ライフサイエンスコーパス: homotetrameric

1 Asp142 in the homotetrameric ADP-glucose pyrophosphorylase (ADP-Glc PP

2 Lysine (Lys)-195 in the homotetrameric ADP-glucose pyrophosphorylase (ADPGlc PPa

3 omologous to those of bacterial and archaeal homotetrameric alcohol dehydrogenases (ADHs) and also to

4 e (Zea mays) rf2a and rf2b genes both encode homotetrameric aldehyde dehydrogenases (ALDHs).

5 esence of secretable and functionally active homotetrameric alpha- and beta-tryptases in transfected

6 The four active sites of the homotetrameric apoenzyme appear to divide into two numer

7 herichia coli MgsA is described, revealing a homotetrameric arrangement for the protein that distingu

8 ined by both the direct DNA contacts and the homotetrameric arrangement of the Cre monomers.

9 functional CRAC channel pore is formed by a homotetrameric assembly of Orai1 subunits.

10 rate that Kir 2.2 channels are formed by the homotetrameric association of Kir 2.2 subunits and do no

11 alcium selectivity filter constructed in the homotetrameric bacterial NaV channel NaVAb.

12 t differences between D. radiodurans SSB and homotetrameric bacterial SSB proteins may confer a selec

13 ly showed that Escherichia coli (Eco) SSB, a homotetrameric bacterial SSB, undergoes not only rapid s

14 biochemical analyses, we identified a single homotetrameric bifunctional ammonia-lyase (PTAL) among e

15 Here we report that KRP130, a homotetrameric BimC-related kinesin purified from Drosop

16 Each pore-forming alpha subunit of the homotetrameric BK(Ca) channel is expected to contain two

17 dimeric by gel filtration chromatography and homotetrameric by dynamic light scattering and to contai

18 the cold receptor that forms a nonselective homotetrameric cation channel.

19 n two adjacent hERG1 subunits, and, hence, a homotetrameric channel has four identical RPR binding si

20 in the fully assembled, membrane-associated, homotetrameric channel protein.

21 of the influenza virus M(2) protein forms a homotetrameric channel that transports protons.

22 e of the complex shows the drug bound in the homotetrameric channel, threaded between the side chains

23 er) and increase the open probability of the homotetrameric channel.

24 ind that each of hBest1, 2, 3, and 4 forms a homotetrameric channel.

25 module between two adjacent subunits of the homotetrameric channel.

26 in tobacco mesophyll protoplasts: KAT2 forms homotetrameric channels active at the plasma membrane, w

27 gion, preventing surface expression of Kv1.1 homotetrameric channels and of heteromeric Kv1 channels

28 eases surface expression of functional Kv1.1 homotetrameric channels and support a model whereby a DT

29 mutation is permissive for the expression of homotetrameric channels that are nonselective for cation

30 e compared this pH-dependence with that from homotetrameric channels with four copies of the mutation

31 However, L18A/L25A channels failed to form homotetrameric channels, as assessed by Co-IP, suggestin

32 inity (K(d) values 7-21 nM) to each of these homotetrameric channels.

33 yl-tRNA synthetase, operates as well in this homotetrameric class II tRNA synthetase.

34 ess at least two distinct PEPC enzyme-forms, homotetrameric Class-1 and heteromeric Class-2, that dif

35 he Kv1.1 outward current when expressed as a homotetrameric complex (EC(50) = 0.34 nM).

36 at RECQ1 can form what appears to be a flat, homotetrameric complex and propose that RECQ1 tetramers

37 l muscle (RyR1) receptor isoforms, RyR3 is a homotetrameric complex comprising two main components, a

38 mass of 270 kDa, compatible with its being a homotetrameric complex of the approximately 64-kDa subun

39 pure SNAP-23N crystallizes as a coiled-coil homotetrameric complex.

40 tracellular superoxide dismutase (SOD3) is a homotetrameric copper- and zinc-containing glycoprotein

41 nformational ensembles of the D2 -symmetric, homotetrameric copper-sensitive operon repressor (CsoR)

42 Cys-504-Cys-504 dithiol-disulfide switch in homotetrameric CRMP2.

43 Homotetrameric Cys10 TTR variants, including TTR-Cys, TT

44 otubule gliding at a rate similar to that of homotetrameric Eg5 in vitro.

45 onucleases, thought to have evolved from the homotetrameric endonucleases.

46 +)-dependent enzyme, GCYH-IB is a bimodular, homotetrameric enzyme activated by a variety of divalent

47 of ATP binds at the subunit interface of the homotetrameric enzyme and that the majority of the ATP-e

48 Each chain of this homotetrameric enzyme consists of 330 residues.

49 a reduction in the overall dimensions of the homotetrameric enzyme following substrate binding and ox

50 e synthase revealed four active sites of the homotetrameric enzyme located within deep tunnels.

51 tes reside in different subunits of a single homotetrameric enzyme molecule.

52 This homotetrameric enzyme possesses 222 symmetry, which impo

53 The homotetrameric enzyme provides a unique environment for

54 The homotetrameric enzyme required NADPH, flavin mononucleot

55 PAAS is a cytosolic homotetrameric enzyme that belongs to group II pyridoxal

56 yl-acyl carrier protein (ACP) reductase is a homotetrameric enzyme that catalyzes the last reductive

57 Pyruvate decarboxylase is a homotetrameric enzyme which crystallizes with two subuni

58 ate dehydrogenase from Escherichia coli is a homotetrameric enzyme which is allosterically regulated

59 manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria agains

60 i pyruvate oxidase (PoxB), a lipid-activated homotetrameric enzyme, upon substrate binding.

61 utamate at residue 487 in the 500 amino acid homotetrameric enzyme.

62 , supporting the conclusion that ACAT-1 is a homotetrameric enzyme.

63 sessed just 16-18% activity of the glutamate homotetrameric enzyme.

64 The homotetrameric enzymes belong to the type I family of ex

65 The homotetrameric Escherichia coli single-stranded DNA bind

66 The homotetrameric Escherichia coli single-stranded DNA-bind

67 The kinetic mechanism of transfer of the homotetrameric Escherichia coli SSB protein between ssDN

68 or DrSSB that strongly resemble those of the homotetrameric Escherichia coli SSB, further supporting

69 ned the kinetic mechanism for binding of the homotetrameric Escherichia coliSSB protein to single-str

70 We demonstrate our approach on the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in

71 dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catalyzes the conversion

72 ort chain acyl-CoA dehydrogenase (SCAD) is a homotetrameric flavoenzyme that catalyzes the first intr

73 7.3 +/- 1.1 mum(2).s(-1), consistent with a homotetrameric form of Kaede.

74 ition, it has not been demonstrated that the homotetrameric form of these proteins is essential for t

75 ntisense response, due to the formation of a homotetrameric G quartet structure.

76 In fluorescently labelled homotetrameric GIRK1 channels and in the heterotetrameri

77 similar to the distal (B/D) subunits in the homotetrameric GluA2 alpha-amino-3-hydroxy-5-methyl-4-is

78 In this study, we expressed homotetrameric HCN2 channels in Xenopus oocytes and perf

79 x cooperative interaction of the subunits in homotetrameric HCN2 pacemaker channels.

80 hese studies to investigate formation of the homotetrameric hemoglobin H, whose formation in vivo is

81 onding enzyme from Saccharomyces uvarum, the homotetrameric holoenzyme assembly has approximate 222 s

82 on equilibrium analysis indicates an alpha 4 homotetrameric holoenzyme structure (4 x 38,861 Da).

83 The structure of homotetrameric htADH is highly homologous to those of ba

84 the same family, kappaM-RIIIK, inhibits the homotetrameric human Kv1.2 channels.

85 Glu162 in homotetrameric human MnSOD spans a dimeric interface and

86 The homotetrameric influenza A M2 channel (AM2) is an acid-a

87 Ryanodine receptors are homotetrameric intracellular calcium release channels.

88 .0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into pot

89 Nematostella Shaker genes express functional homotetrameric K(+) channels in vitro.

90 s with high affinity to membranes expressing homotetrameric K(v)1.3 channels, and high affinity diTC

91 The dynamic behavior of homotetrameric kinesin-5 during mitosis is poorly unders

92 Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separati

93 Eg5 is a homotetrameric kinesin-5 motor protein that generates ou

94 Homotetrameric kinesin-5 motors are essential for chromo

95 ulations to dissect the various roles of the homotetrameric kinesin-5, KLP61F, in astral, centrosome-

96 Eg5/KSP is a homotetrameric, Kinesin-5 family member whose ability to

97 Homotetrameric Kv1.1 channels were localized to endoplas

98 y of tRNA(Met)i The crystal structure of the homotetrameric m1A58 tRNA Mtase from Mycobacterium tuber

99 heart of the H+ conductance mechanism in the homotetrameric M2 H+ channel from influenza A is a set o

100 The homotetrameric M2 integral membrane protein of influenza

101 The homotetrameric M2 proton channel of influenza A plays a

102 The system for this study is the homotetrameric M2 proton channel protein from the influe

103 removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD).

104 otein from influenza A virus is a 97-residue homotetrameric membrane protein that functions as a prot

105 Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric mitochondrial flavoenzyme which catalyzes

106 -CoA dehydrogenase (IVD), a nucleus-encoded, homotetrameric, mitochondrial flavoenzyme that catalyzes

107 al analyses of drug binding to the bacterial homotetrameric model CaV channel CaVAb, which is inhibit

108 Homotetrameric models of three mammalian Kir channels (K

109 Kinesin-5 is a slow homotetrameric motor protein best known for its essentia

110 Kinesin-5 (also called Eg5 or kif11) is a homotetrameric motor protein that functions by modulatin

111 Kinesin-5 is a homotetrameric motor protein that interacts with adjacen

112 The crystal structure of the homotetrameric MtbThyX was determined in the presence of

113 a concatenated channel as that observed for homotetrameric mutant channels.

114 quaternary structure, a potato small subunit homotetrameric mutant, TG-15, was subjected to iteration

115 Escherichia coli NikR is a homotetrameric Ni(2+)- and DNA-binding protein that func

116 NikR is a homotetrameric nickel regulatory protein whose binding t

117 ent, an intrinsic RNA kinase activity, and a homotetrameric or homodimeric quaternary structure, that

118 s are the largest known ion channels, with a homotetrameric organization and approximately 5,000 resi

119 5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dime

120 Homotetrameric P. falciparum aldolase (PfALDO) crystalli

121 The influenza A virus M2 protein (A/M2) is a homotetrameric pH-activated proton transporter/channel t

122 His-37 from symmetry-related monomers of the homotetrameric pore converge to form a coordination site

123 ed that the principal functional unit of the homotetrameric PPK is a dimer.

124 at the MGAT2 enzyme primarily functions as a homotetrameric protein and as a tetrameric protein.

125 ACAT1 is a homotetrameric protein and contains nine transmembrane d

126 to cobalt and nickel regulator) is a 40-kDa homotetrameric protein and metalloregulator that control

127 igand interaction between biotin (B) and the homotetrameric protein complex streptavidin (S(4)) in th

128 In the crystal structure each subunit of the homotetrameric protein contains one substrate-binding si

129 Aldolase (E.C. 4.1.2.13), a homotetrameric protein encoded by the ALDOA gene, conver

130 Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyl

131 of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of th

132 transthyretin (TTR), a human beta-sheet-rich homotetrameric protein that must undergo rate-limiting t

133 67 dihydrofolate reductase (DHFR) is a novel homotetrameric protein that possesses 222 symmetry and a

134 It is a homotetrameric protein that spans the membrane multiple

135 The homotetrameric protein transthyretin (TTR) must undergo

136 The amyloidogenic homotetrameric protein transthyretin (TTR) must undergo

137 The subunit size of this homotetrameric protein was 55 kDa, which is about half t

138 This is the case of transthyretin (TTR), a homotetrameric protein whose dissociation into its monom

139 The ryanodine receptor (RyR) is a large homotetrameric protein with a hydrophobic domain at the

140 Streptavidin, a homotetrameric protein with extremely tight biotin bindi

141 This study shows that MHPCO is a homotetrameric protein with one flavin adenine dinucleot

142 This homotetrameric protein wraps ssDNA in multiple distinct

143 chondrial ssDNA-binding protein (mtSSB) is a homotetrameric protein, involved in mtDNA replication an

144 of symmetry at the dimer interfaces in this homotetrameric protein, suggesting that the quaternary s

145 Transthyretin (TTR) is a homotetrameric protein.

146 a dimer of dimer quaternary structure of the homotetrameric protein.

147 Homotetrameric proteins can assemble by several differen

148 and that selective pressure may have caused homotetrameric proteins to evolve to assemble by a singl

149 ent members of the AQP family, the signature homotetrameric quaternary structure is conserved.

150 A recent crystal structure of active, homotetrameric R67 DHFR indicates that a single active s

151 olate and NADPH by approximately 100-fold in homotetrameric R67 DHFR.

152 wild-type and Lys --> Gln or Glu site mutant homotetrameric rabbit cytosolic SHMTs identified lysine

153 Here, we report a structure of a homotetrameric rat GluA2 receptor in complex with partia

154 4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution i

155 Unlike the homotetrameric recombinant GluR2, the native heterotetra

156 -contraction coupling involves activation of homotetrameric ryanodine receptor ion channels (RyR1s),

157 s of the square-shaped cytoplasmic region of homotetrameric RyR3.

158 Human lung tryptase, a homotetrameric serine protease unique to mast cell secre

159 in the last transmembrane region (S6) of the homotetrameric Shaker K+ channel creates metal binding s

160 We showed that the homotetrameric species exchanged dimers, because when th

161 tein is the adduct of the G26C mutant of the homotetrameric SSB from Escherichia coli and a diethylam

162 many of the same reactions catalyzed by the homotetrameric SSB of bacteria, but its origin, subunit

163 ing properties of these two highly conserved homotetrameric SSB proteins, and these differences might

164 In contrast to homotetrameric SSB proteins, asymmetry exists between th

165 Escherichia coli SSB, a representative homotetrameric SSB, binds to ssDNA by wrapping the DNA u

166 results extend our previous observations on homotetrameric SSBs to homodimeric SSBs, indicating that

167 DrSSB that are analogous to those mapped in homotetrameric SSBs, although there are distinct contact

168 nylated Cp*Ir moiety (Cp* = C5Me5(-)) within homotetrameric streptavidin (Sav) (referred to as Cp*Ir(

169 The purified DAHP synthase displays a homotetrameric structure and exhibits maximal activity a

170 ar mass of 185 +/- 35 kDa, consistent with a homotetrameric structure for the native enzyme.

171 The homotetrameric structure of ES* was solved by MAD phasin

172 The homotetrameric structure of the ryanodine-sensitive intr

173 This homotetrameric structure reveals a novel KaiB interface

174 tes at each protein-protein interface in the homotetrameric structure with binding constants relative

175 Previous studies demonstrated a specialized homotetrameric structure with two pairs of catalytic dom

176 ristics of mammalian class 1 ALDHs include a homotetrameric structure, high expression in liver, sens

177 se product of ca. 50,000 Da assembles into a homotetrameric structure.

178 tuber LS and, in turn, enabling it to form a homotetrameric structure.

179 The building block structure consists of a homotetrameric subunit complex with three unique supramo

180 The pseudo-fourfold homotetrameric synapse formed by Cre protein and target

181 thods to dissect the domain structure of the homotetrameric T4 Pnk protein and to localize essential

182 te editing status, in an otherwise identical homotetrameric TMD.

183 The p53 tumor suppressor gene encodes a homotetrameric transcription factor which is activated i

184 Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifi

185 Transthyretin (TTR) is a homotetrameric transport protein, assembled from monomer

186 single subunit of the previously determined homotetrameric tRNA splicing endonuclease from Methanoco

187 p53 is a homotetrameric tumor suppressor protein that is found to

188 scorpion toxin, Charybdotoxin (CTX), blocks homotetrameric, voltage-gated K(+) channels by binding n

189 Thus eubacterial SSBs are homotetrameric whilst the eucaryal RPA protein is a hete