ライフサイエンスコーパス: homopolymeric

1 s have shown that only NFL can assemble into homopolymeric 10-nm filaments.

2 nditions), T7 RNAP slips efficiently in both homopolymeric A and U tracts, and we have found that rep

3 AAA-lysines followed by ribosome sliding on homopolymeric A sequence.

4 The finding that ribosomes slide on homopolymeric A sequences explains bioinformatic analyse

5 ity assay (SPA) beads, and after addition of homopolymeric A template, NS5B enzyme, and radiolabeled

6 ucleotide steps as well as in varying length homopolymeric A(n).T(n) repeats (A(n)-tracts, where n =

7 ppage of elongating RNA polymerase (RNAP) on homopolymeric A/T tracts in DNA represents a special typ

8 on is due to loss or gain of a nucleotide in homopolymeric adenine or thymine tracts within flgR.

9 y of errors made during the transcription of homopolymeric adenine sequences, such that the A tract i

10 Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Esche

11 The CAG repeats encode long glutamine homopolymeric amino acid chains in the amino-terminal do

12 es, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches.

13 in protein-coding regions result in extended homopolymeric amino acid tracts, often polyglutamine or

14 ase in the Km for the dNTP substrate on both homopolymeric and heteropolymeric RNA and DNA templates.

15 (strain BK) has been investigated using both homopolymeric and heteropolymeric RNA templates.

16 Here we show that both homopolymeric and mixed-sequence 3'-NP-DNA templates can

17 , both parameterized on given error rates in homopolymeric and non-homopolymeric regions.

18 t three different subunit interfaces in this homopolymeric assembly.

19 ication of a specific and highly polymorphic homopolymeric C stretch (D310), located within the displ

20 five (42%) were deletions or insertions in a homopolymeric C-stretch between nucleotides 303-315 (D31

21 eoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) homopolymeric capsular polysaccharide produced by strain

22 Bacillus anthracis elaborates a homopolymeric capsule composed of gamma-D-glutamic acid

23 es encoding the major sugar component of the homopolymeric capsule were up-expressed > 2.5-fold, but

24 secretion, and symbiotic function of the Kdo homopolymeric capsule.

25 mb20805 affect the polymerization of the Kdo homopolymeric capsule.

26 hese cDNAs give rise to RNAs containing a 5'-homopolymeric cytidine (poly(C)) stretch.

27 Altered specificity was observed when the homopolymeric dA.rU tract immediately 5' of the PPT was

28 udies have characterized the role of a 16 bp homopolymeric dA:dT DNA structural element in facilitati

29 ybrid formation: high transcription and long homopolymeric dA:dT tracts.

30 g experiments demonstrate that the MRE and a homopolymeric (dA x dT) element adjacent to the MRE are

31 d into a positioned nucleosome that exhibits homopolymeric (dA x dT)-dependent localized distortion.

32 f AMT1 autoactivation is greatly enhanced by homopolymeric (dA-dT) element (A16)-mediated nucleosomal

33 provide compelling evidence that nucleosomal homopolymeric (dA-dT) elements provide enhanced DNA acce

34 rs 2, 3, and 6 mediated association with the homopolymeric (dA.dT) COL1A1/MMP DNA consensus element.

35 ins known to bind within the minor groove of homopolymeric (dA.dT) DNA.

36 However, upon binding to the COL1A1/MMP homopolymeric (dA.dT) element, the native Nmp4 protein u

37 nduced upon zinc finger association with the homopolymeric (dA.dT) minor groove confer context-specif

38 rdings of DNA polymerase processing multiple homopolymeric DNA templates extended over 600 s and thro

39 on than for dCTP or dGTP into complementary, homopolymeric DNA templates.

40 leic acid (NA) duplexes, from B-like form of homopolymeric DNA, to mixed sequence DNA, to DNA:RNA hyb

41 u- and XLF-independent manner, but not other homopolymeric DNA.

42 Preannealed homopolymeric DNAs or RNAs are often used as templates a

43 teins, however, both in its binding to short homopolymeric dT(n) oligomers (as judged by polyacrylami

44 which crystal structures are available, the homopolymeric duplex sequences poly(dA) and poly(dG), an

45 actic Acid Bacteria (LAB) are well known for homopolymeric exopolysaccharide (EPS) production.

46 we demonstrate that four additional, novel, homopolymeric expansion proteins (polyAla, polySer, poly

47 fected cells secrete overexpressed chains as homopolymeric ferritin into the media.

48 ffer in fibrils composed of single proteins (homopolymeric fibrils) from those generated by co-polyme

49 ible correlation between the ability to form homopolymeric filaments and the accelerated rate of hydr

50 At low ionic strength binding to the homopolymeric fluorescent RNA, poly(epsilonA), is electr

51 share a gene deletion and one-third exhibit homopolymeric frameshift mutations (HFMs).

52 nes from ACV-selected mutants identified two homopolymeric G-C nucleotide stretches as putative hot s

53 ivo analyses, we demonstrate that a variable homopolymeric G-repeat in the leader of the TlpB chemota

54 of the activation domain and insertion of a homopolymeric glutamine stretch was used to increase tra

55 Polysialic acid (PSA) is a homopolymeric glycan that plays crucial roles in the dev

56 uence of deafness/Crohn's disease-associated homopolymeric glycoproteins alpha-tectorin (TECTA) and g

57 A homopolymeric hexamer is optimal for producing mainly si

58 unction topics mainly related to the simpler homopolymeric IF networks composed of vimentin, and spec

59 biquitin-proteasome degradation pathway is a homopolymeric, K48-linked polyubiquitin chain: the chain

60 X-ray structures of homopolymeric L-ferritin obtained by freezing protein cr

61 accumulated in the cytosol as predominantly homopolymeric L-ferritin.

62 1115 coding homopolymeric loci with six or more nucleotides were ide

63 Conjugation of a homopolymeric multiubiquitin chain to a substrate lysine

64 rase RNA template domain may be analogous to homopolymeric mutational hot spots that lead to similar

65 ation to varying degrees included synthetic, homopolymeric nucleic acids such as poly(A) and poly(dT)

66 Homopolymeric nucleotide runs, also called mononucleotid

67 se a model in which DNA templates containing homopolymeric nucleotide runs, when bound to DinB, are i

68 the potential for creating -1 frameshifts in homopolymeric nucleotide runs.

69 function, as well as mutational hotspots at homopolymeric nucleotide stretches.

70 rotein is encoded by a gene that possesses a homopolymeric nucleotide tract containing eight adenine

71 The homopolymeric nucleotide tracts and dinucleotide repeats

72 regional preferences for env recombination, homopolymeric nucleotide tracts, i.e., sequences known t

73 gher than rates in the WT MA lines, although homopolymeric nucleotide-run (HP) loci composed of A:T b

74 ternating base sequence d(TG)n than with any homopolymeric oligodeoxyribonucleotide; thus, it shows a

75 The homopolymeric oligonucleotide dG/dC was modified while n

76 Using homopolymeric oligonucleotide-based substrates, we show

77 f individual AP sites in single molecules of homopolymeric or heteropolymeric DNA sequences.

78 and between C.G and T.A base-pairs from the homopolymeric parts of the simulated sequence.

79 erase ribozyme (RPR) function, as do derived homopolymeric peptides comprising lysine or the non-prot

80 We examined the manner in which the homopolymeric poly(A) and poly(U) portions of poliovirus

81 The homopolymeric poly(A) and poly(U) portions of PV RNA pro

82 ardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract.

83 nt aphthoviruses and cardioviruses have long homopolymeric poly(C) tracts in the 5' untranslated regi

84 nificant variability among genotypes, (ii) a homopolymeric poly(U) tract, (iii) a polypyrimidine stre

85 hier poly(U/UC) sequences, and possibly pure homopolymeric poly(U) tracts, were associated with more

86 or T nucleotides and occur preferentially in homopolymeric (poly A or poly T) genomic stretches.

87 r of guanine (G) residues contained within a homopolymeric [poly(G)]tract located upstream of the usp

88 Homopolymeric polyglutamine forms a mixture of amorphous

89 s and increases the driving force, vis-a-vis homopolymeric polyglutamine, for forming insoluble aggre

90 overed that CAG expansion constructs express homopolymeric polyglutamine, polyalanine, and polyserine

91 eduction of interchain entanglements through homopolymeric polyQ and barriers to intermolecular assoc

92 ents a number of unique challenges: the long homopolymeric polyQ tract contains nearly identical resi

93 on of enzyme when radioactive nucleotide and homopolymeric primer/template substrates are employed.

94 Homopolymeric primer/templates of defined length were us

95 Moreover, these toxic, unexpected, homopolymeric proteins now should be considered in patho

96 These results indicated that the homopolymeric Psa fimbriae are multimeric adhesins.

97 ed proteins that assemble predominantly into homopolymeric (rather than heteropolymeric) fibrils, whi

98 were successfully demonstrated to sequence a homopolymeric region of a DNA template, facilitating the

99 ty resided in the core aspartate hexapeptide homopolymeric region, and MBC50 values of aspartate dipe

100 To sequence DNA, templates containing homopolymeric regions are immobilized on Sepharose beads

101 ent difficulty in accurately deciphering the homopolymeric regions of the DNA templates.

102 A polymerase I, Sequenase could read through homopolymeric regions with more than five T bases.

103 n given error rates in homopolymeric and non-homopolymeric regions.

104 rporated into the growing DNA strand even in homopolymeric regions.

105 nt derivatives, for +1 and -1 base errors in homopolymeric repeat sequences of three to eight base pa

106 ersible gain and loss of single bases within homopolymeric repeats as short as 6 bases, (ii) deletion

107 tern of transcription, and the presence of G homopolymeric repeats of variable lengths upstream of th

108 -I binding, which was primarily dependent on homopolymeric ribonucleotide composition, linear structu

109 r extension; these products are subjected to homopolymeric ribonucleotide tailing at the 3' termini w

110 efficient copying of all four nucleobases on homopolymeric RNA and DNA templates.

111 de a conceptual advance by defining specific homopolymeric RNA motifs within the genome of HCV and ot

112 ve in an in vitro RNA polymerase assay using homopolymeric RNA or BVDV minigenomic RNA templates.

113 nts in which capsid proteins assemble around homopolymeric RNA or synthetic polyelectrolytes.

114 The RdRp used some homopolymeric RNA templates only in the presence of a pr

115 data indicate that rootlets are composed of homopolymeric rootletin protofilaments bundled into vari

116 erein the rate of single-base deletions in a homopolymeric run in the LYS2 gene is 10 000-fold higher

117 decreases substantially as the length of the homopolymeric run increases.

118 s (G8 and G9) or one base deletion (G6) in a homopolymeric run of seven guanines (G string) in the ge

119 Pol adds single nucleotides to homopolymeric runs at particularly high rates, exceeding

120 These data suggest that homopolymeric runs in mitochondrial DNA may be particula

121 iptional slippage, is particularly likely on homopolymeric runs in the template.

122 , the sequence contains motifs consisting of homopolymeric runs of amino acids found in several other

123 These short homopolymeric runs of nucleotides were commonly found in

124 e error rate for one-nucleotide deletions in homopolymeric runs was similar for the polymerase with o

125 Changes within homopolymeric runs within lgtA, lgtC, and lgtD affect th

126 known DNA templates, the ability to quantify homopolymeric runs, and a short sequencing example of se

127 fluorescein labels, which impedes readout of homopolymeric runs, is avoided by diluting the labeled d

128 ads single nucleotide deletion mismatches in homopolymeric runs, such that the error rate is 30 singl

129 one for single nucleotide addition errors in homopolymeric runs.

130 pairs, the last occurring most frequently in homopolymeric runs.

131 mechanism to create single base deletions on homopolymeric runs.

132 e model for investigating whether functional homopolymeric septin filaments also exist.

133 in many Gram-negative organisms that possess homopolymeric sequence repeats or motifs for site-specif

134 patients contain insertions or deletions in homopolymeric sequences in the thymidine kinase (TK) gen

135 However, when copying homopolymeric sequences longer than four nucleotides, po

136 and frequently longer than the corresponding homopolymeric sequences of the respective viral RNA temp

137 t lack TK activity due to mutations on other homopolymeric sequences, reactivation can occur via reve

138 had neither the pentanucleotide sequence nor homopolymeric sequences, yet replacement of the S-segmen

139 ce of several structural features, including homopolymeric serine and threonine residues, a putative

140 Within the variety of homopolymeric single- and double-stranded deoxy- and rib

141 halted complexes that can readily carry out homopolymeric slippage synthesis, this study reveals tha

142 tructure that promotes -1 frameshifting on a homopolymeric slippery sequence.

143 , (GCG)(6) encodes the first 6 alanines in a homopolymeric stretch of 10 alanines.

144 The CREB-binding protein (CBP), containing a homopolymeric stretch of 19 glutamines, was likewise fou

145 on was an insertion of an A:T base pair in a homopolymeric stretch of eight A:T base pairs, and readi

146 (GCG)6 codes for the first six alanines in a homopolymeric stretch of ten alanines.

147 trahigh localized mutation rates in specific homopolymeric stretch regions.

148 at the likelihood of occurrence of indels in homopolymeric stretches is strongly related to stretch l

149 adenylation sites due to internal priming in homopolymeric stretches of adenines.

150 e higher rates were strongly associated with homopolymeric stretches on the 454 platform.

151 ion was also observed for regions containing homopolymeric stretches.

152 eltaC RT) retains DNA polymerase activity on homopolymeric substrates and partial RNase H activity, r

153 Using homopolymeric substrates, the minimal DNA length for act

154 H]poly(rA).poly(dT) or [3H]poly(rG).poly(dC) homopolymeric substrates.

155 ndependent transcription when transcribing a homopolymeric template such as poly(dC).

156 ication wherein reiterative transcription of homopolymeric templates ensures the synthesis of long 3'

157 Experiments with different homopolymeric templates indicate that initial deoxyribon

158 he length of one of these microsatellites, a homopolymeric thymidine [poly(T)] repeat, is measured in

159 In this study, we investigated the role of a homopolymeric thymine [poly(T)] tract -50 to -33 relativ

160 potentially non-ATG-mediated translation of homopolymeric toxic proteins.

161 bstitution at the TA step or in the adjacent homopolymeric tract dramatically affected affinity and p

162 Analysis of the distribution of homopolymeric tract lengths indicates that this species

163 ubject to localized hypermutation in a short homopolymeric tract of adenine residues located in the N

164 This gene contains a homopolymeric tract of cytidine [poly(C)] and we demonst

165 tG phase variation mediated by slippage of a homopolymeric tract of cytidines.

166 C. jejuni 81-176 revealed the presence of a homopolymeric tract of G residues within a gene encoding

167 ns dca is prematurely terminated following a homopolymeric tract of G's, the length of which differs

168 A homopolymeric tract of Gs (poly-G) is present in the pgt

169 d to contain an N-terminal signal peptide, a homopolymeric tract of serine residues, 36 sites of O-li

170 and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N

171 also show that the presence of an intragenic homopolymeric tract renders the expression of a function

172 An exhaustive search for homopolymeric tracts (HPTs) identified a total of 54 var

173 outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding

174 bacter pylori through their association with homopolymeric tracts and dinucleotide repeats.

175 aled variation in the sequence and length of homopolymeric tracts found within these genes, providing

176 e apparently high rate of variation of these homopolymeric tracts may be important in the survival st

177 Homopolymeric tracts of C sequences, which were located

178 Likewise, the homopolymeric tracts of G sequences that are found upstr

179 The genes encoding each protein contain homopolymeric tracts, suggestive of phase variation medi