ライフサイエンスコーパス: impulsivity

1 effects on these different forms of 'waiting impulsivity'.

2 ial risk and a neuropsychological measure of impulsivity.

3 t," including novelty-induced locomotion and impulsivity.

4 ive-limbic subthalamic nucleus in decisional impulsivity.

5 e levels of inattention and hyperactivity or impulsivity.

6 ing-state functional connectivity (RSFC) and impulsivity.

7 tor urgency and SSRT in proactive control of impulsivity.

8 S modulated different components of temporal impulsivity.

9 nhibition, gambling decisions and reflection impulsivity.

10 ssion were included as a model of disordered impulsivity.

11 2B mutant (Htr2B(-/-)) mice also showed high impulsivity.

12 g during adulthood are involved in mediating impulsivity.

13 mental period associated with an increase in impulsivity.

14 entral striatum and related these changes to impulsivity.

15 red with the baseline level of hyperactivity/impulsivity.

16 n fail to improve cognitive problems such as impulsivity.

17 relationship between the accumbal volume and impulsivity.

18 ssion and sex were significant covariates of impulsivity.

19 s and striatum was associated with increased impulsivity.

20 the tendency toward negative affect-provoked impulsivity.

21 CB1Rs reversed and prevented cocaine-induced impulsivity.

22 sive-compulsive spectrum disorders with high impulsivity.

23 ionally implicate the Nrg3 candidate gene in impulsivity.

24 yrus thickness mediated the association with impulsivity.

25 ence and underlie enhanced susceptibility to impulsivity.

26 manifest relatively high levels of cognitive impulsivity.

27 ed by intermediate behavioral traits such as impulsivity.

28 rating lithium's effects to reduce cognitive impulsivity.

29 ts in reducing psychostimulant-induced motor impulsivity.

30 ms by which OXR blockade may influence motor impulsivity.

31 nd delay discounting are forms of decisional impulsivity.

32 ric disorders, which present with disordered impulsivity.

33 ntagonists to attenuate acute cocaine-evoked impulsivity.

34 ventral SN network was associated with motor impulsivity.

35 ociated with better neurocognition and lower impulsivity.

36 exhibited poorer decision making and greater impulsivity.

37 otentially has implications for disorders of impulsivity.

38 sses, which include effects on attention and impulsivity, a mechanism that may contribute to the addi

39 Impulsivity, a multifaceted behavioral hallmark of atten

40 Impulsivity, a risk factor across the addictions, has al

41 accommodates the commonalities of apathy and impulsivity across disorders and reveals their cognitive

42 of institutionalization with inattention and impulsivity; additionally, supramarginal gyrus thickness

43 uding (i) the assessment of either apathy or impulsivity alone, despite their frequent co-existence;

44 In disorders of compulsivity and impulsivity, an unconscious habit system may play a key

45 a fast life-history strategy, one marked by impulsivity and a focus on short-term goals.

46 There are well-established links between impulsivity and alcohol use in humans and animal models;

47 pulse control and out-of-scanner measures of impulsivity and alcohol use.

48 s support a developmental imbalance model of impulsivity and are consistent with the idea that negati

49 in the context of measures of aggression and impulsivity and as a function of intermittent explosive

50 and non-binge drinkers were tested for motor impulsivity and attentional abilities in a human version

51 on training, we observed reduced aggression, impulsivity and behavioral approach tendencies, as well

52 tonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants.

53 -dependent cocaine-seeking habits or whether impulsivity and cocaine-induced intrastriatal shifts are

54 Converging evidence has long identified both impulsivity and compulsivity as key psychological constr

55 ever, the precise nature of the link between impulsivity and compulsivity in anxiety-related compulsi

56 ide insight into the reciprocal influence of impulsivity and compulsivity in compulsive disorders and

57 Trait impulsivity and compulsivity were nonlinearly related.

58 o relationship between the effects of MPH on impulsivity and D2/3 receptor availability in any of the

59 reased impulsivity in LI rats, and modulated impulsivity and D2/3 receptor availability in the dorsal

60 nverse relationships with baseline levels of impulsivity and D2/3 receptor availability, respectively

61 dala connectivity, a neural "switch" between impulsivity and deliberation, further underscores the ph

62 Individual differences in impulsivity and early adversity are known to be strong p

63 borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms

64 rmediate phenotype for genetic dissection of impulsivity and externalizing spectrum disorders.

65 Impulsivity and hyperactivity share common ground with n

66 Impulsivity and inattention related to attention deficit

67 al mechanism may underlie obesity-associated impulsivity and increased consumption of high-calorie fo

68 TO exhibit dose-dependent increments in both impulsivity and intake of fatty foods.

69 of the physiological mechanisms involved in impulsivity and may suggest potential targets for therap

70 stem, particularly with regard to adolescent impulsivity and mental health vulnerabilities.

71 ms enact functionally unique effects on food impulsivity and motivation relative to PFC-based monoami

72 e in young adults is associated with greater impulsivity and neurobiological alterations in executive

73 benefit from focusing on characterizing how impulsivity and other addiction-related features relate

74 lies on a continuum in which both extremes (impulsivity and overcontrol) contribute to psychopatholo

75 Atomoxetine treatment both decreased impulsivity and prevented the development of compulsivit

76 que contribution provides a neural locus for impulsivity and related failures of patience.

77 including noradrenaline, which is linked to impulsivity and response inhibition.

78 ch, we mapped the relationship between trait impulsivity and reward-related brain activity in a large

79 Due to increased impulsivity and risk for mania, however, depressed indiv

80 Indeed, pathological impulsivity and risk taking are common in patients with

81 in NAC than in PFC, which may contribute to impulsivity and risk-taking exhibited by adolescents [5,

82 l cortex was inversely associated with trait impulsivity and risk-taking in the bipolar disorder grou

83 ized by impaired decision-making captured in impulsivity and risk-taking.

84 r-order goals, and how this relates to trait impulsivity and risk-taking.

85 striatum, and that stimulant drugs modulate impulsivity and striatal D2/3 receptor availability thro

86 We investigated the relationship between impulsivity and the development of a compulsive behavior

87 onmental determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues

88 lity to measure the components of apathy and impulsivity and their associated neural correlates acros

89 However, the neurobiological bases of impulsivity and their relation to antisocial behavior an

90 cterize correlations between the measures of impulsivity and to identify covariates.

91 Rats were then reassessed for impulsivity and underwent a second [(18)F]fallypride PET

92 EVANCE-Altered paralimbic reward signals and impulsivity and/or carelessness may facilitate unplanned

93 se regions with individual difference (e.g., impulsivity) and treatment outcome variables.

94 knockout mice show increased aggression and impulsivity, and 5-HT1BR polymorphisms are associated wi

95 positive emotion enhancement and behavioral impulsivity, and another associated with negative emotio

96 ke phenotype with typical high risk seeking, impulsivity, and augmented drug and nondrug reward sensi

97 eeking, increased peer interaction, enhanced impulsivity, and augmented reward sensitivity for drug a

98 t single mutants, exhibited hyperlocomotion, impulsivity, and impaired working memory.

99 ding family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would

100 nt informants for inattention, hyperactivity-impulsivity, and oppositional defiant disorder, and a co

101 nt informants for inattention, hyperactivity-impulsivity, and oppositional defiant disorder, and a co

102 dimensions of normal behavior, such as human impulsivity, and psychopathology, particularly behaviora

103 (LH) stimulation, eliminates cocaine-induced impulsivity, and reduces cocaine self-administration.

104 characteristics of patients, such as gender, impulsivity, and severity of cannabis use, when selectin

105 ration provides new insights into apathy and impulsivity, and the need for a joint therapeutic strate

106 escents may be causal, whereas hyperactivity-impulsivity appears to act indirectly, through shared pr

107 Apathy and impulsivity are common and disabling consequences of fro

108 Pathological forms of impulsivity are manifest in a number of psychiatric diso

109 er, the molecular and cellular substrates of impulsivity are poorly understood.

110 Hyperactivity-impulsivity, as another core symptom of ADHD had a robus

111 Motor impulsivity, as measured by premature responses in the 5

112 tress and problem alcohol use is mediated by impulsivity, as reflected in monetary delay discounting

113 sures and parental reports of aggression and impulsivity, as well as structural and diffusion MRI, fr

114 sed using a validated psychometric tool (Dog Impulsivity Assessment Scale--DIAS).

115 symptoms of inattention, hyperactivity, and impulsivity associated with clinically significant impai

116 current study seeks to examine self-reported impulsivity (Barratt Impulsivity Scale) and performance-

117 xpressions, as well as empathy, risk taking, impulsivity, behavior change, and attentional focus.

118 on-related deficits include distractibility, impulsivity, behavioral rigidity, and reduced habituatio

119 We describe differences in impulsivity between and within two dog breeds with worki

120 r breeders may reduce average differences in impulsivity between breeds in show lines.

121 selection might have lessened differences in impulsivity between breeds.

122 show lines selected for different levels of impulsivity: Border Collies (herding work) and Labrador

123 orsal anterior cingulate connectivity; trait impulsivity, both a risk factor for and a consequence of

124 in 1B receptors (5-HT1BRs) in aggression and impulsivity, but this has never been evaluated in humans

125 -off encompasses elements of risk-taking and impulsivity-common behaviors in psychiatric disorders-an

126 tive control and decision-making and reduced impulsivity, components of behavior mediated in part by

127 This impulsivity-compulsivity relationship was lost after the

128 onto-parietal control mechanisms and greater impulsivity/compulsivity scores.

129 Escalating drinkers displayed greater impulsivity/compulsivity-related domain scores that were

130 ajectories, functional network activity, and impulsivity/compulsivity-related features may lend furth

131 This suggests that, if impulsivity confers an increased propensity to addiction

132 These results reveal that impulsivity confers an increased propensity to develop u

133 pulsive choice, a key component of a broader impulsivity construct.

134 /J (D2) mice (alcohol averse); the degree of impulsivity correlated with subsequent alcohol consumpti

135 dividual variation in the degree of inherent impulsivity could play a role in the generation or exace

136 ty to predict adaptive outcomes may activate impulsivity, delay discounting, and reward seeking.

137 e trained in one of the two animal models of impulsivity: delay-discounting (DD) or stop-signal react

138 sures (i.e., N2, P300, ERN/Ne, age, sex, IQ, impulsivity, depression, anxiety, motivation for change,

139 Correlating with the impulsivity, dopamine in the nucleus accumbens is elevat

140 with alcoholism demonstrate increased motor impulsivity during abstinence; however, the neuronal mec

141 plasma concentration: it reduced reflection impulsivity during information sampling [adjusted R(2) =

142 ortex (vmPFC) contributes to increased motor impulsivity during protracted abstinence from long-term

143 s to directly investigate these, focusing on impulsivity during response inhibition and decision maki

144 the available evidence, suggesting increased impulsivity during withdrawal.

145 expression of two major genes implicated in impulsivity, encoding the dopamine D2 receptor (DA D2R)

146 Trait-level impulsivity exists on a continuum and individual differe

147 ing maladaptive short-lived urges to balance impulsivity, exploration and defiance, while establishin

148 9) = 4.51, P = 0.047] and reduced reflection impulsivity [F(1,9) = 7.86, P = 0.02] and risk taking [F

149 However, the neural mechanisms whereby impulsivity facilitates the development of compulsive di

150 However, whether impulsivity facilitates the transition to dorsolateral s

151 Impulsivity factors were associated with alcohol use mea

152 ts for a range of psychiatric disorders with impulsivity features.

153 hemical mechanisms contributing to increased impulsivity following long-term alcohol exposure and hig

154 tentially responsible for dysregulated motor impulsivity following long-term alcohol exposure.

155 f neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives.

156 Measures of apathy and impulsivity frequently loaded onto the same components r

157 Waiting impulsivity has a preclinical basis as a predictor for t

158 These coefficients quantify impulsivity, have good psychometric properties and can c

159 d ratio: 1.74, 95% CI=1.03-2.93), and higher impulsivity (hazard ratio: 1.17, 95% CI=1.00 to 1.37) we

160 ity with substance abuse in humans, and high impulsivity (HI) in rats has been identified as a predic

161 ter variant at rs12765063 is associated with impulsivity, hyperactivity and addiction-related phenoty

162 al manganese (Mn) exposure with inattention, impulsivity, hyperactivity, and oppositional behaviors,

163 ated with symptoms of inattention as well as impulsivity/hyperactivity) subtypes of ADHD.

164 ructural correlates of sensation seeking and impulsivity in a large cohort of healthy young adults.

165 HT2 receptor induced head twitch response or impulsivity in a serial reaction time task (SRTT), where

166 in mice, we collected behavioral measures of impulsivity in a single cohort of mice using well-valida

167 Males displayed increased impulsivity in both dimensions, whereas 5-HT1BR expressi

168 Higher uric acid was associated with impulsivity in both humans and mice.

169 the neurocognitive components of apathy and impulsivity in frontotemporal lobar degeneration syndrom

170 atomical correlates of sensation seeking and impulsivity in healthy young adults.

171 on to the tests already available to measure impulsivity in humans in a direct translational analog o

172 e effects were probed regularly by measuring impulsivity in intertemporal choices, i.e., the propensi

173 MPH treatment increased impulsivity in LI rats, and modulated impulsivity and D2

174 mbens core (NAcbC) is sufficient to increase impulsivity in LI rats.

175 rally in the NAcbC is sufficient to increase impulsivity in LI rats.

176 a functional link that may help explain high impulsivity in methamphetamine-dependent individuals.

177 e negative biases in emotional processing or impulsivity in non-smoking subjects, thereby not support

178 in the context of measures of aggression and impulsivity in physically healthy subjects with intermit

179 These results reveal a novel mechanism of impulsivity in rats involving gamma aminobutyric aciderg

180 We have previously shown that impulsivity in rats is linked to decreased dopamine D2/3

181 We have previously shown that impulsivity in rats predicts the emergence of compulsive

182 re, we investigated a specific form of motor impulsivity in rats, namely premature responding, on a f

183 rmalities in the NAcbC associated with motor impulsivity in rats.

184 fied clinical trials of atomoxetine to treat impulsivity in selected patients with Parkinson's diseas

185 tment with lithium or valproate on cognitive impulsivity in selectively bred mice previously shown to

186 easures of decision making, risk taking, and impulsivity in smokers and nonsmokers have not been inve

187 Here we assess decisional impulsivity in subjects with obsessive compulsive disord

188 ats, anatomical and functional correlates of impulsivity in the anterior insular (AI) cortex by measu

189 premature responding in the Sx-5CSRTT, trait impulsivity in the BIS-11, and decision making in the TC

190 se (uncorrected P < .046) and elevated trait impulsivity in the CUs (uncorrected P < .012), and an in

191 anatomy predicts sensation seeking and motor impulsivity in the healthy populations, potentially incr

192 that the High-Active line demonstrated motor impulsivity in two different versions of the Go/No-go te

193 ated negatively and significantly with trait impulsivity in unaffected siblings.

194 rrent anxiety, depression, hyperactivity and impulsivity, inattention, and conduct problems.

195 luded anxiety, depression, hyperactivity and impulsivity, inattention, conduct problems, and psychoti

196 Behavioral data showed that choice impulsivity increased in a group of participants who per

197 cies toward increased reward sensitivity and impulsivity, increasing the likelihood of engaging in ri

198 To assess reversal of impulsivity, injections of a CB1R antagonist (1.5 mg/kg,

199 Behavioral impulsivity, IQ, MID task performance, and VS BOLD were

200 Impulsivity is a behavioral trait frequently seen not on

201 Impulsivity is a multidimensional construct, and in this

202 animal models; however, whether exaggerated impulsivity is a premorbid risk factor or a consequence

203 The data we obtained demonstrate that impulsivity is a trait that predicts the development of

204 Impulsivity is a validated endophenotype of both bipolar

205 Impulsivity is an endophenotype found in many psychiatri

206 Impulsivity is an endophenotype of vulnerability for com

207 Impulsivity is an important feature of multiple neuropsy

208 The results demonstrate that high impulsivity is associated with a delayed transition to D

209 Impulsivity is associated with aggression in schizophren

210 Despite the evidence that high impulsivity is associated with altered function of corti

211 These findings indicate that trait-like impulsivity is associated with decreased D2/3 receptor a

212 e present research tests the hypothesis that impulsivity is associated with higher uric acid in human

213 We found that increased motor impulsivity is associated with reduced recruitment of gl

214 Impulsivity is common in Parkinson's disease even in the

215 amphetamine-dependent research participants, impulsivity is correlated negatively with striatal D2-ty

216 hibitory function but its role in decisional impulsivity is less well-understood.

217 airs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse co

218 ty for response inhibition, and this form of impulsivity is significantly associated with heightened

219 important adverse impact on behaviour, with impulsivity its most widely reported manifestation.

220 8, in groups of rats selected for HI and low impulsivity (LI) on a 5-choice serial reaction time task

221 Congenic mice carrying the impulsivity locus (Impu1) confirmed its influence on imp

222 This suggests that impulsivity may be a transnosological endophenotype of v

223 The identification of biological markers of impulsivity may lead to a better understanding of the ph

224 ween uric acid and normal variation in trait impulsivity measured with the Revised NEO Personality In

225 ision-making, risk-taking, and self-reported impulsivity measures were examined.

226 a second approach, we compared one of these impulsivity measures, 5CSRTT performance, in two inbred

227 mixed results in rodents including increased impulsivity, no effect on cognition, impairment or even

228 symptoms, both inattention and hyperactivity-impulsivity, on the development of smoking in male and f

229 or other components of choice such as motor impulsivity or loss aversion, suggesting a direct and sp

230 , several regions were found correlated with impulsivity or risky behaviors in AD and RD values, alth

231 in ASPD, as well as their relationship with impulsivity or risky behaviors.

232 igated their correlations with the scores of impulsivity or risky behaviors.

233 poral preferences in animals may not reflect impulsivity, or even mental discounting of future option

234 Behavioral approach (P = .002) and impulsivity (P = .013) correlated negatively with fronta

235 Delay Discounting Questionnaire, Two-Choice Impulsivity Paradigm (TCIP), Stop Signal Reaction Time,

236 Exploratory analysis revealed that impulsivity positively correlated with caudate baseline

237 s are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the rel

238 However, whether impulsivity predates the development of uncontrollable f

239 readily develop as drug use continues, high impulsivity predicts loss of control over drug seeking a

240 t, among other functions, compute reward and impulsivity processes.

241 g the second experiment, aimed at preventing impulsivity rather than reversing it, CB1Rs were antagon

242 ighlight that ventral striatal CREM mediates impulsivity related to substance abuse and suggest that

243 ormed a Go/No-Go task during fMRI, completed impulsivity-related assessments, and provided monthly re

244 ps with principal component analysis derived impulsivity-related domains were examined.

245 nal activations correlated with alcohol- and impulsivity-related measures.

246 sponse element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability.

247 ociations generalized to self-reported motor impulsivity, replicated in an independent group (n = 219

248 e observed associations generalized to motor impulsivity, replicated in an independent group, and pre

249 een involved in various behaviors, including impulsivity, response to antidepressants, and response t

250 t it is unclear if this is due to changes in impulsivity, risk taking, deliberation or risk adjustmen

251 Impulsivity, risk-taking behavior, and elevated stress r

252 o examine self-reported impulsivity (Barratt Impulsivity Scale) and performance-based behavioral risk

253 he motor impulsivity subscale of the Barratt Impulsivity Scale.

254 racterized by impaired affective processing, impulsivity, sensation-seeking, poor planning skills and

255 Impulsivity shares high comorbidity with substance abuse

256 ogical tests included measures of attention, impulsivity, short-term memory, cognitive processing spe

257 uman samples, the emotional aspects of trait impulsivity, specifically impulsiveness and excitement s

258 Here, we aimed to identify genes regulating impulsivity, specifically of impulsive action, in mice.

259 tly with individual differences on the motor impulsivity subscale of the Barratt Impulsivity Scale.

260 psychiatric disorders characterized by high impulsivity, such as attention-deficit/hyperactivity dis

261 dissociable effects on different measures of impulsivity, suggesting considerable specificity in its

262 ders show greater discounting (suggestive of impulsivity), supports the premise that this component o

263 at the developmental course of hyperactivity/impulsivity symptoms followed a sharp linear decrease (m

264 More symptoms of hyperactivity/impulsivity (t = -2.63; P = .008) and inattention (t = -

265 iculties with overactivity, inattention, and impulsivity that are just under the threshold to meet fu

266 a potential therapeutic target for increased impulsivity that may contribute to relapse risk.SIGNIFIC

267 olescence has been associated with increased impulsivity that persists across the lifespan, an effect

268 Premature responding is a form of motor impulsivity that preclinical evidence has shown to predi

269 et the neurobiological underpinnings linking impulsivity to disease remain poorly understood.

270 In this study, we hypothesized that a high impulsivity trait precedes and confers vulnerability for

271 e of bilateral AI cortex lesions on the high impulsivity trait, as measured in the five-choice serial

272 We demonstrate that a high-impulsivity trait, as measured in the five-choice serial

273 ility to withhold premature responses; motor impulsivity) upon systemic administration or microinfusi

274 We derived dimensions of apathy and impulsivity using principal component analysis and emplo

275 Increased impulsivity was associated with increased Nrg3 gene expr

276 ctivation in the anticipation of losses, and impulsivity was associated with increased striatal and i

277 Waiting impulsivity was associated with lower connectivity of th

278 Self-reported impulsivity was elevated in the bipolar group compared w

279 Impulsivity was estimated with a temporal discounting ta

280 2, an interaction of the group with RSFC on impulsivity was observed.

281 the day confirmed that enhancement of choice impulsivity was related to a specific decrease in the ac

282 Greater temporal discounting (more impulsivity) was associated with 1) lower volume in fron

283 ter adult inattention, but not hyperactivity-impulsivity, was associated with significantly lower fra

284 Furthermore, aggression, but not impulsivity, was significantly explained by multivariate

285 frequency and characteristics of apathy and impulsivity were determined by neuropsychological and be

286 Dopamine levels and resultant variation in impulsivity were likely under differential selection in

287 Apathy and impulsivity were present across diagnostic groups, despi

288 ion, memory problems, and emotional lability/impulsivity were significantly improved with 50 mg of AZ

289 rences in the linear change in hyperactivity/impulsivity were under strong additive genetic influence

290 overexpression of Nrg3 in the mPFC increased impulsivity, whereas a constitutive Nrg3 loss-of-functio

291 to the left ventral striatum with cognitive impulsivity, whereas a negative relationship was observe

292 ational exposure to a high-fat diet promoted impulsivity, whereas exposure to a low-protein diet led

293 ogies induce fast strategy behaviors such as impulsivity, whereas resource-sufficient and predictable

294 y impair response inhibition and may lead to impulsivity, which can occur even in the presence of pro

295 cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors

296 to be more specific to decisional than motor impulsivity, which might reflect differences in ventral

297 Hyperactivity-impulsivity, while also more strongly related to smoking

298 value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN networ

299 liefs and was dissociated from participants' impulsivity, willingness to take risks, and mood.

300 causally implicated in increasing decisional impulsivity with less accumulation of evidence during pr