VE)-cadherin homophilic adhesion controls endothelial barrier permeab

8 least some of which exhibit isoform-specific homophilic adhesion in heterologous cells and are expres

9 n family of cell adhesion proteins, mediates homophilic adhesion in the vascular endothelium.

10 Cadherin-mediated homophilic adhesion is necessary for trans-endocytosis,

11 equirements: intercalating growth depends on homophilic adhesion mediated by extracellular Ig domains

12 Our structures reveal a conserved homophilic adhesion mode for the L1 family and also shed

13 ry-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regen

14 In the current work, we demonstrate that the homophilic adhesion molecule sidekick-1 (sdk-1) is up-re

15 noglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially express

16 Satb1 regulates expression of a homophilic adhesion molecule, Contactin 5 (Cntn5).

17 us in vitro studies have suggested a role as homophilic adhesion molecules in brain neurons, but the

18 rinsic pro-thrombotic activity mediated by 2 homophilic adhesion molecules, CD84 and CD150 (SLAM [sig

19 d together, demonstrating that sidekicks are homophilic adhesion molecules.

20 Homophilic adhesion of vascular endothelial (VE) cadheri

21 ct tracing to show that Cadherin-8 (Cdh8), a homophilic adhesion protein encoded by a gene associated

22 N-cadherin is a homophilic adhesion protein that remains expressed at ma

23 receptor (CAR) is both a viral receptor and homophilic adhesion protein.

24 of efficiently blocking surface attachment, homophilic adhesion, and biofilm accumulation.

25 ic adhesion is not substantially weaker than homophilic adhesion, and the measured differences in adh

26 cessary and sufficient to mediate and target homophilic adhesion, and the QLVILA sequence is critical

27 fects Cad11-mediated cell migration, but not homophilic adhesion, as deletion of Amot binding motif o

28 eterologous cells showed that Cntn2 mediates homophilic adhesion, but does not bind detectably to Sdk

29 potential mechanisms of activity, including homophilic adhesion, homophilic repulsion and heterophil

30 ellular complexes, linked by Celsr1-mediated homophilic adhesion, that coordinate polarity non-autono

31 the appropriate sublaminae and each mediates homophilic adhesion.

32 ltured cerebellar granule neurons (CGNs) via homophilic adhesion.

33 eviously shown to partially inhibit cadherin homophilic adhesion.

34 geting of another lamina neuron, L4, through homophilic adhesion.

35 ether, these data suggest that CadN mediates homophilic adhesive interactions between R7 growth cones

36 s) potentially specify thousands of distinct homophilic adhesive interactions in the brain.

37 ructures are formed by the clustering of the homophilic adhesive protein VE-cadherin, which recruits

38 us reports, demonstrate that the SLAM family homophilic affinities span at least three orders of magn

39 ty is intermediate in strength between the 2 homophilic affinities.

40 stems; for example, an olfactory gene set is homophilic and an immune system gene set is heterophilic

41 The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall

42 sly been shown that small differences in the homophilic and heterophilic binding affinities of differ

43 trafficking, and immune response through its homophilic and heterophilic binding patterns.

44 s of the strengths and dissociation rates of homophilic and heterophilic cadherin (CAD) bonds.

45 ate how graded differences between different homophilic and heterophilic cadherin dimerizaton affinit

46 s neurite outgrowth and neuronal survival in homophilic and heterophilic interactions and enhances ne

47 to drive the beneficial functions of L1 via homophilic and heterophilic interactions are functionall

48 ontains characteristic repeats that regulate homophilic and heterophilic interactions during adhesion

49 ts likely arises as a result of the numerous homophilic and heterophilic interactions that CEACAM1 ca

50 ng and adult nervous system are triggered by homophilic and heterophilic interactions that stimulate

51 functions of CAMs are brought about through homophilic and heterophilic interactions with other cell

52 nt of the binding affinities associated with homophilic and heterophilic interactions within the nect

53 mily that mediate cell-cell adhesion through homophilic and heterophilic interactions.

54 esion between Sertoli and germ cells through homophilic and heterophilic interactions.

55 e activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both

56 c activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both

57 se cell surface receptors thought to provide homophilic and heterophilic recognition specificity for

58 We investigated whether exploitation of homophilic and possibly also heterophilic mechanisms of

59 n-coupled receptors (GPCRs) proposed to form homophilic and/or mixed oligomers on the basis of previo

60 ophilic (parallel) oligomerization and trans-homophilic (anti-parallel) binding.

61 othelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (VE

62 The homophilic asymmetric dimer can potentially offer advant

63 pecificity between synaptic partners through homophilic attraction.

64 We propose that N-cadherin mediates a homophilic, attractive interaction between photoreceptor

65 ior by a few poor may largely compensate for homophilic behavior.

66 mAb-binding properties to EC4-5 and partial homophilic binding activity but did not restore full cel

67 ic binding partner, p120(ctn), increased the homophilic binding affinity of E-cadherin.

68 PTPRM has been shown to exhibit homophilic binding and confer cell-cell adhesion in cell

69 surface-expressed CEACAM1 facilitates trans-homophilic binding and downstream effector signaling.

70 -helix domains in other proteins demonstrate homophilic binding and inhibit function; therefore, we t

71 These exhibit isoform-specific homophilic binding and regulate self-avoidance, the tend

72 majority of Dscam isoforms mediate specific homophilic binding and second by revealing the essence o

73 and rely on a high degree of specificity in homophilic binding as well as heterophilic interactions.

74 e in cell proliferation caused by E-cadherin homophilic binding at the cell surface, independent of o

75 dherin (EC) domains mediate isoform-specific homophilic binding between cells, conferring cell recogn

76 as unaffected by mutations that disrupt Ncad homophilic binding but was inhibited by a mutation in Pc

77 xtinction of SHP-1 expression or blockade of homophilic binding by CEACAM1 using a Fab that specifica

78 neurite arborization being mediated through homophilic binding cell-to-cell.

79 Here we report the direct measurement of homophilic binding forces by the serine-aspartate repeat

80 er, possibly indicating its stabilization by homophilic binding in these regions.

81 able (Ig) domains, exhibits isoform-specific homophilic binding in vitro.

82 Thus, E-cadherin homophilic binding independent of other cell contacts di

83 Moreover, E-cadherin homophilic binding independent of other cell interaction

84 cell interactions by stabilizing the PECAM-1 homophilic binding interface.

85 ety of axon pathways, and suggest that L1-L1 homophilic binding is important in the production of X-l

86 The homophilic binding mechanism of NCAM is still a subject

87 A canonical model suggests that homophilic binding of identical Dscam1 receptor isoforms

88 Homophilic binding of immunoglobulin superfamily molecul

89 Homophilic binding of the highly diverse extracellular d

90 this surface disulfide bond did not inhibit homophilic binding of the purified beta3-Ig domain in fr

91 This may be related in part to its homophilic binding properties that allow cross-linking o

92 Although CEA is a homophilic binding protein that may provide survival sig

93 mbinations to generate an enormous family of homophilic binding proteins.

94 Here, we present the structure of the homophilic binding region of Dscam, comprising the eight

95 using a Fab that specifically recognizes the homophilic binding region of human CEACAM1 increases the

96 This showed that homophilic binding results in productive engagement.

97 de bond itself is unlikely to be part of the homophilic binding site.

98 receptor Dscam is an exceptional example of homophilic binding specificity involved in a number of i

99 that epitope I, but not epitope II, confers homophilic binding specificity of full-length Dscam rece

100 We propose that this preferential homophilic binding specificity regulates interactions be

101 bers of neuronal transmembrane proteins with homophilic binding specificity, individual members of wh

102 idues in epitope I of Dscam is essential for homophilic binding specificity.

103 In vitro experiments showed that L1-L1 homophilic binding was lost, along with L1-alpha5beta1 i

104 Pmu wedge peptides demonstrated PTP-specific homophilic binding, and LAR wedge peptide-coated beads p

105 that LAR wedge domain peptides would exhibit homophilic binding, bind to LAR, and inhibit LAR functio

106 These ectodomains show isoform-specific homophilic binding, leading to speculation that Dscam pr

107 onal effects in humans, rats, and mice block homophilic binding.

108 nteractions between constant domains promote homophilic binding.

109 ining proteins that exhibit isoform-specific homophilic binding.

110 e a horseshoe conformation of L1 that favors homophilic binding.

111 rms proposed to interact by isoform-specific homophilic binding.

112 involved in growth inhibition resulting from homophilic binding.

113 shown previously to disrupt PECAM-1-mediated homophilic binding.

114 m isoforms exhibit striking isoform-specific homophilic binding.

115 rophages, mediates cell-cell attachments via homophilic binding.

116 to clarify the molecular mechanism of N-CAM homophilic binding.

117 ognition diversity, showing isoform-specific homophilic binding.

118 rmining the crystal structure of the PECAM-1 homophilic-binding domain, which is composed of amino-te

119 tion 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an A

120 ature and orientation of the PECAM-1-PECAM-1 homophilic-binding interface, we undertook studies aimed

121 te importantly in the formation of the trans homophilic-binding interface, with a total buried interf

122 how that the beta3 subunit can mediate trans homophilic-binding via its Ig domain and that the beta3-

123 lic E:N-cadherin binding with the respective homophilic bonds and with a suitable control.

124 stion, we have selectively formed E-cadherin homophilic bonds at the cell surface of isolated epithel

125 -cell adhesion via specific Zn(2+)-dependent homophilic bonds between beta-sheet-rich G5-E domains on

126 ell surface, thereby enabling zinc-dependent homophilic bonds between opposing cells.

127 ns form readily, albeit less frequently than homophilic bonds of either cadherin.

128 we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adhesion.

129 We also observe that SasG forms homophilic bonds with the structurally related accumulat

130 Both SALMs 4 and 5 formed homophilic, but not heterophilic associations, whereas n

131 with C3 close to the thioester bond, induced homophilic C3 complexes, and promoted formation of an ov

132 The classical cadherins mediate homophilic calcium-dependent cell adhesion and are found

133 han CD166(-/-) cells, suggesting that HSC-OB homophilic CD166 interactions are critical for HSC engra

134 heterophilic interaction with CD6 and weaker homophilic CD166-CD166 cell adhesion interaction.

135 Cadherins mediate homophilic cell adhesion and contribute to tissue morpho

136 riety of tissue types, is thought to involve homophilic cell adhesion in the developing brain.

137 afadin, thus directing the broadly expressed homophilic cell adhesion molecule Cdh2 toward mediating

138 The homophilic cell adhesion molecule NF-protocadherin (NFPC

139 Here, we show that Cadherin-6 (Cdh6), a homophilic cell adhesion molecule, is a reliable marker

140 nowledge) that apCAM, like NCAM, is indeed a homophilic cell adhesion molecule.

141 protein tyrosine phosphatase mu (PTPmu) is a homophilic cell adhesion molecule.

142 oteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic r

143 Non-clustered delta-protocadherins are homophilic cell adhesion molecules essential for the dev

144 Homophilic cell adhesion molecules of the cadherin famil

145 thout affecting the level of L1-CAM-mediated homophilic cell adhesion when tested in vitro.

146 wth in cerebellar granule neurons (CGNs) via homophilic cell adhesion, fyn kinase, and contactin.

147 that beta1-C121W cannot participate in trans-homophilic cell adhesion, lead to the hypothesis that SC

148 IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction.

149 This behavior requires TraA, a homophilic cell surface receptor that identifies kin bas

150 t gonad formation in Drosophila requires the homophilic cell-adhesion molecule Drosophila E-cadherin

151 tested whether mammalian teneurins also are homophilic cell-adhesion molecules, in addition to bindi

152 urins in Drosophila were suggested to act as homophilic cell-adhesion molecules, whereas our findings

153 Furrowed does so through a homophilic cell-adhesion role that is distinct from its

154 .beta-catenin.alpha-catenin complex mediates homophilic cell-cell adhesion and mechanically couples t

155 Mutual, homophilic cell-cell adhesion between epithelial cells i

156 monstrate the rescue of E-cadherin-dependent homophilic cell-cell adhesion by ectopic expression of f

157 E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits mot

158 Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule, how its mutation

159 Cadherins are homophilic cell-cell adhesion molecules implicated in ma

160 molecule, N-cadherin, which mediates strong homophilic cell-cell adhesion via linkage to the actin c

161 protein complexes, ablates calcium-dependent homophilic cell-cell adhesion, stimulates ubiquitination

162 cadherin family, mediates calcium-dependent homophilic cell-cell adhesion.

163 sence of the shed extracellular fragments of homophilic cell-cell CAMs in serum and tumor tissue of c

164 Proteolysis of homophilic cell-cell CAMs results in a shed extracellula

165 Cadherin 11 is a homophilic cell-to-cell adhesion molecule expressed on j

166 Their ectodomains mediate stable, homophilic, cell-adhesive interactions, whereas the intr

167 In part, CHL1 mediates these roles through homophilic CHL1-CHL1 interactions.

168 h a strand-swap mechanism similar to that of homophilic classical cadherins.

169 ith high similarity to the recently reported homophilic dimer of the SLAM family member NTB-A.

170 bulin variable domain revealed an orthogonal homophilic dimer with high similarity to the recently re

171 which self-associates, forming an orthogonal homophilic dimer.

172 Trans-homophilic dimerization of IGPR-1 stimulates the phospho

173 over, IGPR-1 chimera, which mimics the trans-homophilic dimerization of IGPR-1, induced a sustained p

174 helial adherens junctions and, through trans-homophilic dimerization, regulates endothelial cell-cell

175 so suggest that, like NTB-A, all SLAM family homophilic dimers adopt a highly kinked organization spa

176 ree recent papers show that isoform-specific homophilic Dscam interactions cause dendritic branches o

177 tissues by connecting adjacent cells through homophilic E-cadherin interactions and are linked to the

178 CD84 is a homophilic family member that enhances IFN-gamma secreti

179 may be a kind of "functional kin." Finally, homophilic genotypes exhibit significantly higher measur

180 ermolecular beta-sheet are essential for the homophilic interaction and that the residues at the hydr

181 uantitatively equivalent block, suggesting a homophilic interaction between CD99 on the neutrophil an

182 The homophilic interaction between endothelial PECAM and leu

183 adherins and nectins, are thought to mediate homophilic interaction between neighboring cells.

184 Homophilic interaction between platelet/endothelial cell

185 ETS) family members, through a tyrosine-rich homophilic interaction domain (YRD).

186 cones, and it is not essential for mediating homophilic interaction in cultured cells.

187 s identify a pivotal function of VE-cadherin homophilic interaction in modulating endothelial barrier

188 hematical simulations suggest that the apCAM homophilic interaction is mediated by two distinct bonds

189 mbrane receptor for soluble basigin and this homophilic interaction is not dependent upon glycosylati

190 However, this homophilic interaction is not required for the attachmen

191 n is a specific up-regulation and subsequent homophilic interaction mediated by the cell surface glyc

192 Coordinated dimerization of IGPR-1 and its homophilic interaction modulates its adhesive function a

193 The homophilic interaction of JAM-C can mediate tumor cell-e

194 Here, the homophilic interaction of JAM-C is presented and functio

195 The homophilic interaction of JAM-C was mediated by the isol

196 mutation in this motif (E66R) abolished the homophilic interaction of JAM-C.

197 To date, the mechanism of trans-homophilic interaction of PECAM-1 remains unclear.

198 The trans-homophilic interaction of TAG-1 was sufficient to positi

199 remodeling of the neural network, but their homophilic interaction that mediates adhesion is not wel

200 Thus, JAM-C undergoes a homophilic interaction via the Arg64-Ile65-Glu66 motif o

201 This homophilic interaction was found to be stabilized by res

202 n revealed at least two independent types of homophilic interaction which, taken together, suggest th

203 hin this subdomain are required for the SdrC homophilic interaction.

204 exhibited a faster, more substantial loss of homophilic interactions (tau = 0.86 +/- 0.02 s(-1)), sug

205 ions revealed a sudden, but partial, loss of homophilic interactions (tau = 1.17 +/- 0.06 s(-1)) upon

206 explain stronger heterophilic versus weaker homophilic interactions among these family members and a

207 development of cortical layers, due to their homophilic interactions and their restricted spatiotempo

208 D147 cyclophilin-independent activity, CD147 homophilic interactions are thought to underlie its acti

209 ietic niche and highlight how CD166-mediated homophilic interactions between both cell types may be c

210 ural cell adhesion molecule, N-CAM, mediates homophilic interactions between cells has been variously

211 hows that the basis for specificity involves homophilic interactions between extracellular domains.

212 Examination of homophilic interactions between specific combinations of

213 o a growing body of evidence suggesting that homophilic interactions between surface proteins present

214 maintain neuronal networks, relying on trans homophilic interactions between their extracellular cadh

215 There is growing evidence that specific homophilic interactions between these proteins represent

216 We demonstrate that homophilic interactions between voltage-gated sodium cha

217 Given the importance of PECAM-1-mediated homophilic interactions in mediating each of these cell

218 an IgCAM known to activate the EGFR through homophilic interactions in other systems, is transiently

219 ens up avenues for understanding the role of homophilic interactions in staphylococcal adhesion, and

220 etramerization in cis, coupled with strictly homophilic interactions in trans, predicts that the 22 g

221 Finally, Teneurins promote homophilic interactions in vitro, and Ten-m co-expressio

222 ic in solution and, thus, suggest that CD147 homophilic interactions in vivo are mediated through oth

223 Our data support a model in which Dscam2 homophilic interactions mediate repulsion between neurit

224 Recent studies have implicated homophilic interactions of cell surface molecules, inclu

225 a and SG neurons raises the possibility that homophilic interactions of RPTP-kappa contribute to esta

226 e disulfide bridges are unique for the known homophilic interactions of these domains.

227 Here, we demonstrate that via homophilic interactions ORF3 forms multimeric complexes

228 ious studies have shown that PECAM-1/PECAM-1 homophilic interactions play a key role in leukocyte tra

229 a Fab fragment from a CD5 mAb shown to block homophilic interactions provided evidence that the extra

230 branches of da neurons use isoform-specific homophilic interactions to ensure minimal overlap.

231 tebrate neurons, engaging in highly specific homophilic interactions to mediate important roles in ma

232 ms comprise an Ig superfamily code that uses homophilic interactions to promote lamina-specific targe

233 kocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes.

234 pression in ooDSGCs leads to branch-specific homophilic interactions with interneurons.

235 s of zebrafish, where its mechanism involves homophilic interactions within the developing fiber trac

236 es biophysical evidence that apCAM undergoes homophilic interactions, and that magnetic tweezers-base

237 says revealed that all CadN isoforms mediate homophilic interactions, but the isoforms encoded by exo

238 PECAM-1-mediated homophilic interactions, known to be mediated by its 2 a

239 Previous studies have shown that PECAM-1 homophilic interactions, mediated by amino-terminal immu

240 herins typically function via trans-cellular homophilic interactions, our results suggest presynaptic

241 es of clustered Pcdhs can engage in specific homophilic interactions, that cell surface delivery of P

242 oforms, and distinct Dscam1 isoforms mediate homophilic interactions, which in turn, result in repuls

243 , we show that CD5 mediates species-specific homophilic interactions.

244 regulates immunity through species-specific homophilic interactions.

245 dent of presynaptic ORNs and did not involve homophilic interactions.

246 of the heterophilic bonds are similar to the homophilic interactions.

247 ferentially mediate heterophilic rather than homophilic interactions.

248 L1 mediates neurite outgrowth through L1-L1 homophilic interactions.

249 r E-cadherin domains, reveals a hierarchy of homophilic interactions.

250 e for an Asn-25-associated glycan in PECAM-1 homophilic interactions.

251 quired for TEM at a step downstream of PECAM homophilic interactions.

252 he peptide to a sequence of SdrC involved in homophilic interactions.

253 oform can interfere with these combinatorial homophilic interactions.

254 d in tissue-restricted patterns that mediate homophilic intercellular adhesion.

255 E-cadherin forms calcium-dependent homophilic intercellular adhesions between epithelial ce

256 erentiation and myelination is mediated by a homophilic intercellular interaction.

257 This process may, in part, be dependent on homophilic intercellular interactions between FLRT molec

258 We show that FasIII forms homophilic intercellular interactions that promote inter

259 bind tightly to a groove within the PECAM-1 homophilic interface in an orientation that favors the f

260 Structural and chemical differences in the homophilic interfaces provide a mechanism to prevent the

261 ngulfment ligand or receptor that engages in homophilic intermolecular interaction at intercellular j

262 ssed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the f

263 In the absence of fibronectin, homophilic N-cadherin ligation recruited both tensin and

264 ressed the regulatory mechanisms controlling homophilic Neuroglian-mediated cell adhesion by analyzin

265 es of cell-surface glycoproteins, which form homophilic or heterophilic interactions across the inter

266 identified perspective on the role of ORs in homophilic OSN axon adhesion and lead us to propose a ne

267 molecule 1 (CEACAM1) can engage in both cis-homophilic (parallel) oligomerization and trans-homophil

268 These results suggest that homophilic Pcdhg interactions between sibling neurites (

269 asurements of the forced dissociation of the homophilic protein-protein bonds.

270 tion of an estimated 18,000 isoform-specific homophilic receptor pairs.

271 NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natu

272 NK, T, and B cell Ag (NTB-A), a SLAM family homophilic receptor, in clone 2E2 compared with 2G1.

273 ediated by the cooperative engagement of the homophilic receptors Slamf1 (SLAM) and Slamf6 (Ly108) an

274 undesired heterodimers among the SLAM family homophilic receptors.

275 on sister neurites exhibit isoform-specific homophilic recognition and elicit repulsion between proc

276 in which specific isoforms of Dscam1 mediate homophilic recognition between processes of different ce

277 ealing the essence of the molecular basis of homophilic recognition by Dscams through high-resolution

278 These findings suggest that homophilic recognition molecules that have classically b

279 g Pcdh isoforms encodes their diverse strict homophilic recognition specificities, which are required

280 place limitations on the mechanisms by which homophilic recognition units can function.

281 determinants of gamma-Pcdh isoform-specific homophilic recognition.

282 of activity, including homophilic adhesion, homophilic repulsion and heterophilic interactions.

283 se wiring strategies are established through homophilic repulsion between Dscam proteins expressed on

284 rites expressing the same isoforms engage in homophilic repulsion.

285 egulate interactions between neurons through homophilic repulsion.

286 es as a cell adhesion molecule that mediates homophilic repulsion.

287 Drosophila Dscam1 and Dscam2, genes encoding homophilic repulsive proteins, act redundantly to ensure

288 ster branches from neurons, which depends on homophilic self-recognition by Dscams.

289 adherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growt

290 Sdks mediate cell-cell adhesion with homophilic specificity that underlies their neuronal tar

291 In addition, the complex exhibited homophilic specificity, as beads coated with Pcdh19-Ncad

292 uperfamily member IgSF9/Dasm1 as a candidate homophilic synaptic adhesion protein that regulates inhi

293 gh teneurins bind to each other in solution, homophilic teneurin-teneurin binding is unable to suppor

294 ucture of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended a

295 canonical head-to-tail interaction mode for homophilic trans dimers comprising primary intermolecula

296 ressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are

297 t adhesion to myoblasts and myotubes through homophilic trans-interactions.

298 with an extracellular ligand and/or GPR56 NT homophilic trans-trans associations) can remove this inh

299 re, we found that the GPR56 NT is capable of homophilic trans-trans interactions that enhance recepto

300 hesion mediated by type I cadherins involves homophilic "trans" interactions that are thought to be b