ライフサイエンスコーパス: intraretinal

1 cal coherence tomography, 83% had fluid (61% intraretinal, 38% subretinal, and 36% sub-retinal pigmen

2 Macular hemorrhages most often were intraretinal (40%).

3 Intraretinal 67LR immunoreactivity diminished beyond P17

4 Intraretinal accumulations of fluid with increased OCT s

5 Intraretinal activation of immune modulators was assesse

6 monstrated minimal choroidal contribution to intraretinal analysis.

7 The distinctive intraretinal anatomy suggests that MME is caused by retr

8 segmentation we quantitatively measured the intraretinal anatomy.

9 mechanisms, in addition to playing a role in intraretinal and intratectal organization.

10 curately detect, differentiate, and quantify intraretinal and SRF using area under the receiver opera

11 th gas tamponade for creation of a permanent intraretinal and subretinal fluid barrier.

12 on of brolucizumab-treated eyes had resolved intraretinal and subretinal fluid compared with afliberc

13 in eyes with persistent fluid by fluid type (intraretinal and subretinal fluid).

14 emorrhages involving the optic nerve sheath, intraretinal and subretinal hemorrhages, and macular fol

15 Intraretinal and subretinal hyperreflective foci as seen

16 al telangiectasis') which results in massive intraretinal and subretinal lipid accumulation (exudativ

17 t VEGF overexpression is sufficient to cause intraretinal and subretinal neovascularization.

18 of VEGF in the retina is sufficient to cause intraretinal and subretinal NV and provides a valuable n

19 test antiangiogenic agents for inhibition of intraretinal and subretinal NV.

20 Intraretinal and subretinal temperature increases were m

21 nt epithelium), type 2 (subretinal), type 3 (intraretinal), and mixed neovascularization (NV), respec

22 evaluated while performing retinal surface, intraretinal, and subretinal maneuvers in cadaveric porc

23 eeks of follow-up with gradual resolution of intraretinal- and subretinal fluid, and remained stable

24 uingly, a small population of M1 ipRGCs have intraretinal axon collaterals that project toward the ou

25 and Slit2, regulate two distinct aspects of intraretinal axon guidance in a region-specific manner.

26 In mice lacking robo1 intraretinal axon guidance occurs normally.

27 The intraretinal axon guidance thus serves as an excellent m

28 ay, Robo2 is the major receptor required for intraretinal axon guidance.

29 requirement for Hedgehog (Hh) signaling for intraretinal axon pathfinding and show that Shh acts to

30 regional specificity of Slit function during intraretinal axon pathfinding.

31 idance molecule ephrinB2, was increased, and intraretinal axons were disorganised resulting in a fail

32 Intraretinal axotomy was achieved by multiple treatments

33 cell axons in living rats for 4 weeks after intraretinal axotomy.

34 The intraretinal b- and c-wave amplitudes decreased most dra

35 Longer, weaker flashes were used to elicit intraretinal b- and c-waves.

36 Hyperoxia during occlusion preserved intraretinal b-wave amplitude at 86% +/- 12% of normal;

37 gas tamponade can safely create an effective intraretinal barrier to fluid egress from the optic disc

38 An effective intraretinal barrier to fluid migration from cavitary op

39 a is separated from its normal choroidal and intraretinal blood supplies.

40 Intraretinal blood vessel formation was quantitated by i

41 No effect was seen on intraretinal blood vessel growth.

42 tantial and boosts the membrane potential of intraretinal blood vessels to a suprahyperpolarized leve

43 ied quantum dots in the choriocapillaris and intraretinal capillaries upon i.v. injection and 1-h cir

44 distinctive traits included the presence of intraretinal cavitation that could affect all retinal la

45 Multiple RPE fates in AMD, including intraretinal cells that are highly prognostic for progre

46 ignaling pathway contributes to formation of intraretinal circuitry in the neural retina.

47 Intraretinal concentrations of glutamate and its main tr

48 ers, suggesting a role in the development of intraretinal connections.

49 The intraretinal connectivity consists of the fundamental fe

50 strophy characterized by multiple glistening intraretinal crystals scattered over the fundus, a chara

51 ased macular thickness and the absence of an intraretinal cyst.

52 plete closure of the FTMH with resolution of intraretinal cystic changes was confirmed on OCT at 16 m

53 cribed features such as fluorescein-negative intraretinal cystic changes, choroidal neovascularizatio

54 ic patterns of fluid presentation, including intraretinal cystic spaces (ICS), retinal pigment epithe

55 tical coherence tomography revealed multiple intraretinal cystic spaces and hyperreflective deposit i

56 yporeflective lumen, typically surrounded by intraretinal cystic spaces.

57 earning to automatically detect and quantify intraretinal cystoid fluid (IRC) and subretinal fluid (S

58 Assessed morphologic parameters included intraretinal cystoid fluid (IRC), subretinal fluid (SRF)

59 y masked reading centers for the presence of intraretinal cystoid fluid (IRC), subretinal fluid (SRF)

60 Intraretinal cystoid spaces were observed in 34 eyes (68

61 n sham-treated patients by submacular fluid, intraretinal cystoid spaces, and renal disease.

62 d patients, and by poor baseline BCVA, large intraretinal cystoid spaces, renal disease, and absence

63 showing retinal morphologic changes, such as intraretinal cysts (IRCs), subretinal fluid (SRF), and p

64 was assessed by standardized OCT, including intraretinal cysts (IRCs), subretinal fluid (SRF), and p

65 esence of features of nAMD disease activity (intraretinal cysts [IRC], subretinal fluid [SRF], diffus

66 Intraretinal cysts consistently showed the lowest BCVA g

67 f active myopic CNV (either subretinal fluid/intraretinal cysts on SD OCT or dye leakage on fluoresce

68 Intraretinal cysts resolved most rapidly followed by SRF

69 coherence tomography can clearly demonstrate intraretinal cysts which may not be clinically detectabl

70 Elimination of submacular fluid, intraretinal cysts, and severe thickening are important

71 Occurrence of intraretinal cysts, DRIL length, and lens status were si

72 l 1-mm subfield thickness, the occurrence of intraretinal cysts, ellipsoid zone disruption, and disor

73 Patients with DME and submacular fluid, intraretinal cysts, severe thickening, or renal disease

74 The exact intraretinal depth of microaneurysms on OCTA was localiz

75 roaneurysms than FA, but located their exact intraretinal depth.

76 eration characterized by multiple glistening intraretinal dots scattered over the fundus, degeneratio

77 ing degrees of venous stasis retinopathy and intraretinal edema overlying the macular detachment.

78 f these features include photoreceptor loss, intraretinal edema, and retinal thinning overlying choro

79 oreceptors overlying choroidal melanoma; and intraretinal edema, retinoschisis, and retinal thinning

80 increased retinal vessel leakage and caused intraretinal edema.

81 Intraretinal ERGs were recorded before, during, and afte

82 Vitreal and intraretinal ERGs were recorded from eight dark-adapted,

83 l architecture, cystoid macular edema (CME), intraretinal exudates and subretinal lipid aggregation,

84 ge (n = 4), subretinal fluid (n = 4), and/or intraretinal exudation (n = 1).

85 ssociated with small retinal hemorrhages and intraretinal exudation.

86 as found for eyes that displayed fluid, NSD, intraretinal flecks, and low reflectivity or undefined b

87 fluid; 68% and 88% for NSD; 81% and 83% for intraretinal flecks; 63% and 92% for undefined boundarie

88 8 mm2, P < .001), and higher proportions of intraretinal fluid (82.5% vs 51.0%, P < .001), subretina

89 ere created on the basis of baseline CME and intraretinal fluid (IRF) status: (1) CME, (2) IRF withou

90 dependently graded OCT scans for presence of intraretinal fluid (IRF), subretinal fluid (SRF), and su

91 tal thickness at the foveal center point and intraretinal fluid (IRF), subretinal fluid (SRF), and su

92 At 2 years, intraretinal fluid (IRF), subretinal fluid (SRF), sub-re

93 Intraretinal fluid (IRF), subretinal fluid (SRF), subret

94 TA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathie

95 teristics included subretinal fluid (n = 5), intraretinal fluid and cysts (n = 1), and subretinal hyp

96 reported to be "inactive" (i.e., absence of intraretinal fluid and hemorrhages).

97 differences in the presence of subretinal or intraretinal fluid at final evaluation, dye leakage on a

98 llow eye (aHR, 2.07; 95% CI, 1.40-3.08), and intraretinal fluid at the foveal center (aHR, 2.10; 95%

99 osits, subretinal fibrous scars, and cystoid intraretinal fluid collections in the macula.

100 For C3, the proportion with intraretinal fluid decreased from 78% to 69% to 64% (P =

101 circumscribed vessels, subretinal fluid, and intraretinal fluid each were seen in 71% (22/31).

102 nts (50%) had edema resolution defined as no intraretinal fluid for 6 months or more after the last i

103 here was a reduction of either subretinal or intraretinal fluid in 18 of 36 (50.0%) of the treated ey

104 0% to 12% (P = .05), and the proportion with intraretinal fluid increased from 72% to 71% to 82% (P =

105 7 25-line raster scans confirmed subretinal/intraretinal fluid not identified by the 6-line radial (

106 oth eyes showed improvement in subretinal or intraretinal fluid on OCT.

107 RPE drusen complex abnormal thinning volume, intraretinal fluid or cystoid spaces, hyperreflective fo

108 nable immunoglobulins along with accumulated intraretinal fluid to flow into the subretinal space, cr

109 tion (RAP) lesion, GA in the fellow eye, and intraretinal fluid were associated with a higher risk of

110 sed macular thickness and an accumulation of intraretinal fluid, indicating macular oedema.

111 e risk factors included poor VA, RAP, foveal intraretinal fluid, monthly dosing, and treatment with r

112 reasing age, increasing CST, the presence of intraretinal fluid, pigment epithelial detachment, and s

113 -scans of each cube scan for the presence of intraretinal fluid, subretinal fluid, and sub-retinal pi

114 in year 2 were treated with ranibizumab for intraretinal fluid.

115 lectivity and the presence of subretinal and intraretinal fluid.

116 6/7) had subretinal fluid, and 14% (1/7) had intraretinal fluid.

117 rcumscribed), and presence of subretinal and intraretinal fluid.

118 >/=20/40), scar (OR 2.21, 95% CI:1.22-4.01), intraretinal foveal fluid on optical coherence tomograph

119 The results demonstrated that intraretinal ganglion cell axons are predominantly varic

120 Intraretinal ganglion cell axons of seven human donors (

121 Varicosities of the intraretinal ganglion cell axons were found throughout t

122 In BCNS, the intraretinal glial response results in epiretinal membra

123 zing the PLR as an assay for the efficacy of intraretinal grafts has highlighted the significance of

124 subtle but significant mistakes during their intraretinal growth and inappropriately defasciculate al

125 he retina, the optic disc, a process termed "intraretinal guidance".

126 bullous retinal schisis with pre-retinal and intraretinal haemorrhages.

127 t most features; however, with limitation to intraretinal hemorrhage and pigment migration.

128 namic therapy-related complications included intraretinal hemorrhage in 1 eye.

129 hy; however, lower for pigment migration (or intraretinal hemorrhage).

130 le a vaso-occlusive event and include edema, intraretinal hemorrhage, and nonperfusion detected by fl

131 leads to impaired blood vessel sprouting and intraretinal hemorrhage, particularly during formation o

132 y caused focal columns of retinal injury and intraretinal hemorrhages from retinal vessel bleeding, w

133 g of the optic nerve, macular edema, diffuse intraretinal hemorrhages, and dilated and tortuous retin

134 Cotton-wool spots, intraretinal hemorrhages, and hard exudates in the macul

135 e included multifocal choroiditis, vitritis, intraretinal hemorrhages, iritis, keratic precipitates,

136 This study sought to quantify the change in intraretinal HF distribution and its correlation with ag

137 presence of ultrastructural features such as intraretinal hyperreflective flecks and the inherent ref

138 Intraretinal hyperreflective foci associated with acquir

139 e use of cholesterol-lowering medication and intraretinal hyperreflective foci attributable to RPE ce

140 Intraretinal hyperreflective foci correlated with intrar

141 ons were observed prior to the occurrence of intraretinal hyperreflective foci in 75% of cases.

142 tion was significantly associated with SDOCT intraretinal hyperreflective foci in the 314 study eyes

143 retinal anatomic changes and the pattern of intraretinal hyperreflective foci migration were documen

144 defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT i

145 Histologic evaluation showed that intraretinal hyperreflective foci represent cells of ret

146 One donor eye with intraretinal hyperreflective foci was identified in a pa

147 The occurrence of intraretinal hyperreflective foci was not a significant

148 The appearance of intraretinal hyperreflective foci was preceded by thicke

149 Intraretinal hyperreflective foci were associated with a

150 the abundance of lines and association with intraretinal hyperreflective foci.

151 surrounded by thick delaminated retina with intraretinal hyperreflective lesions.

152 irregularities, abnormal retinal thickness, intraretinal hyperreflective/hyporeflective features, an

153 r than FP for abnormal retinal thickness (or intraretinal hyporeflective features); similar as FP for

154 Intraretinal immunofluorescence of ApoB100 increased wit

155 ation within the retina and exert widespread intraretinal influence.

156 nimals were anterogradely labeled with small intraretinal injections of the lipophilic dye 1,1'-dioct

157 Central intraretinal ion activity and retinal thickness were mea

158 Central retinal thickness and intraretinal ion activity were measured from the MEMRI d

159 Central retinal thickness and intraretinal ion channel regulation were measured from t

160 Intraretinal ion demand and retinal thickness were measu

161 Panretinal TI(v) was not correlated with intraretinal ion demand in any case.

162 owerful approach for measuring alteration in intraretinal ion demand in models of ocular injury.

163 nhanced MRI (MEMRI), assesses alterations in intraretinal ion demand in models of ocular insult.

164 irst-time evidence for changes (P < 0.05) in intraretinal ion regulation before and during pathologic

165 tive foci (HRF), average and largest area of intraretinal (IR) cysts, and extent of disruption of ext

166 Enzymatic cleavage of intraretinal laminin is a biologically plausible mechani

167 OCT scanning, including automated intraretinal layer segmentation, yielded thicknesses of

168 t algorithm (OCTRIMA) to measure locally the intraretinal layer thickness.

169 eflectance and fractal dimension) of various intraretinal layers extracted from optical coherence tom

170 ne photoreceptor length and the thickness of intraretinal layers were measured and compared to previo

171 Among the intraretinal layers, the inner nuclear layer was identif

172 murine retina and visualization of all major intraretinal layers.

173 In Akita mouse retinas, diabetes increased intraretinal levels of oxidized LDL and glycated LDL, in

174 inal injection of 1% hyaluronic acid and the intraretinal levels of the autophagy proteins LC3 and At

175 acute retinal injury (consisting of abnormal intraretinal light scattering) were visualized in vivo i

176 Intraretinal manganese ion uptake and retinal thickness

177 of young and aged mice revealed a subnormal intraretinal manganese uptake (P < 0.05) in aged DBA/2J

178 provide proof-of-concept that the extent of intraretinal manganese uptake after systemic MnCl(2) inj

179 In diabetic WT mice, intraretinal manganese uptake became subnormal between 1

180 In separate experiments, intraretinal manganese uptake was also measured in adult

181 After sodium iodate exposure, intraretinal manganese uptake was supernormal (P < 0.05)

182 adult rats, diltiazem suppressed (P < 0.05) intraretinal manganese uptake.

183 These intraretinal measurements in cats provide further eviden

184 However, macular intraretinal measurements still have not overcome standa

185 raphy showed a normal foveal contour without intraretinal microcystic spaces and a resolution of the

186 In severe NPDR, the eyes with intraretinal microvascular abnormalities (IRMA) had a si

187 Formation of small intraretinal microvascular abnormalities (IRMAs) and mic

188 Moderate agreement of intraretinal microvascular abnormalities and venous bead

189 the percent of capillary length involved in intraretinal microvascular abnormalities, expressed as h

190 ose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium

191 potential of these resident cells to act as intraretinal modulators of immune and inflammatory respo

192 dal anastomosis was found, 3 patients showed intraretinal neovascularization connected with a pigment

193 Abnormal flow was defined as intraretinal neovascularization or retinal choroidal ana

194 tion of Srf in adult murine vessels elicited intraretinal neovascularization that was reminiscent of

195 pithelial detachment, 2 patients showed only intraretinal neovascularization, and in 2 patients flow

196 blood-retinal barrier breakdown and, later, intraretinal neovascularization.

197 nting extrinsic macrophages, were present in intraretinal ON region, but not in the retroscleral (iso

198 t was worst for subretinal fluid compared to intraretinal or sub-retinal pigment epithelial fluid.

199 within 6 months with classic features of new intraretinal or sub-retinal pigment epithelium infiltrat

200 es with and without persistent fluid (cystic intraretinal or subretinal fluid at all 4 initial visits

201 In 11 of 19 patients with intraretinal or subretinal fluid at baseline judged to b

202 eneration who exhibit recurrent or resistant intraretinal or subretinal fluid following multiple inje

203 line at the last follow-up and/or persistent intraretinal or subretinal fluid or detectable choroidal

204 Retreatment indication was recurrence of intraretinal or subretinal fluid or new hemorrhage.

205 Retreatment criteria relying on intraretinal or subretinal fluid or new hemorrhages may

206 nthly with intravitreal bevacizumab until no intraretinal or subretinal fluid was observed on optical

207 ts with resistant or multiple recurrences of intraretinal or subretinal fluid while receiving monthly

208 r irregularity of each category (epiretinal, intraretinal, or RPE/choroidal irregularity), 3D-OCT was

209 n of tempol, a superoxide scavenger, reduced intraretinal oxidized LDL and glycated LDL levels, PGIS

210 Intraretinal oxidized LDL was absent in nondiabetic subj

211 Intraretinal oxygen (PO2) profiles were recorded with ox

212 Intraretinal (P < .001) and subretinal (P < .001) fluid

213 Intraretinal (P = .003) and subretinal (P = .046) fluid

214 e qualitatively and quantitatively identical intraretinal pathfinding errors to those reported previo

215 PL appeared to have a saw-tooth appearance ("intraretinal peaks") in 12 eyes (75%).

216 After 1 day, the intraretinal photocoagulation lesions were sharply demar

217 nation features included macular edema, mild intraretinal pigment migration, and widespread atrophy i

218 heral retinal pigment epithelial atrophy and intraretinal pigment migration.

219 eposits, differing from the classic spicular intraretinal pigmentation observed in other individuals

220 ensitive microelectrodes were used to record intraretinal Po(2) profiles from healed photocoagulation

221 Intraretinal PO2 was measured with microelectrodes in th

222 does not cause the immediate degeneration of intraretinal portions of axons or the immediate death of

223 Finally, all myelinated intraretinal profiles are GABA+, suggesting that some ef

224 s used to calculate the fractal dimension in intraretinal regions of interest identified in the image

225 Increased peripheral intraretinal retinal manganese uptake was associated wit

226 The solid intraretinal retinoblastoma and subretinal seeds showed

227 extent of preretinal neovascularization and intraretinal revascularization was quantified by image a

228 rovascular networks were analyzed to examine intraretinal revascularization, capillary sprouting, and

229 These results support an intraretinal role for Eph family members in addition to

230 retinal hyperreflective foci correlated with intraretinal RPE and lipid-filled cells of probable mono

231 Intraretinal RPE migration was defined by the presence o

232 Overall, our results showed that intraretinal RPE migrations occurred in various AMD stag

233 The OCT showed intraretinal schitic cavities in the majority of eyes.

234 Intraretinal signal intensity returned to baseline by 7

235 results identify retinal Muller cells as an intraretinal source of TNF alpha and IL-6 and support th

236 Hyporeflective intraretinal spaces, indicating cystoid or schitic fluid

237 Here, we test the hypothesis that intraretinal spin-lattice relaxation rate in the rotatin

238 Intraretinal steric interactions as well as electronic e

239 Blood flow was mostly confined to the intraretinal structures with or without a connecting pig

240 and progressing to the subretinal space with intraretinal, subretinal, and choroidal angiogenic stage

241 in optical coherence tomography (presence of intraretinal, subretinal, and subretinal pigment epithel

242 omic improvement in patients with persistent intraretinal, subretinal, or subretinal pigment epitheli

243 aflibercept injection due to the presence of intraretinal/subretinal fluid and pigment epithelial det

244 macular thickness (CMT), and the presence of intraretinal/subretinal fluid and the height and presenc

245 and 25-line raster scans were evaluated for intraretinal/subretinal fluid and, when applicable, vitr

246 dth, as well as of peripapillary and macular intraretinal thickness measurements.

247 ver a mean of 13 months follow-up, there was intraretinal tumor recurrence (n = 1), subretinal seed r

248 Peripheral intraretinal uptake of manganese was significantly super

249 , and a surrogate of retinal ion regulation (intraretinal uptake of manganese) were assessed from MEM

250 Intraretinal variation in opsin abundance consisted of g

251 roduction leads to characteristic defects in intraretinal vascular architecture.

252 eovascular complexes is transmitted into the intraretinal vascular network.

253 cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits

254 e that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and

255 required for generating and maintaining the intraretinal vasculature through precise regulation of h

256 erating vessels and also within the adjacent intraretinal vasculature.

257 Intraretinal vessel development was not altered by the i

258 cytes, and staining was increased around new intraretinal vessels in mouse OIR and rat retinopathy of

259 el, while not significantly affecting normal intraretinal vessels, it holds therapeutic potential for

260 ark adaptation of M-cones driven by both the intraretinal visual cycle and the retinal pigmented epit