ライフサイエンスコーパス: lining

1 phage-like component of the liver sinusoidal lining.

2 s depends on toxin-induced damage to the gut lining.

3 eases are located outside of the endothelial lining.

4 and early preclinical EAC) in the esophageal lining.

5 omplementarity-determining region (CDR) germ-lining.

6 sion was primarily localized to the synovial lining.

7 aspects and chemical properties of the pore lining.

8 ng, and substrate droplet deposition or trap-lining.

9 ield and the need to reconstruct the mucosal lining.

10 liver parenchyma, and lipase in the stomach lining.

11 f cases (22/30) showed discontinuous mucosal lining.

12 in 87.5% of cases with discontinuous mucosal lining.

13 versus bacterial invasion through epithelial linings.

14 es in lipid membranes with the polyol region lining a channel interior that funnels to its narrowest

15 hereby promoting growth of a new endothelial lining across the aneurysm opening.

16 te side chains at the first turn of the pore-lining alpha-helices is a key determinant of the rate of

17 ence of glutamate to open a gate on the pore lining alpha-helix.

18 tivity is provided by highly conserved, pore-lining amino acids.

19 s human pathogens that target the epithelial lining and are associated with a major disease burden.

20 nodules, continuous or discontinuous mucosal lining and cholelithiasis may indicate XGC rather than g

21 emoves the hydrophobic sites from the cavity lining and forms the folding chamber.

22 e CHT niche, and mature into reticular cells lining and interconnecting sinusoids.

23 ial fibroblast (RASF) and macrophages in the lining and sublining layer of the tissue.

24 ls usually did not proliferate inside the CC lining and were only rarely found to be immunoreactive a

25 e and skin to restore bone defects, internal lining, and external coverage.

26 age-like component of the liver blood vessel lining, are traversed by sporozoites to initiate liver i

27 Endoscopy demonstrated a complete mucosal lining at 15 months, despite retention of a stent.

28 ared with the measured cellularity of the CC lining at P15.

29 oliferation, the total cellularity of the CC lining at the L4 spinal segment significantly descended

30 ammogram, uterine ultrasound, or endometrial lining biopsy.

31 Endothelial cells (ECs) lining blood vessels express many mechanosensors, includ

32 ion is bacterial interaction with endothelia lining blood vessels, which is physically challenging be

33 ging pathogen that targets endothelial cells lining blood vessels; the high mortality rate (up to 70%

34 n complex multicellular organisms, epithelia lining body cavities regulate absorption and secretion o

35 GATA-6 is markedly reduced in pulmonary ECs lining both occluded and nonoccluded vessels in patients

36 podocytes are fully differentiated podocytes lining Bowman's capsule where normally only parietal epi

37 es in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithe

38 staining revealed intact colonic epithelial lining, but extensive damage in jejunal villus tips afte

39 Pore-lining carbonyl groups are well situated to stabilize hy

40 profiling in bone cells, we identified bone lining cells as important gatekeepers of estrogen-contro

41 ription 3) was shown to be activated in cyst-lining cells in ADPKD and PKD mouse models and may drive

42 nction, we examined the mitochondria of cyst-lining cells in ADPKD model mice (Ksp-Cre PKD1 (flox/flo

43 cells, with the role of osteocytes and bone lining cells left largely unexplored.

44 hat is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched 'off' by osteo

45 cumulation of phosphorylated SMAD2/3 in cyst-lining cells suggests the involvement of TGF-beta signal

46 cells, stromal ST2 cells on the gel as bone lining cells, and bone marrow cells.

47 tor (pIgR) is highly expressed by renal cyst-lining cells.

48 remodeling compartment canopy cells, or bone lining cells.

49 age and in the meniscus, as well as synovial lining cells.

50 ated suppression of RANKL expression in bone lining cells.

51 ing osteoblast apoptosis and activating bone-lining cells.

52 d that secreted ST6Gal1 is produced by cells lining central veins in the liver and that IgG sialylati

53 fied the small heat shock-like SIEVE ELEMENT-LINING CHAPERONE1 (SLI1).

54 d the lamina propria and an inner epithelial lining composed of layers of basal, intermediate, and su

55 e and subsequent adhesion to the mesothelium lining covering abdominal organs to establish secondary

56 ted residues, interaction of a proposed pore-lining cysteine at position 37 with the positively charg

57 Cd(2+) bridges formed between pairs of pore-lining cysteine residues introduced into different trans

58 mucosal regeneration, and improve urothelial lining defects in KIC.

59 tiation, which might attribute to urothelial lining defects.

60 we revealed that these cells arose in the CC lining during postnatal development and adulthood.

61 orts of the mitotic activity observed in the lining during postnatal development have often been cont

62 the ectoderm and sequestered to the coelomic linings during myotome extension.

63 t-bound LBD from effectively pulling on pore lining elements, thereby destabilizing pore opening.

64 The inner uterine lining (endometrium) is a unique tissue going through re

65 phase air-water-oil mixture, with the liquid lining ensuring sustained antifouling behaviour.

66 MIF was upregulated in cyst-lining epithelial cells in polycystin-1-deficient murine

67 strong dot-like perinuclear staining in the lining epithelial cells, suggesting that RD3 may play an

68 Endothelial cells lining fetal and newborn arteries have an unusual phenot

69 We have shown that human alveolar lining fluid (ALF) contains homeostatic hydrolases capab

70 alveoli and comes into contact with alveolar lining fluid (ALF), which contains homeostatic and antim

71 Infection increased bronchoalveolar lining fluid (BALF) adenosine comparably in WT and A1-KO

72 ctive oxygen species (ROS) in the epithelial lining fluid (ELF) of the human respiratory tract.

73 edizolid penetrates well into the epithelial lining fluid (ELF) of the lung.

74 The lung lining fluid (LLF), which contains phospholipids and sur

75 lung recruitment correlate with altered lung lining fluid composition independent of age or genotype.

76 n the basis of a synthetic respiratory tract lining fluid containing the antioxidants glutathione and

77 lung diffusing capacity, abnormal epithelial lining fluid metabolome profile, increased proportions o

78 as biological parameters of lung epithelial lining fluid metabolome, small airway epithelial (SAE) c

79 n blood, whole lungs, or alveolar epithelial lining fluid to include measurements in specific types o

80 SOCS secretion into lung lining fluid was diminished by cigarette smoking in huma

81 hilia in airway subepithelium and epithelial lining fluid was greater in GSTM1+ compared to GSTM1null

82 Simultaneously, unstimulated airway mucosal lining fluid was obtained and quantified for levels of 2

83 nd levofloxacin penetrations into epithelial lining fluid were 39.3% and 64.3%, respectively.

84 Soluble mediators in the nasal lining fluid were measured using nasosorption.

85 airway epithelial cell membranes or the lung-lining fluid, generating chemically reactive oxysterols.

86 drugs was performed in plasma and epithelial lining fluid, using a population model.

87 chemokines were quantified in airway mucosal lining fluid.

88 iling was performed in plasma and epithelial lining fluid.

89 luding hydrogen peroxide (HOOH), in the lung lining fluid.

90 In nasal lining fluids of allergic patients challenged with aller

91 An endoscopic biopsy of the mucosa lining from the esophagus to the duodenum was performed

92 ful colonizers must attach to the epithelial lining, grow on the nutrient-limited mucosal surface, ev

93 In both states, the inner pore-lining helices are in an 'open' conformation.

94 at the inner and outer ends of adjacent pore-lining helices come closer during opening, likely throug

95 ndle crossing and the splaying apart of pore-lining helices commanding ion passage.

96 SET to substituted cysteines in all the pore-lining helices, we show that the state-dependent accessi

97 en these states through movement of the pore-lining helices.

98 crosslinking to probe movements of the pore-lining helices.

99 The pore-lining helix (PLH) bundles are central to the function o

100 The RyR1 S6 pore-lining helix has two conserved glycines, Gly-4934 and Gl

101 he role of RyR1-G4934 and -G4941 in the pore-lining helix in channel gating and ion permeation was pr

102 ted by palmitoylated cysteines near the pore-lining helix.

103 tion in Gdf5-lineage cells prevents synovial lining hyperplasia and decreases contribution of Gdf5-li

104 P8 and only 0.6% +/- 0.2% of cells in the CC lining in adulthood are proliferating.

105 ion and determines the cellularity of the CC lining in reference to lumbar spinal segment L4 during t

106 , the transformation of the gastrointestinal lining, increases in postprandial gut hormone secretions

107 mational changes coupled to the pair of pore-lining inner helices from the first 6-TM domains, wherea

108 highly conserved TM1 helix acts as the pore-lining inner helix, creating an hourglass-shaped ion per

109 Discontinuous mucosal lining is evident in xanthogranulomatous cholecystitis.

110 has a Pf-specific extension, whose sequence lining is identical in human Hsp90 but which differs by

111 ings, we conclude that discontinuous mucosal lining is not an unusual finding in cases of XGC.

112 The upper aerodigestive tract mucosal lining is often disrupted during surgery, which requires

113 Our findings confirmed that the CC lining is the source of a small number of cells with an

114 ered polypeptides, known as FG nucleoporins, lining its passageway.

115 exRNA was detectable only in the RA synovial lining layer, whereas extracellular DNA was detectable i

116 brane proteins located within the intestinal lining, leading to growth inhibition and mortality.

117 anize three-dimensionally to form a synovial lining-like layer.

118 osine monophosphate (cAMP) in cholangiocytes lining liver cysts.

119 nduce changes that lead to asynchronous pore-lining M2 helix movements.

120 ormation, the extracellular-half of the pore-lining M2 is splayed open, reminiscent of the open confo

121 ent to systematically probe the role of pore-lining M2 residues in GluN1 and GluN2A in the channel bl

122 ency virus (HIV) are first captured by sinus-lining macrophages.

123 uniquely preserved 13,700-11,700-y-old grave linings made of flowers, suggesting that such use began

124 Mucosal lining may be continuous or discontinuous in XGC.

125 chyme miRNAs thus have an indirect effect on lining mucosal epithelial cell growth/differentiation.

126 ulation of Fgf signaling was found in mutant lining mucosal epithelium that was accompanied by an inc

127 nt study demonstrates that endothelial cells lining newborn central arteries express high levels of E

128 CD133(+) ependymal neural stem cells (NSCs), lining not only the lateral but also the fourth ventricl

129 vel, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stoch

130 binding of infected cells to the endothelial lining of blood vessels as a strategy to avoid clearance

131 M scaffold and spontaneously repopulated the lining of decellularized vessels.

132 esentative stromal cell type in the synovial lining of joints that become activated during inflammato

133 Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature

134 alpha immunoreactivity along the endothelial lining of lesions from transgenic animals compared with

135 umor cell clusters into the mesothelial cell lining of peritoneal cavity organs; however, the tumor-s

136 The endodermal lining of the adult gastro-intestinal tract harbours ste

137 cells and their descendants reveals how the lining of the airways is maintained, and how this proces

138 rolled ependymal cells along the ventricular lining of the aqueduct.

139 eases in which cholangiocytes, the epithelia lining of the biliary tree, are the target cells.

140 lig2(+) /Sox-10(+) cells appeared inside the lining of the CC shortly after birth, and their number r

141 bers of Olig2(+) /Sox-10(+) cells inside the lining of the central canal (CC) during postnatal develo

142 cell--polymorphonuclear neutrophils--to the lining of the circulatory system or vascular endothelium

143 phagus (BE) is a common disease in which the lining of the esophagus transitions from stratified squa

144 f the formation of these elaborations of the lining of the gut, essential for providing sufficient su

145 The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proxi

146 The epithelial lining of the intestine forms a barrier that separates t

147 e synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators of inflammation an

148 Inserted in the olfactory mucosa lining of the nasal cavity, they are exposed to the envi

149 The motions of the lining of the peptide tunnel appear to assist in the exp

150 does not change topology to accommodate the lining of the pore lumen by BGH.

151 sp(65)-Ser(68) that form a major part of the lining of the pore.

152 The endothelial cell (EC) lining of the pulmonary vascular system forms a semiperm

153 neurons and glia from the central canal (CC) lining of the spinal cord in rodents should occur in the

154 The mucosal lining of the upper airways represents the outer surface

155 Urothelium is the protective lining of the urinary tract.

156 tyrosine kinase expressed in the epithelial linings of the gastrointestinal tract and the skin, wher

157 contribute significantly to the formation of linings of the mRNA and tRNA paths, suggesting a tailor-

158 How the distinct epithelial linings of these two zones are differentially specified

159 e presence of dividing cells peaks in the CC lining on postnatal day 8 (P8), with division occurring

160 ve stomach acid and decomposed in intestinal linings or after absorption to simultaneously release AS

161 n array of specialized epithelial cell types lining organs, including the thyroid, thymus, lungs, liv

162 ompanied by the suppression of the endosteum-lining osteoblast population.

163 Bzb treatment accelerated DNA repair in bone-lining osteoblasts and thus promoted their survival.

164 sition, although acidic residues at any pore-lining position in the inner cavity are sufficient to co

165 ts of cysteine modification at multiple pore-lining positions on the blocking properties of a library

166 herence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidne

167 n, pore dilatation by a mutation in the pore-lining region alters the anion selectivity of GlyR.

168 Third, we identified a site in the pore-lining region of the AMPAR, close to its Q/R site, that

169 ite-directed mutagenesis shows that the pore-lining residue D47 is critical in determining high Mg(2+

170 that asparagine 171 (N171) is the only pore-lining residue required for high-affinity block, and tha

171 )-binding residue E106 and the adjacent pore-lining residue V102.

172 16A structure and identification of its pore-lining residues are essential.

173 CAM), we evaluated the role of possible pore-lining residues in the permeation of ions and ethidium t

174 data support the following sequence of pore-lining residues located from the narrowest to the widest

175 annels is determined by the polarity of pore-lining residues located on alpha helix 3.

176 We aimed to map the pore-lining residues of claudin-2 by comprehensive cysteine-s

177 within transport-domain TMs, identified pore-lining residues of functional importance, and provided e

178 ect anion selectivity, as well as seven pore-lining residues that cluster near pore constrictions and

179 Replacing 10 pore-lining residues that show different ionization behavior

180 be removed by selective mutation of channel-lining residues, demonstrating the potential for tailori

181 We find that two rings of pore-lining residues, V102 and F99, work together to form a h

182 e, indicating the location of candidate pore-lining residues.

183 ar rotation of the upper portion of the pore-lining S6 helix away from the 4-fold channel axis and tw

184 ture reveals a pore domain in which the pore-lining S6 helix connects to a helical cytoplasmic tail.

185 Endothelial cells lining SC elaborate tight junctions (TJs), down-regulati

186 mutation of the central glycine in the pore-lining second transmembrane segment (TM2) to proline in

187 Our results indicate that CC lining serves as a source of cells beyond ependymal cell

188 P21, Olig2(+) /Sox-10(+) cells inside the CC lining started to express other oligodendroglial markers

189 center, and movements of the peptide tunnel lining that assist in the expulsion of the synthesized p

190 The results indicate that amino acids lining the 14 A cavity are critical for catalytic activi

191 ntamers containing substitutions to residues lining the 5-fold pore did not affect pentamer assembly

192 y functional data on key mutants of residues lining the 5mC and H3K9-binding pockets within KYP, esta

193 ell, as visualized by beta-tubulin antibody, lining the acinar lumen in a web-like fashion.

194 is dispensable for DNA binding but residues lining the active site guide DNA for cleavage.

195 pression and the protein repertoire in cells lining the alimentary tract, the first line of defense.

196 ncreased numbers of TRAP+ osteoclastic cells lining the alveolar bone surface in SPF compared with GF

197 nger is first recognized by epithelial cells lining the alveolar lumen and relayed to vascular respon

198 ducting airways and type II and type I cells lining the alveoli.

199 METHODS AND LD were present in EC lining the aorta after the peak in plasma triglycerides

200 Residues lining the binding site are highly conserved among filov

201 ite this similarity, differences in residues lining the binding site of M11 and Bcl-XL dictate varyin

202 yield tumors in the transitional epithelium lining the bladder, kidneys and ureters.

203 nctional) endothelial cells (ECs), the cells lining the blood vessel lumen.

204 ibuted to mechanisms restricted to the cells lining the boundary.

205 he highly polarized luminal epithelial cells lining the breast ducts.

206 Lymphatic endothelial cells lining the ceiling of the subcapsular sinus, but not tho

207 Additionally, conserved aromatic residues lining the central cavity appear to be essential for bot

208 on alters the positions of the alpha-helices lining the central hole of the PCNA ring, whereas the C8

209 ach other by completing the hydrophobic core lining the central part of HP35.

210 itory FcgammaRIIb receptor in the epithelium lining the cervix initiate expression of genes that bloc

211 andidate for inserting into the membrane and lining the channel.

212 opropane (dmpn) appended to the Mg(2+) sites lining the channels of Mg2(dobpdc) (dobpdc(4-) = 4,4'-di

213 branched dilated microvessels in the tissues lining the clinically healthy GC.

214 th selectively expressed in epithelial cells lining the conducting airways, where they regulate goble

215 d at the plasma membrane of epithelial cells lining the crypts of the small bowel and colon of the PT

216 , we discovered functional lymphatic vessels lining the dural sinuses.

217 stributed P2X2 receptors on epithelial cells lining the endolymphatic compartment.

218 oteasome subunits/targets and lipidated ATG8 lining the enveloping autophagic membranes.

219 l isomerization of the four E177 side chains lining the extracellular end of the selectivity filter.

220 ling of the subcapsular sinus, but not those lining the floor, expressed CCRL1, which scavenged chemo

221 Epithelial cells lining the gastrointestinal tract and kidney have differ

222 the branched dilated microvessels in tissues lining the GC.

223 To understand the influence of amino acids lining the HDAC1 14 A cavity in acetate escape and inhib

224 Videomicroscopic images from tissues lining the healthy GC in 20 healthy volunteers were anal

225 he epicardium, a single layer of mesothelium lining the heart.

226 Stromal cells lining the hepatic sinusoids, such as liver sinusoidal e

227 confirmed by immunohistochemistry in the EC lining the human coronary vessel.

228 Mutagenesis of residues lining the identified interaction site on Bcl-B negated

229 Endothelial cells (ECs), lining the inner layer of blood vessels, constitute barr

230 The endothelium lining the inner wall of SC has both blood and lymphatic

231 accharides comprising part of the host diet, lining the intestinal mucosal layer, and decorating the

232 terminants attributable to distinct residues lining the intramembranous pocket in the two receptor su

233 residues (known as the phenylalanine clamp) lining the junction between the cap and the stem.

234 The data suggest a linkage between residues lining the K(C)-channel and the active site of the enzym

235 G could be imaged in the superficial tissues lining the labial sulcus.

236 RCs), a population of lymphoid stromal cells lining the LN subcapsular sinus.

237 elium, a thin monolayer of specialized cells lining the lumen of blood vessels is the key regulatory

238 The ECG is a surface layer lining the luminal walls of blood vessels composed of pr

239 Though lymphatic endothelial cells (LEC) lining the LV express distinct factors (also called lymp

240 n facing the outer environment (not the skin lining the mantle cavity, for example) is derived from e

241 ZM) are strategically located in the spleen, lining the marginal sinus where they sense inflammation

242 indicated substantial prion seeding activity lining the nasal vault.

243 a characteristic hyperpolarization of cells lining the neural tube; disruption of this spatial gradi

244 f the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membr

245 any microbial pathogens and affect the cells lining the peritoneal cavity by triggering local inflamm

246 dination of CO to the divalent metal cations lining the pores within these frameworks, the C-O stretc

247 a region of lateral prefrontal cortex (LPFC) lining the principal sulcus.

248 Cells lining the proximal tubule (PT) have unique membrane spe

249 Cells lining the proximal tubule (PT) of the kidney are highly

250 Mutations at non-conserved residues lining the putative binding pocket of OCT3 to the corres

251 by mutation of individual conserved residues lining the putative ligand-binding surface of the C-term

252 n many epithelial cell types including those lining the respiratory system.

253 athione) from a synthetic model of the fluid lining the respiratory tract.

254 80-E216 enzymatic tetrad as well as residues lining the RNA binding groove, and offers previously uni

255 target DNA access to key catalytic residues lining the RuvC pocket.

256 also localized NC inside wild-type cores and lining the spherical Gag shell in immature virions.

257 Here, we report that acidic amino acids lining the sRNA binding channel between the inner pore a

258 ectively, on the surface of epithelial cells lining the stomach and duodenum.

259 21 scavenging by lymphatic endothelial cells lining the subcapsular sinus ceiling stabilizes interfol

260 of vSGLT, we identified and mutated residues lining the sugar transport pathway to cysteine.

261 g the tightly packed core and polar residues lining the surface.

262 must rapidly penetrate the mucus secretions lining the surfaces of the respiratory, gastrointestinal

263 yndrome caused by invasion of the epithelium lining the terminal ileum, colon, and rectum by Shigella

264 elial-to-mesenchymal transition (EMT), cells lining the tissue periphery break up their cohesion to m

265 ediated by the movement of the flexible wall lining the two regions.

266 instead suggested redundant proton shuttles lining the ubiquinone-binding site or from direct transf

267 ocalyx, a glycosaminoglycan (GAG)-rich layer lining the vascular lumen, is associated with the onset

268 e, chondroitin sulfate, and hyaluronic acid) lining the vascular lumen.

269 nt activation of the endothelial cells (ECs) lining the vein, in the absence of overt mechanical disr

270 ed within microglia, and the ependymal cells lining the ventricles of the brain expressed all three p

271 grey-white matter junctions, and structures lining the ventricles; all cases of acute blast exposure

272 Endothelial cells lining the vessel wall control important aspects of vasc

273 The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in

274 ns and a decrease in hydrophobic side chains lining the vestibule, and this was reflected in solvatio

275 near the fluorocarbon and the acidic groups lining the water channels than within the water channels

276 mber of transmembrane segments (TMs) as pore-lining, the exact location of CFTR's gate(s) remains unk

277 tion barrier is comprised of the endothelial lining, the glomerular basement membrane, and the podocy

278 cificity is conferred by amino acid residues lining their substrate pocket that distinguish them from

279 oots were found only in the epithelial cells lining these secretory ducts.

280 ic disease, uterine fibroids, or endometrial lining thickness as assessed by clinical examination, ma

281 Residues lining this cavity in EAAT1, including Ser-366, Leu-369,

282 onformational flexibility of the Cys364-loop lining this channel.

283 constructs exchanging the distinct residues lining this pocket.

284 ing amino acid substitutions of the residues lining this pore.

285 ansmembrane domains, and further to the pore-lining TM2 through two pathways: pre-TM1 and the beta1-b

286 a conserved proline at the base of the pore-lining TM6.

287 outer collar of TMs that surrounds the pore-lining TMs.

288 ular tropism from 2,3-linked SA(+) ependymal lining to 2,8-linked PSA(+) migrating progenitors in the

289 s the potential of restoring the endothelial lining to control AAA dynamics and designates ECs as an

290 some flexibility at this point in the cavity-lining transmembrane helix is necessary for normal RyR f

291 n alpha-to-pi-helical transition in the pore-lining transmembrane helix S6 at an alanine hinge just b

292 of these glutamate receptors contains a pore-lining transmembrane M3 helix surrounded by peripheral M

293 measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQ

294 es from the structure-activity relationships lining up the antitubercular activity were exploited for

295 nistered LipoLLA was retained in the stomach lining up to 24 h after the oral administration.

296 observed UII/URP binding sites in structures lining ventricles, comprising the sphenoid nucleus and c

297 ons at its most apical side, the ventricular lining (VL).

298 After reperfusion, the colonic epithelial lining was not affected, whereas the jejunal epithelium

299 Discontinuous mucosal lining was seen in all cases with wall thickness >10 mm,

300 ently, in the extracellular half of the pore lining, where the more pronounced tilt of the closed-cha