ライフサイエンスコーパス: injurious

1 ete development, whereas excess copper maybe injurious.

2 but conflicts can be time-consuming and even injurious.

3 of reperfusion, such as inflammation, may be injurious.

4 mb to, those stressors that are perceived as injurious.

5 culi in children, which was once thought too injurious a process with first-generation machines.

6 at PC protects the intestinal mucosa against injurious actions of BS, possibly by forming less toxic

7 t renders the livers more susceptible to the injurious actions of other fibrotic stimuli.

8 = .04) across all suicide attempts and self-injurious acts combined.

9 tory response to adipokine visfatin, a major injurious adipokine during obesity.

10 auma or microbial invasion that destroys the injurious agent and the injured tissue.

11 permeability coefficients in response to the injurious agent.

12 ability coefficients were not increased when injurious agents were given in the presence of 5-lipoxyg

13 cterial infection, viral infection, or other injurious agents, and known to activate integrins, also

14 otects organisms by removing or neutralizing injurious agents.

15 tudies may identify initial, and potentially injurious, altered processes.

16 Excretory pore plugs are injurious and hermaphrodite activity is compromised in p

17 ically increased in response to a variety of injurious and inflammatory insults.

18 Sciences-sponsored ND dataset comprising 905 injurious and property damage crash events, the magnitud

19 ng of Ngal-Luc2-mC mice and cells identified injurious and reparative agents that affect kidney damag

20 eurobehavioral abnormalities, including self-injurious and risk-taking behaviors, hyperactivity, and

21 spacing of brain cells and blood vessels, is injurious and triggers ischemia, gliosis, and cell death

22 e expected, inducing inflammatory, adaptive, injurious, and reparative processes.

23 relevant pharmacological strategy to reduce injurious angiopoietin-2 synthesis.

24 ApoE was not protective, but was injurious, as deletion of ApoE delayed the neurodegenera

25 Self-injurious behavior (SIB) is a complex condition that exh

26 autism spectrum disorder (ASD) display self-injurious behavior (SIB) ranging from head banging to se

27 splayed self-biting (SB; 7/20 rats) and self-injurious behavior (SIB; 1/20 rats) during APO priming,

28 ns endorse suicidality, and the rate of self-injurious behavior and suicide are markedly higher than

29 ty and elicited profound stereotypy and self-injurious behavior at 30 mg/kg.

30 nied by severe tantrums, aggression, or self-injurious behavior in children 5 to 17 years old.

31 e treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder.

32 The management of nonsuicidal self-injurious behavior is a common focus of clinical care, p

33 nd with recent and repeated suicidal or self-injurious behavior were compared in nine areas of functi

34 ciency, additional abnormalities or any self-injurious behavior were not detected.

35 as triggers to impulsive, suicidal, and self-injurious behavior, affective reactivity, and angry outb

36 Tic severity, OCD, ADHD, self-injurious behavior, and exposure to a variety of prenata

37 multiple hospitalizations, suicidal or self-injurious behavior, and substance abuse or dependence.

38 of psychopathology such as aggression, self-injurious behavior, property destruction, and pica; and

39 al manifestations, including compulsive self-injurious behavior.

40 icit hyperactivity disorder (ADHD), and self-injurious behavior.

41 ed, among other features, by compulsive self-injurious behavior.

42 athetosis, dystonia, and aggressive and self-injurious behavior.

43 tic behavioral abnormalities, including self-injurious behaviors and sleep disturbance, and distinct

44 on measures of suicidal and nonsuicidal self-injurious behaviors, health care utilization, general sy

45 ain, including suicidal and nonsuicidal self-injurious behaviors.

46 activity, and increased risk-taking and self-injurious behaviors.

47 ayer-to-player contact and other potentially injurious behaviors.

48 includes mental retardation, recurrent self-injurious behaviour and motor disability.

49 review literature published in 2004 on self-injurious behaviour in individuals with intellectual dis

50 iewed published studies of relevance to self-injurious behaviour in people with intellectual disabili

51 demonstrate the multiple influences on self-injurious behaviour that must be taken into account in t

52 rum disorders, biological influences on self-injurious behaviour, behavioural assessment and psycholo

53 The review covers the prevalence of self-injurious behaviour, the characteristics of those showin

54 ized dystonia, cognitive disability and self-injurious behaviour.

55 Though none exhibited self-injurious behaviours, many exhibited behaviours that wer

56 an also cause the unusual phenomenon of self-injurious biting, particularly when given to young mice.

57 t mdx muscle fibres are depolarized after an injurious bout of eccentric contractions.

58 receptor NR2B subunit in vivo in mice blocks injurious Ca(2+) influx through NMDA receptor channels a

59 ed a "mild irritant," which by itself is not injurious, can attenuate gastrointestinal mucosal injury

60 onal intracellular Ca(2+)-homeostasis in the injurious cascade associated with axonal degeneration.

61 an initial insult that triggers a cascade of injurious cellular processes.

62 sue responses to many acute inflammatory and injurious challenges, whereas proinflammatory and cell s

63 m, sensitizes mice to acute inflammatory and injurious challenges.

64 Our study demonstrates a highly injurious combination of TLR4-mediated NFKB signalling,

65 s increased atherosclerotic risk because the injurious component of atherosclerosis exceeds the repai

66 e subjected to uniaxial, radially-unconfined injurious compression (50% strain; 100%/second strain ra

67 Injurious compression also caused increased release and

68 Injurious compression caused the release of intracellula

69 Injurious compression of articular cartilage induces an

70 Following injurious compression of the cartilage, matrix metallopr

71 les showed little change in expression after injurious compression, whereas MMP-3 increased approxima

72 sient response of surface-layer cartilage to injurious compression.

73 , and 24 hours after application of a single injurious compression.

74 he adult heart and is induced in response to injurious conditions that promote myocardial hypertrophy

75 scriptionally activated in a wide variety of injurious conditions, including cerebral ischemia, and t

76 matory responses within the CNS milieu under injurious conditions, involving CD200 ligand (CD200L) ex

77 of electrical stimulation, such as occurs in injurious conditions, on P2X receptor-mediated ATP respo

78 To determine the role of P2X receptors under injurious conditions, we examined ATP-evoked responses i

79 r the survival of kidney tubular cells under injurious conditions.

80 he P2X7R-P2Y1-P2X3R inhibitory control under injurious conditions.

81 in the sensitization of P2X receptors under injurious conditions.

82 sue results in oxidative stress with various injurious consequences such as inflammation and fibrosis

83 of cardiac allografts leads to production of injurious cytokines and expression of proinflammatory ad

84 s and/or macrophages that produce a storm of injurious cytokines.

85 downregulating the synthesis of potentially injurious cytokines.

86 the critical organ in determining the lowest injurious dose for (2)(1)(0)Po.

87 S1 transgenic mice are protected against the injurious effect of IFN-gamma.

88 ice, suggesting that CD4 T cells mediate the injurious effect of IL-33.

89 To determine whether microglial cells exert injurious effects after neonatal focal stroke, we select

90 line morphology or morphometry but truncated injurious effects in prevention and recovery rat models

91 Whether COX-2 induces cerebroprotective or injurious effects is probably dependent on which downstr

92 letion were markedly more susceptible to the injurious effects of an intrapulmonary challenge with li

93 rovide evidence that hypoxia may amplify the injurious effects of anti-SSA/Ro antibodies.

94 verts NO(-) to NO(.), completely blocked the injurious effects of AS and exerted significant cardiopr

95 Coactivating TLR2 reduced the injurious effects of dectin-1 activation.

96 the lung may be particularly susceptible to injurious effects of FRH.

97 by the cecal mucosa protects itself from the injurious effects of H(2)S and CH(3)SH, and defects in t

98 r flatus odor and of decreasing the putative injurious effects of H2S on the colonic mucosa.

99 mune functions of neutrophils but reduce the injurious effects of increased neutrophil longevity duri

100 shock with LeTx may be related to the direct injurious effects of lethal factor on endothelial cell f

101 on of the acinar cell is responsible for the injurious effects of low pHe on the exocrine pancreas.

102 The injurious effects of native particles or DEP extracts on

103 mitochondrial delivery may contribute to the injurious effects of neurotoxins.

104 otective effects of LSS while inhibiting the injurious effects of OSS.

105 odegenerative diseases and contribute to the injurious effects of other oxidative pathologies in the

106 er CV11974 (candesartan) attenuated the cell-injurious effects of ox-LDL.

107 nts that not only protect against the direct injurious effects of oxidants, but may fundamentally alt

108 protected to a much greater extent from the injurious effects of reduced-size liver ischemia and rep

109 iet-induced hepatic UPR activation and other injurious effects of the MCD diet including hepatic chol

110 rier enhancement was sufficient to block the injurious effects of thrombin, TNF-alpha, and H2O2 in si

111 ritis model through prevention of the direct injurious effects of TWEAK on the filtration barrier and

112 rated by the respiratory muscles may lead to injurious effects on a regional level.

113 physiological roles with both favourable and injurious effects on human health.

114 High ambient glucose exerts its injurious effects on renal cells through nonenzymatic an

115 how environmental factors may influence the injurious effects on the brain of a neurotoxin such as l

116 PQ(2+)) is a prototypic toxin known to exert injurious effects through oxidative stress and bears a s

117 production of prostaglandins that have many injurious effects.

118 tered perioperatively to compensate for the "injurious" effects of anaesthesia.

119 Tachycardia exacerbates injurious episodes of myocardial ischemia and significan

120 block was sufficient to prevent these acute injurious events in metabolically compromised neurons.

121 at muscularization represents one of several injurious events to the pulmonary artery that may collec

122 Injurious events were reduced by 70% (202 in controls co

123 ave the capacity to sensitise in response to injurious events, and their loss in ageing may predispos

124 therapeutic benefit against a wide array of injurious exposures.

125 production of biologically active and tissue injurious factors by the ischemic gut.

126 buried glands, especially when challenged by injurious factors, remains largely unknown.

127 icut, we matched 122 hospitalizations for an injurious fall (59 hip-fracture and 63 other fall-relate

128 tly increased the likelihood of incurring an injurious fall during the 3-year follow-up period.

129 nits) or in the number of patients who fell, injurious fall rates, or the number of patients physical

130 llow-up, 67 men and 194 women experienced an injurious fall, and over 10 years of follow up, 203 men

131 ignificant trend toward a lower mean rate of injurious falls (13.7 vs 19.9 per 100 person-years, redu

132 1 [95% CI, 0.98-2.04]), and 4.9% vs 5.5% for injurious falls (HR, 0.91 [95% CI, 0.65-1.29]).

133 Injurious falls and fall-related hospitalizations.

134 rventions were associated with lower risk of injurious falls compared with usual care.

135 le is known about the deleterious effects of injurious falls relative to those of other disabling con

136 in men than in women, its impact on risk of injurious falls seems to be greater in men.

137 may be associated with premature mortality, injurious falls, bone fracture, and disability.

138 associated with increased rates of low BMI, injurious falls, incontinence, and vision loss.

139 ere was no association of severe sepsis with injurious falls, incontinence, vision loss, hearing loss

140 ased risk of so-called geriatric conditions (injurious falls, low body mass index [BMI], incontinence

141 d acute kidney injury or failure, but not of injurious falls, were higher in the intensive-treatment

142 in the association between pain and incident injurious falls.

143 ual care, were associated with reductions in injurious falls: exercise (odds ratio [OR], 0.51 [95% CI

144 d to friendly signals, and to defend against injurious foes.

145 or one patient but inadequate or potentially injurious for another.

146 etes) and one individual who engaged in self-injurious head banging behaviour.

147 Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants.

148 Anesthetized mice were ventilated with injurious high tidal volume ventilation for periods up t

149 o not damage tissues directly, but induce an injurious host inflammatory response at the infected sit

150 rs of DRB1*04 are protected from some of the injurious hyperglycemic effects related to nephropathy.

151 Neurons preconditioned with non-injurious hypoxia or the anesthetic isoflurane express d

152 lammasome complex, resulting in IL-1beta and injurious IL-17A production.

153 The scavenger receptor CD36 is injurious in acute experimental focal stroke and neurode

154 aling through the C5a-C5aR axis thus appears injurious in the acute period but serves a protective an

155 paired adenosine-5'-triphosphate release was injurious in vivo, in part through increased red blood c

156 Flunarizine was also able to block the injurious increase of Angpt-2 in murine endotoxemia in v

157 f T cell-mediated immune regulation to limit injurious inflammation during chronic infection.

158 tors, and pathways implicated in this tissue-injurious inflammation.

159 is is essential for clearance of potentially injurious inflammatory cells and subsequent efficient re

160 culatory system, triggering a vigorous, self-injurious inflammatory host response.

161 tive host defense mechanisms and potentially injurious inflammatory processes must be maintained.

162 cent and only poised to initiate potentially injurious inflammatory reactions via immune complex form

163 torm is an intensified, dysregulated, tissue-injurious inflammatory response driven by cytokine and i

164 avage of PLTP by cathepsin G may enhance the injurious inflammatory responses that occur in COPD.

165 rohibit or more closely regulate potentially injurious ingredients and thus promote public safety.

166 The confident identification of injurious ingredients within HDS will require strategic

167 ng axis over the sustained JNK-elevation and injurious insulin resistance in CHIP(-/-)-livers apparen

168 esophageal epithelium when it is faced with injurious insults.

169 Injurious ischaemia induced upregulation of gene express

170 By contrast, preconditioning followed by injurious ischaemia resulted in pronounced downregulatio

171 artery for 15 min (preconditioning), 60 min (injurious ischaemia), or preconditioning followed 72 h l

172 with little overlap among the conditions of injurious ischaemia, ischaemic preconditioning, or both.

173 ), or preconditioning followed 72 h later by injurious ischaemia.

174 a produces resilience to subsequent normally injurious ischemia.

175 ischemia applied at a remote site during an injurious ischemic event (remote postconditioning [RPost

176 CYP1A enzymes have been regarded as injurious largely because of their ability to activate c

177 mechanosensitive ion channels functioning at injurious levels of strain.

178 Fas is also involved in controlling injurious lymphocyte reactions in immunologically 'privi

179 tured in the arterial wall, activates tissue-injurious macrophages.

180 s indicate that disodium cromoglycate blocks injurious mast cell degranulation specifically without a

181 3 days, groups of samples were subjected to injurious mechanical compression (single uniaxial unconf

182 This study was undertaken to determine if injurious mechanical compression of cartilage explants r

183 proteoglycan (PG) degradation after in vitro injurious mechanical compression, including up-regulatio

184 Exposure to a combination of hyperoxia and injurious mechanical ventilation resulted in further mor

185 th decreased patient exposure to potentially injurious mechanical ventilation settings.

186 s induced by lung lavages and 210 minutes of injurious mechanical ventilation using low positive end-

187 s induced by lung lavages and 210 minutes of injurious mechanical ventilation using low positive end-

188 We hypothesized that injurious mechanical ventilation will increase circulati

189 ung injury (surfactant depletion followed by injurious mechanical ventilation) group and ventilated w

190 brane disruptions during another modality of injurious mechanical ventilation, i.e., mechanical venti

191 ial treatment, hospital-acquired aspiration, injurious mechanical ventilation, transfusion, and fluid

192 ome was induced by repeated lung lavages and injurious mechanical ventilation.

193 s and lung parenchyma depends on the type of injurious mechanical ventilation.

194 s induced combining saline lung lavages with injurious mechanical ventilation.

195 e intratracheal LPS treatment is followed by injurious mechanical ventilation.

196 induced by the combination of hyperoxia and injurious mechanical ventilation.

197 de the ability to rest the lungs by avoiding injurious mechanical ventilator settings and the potenti

198 uppresses proinflammatory mediators and cell injurious mechanisms in the developing brain, and postin

199 that are either antiproteinuric or may block injurious mechanisms of proteinuria.

200 nd accumulate free cholesterol, which causes injurious membrane effects.

201 ver, are periodically exposed to potentially injurious microbes and/or microbial products.

202 ocytes displayed a greater susceptibility to injurious morphologic findings induced by neutrophil gra

203 Eighty-nine adolescents who were not self-injurious (N=36) or had recently engaged in nonsuicidal

204 the excessive intracellular accumulation of injurious Na(+) and Ca(2+) and is over-expressed in acut

205 present clear examples of the protective and injurious nature of NO. therapy in I-R.

206 Microcephaly can be caused by many injurious or degenerative conditions, or by developmenta

207 Adenosine, released by cells in an injurious or hypoxic environment, possesses potent anti-

208 In response to injurious or infectious agents caspase-1 activating mult

209 can trigger diverse signaling pathways with injurious or pro-survival consequences.

210 ures are not spontaneous but are provoked by injurious or stressful stimuli.

211 n mitochondrial Ca2+ overload and consequent injurious oxygen radical production.

212 2+ overload and the consequent production of injurious oxygen radicals.

213 ent, thereby shifting the balance toward the injurious pathway.

214 This exaggerated injurious phenotype was absent in Cfh(-/-) mice deficien

215 ting that the pressure wave-transient causes injurious physical stretching and bending of most cells

216 barrier repair and facilitates formation of injurious platelet-neutrophil aggregates, contributing t

217 The injurious potential of inflammatory mediators might have

218 esponse to infection, which is a progressive injurious process that falls under the generalized term

219 gical importance of oxidative stress-induced injurious processes in chagasic heart dysfunction.

220 frequent presence and overlap of concomitant injurious processes, including hepatitis C virus and hep

221 in mitochondrial DNA, a proinflammatory and injurious product of cellular necrosis, in cell-free bro

222 lated oxidase in mediating the production of injurious reactive oxygen species, which contribute to a

223 topoietic stem cells, mediated by both their injurious renal and systemic actions.

224 mice with Shank3 gene deletions exhibit self-injurious repetitive grooming and deficits in social int

225 and dendritic cells) promote immune-mediated injurious responses in the failing heart and retain this

226 s responsible for dysregulated repair during injurious responses.

227 of lung function, enhanced emphysematous and injurious responses.

228 T1) deacetylase during lung inflammatory and injurious responses.

229 gulation of CS-induced lung inflammatory and injurious responses.

230 cal paradigm, in which ROS play an immediate injurious role (as mediators of stunning) followed by a

231 t genetic studies have strongly supported an injurious role for complement in a wide array of human i

232 Having recently described the injurious role of caspase-1-mediated production of the p

233 increased hepatic warm IR injury, suggesting injurious roles of DC infusion.

234 activated macrophages/monocytes mediates the injurious sequelae of inflammation, septic shock, tissue

235 e convergence of Ca(2+)- and Zn(2+)-mediated injurious signaling pathways, providing a potentially un

236 Ischemic stroke results in multiple injurious signals within a cell including dysregulation

237 ive potential of the acinar cell to mitigate injurious states such as pancreatitis.

238 ghts into how the kidney responds to various injurious stimuli and allow evaluation of new therapeuti

239 ndothelial cells in response to a variety of injurious stimuli and recently have been shown to be inc

240 The biochemical pathways activated by these injurious stimuli are described herein and will serve as

241 fluence the sensitivity of neuronal cells to injurious stimuli by modulating calcium-dependent apopto

242 ng system is a point of convergence at which injurious stimuli can trigger and amplify both acute inf

243 Sublethal injurious stimuli in neurons induce transient increases

244 phagocytosing macrophage (Mphis) that clear injurious stimuli leading to resolution and tissue homeo

245 pass (CP/CPB) subjects myocardium to complex injurious stimuli that can result in cardiomyocyte and v

246 ith cystic fibrosis with hypersensitivity to injurious stimuli, biofilm PsaDM activated p38alpha MAPK

247 ng the BSCB and/or removing the BSCB-derived injurious stimuli, we now identify that accumulation of

248 ithelial response to ligands, pathogens, and injurious stimuli.

249 nsmigration, and enhance resistance to local injurious stimuli.

250 of neuronal apoptosis following a variety of injurious stimuli.

251 rticipate in morphogenesis and to respond to injurious stimuli.

252 as an adaptive response to a wide variety of injurious stimuli.

253 aining mucosal homeostasis in the absence of injurious stimuli.

254 ologic responses to a variety of potentially injurious stimuli.

255 volved in early transcriptional responses to injurious stimuli.

256 cells in vivo, are down-regulated following injurious stimuli.

257 ndothelial cell (EC) hyperpermeability after injurious stimuli.

258 roprotective phenomenon by which a sublethal injurious stimulus renders the brain resistant to a subs

259 foundly shift the host response to a defined injurious stimulus, in part by augmenting delivery of ne

260 in critically ill patients in response to an injurious stimulus.

261 zo-mediated cartilage mechanotransduction of injurious strains.

262 in kinase p38 mediates cellular responses to injurious stress and immune signaling.

263 Labeling after removal of injurious stress revealed significantly fewer injured ce

264 es acute inflammation in the adult lung, and injurious styles of mechanical ventilation can result in

265 defects, hearing loss and autistic and self-injurious tendencies also frequently occur.

266 nic inflammation that is characterized by an injurious Th2 immune response.

267 ors examined a new method that measures self-injurious thoughts by using individuals' reaction times

268 The assessment of self-injurious thoughts has been limited by a reliance on wha

269 Test as a performance-based measure of self-injurious thoughts.

270 crobial therapy, mechanical ventilation with injurious tidal volumes, hospital-acquired aspiration, a

271 eyes, although useless, could be in any way injurious to animals living in darkness, I attribute the

272 duction of viral and cellular immune factors injurious to human neurons.

273 ndicating that upregulated COX-2 activity is injurious to neurons.

274 iolence; fighting and fleeing actions can be injurious to patients as well as bed partners.

275 patic accumulation; NSAIDs may be especially injurious to patients with alpha(1)-AT deficiency, possi

276 PF may be difficult and potentially injurious to the donor kidney, especially in grafts with

277 controlled secretion of neutrophil cargos is injurious to the host and should be closely regulated.

278 Anti-OVA IgG is not directly injurious to the islets but rather enhances cross-presen

279 Mechanical ventilation is injurious to the lung.

280 ical ventilation with large tidal volumes is injurious to the lung.

281 ence that poor ventilatory technique that is injurious to the lungs can propagate the systemic inflam

282 hanisms that can diminish lapses in research injurious to the public's trust.

283 protective against infection, these NETs are injurious to tissue.

284 the with large tidal volumes and potentially injurious transpulmonary pressure swings.

285 responses throughout the body, resulting in injurious vascular leakage and organ inflammation.

286 The exposure to potentially injurious ventilation decreased after the intervention f

287 Prone positioning was protective against injurious ventilation in rats.

288 Injurious ventilation induces MAPK in an MKP-1-dependent

289 nd transient, whereas in lungs labeled after injurious ventilation propidium iodide fluorescence iden

290 In lungs labeled during injurious ventilation, propidium iodide fluorescence ide

291 ere perfused ex vivo, either during or after injurious ventilation, with a solution containing the me

292 al target for modulating regional effects of injurious ventilation.

293 m iodide was perfused either during or after injurious ventilation.

294 ated patients accurately detects potentially injurious ventilator settings and is able to influence b

295 e text paging notification about potentially injurious ventilator settings.

296 ation of bedside providers about potentially injurious ventilator settings.

297 Both injurious ventilatory protocols developed comparable lev

298 Biotrauma due to injurious ventilatory strategies can lead to the release

299 ATP levels were maintained during hypoxia to injurious when reoxygenation followed glucose and ATP de

300 ervice listed 201 species of salamanders as "injurious wildlife" under the Lacey Act (18 U.S.C. secti