ライフサイエンスコーパス: naked mole rat

1 fish, insects), and in specialized habitats (naked mole rats).

2 iking considering the small body mass of the naked mole rat.

3 es to the remarkable tumor resistance of the naked mole-rat.

4 e organization of somatosensory areas in the naked mole-rat.

5 ns range from 4 years in mice to 32 years in naked mole rats.

6 , thrips, and beetles), snapping shrimp, and naked mole rats.

7 to eusociality and the unusual physiology of naked mole-rats.

8 se is known to occur in species ranging from naked mole rats [1] to owls [2], chimpanzees are the mos

9 We explore this in the naked mole-rat, a species with the most rigidly organize

10 Naked mole-rats also were completely lacking in cutaneou

11 Recent studies in naked mole rat and long-lived sea urchins showed that th

12 en cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats.

13 oach and examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varyi

14 rs interested in the genome and genes of the naked mole rat, and also to facilitate further studies o

15 into the neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that

16 usion is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenil

17 Naked mole rats are the longest-living rodents, whose ne

18 Naked mole-rats are eusocial rodents that live in large

19 ual features of the cutaneous innervation in naked mole-rats are presumably adaptations to their subt

20 African naked mole-rats are subterranean rodents that have a rob

21 t acid pain, which would be advantageous for naked mole-rats as they normally live under chronically

22 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface

23 hippocampal and olfactory structures of the naked mole rat brain.

24 is and neuronal migration are not unusual in naked mole rat brains.

25 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is ass

26 Furthermore, the naked mole-rat cells are more sensitive to HA signalling

27 erexpressing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant tra

28 In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, su

29 nduce robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse

30 tion of mouse fibroblasts fails to transform naked mole-rat cells.

31 Multi-year observations of large naked mole-rat colonies did not detect a single incidenc

32 The discovery of a disperser morph in naked mole-rat colonies has revealed the first possible

33 othesis that the more stable proteome of the naked mole-rat contributes to its longevity.

34 t, pALT(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance

35 Naked mole-rats, despite having functional ASICs, are in

36 Behaviorally, naked mole-rats did not avoid fumes from moderately high

37 x2 reversibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

38 Finally, somatosensory cortex in naked mole-rats encompasses virtually all of the neocort

39 sites at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include t

40 In cell culture, naked mole-rat fibroblasts arrest at a much lower densit

41 Here we show that naked mole-rat fibroblasts display hypersensitivity to c

42 We report that naked mole-rat fibroblasts have significantly increased

43 We found that naked mole-rat fibroblasts secrete extremely high-molecu

44 developed a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and r

45 ly cutaneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio ( approxim

46 In contrast to the furred species, naked mole-rats had a paucity of Abeta-fiber Merkel endi

47 In contrast, the hairless skin of the naked mole-rats had an exceptional abundance of presumpt

48 However, naked mole-rats had very few VP-ir cells in the bed nucl

49 We speculate that naked mole rats have evolved a higher concentration of H

50 In addition to its longevity, naked mole-rats have an extraordinary resistance to canc

51 The naked mole rat (Heterocephalus glaber) displays exceptio

52 The naked mole rat (Heterocephalus glaber) is a long-lived a

53 The naked mole rat (Heterocephalus glaber) is an exceptional

54 ently showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber def

55 The strictly subterranean naked mole-rat (Heterocephalus glaber) has markedly redu

56 The naked mole-rat (Heterocephalus glaber) is a subterranean

57 The naked mole-rat (Heterocephalus glaber) is unusual in num

58 Naked mole-rats (Heterocephalus glaber) have a large cor

59 Naked mole-rats (Heterocephalus glaber) have numerous an

60 Naked mole-rats (Heterocephalus glaber) live in groups t

61 some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland m

62 African mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity t

63 2 binding, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucle

64 Tumor resistance in the naked mole rat is mediated by the extracellular matrix c

65 as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mec

66 In contrast, early contact inhibition in naked mole-rat is associated with the induction of p16(I

67 hat the retinogeniculocortical system in the naked mole-rat is considerably smaller than that of rode

68 ontribution of the LG to brain volume in the naked mole-rat is less than a third of that of the rat.

69 report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments o

70 The naked mole-rat is the longest living rodent with a maxim

71 s C-fiber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack

72 The preternaturally long-lived naked mole-rat, like other long-lived species and experi

73 Naked mole-rats live in large eusocial colonies that are

74 Naked mole-rats live in large, subterranean colonies whe

75 Naked mole rat (MR) Heterocephalus glaber is a rodent mo

76 , data from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP)

77 In naked mole-rat (NMR) colonies, breeding is monopolized b

78 Naked mole rats (NMRs) live in sizable colonies where br

79 mined the brains of breeding and subordinate naked mole-rats of both sexes, including several regions

80 VP in the brains of subordinate and breeding naked mole-rats of both sexes.

81 When overexpressed in naked mole rat or human cells, pALT(INK4a/b) has stronge

82 at major cortical remodeling has occurred in naked mole-rats, paralleling the anatomical and behavior

83 The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other

84 we identify a mechanism responsible for the naked mole rat's cancer resistance.

85 may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regi

86 The African naked mole-rat's (Heterocephalus glaber) social and subt

87 Overall, we conclude that naked mole rats show an extremely protracted period of b

88 In addition to their longevity, naked mole rats show an unusual resistance to cancer.

89 ery high concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior an

90 We investigated naked mole-rat somatosensory cortex to determine how bra

91 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled b

92 Here, we show that, in the naked mole rat, the INK4a/b locus encodes an additional

93 The exception is the naked mole-rat, the only known vertebrate to show physio

94 dy, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maxim

95 K4a/b) is present in both cultured cells and naked mole rat tissues but is absent in human and mouse

96 is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.

97 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of gly

98 -molecular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity o

99 mers may reflect a further adaptation of the naked mole-rat to living in an environment with high-car

100 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and su

101 eceptor binding densities in female and male naked mole-rats varying in breeding status.

102 body hair follicles, and intervening skin in naked mole-rats was compared with that in rats and a fur

103 rences in other species, its distribution in naked mole-rats was of interest.

104 subordinates from reproducing (for example, naked mole-rats, wasps and ants).

105 ses revealed that the body hair follicles in naked mole-rats were exceptionally large and well innerv

106 sms responsible for the cancer resistance of naked mole-rats were unknown.