ライフサイエンスコーパス: macula

1 tered subretinal hemorrhages external to the macula.

2 al pigment epithelium (CHRRPE) involving the macula.

3 ts of 52 highly myopic eyes with dome-shaped macula.

4 scotomas were more prevalent in the central macula.

5 us cavity, no longer casting a shadow on the macula.

6 eral retina in a single shot centered on the macula.

7 ss associated with geographic atrophy of the macula.

8 on and outer retinal streaks in the superior macula.

9 sess the impact of a vitreous opacity on the macula.

10 domain optical coherence tomography (OCT) of macula.

11 with specific retinal diseases affecting the macula.

12 ion histologic images of the preserved donor macula.

13 least frequently located within the central macula.

14 ans through the center of the optic disc and macula.

15 and 6 x 6-mm OCT angiograms centered at the macula.

16 r cube OCT revealed a circular shadow on the macula.

17 s in which these clearly originated from the macula.

18 e periphery without end-stage disease in the macula.

19 ot optimal for detecting early damage of the macula.

20 cations in the retinal periphery and central macula.

21 esulting in impaired fluid resorption in the macula.

22 used in two consecutive sessions to scan the macula.

23 sed to compare VCT, StCT, and TCT across the macula.

24 oroidal thickness does not change within the macula.

25 l-domain optical coherence tomography of the macula.

26 nds, whereas type 1 lesions spared the outer macula.

27 he transpupillary thermotherapy scar and the macula.

28 nasal to the optic disc, and temporal to the macula.

29 large majority of which affected the central macula.

30 iagnosed with arRP and pseudocoloboma of the macula.

31 strates the arcuate course of the NFL in the macula.

32 nd 7.83 +/- 1.55 mm(3), respectively, at the macula.

33 with IRX1 preferentially expressed in fetal macula.

34 ystoid intraretinal fluid collections in the macula.

35 ere performed to test sensitivity across the macula.

36 ed accordingly to maintain an exudation-free macula.

37 ging of the superior, inferior, and/or nasal macula.

38 red to patients with disease confined to the macula.

39 eral multiple early-onset yellow dots at the macula.

40 mporal margin of the coloboma closest to the macula.

41 ue architecture of the fovea and surrounding macula.

42 ateral symmetric multiple yellow dots at the macula.

43 to quantitate individual networks within the macula.

44 continuously across the central 3 mm of the macula.

45 nd retinal pigment epithelium atrophy in the macula.

46 d by advanced AMD and drusen temporal to the macula.

47 2 patients), or small yellowish spots in the macula (1 patient).

48 Final well-preserved maculas (12.%) needed more injections and treatment chan

49 creased to 0.95, 0.99, 0.87, and 0.93 for 3D macula, 3D optic disc, radial, and line scans, respectiv

50 , 0.98, 0.80, and 0.91, respectively, for 3D macula, 3D optic disc, radial, and line scans.

51 temporal (14%), inferior (11%), and superior macula (5%) (P = .001).

52 er cracks were more prevalent in the central macula (51%) than in the nasal (19%), temporal (14%), in

53 iphery alone (10.1%), and both periphery and macula (57.4%).

54 of AMN that affects the middle layers of the macula above the OPL as diagnosed with SD-OCT imaging.

55 ferent types of retinal fluid in the central macula affect the reproducibility of choroidal thickness

56 examined, 81.1% had AMD-like changes in the macula alone (13.6%), periphery alone (10.1%), and both

57 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular

58 Lutein accumulates in the macula and brain, where it is assumed to play physiologi

59 it is only able to capture a limited view of macula and does not show leakage.

60 rformed on a 3 x 3-mm region centered on the macula and en face angiograms of the superficial and dee

61 pectively, and most were located between the macula and equator (70%).

62 By SD-OCT and OCT-A, thinning of the macula and flow voids in both the superficial and deep r

63 The average total retinal thicknesses of the macula and fovea in the patients with achromatopsia were

64 The macula and fovea located at the optical centre of the re

65 ral and functional traits typical of primate macula and fovea.

66 The images were acquired both from the macula and from 4 peripheral locations: superior and inf

67 treal ranibizumab injections, overall in the macula and in neovascular and non-neovascular areas, fro

68 By comparison, average sensitivity in the macula and mid periphery declined by 0.38 and 0.61 dB/ye

69 All patients underwent OCT testing of the macula and nerve fiber layer (NFL).

70 and pigmentary abnormalities in the central macula and no evidence of macular fluid on routine OCT i

71 s primarily based on animal models having no macula and no fovea.

72 these pigment changes encompassed the entire macula and often encircled the optic disc.

73 within two 45 degrees areas centered on the macula and optic disc is 4.7%.

74 degree digital fundus images centered on the macula and optic disc of 213 patients were graded.

75 and optical coherence tomography imaging of macula and optic disc.

76 ong vitreous traction and adhesion above the macula and optic disc.

77 raster 3D-OCT scans (512 x 128) covering the macula and optic nerve from each eye using 3D-OCT-1000.

78 optical coherence tomography (SD OCT) of the macula and optic nerve head (ONH), infrared reflectance,

79 ively the possible structural changes of the macula and optic nerve head in the free eyes of unilater

80 Macula and optic nerve head SD-OCT volumes were obtained

81 l-domain optical coherence tomography of the macula and optic nerve head using the Heidelberg Spectra

82 etry and optical coherence tomography of the macula and optic nerve head.

83 undilated volume OCT image sets covering the macula and optic nerve were obtained.

84 nd optical coherence tomography (OCT) of the macula and optic nerve.

85 mography (FD-OCT) system was used to map the macula and peripapillary regions of the retina in 56 eye

86 th AMD, RPE mtDNA damage was measured in the macula and peripheral sections from individual donors.

87 between ischemia and vascular leakage in the macula and periphery, it was only macular ischemia and r

88 y allows mapping of light sensitivity of the macula and provides topographic information on visual fu

89 have bilateral outer retinal streaks in the macula and the superior peripheral retina on both ophtha

90 ed with extensive drusen accumulation in the macula and throughout the fundus, as well as with a high

91 hemorrhagic and exudative changes within the macula and/or peripapillary region leading to vision los

92 FHs involved the periphery, 83% involved the macula, and 71% involved multiple layers of the retina.

93 , peripapillary pigment (PPP), drusen in the macula, and drusen elsewhere, whereas 3D-OCT scans were

94 ssed for the presence of jPED, drusen in the macula, and drusen elsewhere.

95 choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subje

96 lated at the cornea, vitreous base, equator, macula, and orbit apex for pressures known to cause tymp

97 ntrast sensitivity, light sensitivity in the macula, and rod-mediated dark adaptation.

98 the position of the lacquer crack within the macula, and the relationships between perforating sclera

99 e at one visit, despite achievement of a dry macula, are associated with retreatment at the next visi

100 blished about choroidal thickness within the macula, as measured by OCT, in eyes with glaucoma.

101 ow that all types of sub-RPE deposits in the macula, as well as in the periphery, contain numerous HA

102 taining during the late phase in the central macula at all follow-up visits after surgery.

103 Atypical for RP features included mottled macula at an early age and peripapillary sparing of the

104 rior to diagnosis and chorioretinitis in the macula at presentation were associated with >/= 2 Snelle

105 ented areas suggestive of atrophy within the macula at some time during follow-up.

106 ement, lesion growth, and involvement of the macula center.

107 n which dilated fundus photographs (disc and macula centered) were obtained and graded for the presen

108 Macula-centered 3D OCT images were segmented with a full

109 The macula-centered 45-degree photographs were graded twice

110 The concentric rings method consists of 6 macula-centered concentric rings divided into 12 segment

111 ild," "moderate," or "severe" and at least 2 macula-centered FA images over a minimum of 6 months wer

112 "macula-centered image(s) only" if only the macula-centered image of one or both eyes was gradable,

113 was gradable, and "unsuccessful" if neither macula-centered image was gradable.

114 53 (72%; 95% CI, 65-78) patients, success of macula-centered image(s) only in 47 (22%; 95% CI, 17-28)

115 ry (P = .093), and the frequency of gradable macula-centered image(s) only increased with increasing

116 ial" if both images of 1 eye were gradable, "macula-centered image(s) only" if only the macula-center

117 Macula-centered images were more often gradable in both

118 For the 6 x 6 mm(2) macula-centered region as depicted by the SD-OCT, averag

119 cluded and underwent consecutive, registered macula-centered spectral-domain optical coherence scans

120 group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), gangli

121 Neurodegenerative diseases affecting the macula constitute a major cause of incurable vision loss

122 ive eyes with senile cataract with a healthy macula (control group) were included.

123 corded region of macular pigment loss in the macula correlated well with Muller's cell depletion.

124 l participants underwent OCTA imaging of the macula covering a 3 x 3-mm area using OCTA software (Cir

125 and volume changes between visits with a dry macula ("D") and immediate preceding visits ("D-1") were

126 Optical coherence tomography of the macula demonstrated complete preservation of the inner s

127 r upregulation of NOS1beta expression in the macula densa affects sodium excretion and salt-sensitive

128 onship between (a) NaCl concentration at the macula densa and (b) glomerular filtration rate or glome

129 a is a primary NOS1 isoform expressed in the macula densa and regulates the tubuloglomerular feedback

130 erences in glomerular tuft contractility and macula densa cell calcium handling were observed.

131 ice had decreased hyperfiltration, decreased macula densa cyclooxygenase-2 expression, decreased albu

132 We recently found that macula densa expresses alpha-, beta-, and gamma-splice v

133 ase 1 (NOS1), and NOS1beta expression in the macula densa increases on a high-salt diet.

134 merular cell granules and exhibit an altered macula densa morphology.

135 Furthermore, macula densa NO production was similar in the isolated p

136 It also suggests that the altered macula densa phenotype is related to the activity of the

137 tubuloglomerular feedback through increased macula densa sodium and chloride delivery, leading to af

138 was unable to rescue the abnormality seen in macula densa structure.

139 Compared with control mice, mice with macula densa-specific knockout of all nitric oxide synth

140 ficant for patients who subsequently require macula detachment for subretinal gene therapy.

141 mmon abnormality associated with dome-shaped macula, detected by SD OCT in 44% of the cases with no a

142 Anatomic characteristics of the macula determine fixation patterns in patients with neov

143 Changes in morphologic features of the macula did not show significant effects.

144 Most dome-shaped maculas did not display a round but a horizontal or vert

145 ed need for anti-VEGF injections to keep the macula dry postoperatively.

146 arcades in 3 eyes (27%), and throughout the macula extending nasal to the optic nerve in 2 eyes (18%

147 ntral macula in 6 eyes (55%), throughout the macula extending to the outside of the temporal arcades

148 uded the deep vascular plexus in the central macula for all 3 instruments.

149 ve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression.

150 nt between FA and OCTA scans centered on the macula for capillary nonperfusion (intraclass correlatio

151 An unprocessed image across the macula from one randomly selected eye of each participan

152 A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared

153 hed: Group 1 had dysfunction confined to the macula; Group 2 had macular and generalized cone system

154 r genes related to zeaxanthin binding in the macula (GSTP1), carotenoid cleavage (BCMO1), cholesterol

155 One patient with end-stage disease in the macula had normal periphery results on the color images.

156 retinal detachment in 2 (12%), a dome-shaped macula in 1 (6%), a choroidal neovascularization-related

157 disc in 122 eyes (86.52%), and involved the macula in 125 eyes (88.65%).

158 Lateral contraction in the temporal macula in 5 eyes created an appearance of vessels radiat

159 strated schisis cavities only in the central macula in 6 eyes (55%), throughout the macula extending

160 d deep capillary plexus (DCP) in the central macula in all 6 patients were compared with 5 normal sub

161 An optically empty space was seen above the macula in all eyes, and corresponded to the premacular b

162 bnormalities in the perifoveal region of the macula in all eyes, whereas FA appeared normal in 9 of 1

163 igate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis a

164 lation of outer retinal fluid in the central macula in any eyes.

165 These should look beyond the central macula in Asian patients.

166 l coherence tomography (SD OCT) scans of the macula in at least 1 eye.

167 nd healthy controls underwent imaging of the macula in both eyes with a swept-source optical coherenc

168 enrolled in the Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 with High Dose (READ-3) s

169 ions could affect clinical evaluation of the macula in healthy patients and disease states.

170 vasive tool for monitoring the status of the macula in patients at risk of DFO toxicity.

171 r thickness due to fluid accumulation in the macula in patients with diabetes mellitus.

172 , we evaluated the functional changes of the macula in response to pharmacological treatment through

173 and analyze retinal light sensitivity of the macula in STGD1 using fundus-controlled perimetry (micro

174 possessing a visual streak similar to human macula-in the study of diabetic retinopathy and diabetic

175 ons typically appear first in the perifoveal macula, initially sparing the foveal center, and over ti

176 We included 69 eyes of 69 patients with macula-involved polypoidal choroidal vasculopathy.

177 easures (occurrence of significant center of macula involvement, optical coherence tomography [OCT]-d

178 e incidence of severe vision loss related to macula-involving retinal detachment.

179 tenance of otolith tethering to the saccular macula is dependent on tectorin alpha (tecta) function,

180 nsduction and survival of cones in the human macula is essential for color vision and for visual acui

181 The macula is essential for visual functioning and is known

182 The finding that the macula is normal in achiasma suggests that reduced acuit

183 To directly test a long-held belief that the macula is selectively damaged with AMD, RPE mtDNA damage

184 The macula lacked the foveal attenuation normally seen with

185 brates possess a third otolith endorgan, the macula lagena.

186 At the macula level, we achieved an area under the ROC of 93.83

187 es were overlaid digitally based on disc and macula location onto stereographically projected UWF ima

188 has been shown that the functionality of the macula lutea depends on the nutritional uptake of lutein

189 The presence of drusen in the macula (macular drusen score) and estimated number (tota

190 evaluating involvement of the center of the macula may differ, probably because of macular pigmentat

191 entially affects perfusion in the SVC in the macula more than the deeper plexuses.

192 7 x 2-mm volumetric scans) was used to image macula morphology.

193 tumors were unilateral (n = 7), involved the macula (n = 3), and had a mean distance to the foveola o

194 tance and MultiColor imaging, located at the macula, nasal or superonasal to the fovea, which did not

195 Only the lateral crista and the macula neglecta were initially Fgf10 negative, although

196 entral ODP were otherwise normal with intact macula, neuroretinal rim, RNFL, and visual field.

197 ted the serial cross-sectional images of the macula obtained using the Spectralis OCT (HRA+OCT; Heide

198 entative histologic section from the central macula of a normal eye was used as an exemplar.

199 o evaluate segmentation accuracy of a normal macula of a white man in his 60s as an emblematic exampl

200 pographical changes could be detected in the macula of AU and IMU patients.

201 al and deep retinal capillary density in the macula of patients with amblyopia.

202 ndomized clinical trial (Lutein Influence on Macula of Persons Issued From AMD Parents [LIMPIA]) with

203 The macula of the primate retina uniquely concentrates high

204 to underlie xanthophyll concentration in the macula of the primate retina.

205 Fundoscopy revealed an inferior macula off rhegmatogenous retinal detachment.

206 1% vs 78.0%; P = 0.88), and macula-on versus macula-off (77.9% vs 81.1%; P = 0.68) groups.

207 Macula-off presentation occurred in 54.5% of all RRD pat

208 years (range, 13-57 years), with 17 cases of macula-off RD and 13 cases of macula-on RD.

209 was diagnosed in 15 patients (88.2%) in the macula-off RD group, leaving 2 patients (11.8%) unaffect

210 Macula-off RD patients had a higher incidence of aniseik

211 significantly increased risk of developing a macula-off retinal detachment in patients who did not un

212 The OCT images obtained outside the macula often show significant retinal and choroidal chan

213 ination, and mild disturbance of the central macula on detailed retinal imaging.

214 enon of an imaging artifact appearing at the macula on near-infrared reflectance and MultiColor imagi

215 Visual outcomes were better in macula-on detachments compared with those in which the m

216 In the macula-on RD group, 3 patients (23.1%) were found to hav

217 higher incidence of aniseikonia, compared to macula-on RD patients, following retina reattachment.

218 Ninety-eight patients with macula-on RD were included.

219 resses during interruptions in patients with macula-on RD.

220 th 17 cases of macula-off RD and 13 cases of macula-on RD.

221 d positioning is prescribed to patients with macula-on retinal detachment (RD) to prevent RD progress

222 In many patients with macula-on retinal detachment, scheduling surgery after a

223 of conjunctival erosion and 1 inferotemporal macula-on retinal detachment, which were successfully re

224 pseudophakic (79.1% vs 78.0%; P = 0.88), and macula-on versus macula-off (77.9% vs 81.1%; P = 0.68) g

225 ome was influenced by tumor growth under the macula or macular ischemia.

226 nges such as circumferential fibrosis of the macula or peripapillary area and "torpedo-like" lesions

227 idal thickness at all measurements along the macula (P = .057 at the fovea).

228 ess was also subnormal in the superotemporal macula (P<0.0001), where it varied with visual acuity (P

229 Three dome-shaped macula patterns were observed: round dome in 10/48 (20.8

230 xanthophyll substrates, including the unique macula pigment meso-zeaxanthin.

231 R for CM (with 100% of the dose given to the macula) present major changes at both plexuses but also

232 ny/increased intraocular pressure (IOP); (7) macula pucker/epiretinal membrane; (8) cataract; and (9)

233 In unaffected regions of the macula, qAF was calculated within predetermined circular

234 ) 6 x 6-mm raster scan of the optic disc and macula, radial, and line scan.

235 haracterized by changes occurring within the macula reflective of the ageing process.

236 ography (SDOCT) images of the optic disc and macula regions at baseline and at 3 and 6 months.

237 Age-standardized global prevalence of macula-related blindness and vision impairment in adults

238 The OCT scan of the macula revealed inner retinal layer edema in active infl

239 jects were imaged using a 3-dimensional (3D) macula scan covering a nominal 6 x 6-mm area with a reso

240 n artifact on 3D scans (optic disc scan, 7%; macula scan, 9%), whereas segmentation failure occurred

241 nts underwent a 3-dimensional optic disc and macula scanning protocol with a prototype SS OCT (Topcon

242 OCT macula scans were obtained by Heidelberg Spectralis, and

243 However, the pigeon retina and the human macula share a number of structural and functional prope

244 SDOCT imaging of the macula showed decreased choroidal thickness in all eyes.

245 Topographical analyses of the macula showed ONL thickening occurring in paradrusen reg

246 The macula showed RNFL thinning of -6.18 mum (-8.07 to -4.28

247 In the macula, significantly thinner RNFL (nasally), ganglion c

248 mates are the only mammals to possess a true macula similar to humans, and spontaneously develop drus

249 Members of the Macula Society were surveyed to retrospectively collect

250 Optic neuropathy after PPV for macula-sparing primary RRD is a rare but potentially dev

251 Angiographic findings in dome-shaped macula suggest the choroid as a target for possible trea

252 ADOA had a thinner GC-IPL in the inferonasal macula than the thinnest healthy control.

253 eye disease characterized by lesions in the macula that can resemble the wings of a butterfly.

254 inherited degenerative disease of the human macula that results in progressive and irreversible cent

255 ic patch of subretinal fluid temporal to the macula that was associated with orange polygonal pigment

256 disease may develop serous elevations of the macula that we classify as acquired vitelliform detachme

257 tic disc and another 3 scans centered on the macula that were acquired by a single operator.

258 itially obtained VA gain and thinning of the macula that were maintained for two years, but were lost

259 ion and metabolism of these nutrients in the macula, the best way to measure MPOD, and the clinical b

260 ep foveal pit, with verticalized edges and a macula thickened by the contraction of an ERM.

261 erence tomography [OCT]-determined center of macula thickness, application of focal photocoagulation)

262 a, subretinal haemorrhage, subretinal fluid, macula thickness, macular scar, subretinal fibrosis).

263 r NF1 who had >/=2 volumes acquired over the macula using handheld OCT during sedation for clinically

264 the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with

265 constituting the BLB in the human vestibular macula utricle from normal and Meniere's disease.

266 domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus aut

267 Predictive model of preserved macula vs. GA/fibrotic scar showed sensibility of 77.78%

268 by pro re nata injections until a fluid-free macula was achieved on optical coherence tomography.

269 anti-VEGF injections were given until a dry macula was achieved, and treatment deferred.

270 tion between baseline and the visit when the macula was completely dry or when the central subfield t

271 detachments compared with those in which the macula was detached (logMAR 0.18 vs 0.42; P <0.005).

272 The appearance of the macula was evaluated by clinical examination, fundus pho

273 The macula was found to be detached in 118 cases (80.3%) and

274 The central macula was imaged with the Optovue RTVue XR Avanti using

275 The center of the macula was involved in 51% of color photographs and 56%

276 Serous RD in dome-shaped macula was likely caused by choroidal vascular changes,

277 osterior retinal cystoid degeneration, a dry macula was obtained in 75% and 25% of the eyes at 1 mont

278 ence group with subretinal fluid only, a dry macula was obtained in 89.5% and 100% of the eyes at 1 m

279 rs with accumulation of fluid in the central macula was present in all eyes.

280 e for vitreous traction on the optic disc or macula was seen in any eye.

281 The macula was thicker (514+/-85 mum vs. 257+/-59 mum; P < 0

282 Retinal photographs of the macula were acquired digitally and evaluated for the pre

283 elay of diagnosis and chorioretinitis in the macula were associated with visual loss in these patient

284 ssociated with less probability of preserved macula were diagnosis in 2009, older age, worse vision,

285 Patients with unilateral BRVO involving the macula were enrolled.

286 d axial (vertical) distribution of HF in the macula were evaluated with pairwise signed-rank tests.

287 Cystoid fluid collections in the macula were found in 50% of RP patients.

288 tomic features and function of the fovea and macula were normal by OCT and multifocal ERG.

289 Volumetric images of the macula were obtained using spectral domain optical coher

290 Individual retinal layers at the macula were quantified by analyzing tomograms using Imag

291 0/32 to 20/320 and DME involving the central macula were randomly assigned to intravitreous ranibizum

292 nd retinal ganglion cell layer (RGCL) in the macula were segmented using an ETDRS grid.

293 the relative anatomical preservation of the macula, which suggested the presence of a therapeutic wi

294 ease, one developed tractional detachment at macula while the other, an epiretinal membrane.

295 s of 48 eyes in 33 patients with dome-shaped maculas who were referred because of decreased vision.

296 s and a large yellowish lesion involving the macula with an overlying sub-retinal detachment, extendi

297 ve fiber layer (RNFL), optic nerve head, and macula with Cirrus OCT.

298 s characterized by cavitation in the central macula with or without typical cystoid macular edema.

299 nts demonstrated splitting of the OPL in the macula with relatively preserved visual acuity (>/= 20/4

300 weeks in eyes with DME involving the central macula with vision impairment.