ライフサイエンスコーパス: naked

1 ced significantly higher GFP expression than naked Ad in both coxsackie and adenovirus receptor (CAR)

2 e therapy, the intravenous administration of naked Ad still encounters unfavorable host responses, no

3 c uptake and transduction compared to either naked Ad/GFP or Ad/GFP-ABP.

4 he condensed phase and that the existence of naked alpha-oxo carbenes is highly improbable.

5 Moreover, administration of naked and AAV-packaged AONs to the retina of a humanized

6 We here explore the therapeutic potential of naked and adeno-associated virus (AAV)-packaged AONs in

7 d regulated budding yeast DNA replication on naked and chromatinized templates in vitro, providing ke

8 ntext of microtubule-mediated trafficking of naked and enveloped alphaherpesvirus capsids.

9 ansfection efficiencies of mRNA delivered in naked and nanoparticle format in vitro and in vivo using

10 on of messenger RNA (mRNA) delivered in both naked and nanoparticle formats are actively investigated

11 carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, g

12 stinguish between the movement of so-called "naked" and membrane-associated cytoplasmic alphaherpesvi

13 trategies that involve encapsulation of the "naked" anion.

14 Although naked antibodies have proven valuable as pharmaceutical

15 ity attributes: drug distribution, amount of naked antibody, and average drug to antibody ratio (DAR)

16 sed ADC samples when compared to that of the naked antibody.

17 Previously, we showed that naked antisense oligonucleotides (AONs) effectively rest

18 Although current naked AONs do not enter the heart or cross the blood-bra

19 tudies thus characterize the reactivity of a naked aryl anion in solution and contrast it with the re

20 goes hydronation is not an aryllithium but a naked aryl anion.

21 platforms were carried out and compared with naked AuE, BPDT/AuE, AuNPs/AuE, and AgNPs/AuE.

22 an be explained by first-time myelination of naked axons.

23 infectious HSV particles in their lumens and naked capsids docked to their cytoplasmic surfaces.

24 Our results challenge the old vision of "naked" chromium species (i.e., low coordinated) as the a

25 sis of multisubstituted chrysenes as well as naked chrysene under mild conditions.

26 ration of heme-peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeT

27 e-wrapped virions are as infectious as their naked counterparts, although they do not express a viral

28 ty to overcome cancer resistance compared to naked counterparts.

29 One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), which is a repressor of

30 tumors identified the downregulation of the naked cuticle homolog 2 (NKD2) gene, a negative regulato

31 Naked cuticle results from Wg repression of shavenbaby (

32 n of denticle belts separated by smooth, or 'naked', cuticle.

33 e first time, the formation of O(4)-POBdT in naked DNA and in genomic DNA of cultured mammalian cells

34 luorescence in the eyes injected with NP and naked DNA compared to uninjected counterparts.

35 MV-qPCR) was developed to differentiate free naked DNA from virion DNA.

36 similar to those occurring in vivo, whereas naked DNA gave many aberrant transcripts.

37 cal pH (pH 7-8), G.C Hoogsteen base pairs in naked DNA have a population of 0.02-0.002%, as compared

38 While the effects of torsional stresses on naked DNA have been well studied, little is known about

39 th high processivity and at rates similar to naked DNA in vitro.

40 ndamental question of whether nucleosomal or naked DNA is the preferred substrate of plant and animal

41 dingly, we demonstrate confluent staining of naked DNA molecules presented within microfluidic device

42 ect on MeCP2-mediated repression with either naked DNA or chromatin templates.

43 ted more potent B- and T-cell responses than naked DNA or DCs pulsed with inactivated HIV.

44 n repair factors, the damage is removed from naked DNA or nucleosomes in the form of 24- to 32-nucleo

45 s [(6-4)PPs] from UV-irradiated cellular and naked DNA revealed that the effect of transcription fact

46 Although nicks in naked DNA stimulate PARP3 autoribosylation, nicks in mon

47 relatively little effect on Cas9 cleavage of naked DNA substrates, but strongly inhibit cleavage of n

48 NPs or naked DNA were subretinally injected in rpe65(-/-) mice

49 of wild-type [WT] for NPs and 44% of WT for naked DNA).

50 was at least sevenfold greater than that of naked DNA, and chromatin gave patterns of transcription

51 As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex a

52 solated nucleoprotein complexes on otherwise naked DNA.

53 bserved with the non-targeted dendriplex and naked DNA.

54 ing tumor DNA (ctDNA) is a component of the "naked" DNA found in blood.

55 by using a candidate preventive/therapeutic naked-DNA vaccine that expresses human calreticulin (hCR

56 urdles, we successfully used minicircle (MC) naked-DNA vectors devoid of any viral or bacterial seque

57 ing lncRNA (Mhrt) and chromatinized--but not naked--DNA.

58 e of Chromosome (SMC)1-SMC3 heterodimer with naked double-helix DNA.

59 and that it is capable of using the size of naked dsDNA as a molecular ruler to distinguish self fro

60 However, the instability of naked dsRNA sprayed on plants has been a major challenge

61 nfectious as a purified entity but also as a naked dsRNA.

62 (Zea mays [Zm]) has a single aleurone layer, naked endosperm (nkd) mutants produce multiple outer cel

63 NAKED ENDOSPERM1 (NKD1) and NKD2 are duplicate INDETERMI

64 etic parameters are improved compared to the naked enzyme suggesting longer blood circulation after i

65 rotein and c-DNA were detected both with the naked eye and a strip reader.

66 ssembled monolayer (SAM) was detected by the naked eye and analysed using an image analysis software

67 netic nanobeads moieties was detected by the naked eye and analysed using ImageJ analysis software fo

68 entify significant traces not visible to the naked eye and not detectable by XRF spot measurements or

69 ydrogen mixture is clearly noticeable to the naked eye as a change in the brightness of light transmi

70 oteins have been well distinguished with the naked eye at the 50 nM level.

71 ation, which can be easily observed with the naked eye at the nanomolar level.

72 show any obvious signs of iridescence to the naked eye but where a highly ordered chloroplast structu

73 The synthesized CNDs showed dual mode naked eye colorimetric ultrasensitive sensing capability

74 A naked eye detection of 50 ppb dichlorvos is achievable b

75 etter demonstrates a biosensing platform for naked eye detection of miRNA, fabricated using a poly(vi

76 substrate synthesis, and is also amenable to naked eye detection.

77 ferent optical signals, thereby facilitating naked eye detection.

78 s is that volume shrinking is visible to the naked eye down to femtomolar concentrations of protein.

79 Counting the plaques by the naked eye enables the quantification of miRNAs with dete

80 Negative read-out was observed by the naked eye for all tested isolates except for MRSA.

81 a stronger ECL, which can be observed by the naked eye in a lighted room, on reduction in the presenc

82 ion of adenosine as a model analyte with the naked eye in buffer samples and undiluted human serum.

83 orm in its identification and detection with naked eye in point-of-care.

84 difficult to percept adulterations with the naked eye in samples of roasted and ground coffee.

85 etection of small-molecule targets using the naked eye is demonstrated.

86 A color response visible to the naked eye is observed at 5 ppb of CO, and a remarkably c

87 , real-time detection of metastases with the naked eye is possible.

88 les such as cancer-biomarker miRNAs with the naked eye is seemingly impossible in molecular diagnosti

89 e target concentration required for reliable naked eye observation with unmodified AuNPs in well-opti

90 source and a colored plastic gel filter, the naked eye or a camera can easily discriminate between po

91 Results can be visually observed by the naked eye or imaged by a smartphone camera under a porta

92 umor phenotypes that fail to be perceived by naked eye that semantic features do not describe and vic

93 diffraction, and the system can read by the naked eye to detect the Apple Stem Pitting Virus (ASPV)

94 This quenching could be visualized by the naked eye under a UV (365 nm) lamp and performed almost

95 e sample vials were easily visualized by the naked eye under ultraviolet light illumination.

96 s enable the detection of hydrazine with the naked eye well below sub-ppm concentrations (ca. 30 ppb)

97 ntrations of rabbit IgG and human PSA by the naked eye were down to 0.1 and 4 ng/mL, respectively.

98 rations through UV-vis absorption and by the naked eye were estimated to be 0.3 and 60nM, respectivel

99 detection of 1ngmL(-1) and assessed with the naked eye within 10min.

100 extent that they become imperceptible to the naked eye yet are not significantly reduced in total mas

101 lue, which allows a prospective use for the "naked eye" detection of Pb(2+) ion over other competitor

102 k bar charts can be directly read out by the naked eye, and the signal shows little interference from

103 ctrode, which is clearly measurable with the naked eye, correlates linearly with an analyte concentra

104 h deposits or cryptotephra, invisible to the naked eye, discovered within Greenland ice-cores, and ra

105 A allows the results to be visualized by the naked eye, enabling instant, cost-efficient, and on-site

106 examining the samples surfaces with both the naked eye, first, and microscopically (10x and 50x), imm

107 he presence of the final DNA amplicon to the naked eye, providing a "sample-to-answer" diagnosis from

108 ary tumors before they become visible to the naked eye, supporting the added value of this technique

109 ride ions at micromolar concentration by the naked eye, UV-vis absorption, and fluorescence.

110 ponse, which could be followed easily by the naked eye, was found to depend on the specifics of the a

111 ss to dark yellow/brown, also visible to the naked eye, with a detection limit of 500 ppm.

112 blue ECL emission, easily observable even by naked eye, with quantum yield higher than the standard 9

113 mm in diameter and was not visible with the naked eye.

114 absorbing at 537 nm, which is visible to the naked eye.

115 or growth, before they became visible to the naked eye.

116 of oxygenation under ambient light with the naked eye.

117 or change of the EC sensor is visible to the naked eye.

118 olor of the sensor surface observable by the naked eye.

119 quantification of disease biomarkers by the naked eye.

120 hange in turbidity that could be seen by the naked eye.

121 orescence changes are easily observed by the naked eye.

122 od for detecting disease biomarkers with the naked eye.

123 orogenic responses even conspicuous with the naked eye.

124 green, which can be clearly observed by the naked eye.

125 h UV-vis spectroscopy and estimated with the naked eye.

126 th mastitis could be determined based on the naked eye.

127 f the color could be clearly observed by the naked eye.

128 especially if the results can be read by the naked eye.

129 o isomeric states to be distinguished by the naked eye.

130 with a colorimetric output observed with the naked eye.

131 nfirmed the viability of all isolates by the naked eye.

132 changes in color that can be followed by the naked eye.

133 at concentrations as low as 0.5 nM with the naked eye.

134 rption behavior which can be followed by the naked eye.

135 homogenous one-step reaction visible to the naked eye.

136 able, and if possible allow detection by the naked eye.

137 ives distinct optical signals visible to the naked eye.

138 emoved that are difficult to detect with the naked eye.

139 s exosome surface proteins in minutes by the naked eye.

140 linical disease not readily visible with the naked eye.

141 ith traditional RGB intensity sensors or the naked eye.

142 le by UV-vis spectroscopy and obvious to the naked eye.

143 he oscilloscope that wiggle similarly to the naked eye.

144 ing color changes that are detected with the naked eye.

145 ELISA can be observed within an hour by the naked eye.

146 ctive route for halocarbon analysis with the naked eye.

147 he developed mini-column at visible light by naked eye; where MG was seen as compact green band at th

148 otein (AFP) with the lowest concentration of naked-eye detection down to 1.0 x 10(-12) g mL(-1).

149 generation, enabling unprecedented one-pot, naked-eye detection of a catalytic reporter from 1 mum d

150 cribes a signal-generation mechanism for the naked-eye detection of analytes at low concentrations wi

151 This allows for the naked-eye detection of analytes by observing the generat

152 s signal-generation procedure allows for the naked-eye detection of analytes within 1 h.

153 er the cellulosic strips and applied for the naked-eye detection of PA down to 1muM.

154 and avidin-conjugated GOx for the selective naked-eye detection of rabbit immunoglobulin G (IgG) and

155 nt a simple platform that enables sensitive, naked-eye detection of SNPs with minimal reagent and equ

156 a surfactant-induced aggregation, results in naked-eye detection of these common anionic surfactants

157 Naked-eye fluorescent visualization of amplicons reveale

158 most cases, the detection is made by simple naked-eye observation of agglutinates without any access

159 assay has some advantages such as useful for naked-eye observation, disposable, not time-consuming, i

160 e proposed plasmonic immunoassay allowed the naked-eye quantification of 0-10 ng/mL PSA at an interva

161 initially describes the design of low-cost, naked-eye quantitative aptamer-based assays by using mic

162 sulfonamides using spectrophotometry and for naked-eye semi-quantitative estimation.

163 yes with high molar absorptivities to permit naked-eye sensing.

164 e observed enhanced "turn-on" emission and a naked-eye sensitive blue-green color in the medium is at

165 and Hg(2+) in 1:2 stoichiometry, in which a naked-eye sensitive fluorescent blue color of solution c

166 nt, the proposed method was further used for naked-eye tracking glycolytic inhibition in living cells

167 s are fused in the form of fluorene, allows "naked-eye" detection of fluoride in subppm levels (<1.0

168 can be simply interpreted through the human naked-eye, it provides a simple method for fast-screenin

169 Here, we show an ultrasensitive naked-eye-counting strategy for quantifying miRNAs by em

170 or change from pure blue to red, observed by naked eyes along an incident angle of 20-30 degrees .

171 spray kit to directly spot the explosives by naked eyes, implying great potential for quick, low-cost

172 ich can be used to detect Hg(2+) in water by naked eyes.

173 the target DNA, which could be recognized by naked eyes.

174 0 nM Cu(II) in solution can be achieved with naked eyes.

175 as confirmed endoscopically by "pillow" and "naked fat" signs.

176 de extrusion step through protonation of the naked fluoride.

177 4h, and most sustained when delivered in the naked format subcutaneously at the base of tail with an

178 mRNA is delivered in nanoparticle but not in naked format.

179 he chromatin so that the chromatin was left "naked" (free from the nuclear lamina).

180 illions of DNA backbone hydrolysis events on naked genomic DNA, we show that the intrinsic rate of cl

181 ransglycosylase with a strong preference for naked glycan strands.

182 li with purified RlpA resulted in release of naked glycans containing 1,6-anhydro N-acetylmuramic aci

183 s that lack stem peptides (hereafter called 'naked glycans').

184 cal studies are reviewed which show that the naked group 14 atoms E = C-Pb in the singlet (1)D state

185 he immunologic effectors stimulated by these naked HER2 antibodies provide only modest activity as mo

186 hMSCs remaining highly viable within BaCaps; naked hMSCs were poorly retained.

187 eive either BaCaps with hMSCs, empty BaCaps, naked hMSCs, or saline by using a percutaneous subxiphoi

188 RNAs vectors targeting the IL-8 gene and the naked homologous repair DNA carrying different haplotype

189 arrangements, resulting in the expression of naked IgL on a surface of precursor B cells.

190 ve transcription factor MONOPTEROS (MP) form naked inflorescence "pins" lacking flowers.

191 t syngeneic CC islets was lower than that of naked islets, we showed that CC (PEG MG) islets from ful

192 , and cancer cell killing effect compared to naked KOX or KOX/PEGbPHF at pH7.4, demonstrating that KO

193 model was significantly higher than that of naked KOX.

194 tic efficacy, and lower toxicity compared to naked KOX.

195 a simple [Cr(III) L3 ] metalloligand and a "naked" M(II) salt.

196 story nicely demonstrates that the future of naked mAbs is to design agents with optimized and tailor

197 A single weekly administration of the naked mAbs reduced splenomegaly, liver tumor spots, and

198 Compared to naked mAbs, ADCs have an increased level of complexity a

199 The naked mole rat (Heterocephalus glaber) displays exceptio

200 The naked mole rat (Heterocephalus glaber) is a long-lived a

201 The naked mole rat (Heterocephalus glaber) is an exceptional

202 Recent studies in naked mole rat and long-lived sea urchins showed that th

203 hippocampal and olfactory structures of the naked mole rat brain.

204 is and neuronal migration are not unusual in naked mole rat brains.

205 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is ass

206 developed a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and r

207 Tumor resistance in the naked mole rat is mediated by the extracellular matrix c

208 When overexpressed in naked mole rat or human cells, pALT(INK4a/b) has stronge

209 K4a/b) is present in both cultured cells and naked mole rat tissues but is absent in human and mouse

210 is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.

211 we identify a mechanism responsible for the naked mole rat's cancer resistance.

212 may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regi

213 rs interested in the genome and genes of the naked mole rat, and also to facilitate further studies o

214 t, pALT(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance

215 Here, we show that, in the naked mole rat, the INK4a/b locus encodes an additional

216 iking considering the small body mass of the naked mole rat.

217 Naked mole rats (NMRs) live in sizable colonies where br

218 en cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats.

219 usion is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenil

220 Naked mole rats are the longest-living rodents, whose ne

221 We speculate that naked mole rats have evolved a higher concentration of H

222 Overall, we conclude that naked mole rats show an extremely protracted period of b

223 In addition to their longevity, naked mole rats show an unusual resistance to cancer.

224 some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland m

225 ns range from 4 years in mice to 32 years in naked mole rats.

226 The naked mole-rat (Heterocephalus glaber) is a subterranean

227 In naked mole-rat (NMR) colonies, breeding is monopolized b

228 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface

229 Furthermore, the naked mole-rat cells are more sensitive to HA signalling

230 erexpressing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant tra

231 In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, su

232 tion of mouse fibroblasts fails to transform naked mole-rat cells.

233 Multi-year observations of large naked mole-rat colonies did not detect a single incidenc

234 othesis that the more stable proteome of the naked mole-rat contributes to its longevity.

235 x2 reversibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

236 We report that naked mole-rat fibroblasts have significantly increased

237 We found that naked mole-rat fibroblasts secrete extremely high-molecu

238 as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mec

239 report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments o

240 The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other

241 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled b

242 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of gly

243 -molecular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity o

244 mers may reflect a further adaptation of the naked mole-rat to living in an environment with high-car

245 The African naked mole-rat's (Heterocephalus glaber) social and subt

246 The preternaturally long-lived naked mole-rat, like other long-lived species and experi

247 Naked mole-rats (Heterocephalus glaber) live in groups t

248 oach and examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varyi

249 sites at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include t

250 2 binding, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucle

251 Naked mole-rats live in large eusocial colonies that are

252 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and su

253 eceptor binding densities in female and male naked mole-rats varying in breeding status.

254 into the neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that

255 Naked mole-rats, despite having functional ASICs, are in

256 dy, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maxim

257 dendritic cells (DCs) efficiently in vitro, naked mRNA could not produce any detectable gene product

258 In vivo, naked mRNA is more efficient than mRNA nanoparticles whe

259 d of Micro encapsulated (MRT, 8 days) versus naked (MRT, 36 days; P < 0.01) baboon islets transplante

260 Cationic naked nanocrystals (NCs) are useful building units for a

261 e insights enabled the preparation of stable naked NC inks of desorption-susceptible NC compositions

262 s these human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that

263 tumor growth suppression when compared with naked oAd and 9.5 x 10(6)-fold increased tumor-to-liver

264 oor stability and low delivery efficiency of naked oligonucleotides.

265 y clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies.

266 MusPV1 DNA, whether naked or encapsidated by MusPV1 or human papillomavirus

267 in vivo regardless of the mode of delivery (naked or nanoparticle) or the site of administration.

268 proach and a step toward the development of "naked" or toxin-conjugated KIT antibodies for the treatm

269 ic chemicals was first demonstrated using a "naked" PAO chip placed on solid agar, and later in a chi

270 Naked pDNA (200 mug) encoding luciferase and SonoVue(R)

271 nd reproducible gene expression of exogenous naked pDNA in human skin using volumes that are consider

272 overwriting the original precursor with the naked peptide m/z and removing all of the glycan-related

273 ogens that are mechanistically distinct from naked peptide or protein-based tolerogens.

274 to produce cotyledons and leaves and grow a naked pin while maintaining an active SAM.

275 h HSV or CMV, or transient transfection with naked plasmid DNA, HIRA re-localizes to PML bodies, site

276 onstrate that L alone initiates synthesis on naked RNA and that P serves to enhance the initiation an

277 se of VSV P stimulated RABV RdRP activity on naked RNA but was insufficient to permit initiation on t

278 ve that these assemblies can be connected by naked RNA regions of the transcript.

279 shift assays, we demonstrate the absence of naked (-)RNA templates during replication.

280 Naked RNAs are difficult to crystallize and NMR spectros

281 e to the issues regarding to the delivery of naked siRNA predominantly to target cells.

282 ilencing of 28% (rHSA/siRNA) compared to 4% (naked siRNA) 6days post-injection.

283 with serum-containing media when compared to naked siRNA, and 25k-branched-polyethylenimine (bPEI) re

284 ow the properties of AID acting freely on a "naked" ssDNA relate to the constrained action of AID dur

285 of-magnitude lower than required by standard naked SSOs.

286 Naked surgeons shed fewer bacteria into the operating ro

287 the plant cell nucleus, possibly by binding naked T-strands and blocking their conversion into doubl

288 ernalized, consistent with slow recycling of naked TAS2R14 in the absence of the heterodimeric milieu

289 ransition metal complexes [TM]-E which carry naked tetrele atoms E = C-Sn as ligands.

290 life extension in NMRI mice from t1/2 12min (naked) to t1/2 45min (single cholesteryl) and t1/2 71min

291 ic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither U

292 However, naked valley size also varies among populations of D. me

293 mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression

294 hown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. si

295 e on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithora

296 ethod development to effect a coupling of a "naked" vinylogous anion with an aldehyde.

297 he HIRA chaperone complex represses incoming naked viral DNAs through chromatinization as part of int

298 udes populations of both viral particles and naked viral genomes.

299 7 degrees C identified numerous examples of naked virus capsids located immediately beneath the plas

300 er, we and others have observed that various naked viruses, such as CVB, can trigger the release of i