ライフサイエンスコーパス: nucleus pulposus

1 cal stress and the resulting prolapse of the nucleus pulposus.

2 n the intervertebral disc, especially in the nucleus pulposus.

3 were used to measure CCN3 expression in the nucleus pulposus.

4 part of the intervertebral disc, called the nucleus pulposus.

5 differentiation and function of cells of the nucleus pulposus.

6 were used to measure CTGF expression in the nucleus pulposus.

7 positive regulator of CTGF expression in the nucleus pulposus.

8 -regulatory protein, TonEBP, in cells of the nucleus pulposus.

9 course of sciatica secondary to a herniated nucleus pulposus.

10 k pain who are suspected of having herniated nucleus pulposus.

11 There was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-de

12 Cells of the nucleus pulposus and annulus fibrosus of rat disc tissue

13 elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lum

14 hat of the other Notch receptors in both the nucleus pulposus and annulus fibrosus.

15 ort and long forms of alpha1(IX) from bovine nucleus pulposus and articular cartilage.

16 bolic and pro-angiogenic phenotype in bovine nucleus pulposus and cartilage endplate cells at the gen

17 recan extracted from the anulus fibrosus and nucleus pulposus, and of these aggrecan preparations fol

18 lly fixed yet unstained samples resolved the nucleus pulposus, annulus fibrosus and constituent lamel

19 more inhibitory than that isolated from the nucleus pulposus, but enzymic pretreatments to reduce th

20 disc disease may restore NOTCH signaling and nucleus pulposus cell function.

21 on and promoter activity was observed in rat nucleus pulposus cells after TGFbeta treatment.

22 crease in promoter activity was seen both in nucleus pulposus cells and in N1511 chondrocytes.

23 lyses were used to measure ANK expression in nucleus pulposus cells from rats and humans.

24 ssion and the suppression of CCN2 by CCN3 in nucleus pulposus cells further the paradigm that these C

25 transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axi

26 Adenovirus-mediated gene transfer to nucleus pulposus cells may be the initial stage of a new

27 Adaptive response to hypoxia in nucleus pulposus cells of the intervertebral disc is reg

28 ation through controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc.

29 ss of all the PHDs is maintained in isolated nucleus pulposus cells regardless of the disease state.

30 Since nucleus pulposus cells reside under conditions of hypoxi

31 erexpression of HIF-1alpha and HIF-2alpha in nucleus pulposus cells resulted in a significant suppres

32 stochemically in disc tissue, and numbers of nucleus pulposus cells staining positive for ADAMTS 4, 5

33 ng CCN3 expression in Smad3-null mice and in nucleus pulposus cells transduced with lentiviral short

34 Above 330 mosmol/kg, cultured nucleus pulposus cells up-regulated target genes TauT, B

35 xygen-dependent changes in ANK expression in nucleus pulposus cells were minimal.

36 Results of this study indicate that in nucleus pulposus cells, HIF-2 and HIF-1 modulate their o

37 Here, we show that in nucleus pulposus cells, hypoxia robustly induces PHD3 ex

38 suppressed GlcAT-1 promoter activity only in nucleus pulposus cells, suggesting a cell type-specific

39 T-1 promoter activity and expression only in nucleus pulposus cells.

40 CCN3 and suppressed its promoter activity in nucleus pulposus cells.

41 e-dependent decrease in the proliferation of nucleus pulposus cells.

42 cules, and that this regulation is unique to nucleus pulposus cells.

43 fect of HIFs on GlcAT-1 promoter function in nucleus pulposus cells.

44 umber of human studies focusing primarily on nucleus pulposus cells.

45 ommon target gene for HIF-1 and HIF-2 in the nucleus pulposus cells.

46 findings indicate that the matrix of bovine nucleus pulposus contains only the short form of alpha1(

47 inate the notochord from the surrounding the nucleus pulposus, especially in murine models.

48 e alpha1(IX)COL3 domain purified from bovine nucleus pulposus gave a different sequence to that of th

49 ith increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +/- 1.3; grade 5, 16.

50 r third of the annulus fibrosus and into the nucleus pulposus in 21 (46%) and ten (22%) samples, resp

51 tabolism, function, and fate of cells of the nucleus pulposus in the intervertebral disk.

52 re was a robust expression of GlcAT-I in the nucleus pulposus in vivo.

53 The nucleus pulposus is an aggrecan-rich hydrated tissue tha

54 progenitors of cells that populate the adult nucleus pulposus (NP) and are an important source of sec

55 o production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells.

56 of stem cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specif

57 L-1beta regulation of ADAMTS-4 expression in nucleus pulposus (NP) cells and its role in aggrecan deg

58 of FIH-1 in regulating HIF-1 activity in the nucleus pulposus (NP) cells and the control of this regu

59 ic mediator LPS and IL-1 in bovine and human nucleus pulposus (NP) cells by assessing matrix-degradin

60 al treatments and combined therapy on bovine nucleus pulposus (NP) cells by assessing proteoglycan (P

61 Nucleus pulposus (NP) cells cultured with UCNPs are viab

62 Human nucleus pulposus (NP) cells derived from nondegenerated

63 Monolayer cultures of nucleus pulposus (NP) cells from the intervertebral disc

64 tion and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue n

65 However, in nucleus pulposus (NP) cells of the healthy intervertebra

66 Nucleus pulposus (NP) cells of the intervertebral disc a

67 Nucleus pulposus (NP) cells reside in a physiologically

68 3 controls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase

69 Bovine nucleus pulposus (NP) cells were treated with BMP-7 and

70 ite for SOX9 binding to the Ctgf promoter in nucleus pulposus (NP) cells.

71 1beta-dependent catabolic gene expression in nucleus pulposus (NP) cells.

72 NF-alpha control NOTCH signaling activity in nucleus pulposus (NP) cells.

73 y a new set of genes characterizing immature nucleus pulposus (NP) cells.

74 (CCN2) form a regulatory network in hypoxic nucleus pulposus (NP) cells.

75 ctor (HIF)-alpha degradation and activity in nucleus pulposus (NP) cells.

76 The nucleus pulposus (NP) of the intervertebral disc (IVD) d

77 The nucleus pulposus (NP) of the intervertebral disc develop

78 Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibr

79 lus fibrosus (AF), transition zone (TZ), and nucleus pulposus (NP), respond to osmotic stress with al

80 oss of proteoglycan and water content in the nucleus pulposus of intervertebral discs.

81 differentiation; and directly by forming the nucleus pulposus of intervertebral discs.

82 abolic proteins (MMP-13 and ADAMTS-5) in the nucleus pulposus of the disc.

83 From nucleus pulposus of the intervertebral disc (in which th

84 elopment, and it becomes embedded within the nucleus pulposus of the intervertebral disc (IVD) during

85 the inner third of the annulus fibrosus, the nucleus pulposus, or both was seen in four (25%) of 16 b

86 r with an unconfirmed diagnosis of herniated nucleus pulposus, outcome at 2-year follow-up was no bet

87 rning and afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.

88 y in anulus fibrosus regions and modestly in nucleus pulposus regions.

89 btained (n = 8) from the anulus fibrosus and nucleus pulposus regions.

90 Analysis of human nucleus pulposus samples indicated a trend toward increa

91 king sites occupied in type IX collagen from nucleus pulposus showed that usage of the short alpha1(I

92 ssue-engineered IVD composed of a gelatinous nucleus pulposus surrounded by an aligned collagenous an

93 e intervertebral discs, normally composed by nucleus pulposus surrounded by the annulus fibrosus, wer

94 Nucleus pulposus, the central zone of the intervertebral

95 regulates GlcAT-I expression in cells of the nucleus pulposus through a signaling network comprising

96 Finally, analysis of human nucleus pulposus tissue showed that while ANK was expres

97 We conclude that in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 e

98 As in cartilage, type IX collagen of nucleus pulposus was heavily cross-linked to type II col