ライフサイエンスコーパス: myeloid progenitor cell

1 d1 is greater in mature granulocytes than in myeloid progenitor cells.

2 specific genes during the differentiation of myeloid progenitor cells.

3 orresponding to the two alternative fates of myeloid progenitor cells.

4 of gene expression in primary human CD15(+) myeloid progenitor cells.

5 ignancy characterized by clonal expansion of myeloid progenitor cells.

6 nulocytic differentiation in these and other myeloid progenitor cells.

7 ll proliferation by overexpressing it in 32D myeloid progenitor cells.

8 expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.

9 -delta and -epsilon individually in the 32D myeloid progenitor cells.

10 g of diverse leukocytes and proliferation of myeloid progenitor cells.

11 ony growth of autologous CML blast cells and myeloid progenitor cells.

12 or to control leukemogenic transformation in myeloid progenitor cells.

13 optosis of interleukin 3 (IL-3)-deprived 32D myeloid progenitor cells.

14 ferentiation, survival, and proliferation of myeloid progenitor cells.

15 ibit the granulocytic differentiation of 32D myeloid progenitor cells.

16 of pre-B cells, but to have no influence on myeloid progenitor cells.

17 cDNAs were transfected and expressed in 32D myeloid progenitor cells.

18 ntiation of autonomously proliferating HL-60 myeloid progenitor cells.

19 he gene encoding Fanconi C (Fancc) in murine myeloid progenitor cells.

20 by the proliferation of a malignant clone of myeloid progenitor cells.

21 and Ig synthesis, and enhances maturation of myeloid progenitor cells.

22 d a growth advantage over wild-type HOXB4 in myeloid progenitor cells.

23 n of Fap1 with the Apc complex in Bcr-abl(+) myeloid progenitor cells.

24 genes that are activated by beta-catenin in myeloid progenitor cells.

25 gene expression in T cells, mast cells, and myeloid progenitor cells.

26 e properties of the Pu/Gata toggle switch in myeloid progenitor cells.

27 iption factor that is maximally expressed in myeloid progenitor cells.

28 ow previously to inhibit colony formation by myeloid progenitor cells.

29 ormal and transformed hematopoietic stem and myeloid progenitor cells.

30 that Tregs can affect the differentiation of myeloid progenitor cells.

31 ic and carcinogenic species in human CD34(+) myeloid progenitor cells.

32 ed fewer nucleated cells and was enriched in myeloid progenitor cells.

33 e GAS2 promoter and repress transcription in myeloid progenitor cells.

34 iption factor that is maximally expressed in myeloid progenitor cells.

35 g to monocyte/DC lineage commitment of human myeloid progenitor cells.

36 ss of Notch-dependent signal transduction on myeloid progenitor cells.

37 tion factor HoxA10 is maximally expressed in myeloid progenitor cells.

38 ered in these leukemias compared with normal myeloid progenitor cells.

39 Further, CFU-ECs possess myeloid progenitor cell activity, differentiate into pha

40 marily attributable to autonomous defects in myeloid progenitor cells, although the hematopoietic mic

41 eletion of 2 alleles of p53 rescued both the myeloid progenitor cell and long-term hematopoietic stem

42 induces a select set of micro-RNAs (miR) in myeloid progenitor cells and AML patients with t(8;21).

43 (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circul

44 ement of adhesion between BCR/ABL-expressing myeloid progenitor cells and bone marrow stroma may be o

45 ignaling pathway, we observed an increase in myeloid progenitor cells and CDllb(lo)Gr1(lo) promyelocy

46 expression of HoxA10 is maximal in committed myeloid progenitor cells and decreases as differentiatio

47 GF2 promoter that are activated by HoxA10 in myeloid progenitor cells and differentiating phagocytes.

48 AcmvIL-10 during latent infection of primary myeloid progenitor cells and found that LAcmvIL-10 is re

49 These studies demonstrate that both myeloid progenitor cells and HSCs resist TMTX by using n

50 The oncoprotein BCR-ABL transforms myeloid progenitor cells and is responsible for the deve

51 , a CC chemokine, is a specific inhibitor of myeloid progenitor cells and is the most potent activato

52 support interleukin-3-independent growth of myeloid progenitor cells and long-term outgrowth of B-ly

53 survival of preleukemic short-term HSCs and myeloid progenitor cells and maintains the differentiati

54 lso typically TRAF-3 immunonegative, whereas myeloid progenitor cells and megakaryocytes were often T

55 is also expressed during latent infection of myeloid progenitor cells and monocytes and facilitates p

56 OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted

57 letion analysis of TLS-ERG in both mouse L-G myeloid progenitor cells and NIH 3T3 fibroblasts reveale

58 taY187F cDNAs were transfected into both 32D myeloid progenitor cells and NIH 3T3 fibroblasts.

59 xpression of mouse Gr-1(+) and human CD15(+) myeloid progenitor cells and showed that the pattern of

60 romoted the outgrowth of Ly6C(+) and Ly6G(+) myeloid progenitor cells and their mobilization to tumor

61 fied LYL1 promoter showed strong activity in myeloid progenitor cells and was bound in vivo by Fli1,

62 pa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cel

63 and survival of hematopoietic stem cells and myeloid progenitor cells, and increased Fgf2-expression

64 s a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation i

65 ative capacity and self-renewal potential of myeloid progenitor cells; and support the hypothesis tha

66 that HoxA9 repressed ARIH2 transcription in myeloid progenitor cells, antagonizing the effect of Hox

67 all RNAs, termed microRNAs, encoded by human myeloid progenitor cells are capable of repressing a key

68 (-/-) and Glc-6-PT(-/-) mice, the numbers of myeloid progenitor cells are increased, while in the ser

69 ated by up to 4 h in AML-1B-expressing 32D.3 myeloid progenitor cells as compared with control cells

70 XC chemokine, were enhanced with bone marrow myeloid progenitor cells as well as macrophages, T cells

71 ted C57BL/6 mice, we observed a reduction in myeloid progenitor cells, as defined both phenotypically

72 ting proliferation and enhancing survival of myeloid progenitor cells at concentrations as low as 3 n

73 imulates the proliferation and maturation of myeloid progenitor cells both in vitro and in vivo.

74 g receptor family and is expressed highly on myeloid progenitor cells but at much lower levels in dif

75 tro phenotypes observed with loss of Gfi1 in myeloid progenitor cells but did not rescue Gfi1-/- bloc

76 air of our bones are formed from bone marrow myeloid progenitor cells by a complex differentiation pr

77 ICSBP inhibits growth of Bcr/Abl-transformed myeloid progenitor cells by activating several genes tha

78 interleukin-6 receptor (IL-6R) expression on myeloid progenitor cells by Delta-1 treatment combined w

79 and F1009/F1021 were overexpressed in FDC-P2 myeloid progenitor cells by retroviral-mediated gene tra

80 Moreover, murine myeloid progenitor cells carrying an Mll-CBP knock-in al

81 nimals bear distorted hematopoietic stem and myeloid progenitor cell compartments compared with euplo

82 IRS-4, we expressed them individually in 32D myeloid progenitor cells containing the human insulin re

83 by colony-forming assays (for erythroid and myeloid progenitor cells), cytochemical staining, and mi

84 cell production or runting but corrected the myeloid progenitor cell deficiency seen in these mutants

85 s (AAV) vectors to transduce primitive human myeloid progenitor cells derived from marrow and cord bl

86 neovasculogenesis and that CD133(+)CXCR4(+) myeloid progenitor cells directly participate in new blo

87 Apc heterozygous myeloid progenitor cells display an increased frequency

88 ly regulates the maturational advancement of myeloid progenitor cells during transitions between two

89 ll development, the gene was introduced into myeloid progenitor cells established from ICSBP-/- mice.

90 anced SCF, Flt3 ligand, and TPO expansion of myeloid progenitor cells ex vivo.

91 MBT-1(-/-) myeloid progenitor cells exhibit a maturational deficien

92 In contrast, HoxA10-overexpressing myeloid progenitor cells exhibited increased proliferati

93 y increases atherogenesis through regulating myeloid progenitor cell expansion and differentiation, f

94 d CD34(+)KIT(+) cells, which are enriched in myeloid progenitor cells, expressed and secreted the CCR

95 roarray gene expression analysis of Irf-8-/- myeloid progenitor cells expressing an IRF-8/estrogen re

96 Consequently, myeloid progenitor cells expressing oncogenic Kras and l

97 w here that hnRNP A1 levels are increased in myeloid progenitor cells expressing the p210(BCR/ABL) on

98 ew growth factors from IL-3-dependent murine myeloid progenitor cells (factor dependent cell progenit

99 cellularity of the bone marrow, elevation of myeloid progenitor cell frequencies in both organs and a

100 nalysis of gene expression (SAGE) on CD15(+) myeloid progenitor cells from 22 AML patients who had fo

101 okines in a manner similar to that of normal myeloid progenitor cells from bone marrow and cord blood

102 d expression of Fap1 and Gas2 in bone marrow myeloid progenitor cells from Icsbp(-/-) mice in compari

103 results document selective insensitivity of myeloid progenitor cells from mIL-8Rh(-/-) mice to inhib

104 We show here that in normal myeloid progenitor cells FUS, although not visibly ubiqu

105 n of haematopoietic stem cell/progenitor and myeloid progenitor cell genes.

106 During hematopoiesis, myeloid progenitor cells give rise to granulocytes and m

107 n of KLF7 results in a marked suppression of myeloid progenitor cell growth and a loss of short- and

108 ogenitor cells and may also be necessary for myeloid progenitor cell growth in a variety of hematopoi

109 In myeloid progenitor cells, HoxA10 represses transcription

110 and critical matrix-degrading activities of myeloid progenitor cells in an autocrine manner by augme

111 vival and abnormal cell cycle progression of myeloid progenitor cells in both cyclic and severe conge

112 due to accelerated apoptosis of bone marrow myeloid progenitor cells in CN.

113 rated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

114 peripheral blood, and the numbers of porcine myeloid progenitor cells in marrow, were increased in co

115 Myc preferentially stimulated the growth of myeloid progenitor cells in methylcellulose.

116 the phenomenon of microglial augmentation by myeloid progenitor cells in the adult brain.

117 LHRHa), increases the number of lymphoid and myeloid progenitor cells in the bone marrow and developi

118 ncer, we have shown that bone marrow-derived myeloid progenitor cells in the premetastatic lung secre

119 itment of bone marrow-derived CD11b(+)Gr1(+) myeloid progenitor cells in the premetastatic lungs.

120 trafficking was linked to redistribution of myeloid progenitor cells in the spleen.

121 arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP transgenic mice suggest

122 (CXCL)12) enhances survival/antiapoptosis of myeloid progenitor cells in vitro.

123 lso determined that HoxA10 overexpression in myeloid progenitor cells increased Tgfbeta2 production b

124 on of the CML-related Bcr-abl oncoprotein in myeloid progenitor cells increases expression of Fas-ass

125 vere anemia and thrombocytopenia and expands myeloid-progenitor cells, indicating that FOG-1 is requi

126 sed Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kin

127 Enforced expression of Id1 in committed myeloid progenitor cells inhibits granulocyte but not ma

128 addition, the regeneration of erythroid and myeloid progenitor cells is delayed during stress hemato

129 3-mediated cleavage of cyclin A in dividing myeloid progenitor cells is important for the onset of d

130 viral infection using a clonal population of myeloid progenitor cells (Kasumi-3 cells).

131 e growth factor I receptor (IGF-IRWT) in 32D myeloid progenitor cells led to cell proliferation in re

132 To study these pathways, we have used a myeloid progenitor cell line (32D) which is dependent on

133 erence analysis (RDA) to compare a committed myeloid progenitor cell line (EPRO) with the multipotent

134 t proliferation of the IL-3-dependent murine myeloid progenitor cell line 32D is suppressed by human

135 ivation of STAT3-p27(Kip1) pathway in murine myeloid progenitor cell line 32D-G-CSFR cells was marked

136 esponse nor affects the proliferation of the myeloid progenitor cell line 32D-GR that is deficient in

137 on of cell surface adhesion molecules in the myeloid progenitor cell line 32D.

138 ar calcium and inhibits the proliferation of myeloid progenitor cell line 32D.

139 ide (DMSO) to induce apoptosis in the murine myeloid progenitor cell line 32Dcl3, we examined the eff

140 y we have sought to characterize a committed myeloid progenitor cell line in an attempt to isolate ge

141 in the human pre-B-cell line 697, the human myeloid progenitor cell line K562, and the murine fibrob

142 ion library derived from the B6SutA(1) mouse myeloid progenitor cell line to search for novel oncogen

143 phages, and ectopic expression of VentX in a myeloid progenitor cell line triggered its differentiati

144 over-expressed in the IL-3 dependent, murine myeloid progenitor cell line, 32D cl3 in order to test w

145 r interleukin-3 (IL-3) modulates MAPK in the myeloid progenitor cell line, 32D.

146 Expression of exogenous Fms in a murine myeloid progenitor cell line, FDC-P1 (FD-Fms), results i

147 A primitive human hematopoietic myeloid progenitor cell line, KG1a, characterized by hig

148 sitive increase in mTOR kinase activity in a myeloid progenitor cell line.

149 ed signal in an interleukin (IL)-3-dependent myeloid progenitor cell line.

150 ematopoietic growth factor-dependent, lympho-myeloid progenitor cell lines from the fetal livers of b

151 Thus, unlike platelets and myeloid progenitor cell lines, fully differentiated huma

152 the development of bipotent cells using two myeloid progenitor cell lines, KG-1 and KG-1a, as models

153 s and used to transduce precursor B-cell and myeloid progenitor cell lines.

154 In both cases, myeloid progenitor cells lose the ability to distinctly

155 When transformed with p210 Bcr/Abl, ICSBP-/- myeloid progenitor cells lost growth factor dependence a

156 onsils; (b) mature neutrophils (high) versus myeloid progenitor cells (low) in bone marrow; (c) corpu

157 CD33 (Siglec-3) is a marker of myeloid progenitor cells, mature myeloid cells, and most

158 strate that a population of adult BM-derived myeloid progenitor cells migrated to avascular regions o

159 ly due in part to SDF-1 alpha enhancement of myeloid progenitor cell (MPC) survival.

160 t by influencing the proliferative status of myeloid progenitor cells (MPC).

161 ation of hematopoietic stem cells (HSCs) and myeloid progenitor cells (MPCs) has been shown to mediat

162 enhances proliferation of mature subsets of myeloid progenitor cells (MPCs), suppresses proliferatio

163 study, we examined the capacity of malignant myeloid progenitor cells of patients in the chronic phas

164 n to Ba/F3 murine pro-B cells but not to 32D myeloid progenitor cells or CTLL-2 murine helper T cells

165 In 32D myeloid progenitor cells, phosphorylation of Ser(307) in

166 Finally, overexpression of AML-1-ETO in myeloid progenitor cells prevented granulocyte colony-st

167 o more pronounced suppression of bone marrow myeloid progenitor cell proliferation and monocytosis, a

168 G-CSF signaling in the regulation of marrow myeloid progenitor cell proliferation in mice with Strep

169 This impairment of myeloid progenitor cell proliferation was not attenuated

170 ly test whether G-CSF can compensate for the myeloid progenitor cell reduction in the T(-) model of h

171 We determined that expression of Mll-Ell in myeloid progenitor cells resulted in autocrine productio

172 s, we demonstrated that AML EVs are taken-up myeloid progenitor cells, resulting in the selective pro

173 wth factor 2 (Fgf2) by HoxA10-overexpressing myeloid progenitor cells results in activation of beta-c

174 NF1 deficiency in myeloid progenitor cells results in cytokine hypersensit

175 ed and sufficient for the immortalization of myeloid progenitor cells, shares strong similarities to

176 lin-stimulated processes in 32D(IR) cells, a myeloid progenitor cell stably overexpressing the insuli

177 induced IL-2Ralpha mRNA expression using 32D myeloid progenitor cells stably transfected with either

178 of p53 in limiting aberrant self-renewal of myeloid progenitor cells, such that loss of p53 counters

179 d the apoptotic and growth properties of 32D myeloid progenitor cells, suggesting DeltaTrkA may have

180 llular effects were consistent with enhanced myeloid progenitor cell survival by SDF-1 alpha after de

181 Human myeloid progenitor cells temporarily express HLA class I

182 oxidase (MPO), an enzyme found in developing myeloid progenitor cells, the likely origin for myeloid

183 Nf1) increases the proliferative response of myeloid progenitor cell to hematopoietic cytokines.

184 es have relied on ex vivo differentiation of myeloid progenitor cells to DCs in culture.

185 ed that differentiation of latently infected myeloid progenitor cells to dendritic or macrophage-like

186 Mcl1 facilitates AML development by allowing myeloid progenitor cells to evade Myc-induced cell death

187 hich is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colon

188 JMML is acquired hypersensitivity by clonal myeloid progenitor cells to granulocyte macrophage-colon

189 pression enhanced the sensitivity of primary myeloid progenitor cells to granulocyte-macrophage colon

190 nal activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted

191 mitogenic response of M07e cells and murine myeloid progenitor cells to these cytokines and particul

192 mirrored by impairment of the ability of 32D myeloid progenitor cells to undergo proper terminal diff

193 Inactivation of Mtg16 skewed early myeloid progenitor cells toward the granulocytic/macroph

194 We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1

195 and colleagues examine deletion of Dicer1 in myeloid progenitor cells using a conditional Cebpa-Cre a

196 the enhanced self-renewal of early postnatal myeloid progenitor cells was limited and did not result

197 tand the pattern of gene expression in mouse myeloid progenitor cells, we carried out a genome-wide a

198 and induced trafficking and proliferation of myeloid progenitor cells were disordered in -/- mice.

199 marrow was protected and enhanced numbers of myeloid progenitor cells were found in S and G2/M.

200 Under the condition used, both erythroid and myeloid progenitor cells were generated.

201 Normal numbers of myeloid progenitor cells were present in Nr4a1-/- mice,

202 To approach these aims, FDC-P1 murine myeloid progenitor cells were transfected with vectors d

203 ucing transcription factors IRF8 and PU.1 in myeloid progenitor cells, whereas it reduces G-CSF-drive

204 leen and liver, and the presence of immature myeloid progenitor cells with high nucleus-to-cytoplasm

205 lso compared the expression of mouse Gr-1(+) myeloid progenitor cells with that of mouse brain tissue

206 ated in interleukin 3 (IL-3)-dependent 32D.3 myeloid progenitor cells, yet this induces apoptosis whe