ライフサイエンスコーパス: nucleophilic attack

1 manner through an unexpected intramolecular nucleophilic attack.

2 ys and the susceptibility of the products to nucleophilic attack.

3 Thioester linkage is cleaved by nucleophilic attack.

4 ost electron-deficient and might be prone to nucleophilic attack.

5 ically raises the activation barrier for the nucleophilic attack.

6 nd interact directly with Thr-413 to promote nucleophilic attack.

7 o a different reaction mechanism involving a nucleophilic attack.

8 , such as nitro groups, to superoxide-driven nucleophilic attack.

9 es its ability to activate pi-systems toward nucleophilic attack.

10 can efficiently protect the loaded dye from nucleophilic attack.

11 s correctly orient the carboxamide group for nucleophilic attack.

12 +), and Cys348 faces the wrong direction for nucleophilic attack.

13 hydrolytic water molecule more favorably for nucleophilic attack.

14 ade between this reaction and other modes of nucleophilic attack.

15 and the cofactor, priming the substrate for nucleophilic attack.

16 Fenton chemistry, heterolytic cleavage, and nucleophilic attack.

17 Glu76 may facilitate this autocleavage in a nucleophilic attack.

18 activating the aziridine intermediate toward nucleophilic attack.

19 activate the cysteines in the substrate for nucleophilic attack.

20 ars to be crucial for setting up the in-line nucleophilic attack.

21 oxygen of PAM, positioned correctly for the nucleophilic attack.

22 e is highly susceptible to electrophilic and nucleophilic attack.

23 hyrin carbene accomplishes N-H insertion via nucleophilic attack.

24 s create the in-line trajectory required for nucleophilic attack.

25 roles in activating the target cytosine for nucleophilic attack and contributes to tight DNA binding

26 se structural methods reveals details of the nucleophilic attack and identifies a novel enzyme-produc

27 s to accomplish this step, single-site water nucleophilic attack and O-O radical coupling, are discus

28 urther reveal that both intermolecular water nucleophilic attack and redox isomerization of {[LCu(III

29 embled to optimally align the pyrimidine for nucleophilic attack and subsequent methyl transfer, cons

30 A variety of nucleophilic attacks (and THF polymerization) on the coo

31 d to a proton transfer (PCNA: proton-coupled nucleophilic attack) and a subsequent decomposition of t

32 rn motif activates the carbonyl group toward nucleophilic attack, and chemical transformation of this

33 ion include azide and nitro group reduction, nucleophilic attack, and CuS precipitation.

34 s in this reaction: it decomposes the PCs by nucleophilic attack, and in the subsequent polyether for

35 steps involving primer 3' OH deprotonation, nucleophilic attack, and pyrophosphate leaving-group eli

36 lso positions the labile linkage for in-line nucleophilic attack, and thus twister appears to simulta

37 ng "preactivation" of the (1)C(4) complex to nucleophilic attack as reflected by free energy, C1-O1/O

38 The amine is proposed to perform a nucleophilic attack at a terminal eta(2)-carboxylate lig

39 Products arising from nucleophilic attack at all conceivable sites, that is, a

40 r)-2-azabicyclo[2.2.2]octanes were formed by nucleophilic attack at C(5) on syn-halonium ions.

41 ubsequent preferred mode of fragmentation by nucleophilic attack at C9 or C12.

42 stitution of iodide at the metal followed by nucleophilic attack at carbon by a second amine.

43 ch aliphatics, showing no apFr, preventing a nucleophilic attack at P after lithiation.

44 ples of iriduim allyl complexes that undergo nucleophilic attack at terminal position, rather than th

45 s proceed with high regioselectivity through nucleophilic attack at the C-6 position of the pyrone ri

46 (1) the "anchor-relay" mechanism mediated by nucleophilic attack at the carbonyl and (2) direct attac

47 such as Fe(CO)5 and Cr(CO)6 react with 1 via nucleophilic attack at the carbonyl carbon atom to give

48 ntified as the base that activates water for nucleophilic attack at the chorismate C2 carbon.

49 of the ligand framework directs and promotes nucleophilic attack at the ligand gold complex-activated

50 is the initial deprotonation in concert with nucleophilic attack at the phosphate center; however, th

51 aziridines by trimethylsilylazide, inducing nucleophilic attack at the primary position of one enant

52 h ARH3- and ARH1-catalyzed reactions involve nucleophilic attacks at the C-1'' position, it was perpl

53 fonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroac

54 ate formed by Flp(R191A) can be targeted for nucleophilic attack by a 5'-hydroxyl or water and channe

55 hiometric Si-N bond-forming reaction suggest nucleophilic attack by a magnesium amide as the turnover

56 rgo self-catalyzed endoproteolysis involving nucleophilic attack by a molecule of cholesterol.

57 ) is a much better target for the subsequent nucleophilic attack by a negatively charged OH(-) than t

58 This species subsequently undergoes nucleophilic attack by a second equivalent of NH2OH, for

59 This process depends on nucleophilic attack by a substrate lysine on a thioester

60 The oxyl radical is susceptible to nucleophilic attack by a substrate water molecule initia

61 a(5) -Cp)(BDI)](+) (3(+) ), which allows for nucleophilic attack by a variety of reagents under mild

62 ate of an ATP molecule is undergoing in-line nucleophilic attack by a water molecule.

63 This intermediate undergoes nucleophilic attack by an N-terminal poly-Gly sequence t

64 The rates of nucleophilic attack by aniline and by N-methylaniline on

65 and a multistep mechanism starting with the nucleophilic attack by benzamidine on an in situ generat

66 n of a diazo intermediate which encounters a nucleophilic attack by carbonyl oxygen on the electrophi

67 avage of P horizontal lineSe bond is through nucleophilic attack by carboxylate instead of alkylamine

68 es the electrophilic carbonyl group toward a nucleophilic attack by CN(-) in aqueous environment.

69 The reaction catalyzed by APR involves the nucleophilic attack by conserved Cys-249 on adenosine 5'

70 Overall, the nucleophilic attack by Cys25 thiolate and the proton-tra

71 This makes this Si-C bond subject to nucleophilic attack by F(-), triflate, and alkoxide/ethe

72 Nucleophilic attack by free pyridine at the alpha-carbon

73 wide pH range, providing rate constants for nucleophilic attack by hydroxide ion (kOH), by water (kH

74 oned mechanisms because the rate-determining nucleophilic attack by hydroxide is relatively slow.

75 of the N-chlorinated amidic N-C bond due to nucleophilic attack by hydroxyl ions.

76 uces CO(2) by one electron transfer (ET) via nucleophilic attack by its N lone pair on the C of CO(2)

77 in polarizing a substrate carbon center for nucleophilic attack by metal activated water and acting

78 ent with Lewis acid/base chemistry involving nucleophilic attack by N5 of FAD(red) at C1 of UDP-Galf/

79 a concerted S(N)2-like mechanism, in which a nucleophilic attack by O(Ser), facilitated by proton tra

80 C2 position, which is usually susceptible to nucleophilic attack by OH(-).

81 Cys-256 of PaAPR is the point of the initial nucleophilic attack by reduced thioredoxin, mutagenic re

82 h formation of a tetrahedral oxyanion during nucleophilic attack by Ser112.

83 tants suggests a reaction mechanism in which nucleophilic attack by sulfate on the alpha-phosphate of

84 tion of C with arginine 224 and prevents the nucleophilic attack by the 3' hydroxyl group of cytidine

85 sitioning of the phosphotyrosine linkage for nucleophilic attack by the 3'-OH end to result in DNA re

86 RNA substrate for activation and subsequent nucleophilic attack by the 5'-hydroxyl of the second RNA

87 acarbenium ion like transition states during nucleophilic attack by the acceptor.

88 mbers of the nitrilase superfamily, in which nucleophilic attack by the active site cysteine generate

89 tion of the N-allyl imine and the subsequent nucleophilic attack by the alpha-alkyl cyanoester produc

90 In contrast, nucleophilic attack by the alpha-aryl cyanoester exclusi

91 y undergo aminolysis with amines in water as nucleophilic attack by the amine is preferred to hydroly

92 bstrate with the metal center and subsequent nucleophilic attack by the bridging hydroxide.

93 esolution of this intermediate upon specific nucleophilic attack by the conserved lysine located with

94 ine with the anomeric carbon atom poised for nucleophilic attack by the FAD N5 atom.

95 ergy of its carbonyl LUMO, activating it for nucleophilic attack by the Fe-O2 intermediate formed alo

96 urcumin molecule are highly susceptible to a nucleophilic attack by the hydroxyl group of the NH(2)-t

97 placing BPDE in a favorable orientation for nucleophilic attack by the N(2) position of guanine.

98 rted back to the enzyme-inhibitor complex by nucleophilic attack by the newly created amino group.

99 amide derivatives followed by intramolecular nucleophilic attack by the nitrogen of the benzamide moi

100 th carbonyl oxygen, promoting intermolecular nucleophilic attack by the only weakly nucleophilic amid

101 with a minimal amount of chain transfer from nucleophilic attack by the phosphite.

102 ation of the analogs is suitable for in-line nucleophilic attack by the ribose O3' on alpha-phosphate

103 It is demonstrated that the nucleophilic attack by the serine residue on the substra

104 32 intermediates, the latter is subject to a nucleophilic attack by the unmodified histidine; and fin

105 ubiquitin-conjugating enzyme (E2) undergoes nucleophilic attack by the varepsilon-amino group of an

106 This facilitates the nucleophilic attack by the water oxygen at the phosphate

107 One frequently cited proposal is the nucleophilic attack by water hydroxide on a pendant Mn h

108 of a reaction that utilized a metal-mediated nucleophilic attack by water on the phosphoester.

109 phosphate surrogate is arranged to disfavor nucleophilic attack by water.

110 tion and reactants prior to the irreversible nucleophilic attack by water.

111 ty promotes the sealing of DNA backbones via nucleophilic attacks by the 5'-hydroxyl on the 2',3'-cyc

112 sient phosphorane formed as a result of this nucleophilic attack decays by breaking the bond between

113 The preferred mode of nucleophilic attack forms the product in a conformation

114 oy carbon-based electrophiles, which undergo nucleophilic attack from limited spatial orientations an

115 heir d-orbitals and consequently can undergo nucleophilic attack from many spatial orientations.

116 The latter undergoes intramolecular nucleophilic attack from Nbeta to the protonated -CN gro

117 cyclization, consisting of an intramolecular nucleophilic attack from the central carbon of the allen

118 coming nucleotide, which is essential before nucleophilic attack from the primer RNA 3'-hydroxyl.

119 different reactivities of E/Z-dienamines in nucleophilic attacks from the other face.

120 redirect the actions of these side chains to nucleophilic attack, generating rate enhancements that a

121 obenzyl alcohols --> in situ intramolecular "nucleophilic attack" --> "hydrolysis" is presented, for

122 The protonation state of His523 during nucleophilic attack has also been investigated, and our

123 ion that helps activate the 2'-hydroxyl for nucleophilic attack has been characterized biochemically

124 substrate isochorismate positioned to accept nucleophilic attack has been prepared.

125 orients the S-sulfocysteine Sgamma atom for nucleophilic attack in a subsequent step.

126 the catalytic base that activates water for nucleophilic attack in IS and SS reactions; in AS and AD

127 hile the benzoquinone form is susceptible to nucleophilic attack in Michael-type additions, hydroquin

128 The ester bond of peptidyl-tRNA undergoes nucleophilic attack in solution and when catalyzed by th

129 n state, in such a way that the preferential nucleophilic attack is oriented to the opposite enantiot

130 hosphine-assisted C-F activation in terms of nucleophilic attack is supported by the reduced activati

131 on and DFT calculations indicate a concerted nucleophilic attack mechanism.

132 chanics (QM/MM) simulation, we show that the nucleophilic attack occurs at the alpha-phosphate site.

133 n in the GMII Michaelis complex and that the nucleophilic attack occurs before complete departure of

134 ceed via a common rate-determining step, the nucleophilic attack of 3-5 at the Michael acceptors with

135 allenes via a tandem process that involves a nucleophilic attack of a cyanide ion and a Brook rearran

136 hat the major decomposition pathway involves nucleophilic attack of a dissociated phosphine on the me

137 tions revealed that the reactions proceed by nucleophilic attack of a metal amide at the incoming sil

138 Although nucleophilic attack of a peroxide anion is believed to b

139 med early and a higher energetic barrier for nucleophilic attack of a water molecule on the high ener

140 lves three sequential steps and requires the nucleophilic attack of a water molecule on the substrate

141 in which GTP is cleaved into GDP and P(i) by nucleophilic attack of a water molecule.

142 ng the zinc rearrange quickly to promote the nucleophilic attack of a zinc-bound hydroxide ion onto t

143 echanism to hydrolyze the DNA substrate is a nucleophilic attack of an active site water molecule to

144 rnover-limiting step involves intramolecular nucleophilic attack of an amido ligand on the coordinate

145 etc.) are consistent with turnover-limiting nucleophilic attack of an electrophilic [L2Pd(allyl)]+ c

146 ed by N activation of the azine, followed by nucleophilic attack of an isocyanide in a Reissert-type

147 catalytic base is responsible for initiating nucleophilic attack of ATP and for relaying the positive

148 formation of azido-pyranoquinolines through nucleophilic attack of azide on pyrilium intermediate ov

149 -phase N-glycosidic bond cleavage induced by nucleophilic attack of C1' with a hydroxide ion in 5-sub

150 the P horizontal lineSe bond is initiated by nucleophilic attack of carboxylate on a Cd(2+)-activated

151 This can be attributed to the nucleophilic attack of Cys to the alpha,beta-unsaturated

152 oposed catalytic mechanism of DNMT1 involves nucleophilic attack of Cys(1226) to cytosine (Cyt) C6, m

153 Using force-clamp spectroscopy, we monitor nucleophilic attack of Cys-111 at either sulfur of the d

154 ates that denitration of GTN is initiated by nucleophilic attack of Cys-302 at one of the terminal ni

155 r pH > 12: (1) an essentially pH-independent nucleophilic attack of cysteinate on cysteine thiosulfin

156 cysteine thiosulfinate ester followed by the nucleophilic attack of cysteinate on cysteine thiosulfin

157 n energetically preferred mechanism in which nucleophilic attack of cytosine C5 on the S-adenosyl-L-m

158 -diamine complex or a thiol adduct formed by nucleophilic attack of either the amine group or the sul

159 ction proceeds via an inner-sphere mechanism-nucleophilic attack of enolate oxygen on Palladium follo

160 RuCl2((13)CH2PCy3)(NHC) (py)2 resulting from nucleophilic attack of free PCy3 on the methylidene liga

161 mbers of this superfamily typically catalyze nucleophilic attack of glutathione upon an electrophilic

162 FEPO functions via epoxide ring opening upon nucleophilic attack of H2S.

163 nd enhance the autoxidation by promoting the nucleophilic attack of heme.

164 ions showed that the scission takes place by nucleophilic attack of hydroxide on the ketone followed

165 ss the double bond to trigger the subsequent nucleophilic attack of NADPH, by the negatively charged

166 via a mechanism that involves rate-limiting nucleophilic attack of OH- on OSCN-, followed by fast pr

167 by an intramolecular N-N bond formation via nucleophilic attack of one of the azo nitrogen onto the

168 resence of either DBU, or enolates formed by nucleophilic attack of PCy3 on methyl acrylate.

169 cogenide double bond (TOP=E) proceeds by the nucleophilic attack of phosphonate or oleate on a (TOP=E

170 en atom transfer reaction is consistent with nucleophilic attack of phosphorus on an electrophilic me

171 Conformational analysis of nucleophilic attack of putative intermediate glycosyl ox

172 n of the oxyanion ligand (RO(-)) followed by nucleophilic attack of RO(-) on a cationic Pd(IV)-alkyl

173 Nucleophilic attack of silanolate onto the carbonyl of t

174 dopalladation pathway with turnover-limiting nucleophilic attack of sulfonamide on the coordinated al

175 ibitors of reactive oxygen species suggest a nucleophilic attack of superoxide radical anion followed

176 structures and fundamental pathways for the nucleophilic attack of terminal Zn-OH sites are comparab

177 trate, UDP-N-acetylglucosamine, promotes the nucleophilic attack of the 3-hydroxyl group of 1-L-myo-i

178 ing step in the reaction, the intramolecular nucleophilic attack of the alcohol into the enol ester r

179 igh selectivity is attributed to the ease of nucleophilic attack of the aldehydes by the methoxy inte

180 ction is best described as an intramolecular nucleophilic attack of the amidate ligand on the coordin

181 many bases, with subsequent cyclization via nucleophilic attack of the amide N(-) to alkynyl.

182 ed to yield five- or six-membered lactams by nucleophilic attack of the amide nitrogen onto the tripl

183 hemistry implies that the reaction occurs by nucleophilic attack of the amine on a coordinated alkene

184 e complex as the resting state, implies that nucleophilic attack of the amine on the alkene is revers

185 lexibility of the alkylamine facilitates the nucleophilic attack of the amine on the reactants.

186 p by adenylation, followed by PubC-catalyzed nucleophilic attack of the amino group on the carbonyl c

187 ted by an electron transfer step followed by nucleophilic attack of the aryl ring onto the nitrogen o

188 the acidic surface silanols followed by the nucleophilic attack of the basic amine functional group

189 wc25 lock the branch helix into position for nucleophilic attack of the branch adenosine at the 5' sp

190 volves protonation of the carbamate species, nucleophilic attack of the carbamic acid, and formation

191 vorable pathways were predicted instead: the nucleophilic attack of the carbene lone pair on the imin

192 , promoted by halide anion, with concomitant nucleophilic attack of the created carboxylate anion on

193 ages: (i) a thiol-disulfide exchange through nucleophilic attack of the Cys53-thiolate to the GSSG-di

194 a necessary deprotonation step prior to its nucleophilic attack of the DNA.

195 )2(PH2Et)], a low-energy mechanism involving nucleophilic attack of the electron-rich Ir metal center

196 ne more than one mechanism on the basis of a nucleophilic attack of the formaldehyde O atom to the W

197 Notably, the intramolecular nucleophilic attack of the hydroxyl group took place on

198 nfluence of structural factors affecting the nucleophilic attack of the imidazolyl group on the phosp

199 ts a stepwise mechanism in which the initial nucleophilic attack of the iodonium ylide at the iminium

200 provide cyclic peroxyketals, presumably via nucleophilic attack of the methyl ketone product.

201 rdered sequential mechanism involving direct nucleophilic attack of the N-epsilon-lysine on the enzym

202 ep of the mechanism is proposed to involve a nucleophilic attack of the Ni(I) active state (MCR(red1)

203 r-catalyzed cyclization by an intramolecular nucleophilic attack of the nitrogen on the ketene, affor

204 corresponded to the 5-exo-dig intramolecular nucleophilic attack of the oxygen of the benzamide moiet

205 t the translocase reaction can proceed via a nucleophilic attack of the phosphate moiety of C35-P on

206 two zinc ions activate a water molecule for nucleophilic attack of the phosphodiester bond.

207 ions indicate that the reaction proceeds via nucleophilic attack of the phthalimide on an aromatic ra

208 ctivity was modeled theoretically, revealing nucleophilic attack of the pi* orbital of CO by the nitr

209 hanistic step between nucleotide binding and nucleophilic attack of the primer 3'-hydroxyl group on t

210 that involves H-bonding Pd-O(H)...H-CF3 and nucleophilic attack of the promoter on the metal, follow

211 mical assays to suggest that Lys33 initiates nucleophilic attack of the propeptide by deprotonating t

212 Neither nucleophilic attack of the resonance-stabilized ester by

213 Both paths are initiated by nucleophilic attack of the ribose O2' oxygen on the neig

214 ridging hydroxide is in optimal position for nucleophilic attack of the scissile phosphate.

215 acyl enzyme intermediate is relieved by the nucleophilic attack of the side-chain amino group of lys

216 e adsorbed amine to differ with respect to a nucleophilic attack of the surface species.

217 e, supporting a reaction mechanism involving nucleophilic attack of the triphenylphosphine HOMO at th

218 mechanism for this reaction consisting of a nucleophilic attack of the urate anion on the flavin hyd

219 The reaction is initiated by nucleophilic attack of the vinyl ethers at the vinylogou

220 hedral intermediate that is formed after the nucleophilic attack of the water molecule to the substra

221 , at copper this conversion proceeds through nucleophilic attack of thiol RSH on the bound nitrite in

222 2)R(-) from the platinum center, followed by nucleophilic attack of this anion on a methyl group of t

223 nked via a mixed disulfide that forms during nucleophilic attack of Trx's N-terminal cysteine on the

224 on process and that the adduct is formed via nucleophilic attack of UAE thioester by the sulfamate gr

225 tions, a mechanism is proposed that involves nucleophilic attack of water at boron followed by rate-l

226 Concurrent nucleophilic attack of water molecules coming directly f

227 n of the O-O bond proceeds on these sites by nucleophilic attack of water on a bridging oxo.

228 properties of the transition state (TS) for nucleophilic attack of water on the gamma-PO3(-) group b

229 thyridine-based ligand architecture promotes nucleophilic attack of water to the metal-bound COD.

230 dicate the formation of alpha-terpineol by a nucleophilic attack of water.

231 ion-state intermediate that results from the nucleophilic attack of zinc-bound water at the active si

232 cles and polycyclic amines by intramolecular nucleophilic attack on a Michael acceptor with an allyli

233 anistic possibilities include intramolecular nucleophilic attack on an aryne intermediate leading to

234 ated in the correct position to initiate the nucleophilic attack on ATP to form the carboxyphosphate

235 ch now can cleave the target disulfide via a nucleophilic attack on either one of its two sulfur atom

236 f copper(I)-catalyzed cascade intramolecular nucleophilic attack on N-sulfonylketenimine followed by

237 ion, suggesting how Cbl can be activated for nucleophilic attack on oQ.

238 Nucleophilic attack on phosphorus is confirmed by the de

239 Moreover, MS data also indicated that nucleophilic attack on PL at the C2-C3 olefin led to PL

240 Recent computer simulations of the cysteine nucleophilic attack on propanal in human mitochondrial a

241 Nucleophilic attack on seven-membered-ring oxocarbenium

242 gly, we observe that the peptide causing the nucleophilic attack on the acyl-enzyme intermediate must

243 gen bonding between diol groups that induces nucleophilic attack on the alkene and then proton transf

244 with the dATP substrate suggests an in-line nucleophilic attack on the alpha-phosphate center as a p

245 e of the catalytic threonines during L-ASP's nucleophilic attack on the amide carbon.

246 , cellobiose, positions a water molecule for nucleophilic attack on the anomeric carbon of the glycos

247 asynchronous transition state, resembling a nucleophilic attack on the aryne.

248 motif is the likely candidate for initiating nucleophilic attack on the ATP gamma-phosphate group by

249 or deprotonation of Tyr77 of Rab1b to enable nucleophilic attack on the ATP.

250 nitial peroxo-anion intermediate, poised for nucleophilic attack on the C20 position by a substrate-a

251 automerization and generating a serinate for nucleophilic attack on the C6-carbonyl.

252 ect stereoelectronic alignment to enable the nucleophilic attack on the carbonyl carbon by the cataly

253 and the water molecule that carries out the nucleophilic attack on the carbonyl carbon of the scissi

254 itin and positions its alpha-amino group for nucleophilic attack on the E3 approximately ubiquitin th

255 bunit interface, is positioned to catalyze a nucleophilic attack on the gamma-phosphate of a bound nu

256 to position the catalytic water molecule for nucleophilic attack on the gamma-phosphate of GTP.

257 a weakly coordinating counterion showed that nucleophilic attack on the less stable allyliridium spec

258 r protonated forms could react with HANs via nucleophilic attack on the nitrile carbon, forming the c

259 explained by a mechanistic scheme involving nucleophilic attack on the nitrogen of the aldoxime ethe

260 site but is imperfectly oriented to launch a nucleophilic attack on the phosphate backbone.

261 lysis of the ester is followed by a putative nucleophilic attack on the phosphorus by the carboxyl gr

262 oxyl pinned in place by a serine, leading to nucleophilic attack on the scissile phosphate.

263 drogen bond is no longer present, leading to nucleophilic attack on the substrate intermediate C-S bo

264 the metal-bound water ligand for subsequent nucleophilic attack on the substrate.

265 l theory calculations suggest that the water nucleophilic attack on the surface-bound Ru(V) horizonta

266 the tetrahedral intermediate is formed upon nucleophilic attack on the thioester carbonyl of acetyl-

267 leophiles which give four consecutive tandem nucleophilic attacks on electrophiles.

268 ting an adjacent serine residue carrying out nucleophilic attack, opening the cyanuric acid ring, and

269 e167 mutation does not alter the kinetics of nucleophilic attack or methyl transfer.

270 ents show the viability of an intramolecular nucleophilic attack over an intermolecular attack of the

271 atalysts proceed through a single-site water nucleophilic attack pathway.

272 ine configuration (E- or Z-imine) and on the nucleophilic attack site (top or bottom).

273 xperiments, involves a multistep sequence of nucleophilic attacks, starting with an attack of a rheni

274 4 kcal/mol calculated for the barrier of the nucleophilic attack step to reach a definitive conclusio

275 ter molecule in the initial rate-determining nucleophilic attack step, and then shuttles it to the am

276 Subsequently, the nucleophilic attack takes place followed by a second pro

277 Subsequently, the nucleophilic attack takes place, with the formation of a

278 e CRISPR repeat, and finally, it catalyses a nucleophilic attack that connects one strand of the lead

279 ion from the terminal DNA primer O3'H group, nucleophilic attack that extends the DNA primer chain, a

280 f configuration, followed by an outer sphere nucleophilic attack that leads to a second inversion of

281 nd are consistent with an hGSTA4-4-catalyzed nucleophilic attack that produces only the S-configurati

282 oxide activation of persulfate (reduction or nucleophilic attack) the results were consistent with re

283 x activates the alkene toward intramolecular nucleophilic attack to form a dicationic palladium alkyl

284 rm the C-Cl bond prior to the intramolecular nucleophilic attack to form the C-N bond, while one path

285 ut a reaction pathway that is concerted with nucleophilic attack to generate a similar phosphorane.

286 The proposed mechanism involves a nucleophilic attack to NO by the alcohol, coupled to a p

287 the interrupted cascade from the 6-endo-dig nucleophilic attack to the fragmentation of the central

288 Comparison of the rates of nucleophilic attack to the rates of epimerization of the

289 s has been explained in terms of competitive nucleophilic attacks to different positions of the carbe

290 fluoride group can be the exclusive site of nucleophilic attack under defined conditions, making the

291 talyzed mechanism for hydrolysis rather than nucleophilic attack was also deduced for the reaction of

292 The site of nucleophilic attack was determined by conducting the hyd

293 Nucleophilic attack was observed at the carbon that is b

294 from A-1(O2') to a nonbridging oxygen during nucleophilic attack, was also considered but deemed to b

295 n N-terminal cysteine pKa lower than 6.5 for nucleophilic attack, whereas the pKa of the C-terminal c

296 y a dual role in activating the donor toward nucleophilic attack while at the same time providing tra

297 Based on these data, we proposed that nucleophilic attack with a subsequent water-assisted Los

298 Finally, we probe the initial nucleophilic attack with ab initio simulations.

299 on treatment with aqueous H2SO4 proceeded by nucleophilic attack with inversion at C(2) preferentiall

300 observed directly, and its susceptibility to nucleophilic attack with various nucleophiles as well as