ライフサイエンスコーパス: lamellipodia

1 een the long-axis direction of two different lamellipodia).

2 activity and drives its localization within lamellipodia.

3 MRCKalpha colocalize at the cell membrane in lamellipodia.

4 y compressed axial cell length and collapsed lamellipodia.

5 location to and efficient incorporation into lamellipodia.

6 d is required for Rac1-mediated formation of lamellipodia.

7 cells, where it colocalizes with F-actin in lamellipodia.

8 number and disturbed orientation of cellular lamellipodia.

9 unction in live fibroblasts with established lamellipodia.

10 tion between cells is mediated by protruding lamellipodia.

11 ited elongated cellular tails and diminished lamellipodia.

12 axillin-based focal adhesion within the same lamellipodia.

13 leton in the apical cortex and in protruding lamellipodia.

14 play growth cones with significantly smaller lamellipodia.

15 protein accumulation at the leading edge of lamellipodia.

16 e line depleted of Arp2/3 complex that lacks lamellipodia.

17 of SMN and actin at the leading edge at the lamellipodia.

18 n inactive conformation and localizes to the lamellipodia.

19 elationship between VIF and the formation of lamellipodia.

20 timal protrusion speed for the actin mesh in lamellipodia.

21 h APCs, likely due to defective formation of lamellipodia.

22 nt to induce filopodia, together they induce lamellipodia.

23 dilator-stimulated phosphoprotein-containing lamellipodia.

24 nding to integrin-linked kinase (ILK) in the lamellipodia.

25 anized actin filament structures and induced lamellipodia.

26 modulates the balance between filopodia and lamellipodia.

27 ce of paxillin-containing focal adhesion and lamellipodia.

28 wth factor-stimulated membrane protrusion at lamellipodia.

29 ovarian cancer cells with PI3KC2beta-driven lamellipodia.

30 lting in FAK activation and the formation of lamellipodia.

31 logy of their tips, which lack filopodia and lamellipodia.

32 ells increased F-actin and Arp2/3 complex in lamellipodia.

33 s templates for formation and orientation of lamellipodia.

34 ated by the Arp2/3 complex, forming ruffling lamellipodia.

35 (Arp2/3) complex in the membrane ruffles and lamellipodia.

36 and filopodial spike-based protrusions, not lamellipodia.

37 es, which are essentially stand-alone motile lamellipodia.

38 luding protrusions ranging from filopodia to lamellipodia.

39 zed HGF-mediated effects on the formation of lamellipodia, a pre-requisite for migration using human

40 on two-dimensional (2D) surfaces by forming lamellipodia-actin-rich extensions at the leading edge o

41 rin-mediated adhesion and down-regulation of lamellipodia activity and a cytosolic pool that down-reg

42 sion complexes and that E-cadherin regulates lamellipodia activity and cell migration directionality,

43 However, E-cadherin adhesion dampened lamellipodia activity on both collagenIV and EcadFc surf

44 bsence of INF2 led to defective formation of lamellipodia and abnormal SD trafficking.

45 KAI1/CD82, consistent with the diminution of lamellipodia and actin cortical network; while the growt

46 riphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent w

47 ion of SphK1/p-SphK1 with actin/cortactin in lamellipodia and down-regulation or inhibition of SphK1

48 lls along the edge of a wound still extended lamellipodia and elongated toward the wound but were inh

49 filament networks required for formation of lamellipodia and endocytic actin structures.

50 The formin mDia2 mediates the formation of lamellipodia and filopodia during cell locomotion.

51 ct in parallel to control actin dynamics and lamellipodia and filopodia formation during axon guidanc

52 well as p21-activated kinase (PAK)-mediated lamellipodia and filopodia formation following bradykini

53 imulation, but does not affect PAK-meditated lamellipodia and filopodia formation following PDGF and

54 nteraction is essential for the formation of lamellipodia and filopodia in migrating cells.

55 rc2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones.

56 In lamellipodia and filopodia, actin polymerization directl

57 growth cone reads guidance cues and extends lamellipodia and filopodia, actin-based structures that

58 trated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in o

59 , observed as cytoskeleton protrusions-i.e., lamellipodia and filopodia-were reduced after treatment.

60 nt manner and induced the retraction of MVEC lamellipodia and filopodia.

61 actin-rich cell surface projections such as lamellipodia and filopodia.

62 es of cell-cell contact, the leading edge of lamellipodia and focal adhesions.

63 from a dense meshwork of actin filaments in lamellipodia and from actin bundles in the filopodia.

64 ed, in neuronal cells alpha-COP localizes to lamellipodia and growth cones and moves within the axon,

65 Actinin-4 associates with lamellipodia and has been implicated in regulating lamel

66 actuated retraction of macrophage front end lamellipodia and induced loss of cell polarity.

67 romoted nascent FA formation and turnover in lamellipodia and inhibited the frequency and rate of FA

68 that did not diffuse rapidly enough to enter lamellipodia and instead stably bound adhesion complexes

69 and kinetics of cell protrusions, including lamellipodia and invadopodia.

70 Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, bu

71 CARMIL1 localized to lamellipodia and macropinosomes, and loss of its functio

72 rotein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to B

73 Arpc2(-/-) cells lack lamellipodia and migrate more slowly than WT cells but h

74 the newly accessible free space by extending lamellipodia and migrating into the gap.

75 actin bundling facilitates the formation of lamellipodia and normal immunological synapses and there

76 inct F-actin-rich membrane structures called lamellipodia and phagocytic cups.

77 f small, mobile M1-AQP4-enriched arrays into lamellipodia and preferential interaction of large, M23-

78 generated branched actin networks comprising lamellipodia and pseudopodia by virtue of its ability to

79 we triggered highly localized retraction of lamellipodia and redirection of polarization and migrati

80 ed p47(phox)/Cortactin/Rac1 translocation to lamellipodia and ROS generation.

81 , which is essential for AbpG to localize to lamellipodia and to rescue the phenotype of abpG(-) cell

82 ed geometries exhibit polarized extension of lamellipodia and upon release, migrate preferentially al

83 cells trigger cycles of retraction of local lamellipodia and, concomitantly, strengthen local adhesi

84 types, including actin polymerization-driven lamellipodia, and contractility-driven blebs.

85 The activity of Rac, formation of stable lamellipodia, and directed migration are restored in bet

86 l elongation and cell body rounding, loss of lamellipodia, and formation of thick membrane extensions

87 morphology, the development of filopodia and lamellipodia, and phagocytosis of WNV-infected cells and

88 ocal adhesions, as well as from the front of lamellipodia, and strongly reduced cell invasion.

89 EGF led to cell polarization in the form of lamellipodia, and this occurred through a mechanism invo

90 osolic alphaE-catenin to mitochondria alters lamellipodia architecture and increases membrane dynamic

91 Protrusion and retraction of lamellipodia are common features of eukaryotic cell moti

92 Lamellipodia are dynamic actin-rich cellular extensions

93 r order structures such as stress fibers and lamellipodia are fundamental for cell migration and adhe

94 However, the mechanisms by which new lamellipodia are initiated and directed are unknown.

95 Lamellipodia are networks of actin filaments generated a

96 However, recent reports indicate that lamellipodia are not required for cell movement, suggest

97 o shallow gradients of PDGF, indicating that lamellipodia are not required for fibroblast chemotaxis.

98 One implication is that lamellipodia are only marginally important for cell migr

99 Lamellipodia are sheet-like protrusions formed during mi

100 Lamellipodia are sheet-like, leading edge protrusions in

101 Although lamellipodia are widely believed to be critical for dire

102 unction formation in endothelial cells using lamellipodia as the initial protrusive contact, subseque

103 to larger cell size and remarkably developed lamellipodia as well as accumulation of filamentous acti

104 equirements of transitions between blebs and lamellipodia, as well as the time scales on which they o

105 he Scar/WAVE regulatory complex (WRC) drives lamellipodia assembly via the Arp2/3 complex, whereas th

106 vestigated the possible role of INF2 in both lamellipodia-associated actin dynamics and actin-depende

107 adhesion sites via intermittently appearing lamellipodia at established cell junctions.

108 thesis that the principal role of cofilin in lamellipodia at steady state is to break down F-actin, c

109 a stationary cell, the cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the

110 ep during cell migration is the formation of lamellipodia at the leading edge of migrating cells.

111 cell migration by securing the formation of lamellipodia at the leading edge of the cell.

112 ment of front-rear polarity and formation of lamellipodia at the leading edge.

113 y, tumor cells overexpressing Dyn2 protruded lamellipodia at twice the rate, migrated faster (180%) a

114 or myosin II activity switched the cells to lamellipodia-based 3D migration.

115 A second lamellipodia-based function-cell spreading-was also defe

116 Arp2/3 complex is also crucial to lamellipodia-based migration of keratocytes.

117 ablished that nonlinear elasticity supported lamellipodia-based migration, whereas linear elasticity

118 argeted to the leading edge, consistent with lamellipodia-based migration.

119 by implicating CP in filopodia as well as in lamellipodia, both of which are important for locomotion

120 the distal margin of membrane protrusions or lamellipodia but a mutant NHE1-KRA2 lacking binding site

121 ARPC3(-/-) fibroblasts were unable to extend lamellipodia but generated dynamic leading edges compose

122 bolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and m

123 etwork density and protrusion persistence of lamellipodia by controlling the state of actin-driven pr

124 They also regulate lamellipodia, can promote actin nucleation, and are requ

125 embrane protrusions, such as multiple blebs, lamellipodia, combinations of both, or absence of any su

126 animal cells initiate crawling by protruding lamellipodia, consisting of a dense network of actin fil

127 hermore, rapid transitions between blebs and lamellipodia could also be triggered upon changes in sub

128 In lamellipodia, CP dissociates from the actin cytoskeleton

129 cells, showing the cytoskeleton dynamics in lamellipodia during protrusion and mitochondria displace

130 ortant in vivo as well, for the formation of lamellipodia during the ventral enclosure event of Caeno

131 cell types, coronins exert their effects on lamellipodia dynamics by an inhibitory interaction with

132 Capping protein in regulating filopodia and lamellipodia dynamics in Drosophila melanogaster cells a

133 f polarity, as evidenced by the formation of lamellipodia encircling the entire cell, as well as redu

134 First, polarized lamellipodia extend mediolaterally and make new C-cadher

135 s into the Arp2/3 complex's critical role in lamellipodia extension and directional fibroblast migrat

136 inant-negative (DN) tail-tip expression lack lamellipodia, fail to migrate into the wound, and form s

137 f actin filament-based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs

138 These changes manifest as loss of lamellipodia/filopodia and appearance of membrane ruffle

139 ed colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding

140 followed by relocalization to the actin-rich lamellipodia for dynamic forward protrusion of the cells

141 he observed dynamic: (1) competition between lamellipodia for shared pools of Rac and Rho, (2) activa

142 calize actin monomers to the leading edge of lamellipodia for their motility.

143 t and retraction from the cell surface where lamellipodia form.

144 dependent effect, coupled with filopodia and lamellipodia formation and an enrichment of a pool of th

145 tive mutant of ARF6 attenuates inhibition of lamellipodia formation and cell migration by PITs, confi

146 to rapamycin inhibition of IGF-1-stimulated lamellipodia formation and cell migration.

147 nsulin-like growth factor (IGF-1)-stimulated lamellipodia formation and cell motility, indicating inv

148 ation of kindlin-2 binding to Arp2/3 impairs lamellipodia formation and cell spreading.

149 ine triphosphate synthesis inhibitor reduced lamellipodia formation and decreased breast cancer cell

150 t, PI3k, and Akt phosphorylation, suppressed lamellipodia formation and endothelial cell migration.

151 Thr-308 and phospho-Ser-473) and potentiated lamellipodia formation and HLMVEC migration.

152 as aberrant and associated with dysregulated lamellipodia formation and impaired persistence of migra

153 Strikingly, lamellipodia formation and in vivo ENCC chain migration

154 with thrombin) inhibited focal adhesions and lamellipodia formation and led to impaired cell migratio

155 Exo70 on the Arp2/3 complex is required for lamellipodia formation and maintaining directional persi

156 30(Cas)-deficient murine fibroblasts induced lamellipodia formation and membrane ruffling, which was

157 e in the cellular membrane are essential for lamellipodia formation and metastasis.

158 Moreover, cortistatin impaired lamellipodia formation and migration of human aortic SMC

159 uing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be importan

160 have previously reported that HGF stimulates lamellipodia formation and motility of human lung microv

161 kt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial

162 MEK inhibition was sufficient to promote lamellipodia formation and oppose filopodial actin-spike

163 omolog 2 (Spns2), and S1P receptor, S1P1, in lamellipodia formation and perhaps motility of HLMVECs.

164 MYH9(E1841K/E1841K) mice exhibited increased lamellipodia formation and reorganization of F-actin str

165 ibit growth factor-induced actin remodeling, lamellipodia formation and, ultimately, cell migration a

166 breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines.

167 d with actin cytoskeleton reorganization and lamellipodia formation in FLS from rats and RA patients.

168 r inhibition of SphK1 attenuated HGF-induced lamellipodia formation in HLMVECs.

169 Moreover, an S1P(1) antagonist inhibited the lamellipodia formation induced by heregulin.

170 Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractil

171 the predominant isoform of PI3K involved in lamellipodia formation of ovarian cancer cells.

172 factor for the recruitment of modulators of lamellipodia formation such as capping protein or cofili

173 he increase in endocytosis and the defect in lamellipodia formation were associated with reduced chem

174 and decreased the frequency of RAC1-positive lamellipodia formation while CERS6 overexpression promot

175 enriched at the cell periphery to facilitate lamellipodia formation while Rho kinase exhibited a sign

176 The WASP relative WAVE regulates lamellipodia formation within a 400-kilodalton, hetero-p

177 ing Drp1 or overexpression of Mfn1 inhibited lamellipodia formation, a key step for cancer metastasis

178 ne receptor 4, RGS4 disrupted Rac1-dependent lamellipodia formation, a key step involved in cancer mi

179 e precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation.

180 n dynamics associated with barrier function, lamellipodia formation, and cell migration via modulatio

181 ells and was also required for polarization, lamellipodia formation, and chemotaxis.

182 mbrane, as well as promoting cell spreading, lamellipodia formation, and membrane ruffling, cell morp

183 hese results suggest that HGF/c-Met-mediated lamellipodia formation, and perhaps motility is dependen

184 S precursor migration, cell polarization and lamellipodia formation, and that vitamin A depletion cau

185 proteins resulted in more cell spreading and lamellipodia formation, causing accumulation of more mit

186 Drosophila macrophages results in defects in lamellipodia formation, cell spreading, and redistributi

187 Crk-associated substrate (p130Cas)-mediated lamellipodia formation, countering the invasive phenotyp

188 o reduced ENS precursor migration as well as lamellipodia formation, proliferation, and survival in c

189 is and NADPH oxidase attenuated HGF- induced lamellipodia formation, ROS generation and cell migratio

190 ulation of Spns2 also suppressed HGF-induced lamellipodia formation, suggesting a key role for inside

191 tion in 3D collagen, but was dispensable for lamellipodia formation, suggesting that vinculin-mediate

192 ssion of wild type Nanog increased filopodia/lamellipodia formation, whereas mutant Y35F and Y174F Na

193 c-Met signaling in HGF-induced sprouting and lamellipodia formation.

194 shed TWEAK activation of Rac1 and subsequent lamellipodia formation.

195 ely elevates Rac-GTP levels to induce radial lamellipodia formation.

196 decreased cell-matrix adhesion and enhanced lamellipodia formation.

197 tion to the leading edge, thereby inhibiting lamellipodia formation.

198 vation of focal adhesion kinase, and reduced lamellipodia formation.

199 migration and invasion through Rac-dependent lamellipodia formation.

200 , with specific siRNA attenuated HGF-induced lamellipodia formation.

201 sion of Schwann cell processes and disrupted lamellipodia formation.

202 Slit2- and VEGF-induced Rac1 activation and lamellipodia formation.

203 and Ser-473) phosphorylation and suppressed lamellipodia formation.

204 dothelia and epithelia suggests that ventral lamellipodia formed as a response to force imbalance and

205 ide and cyclodextrin on the force exerted by lamellipodia from developing growth cones (GCs) of isola

206 ACF), is similar to retrograde actin flow in lamellipodia, growth cones, immunological synapses, dend

207 The presence of Tpm in lamellipodia, however, is disputed in the literature [9-

208 t STRADalpha depletion results in misaligned lamellipodia, improper Golgi positioning, and reduced in

209 focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin

210 Stat3 induced the formation of lamellipodia in both DU145 and PC-3 cells, further suppo

211 ng, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a centra

212 em, we tested the role of Arp2/3 complex and lamellipodia in directional cell migration.

213 s to immediate transitions between blebs and lamellipodia in migrating cells.

214 ses required for retraction and extension of lamellipodia in motile cells.

215 a membrane and induce the local formation of lamellipodia in response to focal illumination.

216 miR-196a also reduces the formation of lamellipodia in response to VEGF suggesting that ANXA1 r

217 f Erg-deficient HUVECs showed a reduction in lamellipodia, in line with decreased motility.

218 in generated several profound effects on the lamellipodia, including an increase of F-actin, a rearwa

219 udies have suggested that structures besides lamellipodia, including lamella and filopodia, may have

220 us and the leading edge of the cell to drive lamellipodia-independent 3D cell migration.

221 Likewise, the retraction phase of lamellipodia is controlled by PDK1 through an MRCKalpha-

222 at their tips, the protrusion efficiency of lamellipodia is determined by a finely tuned balance bet

223 s, suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a s

224 al exerted force and maximal velocity during lamellipodia leading-edge protrusion.

225 r structures, to the plasma membrane, and to lamellipodia-like membrane protrusions.

226 Also revealed was a lamellipodia-like process physically inhibiting the syna

227 During development, Schwann cells extend lamellipodia-like processes to segregate large- and smal

228 We find that lamellipodia-like protrusions and retrograde actin flow

229 Directed apical lamellipodia-like protrusions propel the cells.

230 malian cells lacking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1

231 about the architecture and dynamics of thin lamellipodia made by slow-moving cells on flat surfaces,

232 partial retraction of the nearby protruding lamellipodia membrane and a strengthening of paxillin-ba

233 ions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the c

234 ho-Elmo and ITSN1 co-localize with GPR124 at lamellipodia of adhering endothelial cells, where GPR124

235 rom sparsely distributed algal cells and the lamellipodia of human hepatocytes.

236 FM force-distance (f-d) curves obtained from lamellipodia of live cells often exhibit a signal from w

237 localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkali

238 riven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant f

239 dependent on Tn-bearing proteins present in lamellipodia of migrating cells.

240 o9b localizes to the extreme leading edge of lamellipodia of migrating cells.

241 d PTP-PEST, which colocalize with FAK at the lamellipodia of migrating cells.

242 etween actin assembly and disassembly in the lamellipodia of migrating cells.

243 PC1 and Pacsin 2 co-localize on the lamellipodia of migrating kidney epithelial cells.

244 ctin filament nucleation and assembly in the lamellipodia of moving cells.

245 paired localization of LPL to the actin-rich lamellipodia of T cells.

246 s and a reduction in the number of polarized lamellipodia on intercalating cells.

247 We imaged XTC cells that exhibit flat lamellipodia on poly-L-lysine-coated coverslips.

248 In these contexts, protrusions adopt lamellipodia or an amoeboid morphology.

249 ized, random, or oscillatory, with competing lamellipodia oscillating out of phase.

250 Lamellipodia overlap the VE-cadherin-free adjacent plasm

251 ng diverse actin-based structures, including lamellipodia, podosomes, and endocytic actin networks.

252 ow-curvature areas favored the appearance of lamellipodia, promoting faster closure.

253 loration, with F-actin bundles directing and lamellipodia propagating the process and with signaling

254 er, exhibit retarded migration regardless of lamellipodia protrusion activity.

255 increase in plasma membrane tension stopped lamellipodia protrusion and activated an exocytotic burs

256 the Arp2/3 complex plays a critical role in lamellipodia protrusion and cell motility.

257 Lamellipodin (Lpd) is known to control lamellipodia protrusion by regulating actin filament elo

258 s study, we show that during cell spreading, lamellipodia protrusion flattens plasma membrane folds a

259 cin 1 expression drives faster migration and lamellipodia protrusion in melanocytes in vitro.

260 for cell movement, including actin dynamics, lamellipodia protrusion, and membrane ruffling.

261 Thereby, Lpd supports lamellipodia protrusion, cell migration and endocytosis.

262 causing accumulation of more mitochondria in lamellipodia regions.

263 rganization to form cell surface extensions (lamellipodia) required for cell migration/invasion durin

264 In contrast, contraction of lamellipodia results in reduced integrin engagement that

265 by confined Ca(2+) pulses that promote local lamellipodia retraction and adhesion cycles along the le

266 clodextrin affected force or velocity during lamellipodia retraction.

267 Moreover, our analysis of the tip cell lamellipodia revealed the diversity in their interaction

268 t and fusing myoblasts, as well as triggered lamellipodia, spreading, and fusion of myoblasts through

269 Rac inhibition negated ICAM-1 mediated lamellipodia, spreading, and fusion of myoblasts.

270 numerous endocytic cups instead of the broad lamellipodia structure characteristic of moving cells.

271 ance between formation of endocytic cups and lamellipodia structures.

272 peptide (2B2) disassemble VIF at sites where lamellipodia subsequently form.

273 s, endothelial cells generate unique ventral lamellipodia that propagate via integrins toward and acr

274 the ECM enforces spatial constraints on the lamellipodia that result in cell shape elongation and en

275 ing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, an

276 interaction is essential for the assembly of lamellipodia, the formation of ruffles, and the process

277 ular fibronectin formed increased numbers of lamellipodia; their random motility and chemotaxis also

278 itochondria actively infiltrate leading edge lamellipodia, thereby increasing local mitochondrial mas

279 ac1 activation around the periphery in broad lamellipodia, thereby inhibiting directed migration and

280 ated protein 2/3 complex (ARP2/3)-controlled lamellipodia to appear intermittently at those sites.

281 bilization, and timely turnover of NA within lamellipodia to couple actin-driven protrusion to adhesi

282 dia, to growth cones combining filopodia and lamellipodia, to dendritic spines.

283 t protrusions, from keratocytes dominated by lamellipodia, to growth cones combining filopodia and la

284 Moreover, a novel lamellipodia-to-filopodia transition is used in this con

285 Lamellipodia treated with 2.5 mM of cyclodextrin exerted

286 Lamellipodia undergo periodic extension and retraction c

287 lysis revealed that G-actin concentration in lamellipodia was comparable to that in the cell body.

288 phorylation of SphK1 and its localization in lamellipodia was dependent on c-Met and ERK1/2 signaling

289 that can be induced to form either blebs or lamellipodia, we systematically assessed the mechanical

290 Ventral lamellipodia were enriched in the Rac1 effectors cortact

291 ntoured than static tips but no filopodia or lamellipodia were observed, even in db-cAMP; and 5) duri

292 in increases the number of ARP2/3-controlled lamellipodia, whereas overexpression of wild-type VE-cad

293 CK2-mediated suppression of Rac1 activity in lamellipodia, whereas RhoC promotes polarized migration

294 bstratum, eukaryotic cells project sheetlike lamellipodia which contain a dynamically remodeling thre

295 ls spontaneously formed protrusions, such as lamellipodia, which are required for generating locomoti

296 We found STIM1 protrusions in lamellipodia, which co-localized with FAs, whereas major

297 olarity by increasing myosin accumulation in lamellipodia, which locally decreases protrusion lifetim

298 CB2 stimulation decreased formation of lamellipodia, which play a key role in monocyte migratio

299 ratinocytes lack polarity, assemble multiple lamellipodia with a 2x increased area over controls, dis

300 gion, formation of cortical actin-rich large lamellipodia with an upregulation of cortactin, and decr