ライフサイエンスコーパス: ictal

1 This was a retrospective analysis of 72 ictal (99m)Tc-ethylcysteinate dimer SPECT studies in 43

2 We propose that normal and ictal activities coexist: a separatrix acts as a barrier

3 In these patients, ictal activities spread to frontal (lateral premotor are

4 effective as inhibition of mTOR in reducing ictal activity and cell death.

5 Steroids have long been known to influence ictal activity and may have a therapeutic role.

6 We assessed the effect of endogenous GABA on ictal activity and neuronal firing rate in hippocampal s

7 izing effects of GABA and the propensity for ictal activity are causally linked.

8 These findings indicate that interictal and ictal activity can originate in the same neural network,

9 tential frequency (P23) and the age at which ictal activity could be induced by elevated potassium (P

10 by ICE, scalp EEG demonstrated no concurrent ictal activity in six, nonictal-appearing rhythmic delta

11 iode (LED), on the frequency and duration of ictal activity in the presence and absence of RuBi-GABA.

12 very characteristic pattern of evolution of ictal activity in the zero magnesium (0 Mg2+) model of e

13 BA-mediated excitation is causally linked to ictal activity in this developmental window.

14 delta in two, and intermittently correlated ictal activity in two.

15 Finally, ictal activity induced by elevated potassium was blocked

16 propensity of the developing hippocampus for ictal activity is highly correlated with the effect of G

17 izures that (1) progression from preictal to ictal activity was characterized in seizure-onset zones

18 tion between the fraction of slices in which ictal activity was induced by elevated potassium concent

19 Ictal activity was quantified by measurement of lactate

20 ning 3 days after injury virtually abolished ictal activity.

21 ted signalling contributes to interictal and ictal activity.

22 that is suspicious for but not diagnostic of ictal activity.

23 ilepsy, acute or chronic stress can increase ictal activity.

24 alorhodopsin activation rapidly induced full ictal activity.

25 Endocannabinoid involvement in post-ictal analgesia in GEPRs was evaluated, using focal bila

26 antagonist (capsazepine) did not affect post-ictal analgesia in GEPRs.

27 ptors in PAG are critical for mediating post-ictal analgesia in GEPRs.

28 /side) into PAG significantly decreased post-ictal analgesia in GEPRs.

29 This study evaluated if post-ictal analgesia occurs in GEPRs, following audiogenic se

30 e brain sites and mechanisms, mediating post-ictal analgesia, are unclear.

31 sults indicate that AGS in GEPRs induce post-ictal analgesia, which is the first observation of this

32 ngs suggest an important role of PAG in post-ictal analgesia.

33 reoperative seizures, neuroimaging findings, ictal and interictal ECoG measures were preoperatively o

34 the full regression model incorporating both ictal and interictal measures [R(2) 0.44; Area under the

35 and the frequent subtle differences between ictal and interictal patterns.

36 A total of 36 subtraction ictal and interictal perfusion studies were analysed in

37 Subtraction ictal and interictal single photon emission computed tom

38 lpropyleneamine Oxime (Tc-99 m HMPAO) during ictal and interictal state confirmed by video-electroenc

39 Ictal and interictal studies were coregistered with pati

40 , and whether discrete interictal, preictal, ictal and post-ictal physiologies exist, or blend togeth

41 The contrasting clinical profiles of ictal and postictal arrhythmias suggest different pathom

42 The duration of ictal and postictal generalized EEG suppression periods

43 ernative stable attractors, representing the ictal and postictal states, emulate the observed dynamic

44 TTX blocked both ictal- and interictal-like epileptiform activity without

45 -containing saline result mainly in neuronal ictal- and interictal-like epileptiform activity, respec

46 Postictal rather than ictal arrhythmias seem of greater importance to the path

47 patterns of (post)ictal cardiac arrhythmias: ictal asystole (103 cases), postictal asystole (13 cases

48 le, we observed 76 clinical seizures with 26 ictal asystole episodes, 15 of which led to syncope.

49 During ictal asystole events, 4 patients had left temporal seiz

50 ober 2003 to July 2013 for all patients with ictal asystole events.

51 Ictal asystole had a mean prevalence of 0.318% (95% CI 0

52 Ictal asystole is a rare, serious, and often treatable c

53 Ictal asystole>6 s is strongly associated with ictal syn

54 Ictal asystole, bradycardia and AV-conduction block were

55 In 10 patients with ictal asystole, we observed 76 clinical seizures with 26

56 stictal AV-conduction block (2 cases), (post)ictal atrial flutter/atrial fibrillation (14 cases) and

57 le (13 cases), ictal bradycardia (25 cases), ictal atrioventricular (AV)-conduction block (11 cases),

58 eluded recognition because emetic and other ictal autonomic manifestations were dismissed as non-epi

59 cortex, these short EEEs were accompanied by ictal behaviour detectable with simultaneous surface ele

60 tiform electrocorticography and simultaneous ictal behaviour, and examined post-traumatic epilepsy in

61 ity that undetected ischemic hypoxia, due to ictal blood flow restriction, could contribute to neurod

62 Ictal bradycardia (<40 beats per min) was rare, occurrin

63 (103 cases), postictal asystole (13 cases), ictal bradycardia (25 cases), ictal atrioventricular (AV

64 opolamine treatment reduced the incidence of ictal bradycardia and SUDEP in DS mice.

65 sting heart-rate variability and episodes of ictal bradycardia associated with the tonic phases of ge

66 Prolonged atropine-sensitive ictal bradycardia preceded SUDEP.

67 monitoring, brain MR imaging, interictal and ictal brain perfusion SPECT, SISCOM, and (18)F-FDG PET w

68 The most challenging technical problem in ictal brain SPECT for localization of an epileptogenic f

69 (99m)Tc-ethylcysteinate dimer ((99m)Tc-ECD) ictal brain SPECT studies were retrospectively analyzed

70 y smaller in the reduced model incorporating ictal but not interictal measures (R(2) 0.40; Area under

71 inical characteristics of patients with peri-ictal cardiac abnormalities are closely similar to those

72 nical profiles associated with various (post)ictal cardiac arrhythmias.

73 identified seven distinct patterns of (post)ictal cardiac arrhythmias: ictal asystole (103 cases), p

74 ective was to demonstrate common patterns of ictal cerebral blood flow changes in a group of patients

75 However, the ictal characteristics of these rat models, including SWD

76 oncordance (4/13; 31%) = 9/13; 69%] and late ictal [concordant plus (1/9; 11%) + some concordance (4/

77 rms of two distinct spatial territories: the ictal core and penumbral territories.

78 method for using them to identify the small ictal core regions.

79 In contrast, within the ictal core territories, regions characterized by intense

80 The pre-ictal decrease in spike rate is not consistent with spik

81 However ictal deja vu occurs more frequently and is accompanied

82 50 epileptic patients with ictal deja vu, 50 non-epileptic patients attending gener

83 Post-ictal depression of consciousness occurs after generaliz

84 s of stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) sometimes found on prolonged

85 d find a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus (DGH) to t

86 types reduced the frequency and duration of ictal discharges in some trials, while completely blocki

87 guinea pig brain during focal interictal and ictal discharges induced in the limbic network by intrac

88 n an intensive care unit setting, can detect ictal discharges not readily apparent on scalp EEG, and

89 Using video/EEG analysis, we detect ictal discharges that coincide with convulsive seizures

90 period of silence ranging from 67 to 135 s, ictal discharges were re-established with similar durati

91 Even after the termination of ictal discharges, during the post-ictal period, loss of

92 type significantly reduced the occurrence of ictal discharges, principal cell stimulation resulted in

93 ctivity alone may underlie the generation of ictal discharges.

94 ment of strategies to confine propagation of ictal discharges.

95 ivity to persistent, prolonged synchronized (ictal) discharges.

96 ocus blocked ictal propagation and shortened ictal duration at the focus.

97 We revealed that the reduced ictal duration was a direct consequence of the ictal pro

98 eictal depolarization, with no effect on the ictal duration, whereas SLEs were blocked by glutamate r

99 cal outcome may be modest in the presence of ictal ECoG and neuroimaging data.

100 Ictal EEG analysis of 10 seizures from 7 patients are in

101 Both patterns were followed by generalized ictal EEG discharges and behavioral seizures.

102 However, the wave morphology of the ictal EEG is quite different for electrodes placed in di

103 low wave component of the GEPR9 epileptiform ictal EEG pattern is associated with a midbrain-forebrai

104 % CI = 1.12-2.69), generalized/non-localized ictal EEG patterns (RR = 1.83, 95% CI = 1.15-2.87), occu

105 s, through wavelet analysis of multi-channel ictal EEG.

106 Interictal and ictal EEG/fMRI can provide helpful information in the pr

107 study investigates the temporal dynamics of ictal electrical activity induced by injection of the GA

108 ho had intractable partial epilepsy based on ictal electro-clinico-anatomical features were screened.

109 of single neurons before, during, and after ictal electroencephalogram (EEG) discharges.

110 n of a seizure origin through an analysis of ictal electroencephalogram (EEG), which is proven to be

111 Ictal electroencephalogram results correspond to human i

112 owed atypical handedness, a left perisylvian ictal electroencephalographic focus, and a lesion in lef

113 erential spectral and spatial shifts of post-ictal electroencephalography activity in simple partial,

114 ad unilateral temporal seizure foci based on ictal electroencephalography and structural magnetic res

115 ells, an essential component in the onset of ictal epileptic events.

116 tor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations d

117 In the developing rat hippocampus, ictal epileptiform activity can be elicited easily in vi

118 RIs, but electroencephalography demonstrated ictal epileptiform activity in 7 patients (24%).

119 mens, where the occurrence of interictal and ictal epileptiform activity was confirmed by either ster

120 Ictal epileptiform electroencephalographic changes were

121 e concordance (4/20; 20%) = 17/20; 85%] than ictal-established [entirely concordant/concordant plus (

122 With each successive ictal event, the number of preictal inhibitory barrages

123 limiting further neuronal recruitment to the ictal event.

124 g associated with imminent recruitment to an ictal event.

125 g seizures and recovers after the end of the ictal event.

126 We discovered a novel phenomenon, in which ictal events are preceded by preictal vasoconstriction o

127 ked seizures in which the individual seizure-ictal events are self-limiting.

128 g of blood vessel diameter in a rat model of ictal events elicited with focal injection of 4-aminopyr

129 ctured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in

130 e generation and propagation of seizure-like ictal events is accurately analyzed by a combination of

131 Ictal events occurring in temporal lobe epilepsy patient

132 ium indicator to measure prolonged seizures (ictal events) and brief interictal events.

133 ghly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were

134 oride loading by itself did not trigger full ictal events, even with additional electrical stimulatio

135 view that principal cell discharges dominate ictal events, the ictal sequences were predominantly com

136 eriods without behavioural or electrographic ictal events.

137 rominent automatisms, sensory aura, and post-ictal fear and speech arrest.

138 abolism and cerebral blood flow (CBF) to the ictal focus.

139 Pv interneurons at the focus failed to block ictal generation and induced postinhibitory rebound spik

140 , enhancing neuronal synchrony and promoting ictal generation.

141 In conclusion, preictal and ictal haemodynamic changes in refractory focal seizures

142 ed the cellular correlates of interictal and ictal HFO events.

143 dily identified, to investigate the basis of ictal high frequency activity at the cortical (subdural)

144 t measure to detect delayed-onset, sustained ictal high frequency oscillations based on cross-frequen

145 eural mechanism for delayed-onset, sustained ictal high frequency oscillations, and provide a practic

146 Although interictal hypoperfusion and ictal hyperperfusion are established localizing findings

147 Regions with ictal hyperperfusion are suggested to reflect seizure on

148 Early ictal hypometabolism, transient decreases in cell swelli

149 The significance of ictal hypoperfusion is not well understood.

150 Understanding the cause of this peri-ictal hypoventilation may lead to preventative strategie

151 Ictal hypoxemia and hypercapnia may contribute to SUDEP.

152 Ictal hypoxemia has been reported in small series of cas

153 t to determine the incidence and severity of ictal hypoxemia in patients with localization-related ep

154 Ictal hypoxemia occurs often in patients with localizati

155 thus conclude that EEEs lasting 0.8-2 s are ictal in the rat.

156 to travel backwards to the original focus of ictal initiation.

157 to demonstrate the improved success rate of ictal injection by use of the automatic injector in the

158 o not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroence

159 sistently predicted the timing or failure of ictal invasion, and revealed a surprisingly small and sl

160 mic hamartomas present with isolated fits of ictal laughter (gelastic epilepsy) or a combination of g

161 ery of the mean firing rate was close to pre-ictal levels also within this time frame, suggesting tha

162 ve potentials, which appeared to trigger the ictal-like activities, remained.

163 mulative duration of 4-aminopyridine-induced ictal-like activities, with a slower time course in epil

164 The pattern of hippocampal ictal-like activity was unaffected by removal of the ent

165 ulation activity characteristic of seizures (ictal-like activity) was recorded in juvenile rat hippoc

166 experimental model, the onset and offset of ictal-like discharges are well-defined mathematical even

167 escribe the onset, time course and offset of ictal-like discharges as well as their recurrence.

168 As an experimental model system, we used ictal-like discharges induced in vitro in mouse hippocam

169 induced preictal discharges (PIDs) preceding ictal-like events.

170 ons included transient discharges leading to ictal-like field events with frequency spectra as in vit

171 The transition from IEDs to ictal-like sustained epileptiform activity was reliably

172 Ictal-like sustained network oscillations (10-20 Hz) ori

173 s induces persistent prolonged synchronized (ictal-like) discharges in CA3 that are associated with t

174 , and that the transition from interictal to ictal-like-sustained activity is preceded by predictable

175 stic link between Ca(V)1.1 mutations and the ictal loss of muscle excitability during an attack of we

176 duced model incorporating interictal but not ictal measures (R(2) 0.27; Area under the ROC curve: 0.7

177 nts' MRI scans using automated software, and ictal minus interictal subtraction images were obtained.

178 ic discharges through the network underlying ictal motor manifestation.

179 the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments

180 Ictal neocortical slow waves have been interpreted as se

181 These findings suggest that ictal neocortical slow waves represent an altered cortic

182 totoxicity is the prevalent model to explain ictal neurodegeneration.

183 riven by capillary blood flow restriction in ictal neurodegeneration.

184 When the stimulated ictal onset area was hyperperfused, 82% of studies demon

185 Six patients had postcingulate ictal onset identified by stereotactic EEG (SEEG) evalua

186 ng connectivity was demonstrated between the ictal onset zone and hyperperfused regions, while connec

187 AFI was extremely sensitive to the ictal onset zone and may be a useful mapping technique w

188 ree outcome given strict localization of the ictal onset zone to the lateral temporal region, highlig

189 With accurate identification of the ictal onset zone with intracranial electroencephalograph

190 ses on several methods used to identify this ictal onset zone, with emphasis on the impact each modal

191 ter repetitive electrical stimulation of the ictal onset zone.

192 to properly characterize the location of the ictal onset zone.

193 e FPs markedly increased to a maximum at the ictal onset.

194 cation, were diminished, disappearing at the ictal onset.

195 termine bandwidths with significant power at ictal onset.

196 was significantly better (P < 0.05) for the ictal-onset phase [entirely concordant/concordant plus (

197 ases that underwent invasive evaluation, the ictal-onset phase-related maps had a degree of concordan

198 In the remaining 14 cases, the ictal-onset phase-related maps had a degree of concordan

199 trographic seizure onset) and ictal phases, 'ictal-onset'; 'ictalestablished' and 'late ictal', were

200 Cs, did not prevent the generation of either ictal- or interictal-like events.

201 ses in ETCO2, supporting the assumption that ictal oxygen desaturation is a consequence of hypoventil

202 Ictal patterns on scalp-electroencephalography are often

203 The defining feature of the 'ictal penumbra' is the contrast between the large amplit

204 tory of recruited neurons and a surrounding 'ictal penumbra'.

205 The aim of this study was to verify whether ictal perfusion changes, both hyper- and hypoperfusion,

206 computed tomography can demonstrate complex ictal perfusion patterns.

207 sponses at these electrodes were compared to ictal perfusion values noted at these locations.

208 n, cerebral blood flow increases in the post-ictal period and cerebral blood flow decreases during or

209 amics across space and throughout the entire ictal period are rare.

210 irs of electrodes during the initial part of ictal period of the seizure.

211 ripple rates and (2) ripple rates during the ictal period were higher compared with fast ripple rates

212 ination of ictal discharges, during the post-ictal period, loss of consciousness, decreased responsiv

213 s and regions of secondary spread during the ictal period.

214 ring generalization or in the immediate post-ictal period.

215 cluding the alternation between 'normal' and ictal periods (slow time scale).

216 stically significant increased value for the ictal periods and that the epileptic focus can be locate

217 using statistical parametric mapping to map ictal phase-related haemodynamic changes consistent acro

218 hich abruptly turns into a higher frequency "ictal" phase.

219 ceding the electrographic seizure onset) and ictal phases, 'ictal-onset'; 'ictalestablished' and 'lat

220 iscrete interictal, preictal, ictal and post-ictal physiologies exist, or blend together in a continu

221 al wavefront acts as the forcing term of the ictal process, while the macroscopic, centimeter-sized n

222 providing new localizing information on the ictal processes and epileptogenic zone.

223 interneurons distant from the focus blocked ictal propagation and shortened ictal duration at the fo

224 tal duration was a direct consequence of the ictal propagation block, probably by preventing newly ge

225 Here we report the dissection of ictal propagation in the hippocampal-entorhinal cortex (

226 e seizure spread and the exact directions of ictal propagation remain largely unknown.

227 Ictal propagation-related haemodynamic changes were also

228 ephalography (EEG) and video monitoring with ictal recording, magnetic resonance imaging, single-phot

229 All patients showed significant ictal-related haemodynamic changes.

230 seizure onset and body mass index influenced ictal-related hypoxemia.

231 phase-locked to the low-frequency (1-25 Hz) ictal rhythm, correlated with strong multi-unit firing b

232 ma amplitude and the low-frequency (1-25 Hz) ictal rhythm.

233 Brief potentially ictal rhythmic discharges in critically ill patients are

234 Brief potentially ictal rhythmic discharges were identified before seizure

235 Brief potentially ictal rhythmic discharges, termed B(I)RDs, have been des

236 the following point assignments: (1) brief (ictal) rhythmic discharges (B[I]RDs) (2 points); (2) pre

237 seizure onset at sub-lobar/gyral level when ictal scalp-electroencephalography is not helpful.

238 of epilepsy have been encouraged to perform ictal scanning or interictal and postictal SPECT studies

239 ity that it may modulate the strength of the ictal (seizure)-like event.

240 rons can significantly inhibit the spread of ictal seizures and largely rescue behavioural deficits i

241 es indicate the potentially valuable role of ictal semiology in localizing the source of epileptiform

242 Correlating the ictal semiology of the "dreamy state" with consciousness

243 l cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spik

244 arison with the findings of invasive EEG and ictal single-photon emission computed tomography, using

245 lly generated EEEs that occurred in the same ictal sites as obvious complex partial seizures, were el

246 al features and spatial distribution of post-ictal slow waves with comprehensive spatial coverage.

247 y and source imaging to reconstruct the post-ictal slow-wave distribution.

248 Moderate redundancy was seen between PET and ictal SPECT (kappa = 0.452; p = 0.011).

249 that administers an automated injection for ictal SPECT after calculating the volume of tracer to be

250 ralizing uptake in subcortical structures on ictal SPECT and postsurgical outcome in intractable epil

251 Ictal SPECT and SISCOM successfully localized the seizur

252 The SISCOM (Subtraction Ictal Spect Co-registered to MRI) procedure was used to

253 , interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR imaging (SISCOM), and int

254 using the technique of composite subtraction ictal SPECT coregistered to MRI (SISCOM).

255 However, cerebral blood flow increases on ictal SPECT correctly identified the hemisphere (left ve

256 MSI, FDG-PET, and ictal SPECT each have clinical value in predicting seizu

257 We analysed ictal SPECT from 59 secondarily generalized tonic-clonic

258 Ictal SPECT from secondarily generalized seizures has no

259 In the cases with all three tests (n = 27), ictal SPECT had the highest OR of 9.1 (p = 0.05).

260 t, with appropriate cautious interpretation, ictal SPECT in secondarily generalized seizures can help

261 eizure onset impossible 50% of the time with ictal SPECT in secondarily generalized seizures.

262 ese recommendations are valid, but obtaining ictal SPECT is often serendipitous.

263 raphy (EEG) monitoring, MRI, and one or more ictal SPECT scans as well as an interictal SPECT scan.

264 re-generalization and generalization phases, ictal SPECT showed significantly more regions of cerebra

265 or thalamic activation has been reported in ictal SPECT studies of patients with intractable epileps

266 clinical interpretation and localization of ictal SPECT studies.

267 In cases of false ictal SPECT subcortical lateralization, the basal gangli

268 come was not observed in patients with false ictal SPECT subcortical lateralization; however, the pre

269 y be achieved with addition of either PET or ictal SPECT to MSI.

270 h available comparison subgroups FDG-PET and ictal SPECT values were similar to MSI.

271 Tracer for ictal SPECT was injected using automated injection in 27

272 single photon emission computed tomography (ictal SPECT), providing a useful clinical tool for seizu

273 lization purposes when possible, rather than ictal SPECT, IISPECT, or PISPECT by itself.

274 y (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR

275 of cerebral blood flow increase was seen on ictal SPECT, this was the correct localization 80% of th

276 th the combination of MSI and PET or MSI and ictal SPECT.

277 Increased pre-ictal spike rate was linked to improved predictability;

278 ikes associated with seizure initiation (pre-ictal spikes; PSs) is still undetermined.

279 me, suggesting that the more protracted post-ictal state cannot be explained by persistent cellular n

280 ase in tracer uptake was observed during the ictal state in the medial temporal region, cerebellum, t

281 al and peripheral metabolism during the post-ictal state that lasted up to 1 h.

282 and prevent anaerobic shift during the post-ictal state.

283 granule cell hyperinhibition extended to the ictal state; granule cells did not discharge synchronous

284 urther compromised during the period of post-ictal suppression, during interictal bursts, and also at

285 me in the surround are consistent with early ictal surround inhibition as a precipitating event in se

286 ovascular and neurometabolic coupling in the ictal surround using optical imaging of light scattering

287 g pathological electric activity or inducing ictal symptomatology.

288 s were examined for their relationships with ictal syncope events.

289 emaker should be considered in patients with ictal syncope if they are not considered good candidates

290 Ictal syncope is more common in left than in right tempo

291 Characterization of ictal syncope predictors may aid in the selection of hig

292 tal asystole>6 s is strongly associated with ictal syncope.

293 Ictal versus baseline interictal SPECT difference analys

294 we aimed to investigate state specific (i.e. ictal versus interictal) perfusional limbic networks in

295 powerful feedforward inhibition ahead of the ictal wave.

296 , this correlation effect is specific to the ictal wavefront and is absent interictally or from actio

297 veral seconds after seizure onset, following ictal wavefront passage.

298 as well as shaping the evolving propagating ictal wavefront, although the exact mechanism of these c

299 gradient in modulating the susceptibility to ictal weakness and establishes bumetanide as a potential

300 'ictal-onset'; 'ictalestablished' and 'late ictal', were defined based on the evolution of the elect