ライフサイエンスコーパス: para position

1 troducing onium cationic substituents in the para position.

2 a strongly electron-withdrawing group at the para position.

3 d was further diminished by moving it to the para position.

4 nable site-selective radical addition at the para position.

5 anilines bearing a donor substituent in the para position.

6 drawing properties of the substituent at the para position.

7 formation between two pyridine rings at the para position.

8 -) linker connecting the two moieties at the para position.

9 onosubstituted benzenes predominantly at the para position.

10 -yl are among the better substituents at the para-position.

11 and electron-deficient substituents in their para-position.

12 ct of an electron-withdrawing substituent in para-position.

13 functionalized substituents on the meta- or para-position.

14 boronic acid and the dimethylamino groups in para positions.

15 shifted from ortho to meta, and from meta to para positions.

16 the pyridyl nitrogen from ortho to meta and para positions.

17 tive toward electrophilic palladation at the para-positions.

18 ly feature bromo-substitutents in ortho- and para-positions.

19 quinoline-8-sulfonamide), rather than at the para position (4BP-TQS), display no allosteric agonist a

20 hydroxylates monosubstituted benzenes at the para position and toluene ortho-monooxygenase (TOM) of B

21 ongly decreasing the addition barrier in the para position, and it is shown that the calculated barri

22 five hydroquinone rings linked through their para positions by methylene bridges, modifies the bindin

23 ith a halide or methyl halide in the meta or para position containing no strong hydrogen bond accepti

24 n-withdrawing CN substituent at the ortho or para position could slow down the tau torsion.

25 ers) that incorporate a siletane ring at the para position creates a deprotection pathway without aff

26 itution with electron-donating groups at the para position (e.g., the methoxy group in [(H3CO-C6H4-Im

27 with small hydrophobic groups in the meta or para position enhanced both antipolymerase and antimicro

28 ectron-donating substituents in the ortho or para positions favor formation of the allylic halide.

29 The -N(2)(+) group in the para position has a similar effect.

30 rawing protonated dimethylamino group at the para position, hydrogen coordination is enhanced.

31 s the amidine at the phenyl shifted from the para position in DB921 to the meta position, has also be

32 tivity for electrophilic attack at the ortho/para positions in electron-rich substrates and at the me

33 th modifications at the carbonyl linker, the para-position in the C ring of SMART template, and modif

34 the presence of a substituent at the aniline para-position in these compounds.

35 unctionalization of phenols at the ortho and para position is generally facilitated by the electron-d

36 g tetragonally via alkynyl linkages from the para positions is described.

37 atic ring, whereas the hydroxyl group in the para-position is not essential, but strongly enhances th

38 chlorides having electron-donating group at para-position is reported.

39 bic residues, such as propyl or butyl in the para position (not ortho or meta) of the A-ring and a m-

40 by an alkyne-Co2(CO)6 complex bonded to the para position of a benzene ring.

41 haptens were synthesized by derivatizing the para position of a phenyl moiety of TCC.

42 s a choice between arylation at the ortho or para position of anisole substrates, we find that arylat

43 presence of a methoxy group in the ortho or para position of at least one phenyl ring is beneficial

44 achment of the tripeptide Gly-Glu-Glu to the para position of cinnamaldehyde resulted in an inhibitor

45 ) containing an isothiocyanate moiety at the para position of either Phe(3) or Phe(4) were prepared a

46 eric hindrance from tert-butyl groups in the para position of p-tert-butylcalix[4]arene (Bu(t)C4), th

47 In general, substitution at the para position of Phe(4) decreased binding affinity at bo

48 Substitution of H by Cl in the para position of tetraphenylborate leads to a 100-fold e

49 imide) electron acceptors is attached to the para position of the 20-phenyl group.

50 at attaching a large lipophilic group at the para position of the 4-(arylamino) ring results in impro

51 droxy group meta to the amino rather than in para position of the aniline moiety were prepared.

52 h a single electron-withdrawing group at the para position of the arene, but are formed when the fluo

53 ng (1) a single substitution at the ortho or para position of the aromatic A-ring, (2) a heteroaryl o

54 ligand presenting different Y groups in the para position of the aromatic N-substituent.

55 upon substitution of a methoxy group at the para position of the aromatic phenyl ring.

56 ies indicated that polar substituents at the para position of the B-ring are critical for potent acti

57 s 9m with water-solubilizing moieties at the para position of the B-ring inhibited the autophosphoryl

58 protease inhibitors (PIs), decorated at the para position of the benzyl group in the P1' side with (

59 Paclitaxel was labeled with (19)F at the para position of the C-2 benzoyl substituent and with (1

60 inomethyl and aminoethyl substituents on the para position of the C-2 phenyl group retained the activ

61 ed the importance of the bromine atom in the para position of the N1 side chain phenyl ring for the i

62 s found that appropriate substitution at the para position of the P1' phenyl group of 1 resulted in t

63 The para position of the PCBM's phenyl ring was substituted

64 ngly, introduction of a chlorine atom at the para position of the pendant 5'-phenyl group of 6c not o

65 trophilic substitution of Cl at the ortho or para position of the phenol structure of THC-COOH was co

66 n-withdrawing groups are incorporated in the para position of the phenol substrate and decrease when

67 hobic, electron-donating substituents at the para position of the phenyl group (RBpT).

68 hile addition of hydrogen bond donors in the para position of the phenyl group enhanced NR1A/2B poten

69 e variation of the substituting group on the para position of the phenyl moiety, as supported by DFT

70 If a methoxy substituent is located in the para position of the phenyl ring adjacent to the ether o

71 Substitutions at the para position of the phenyl ring at C3 were generally we

72 on of an activated ferryl-oxo species at the para position of the side chain of the amino acid to for

73 Substituents at the para position of the single phenyl ring were either an e

74 In particular, the substitution of the para position of the terminal phenyl ring of GV150526 wi

75 esonance effect of the groups present in the para position of the terminal phenyl ring.

76 various substituents at the ortho, meta and para positions of the aromatic core of phenols on the bo

77 th chiral auxiliaries placed at the meta and para positions of the benzoyl group have been examined b

78 rawing functional groups at ortho, meta, and para positions of the diallylanilines.

79 For the diradical, in which all ortho and para positions of the m-phenylene are sterically shielde

80 with different substituents at the ortho and para positions of the phenolate ring and substituents at

81 the aromatic COOH group was at the meta and para positions of the phthaloyl ring had IC(50) values o

82 mple procedure, the substitution of the free para positions of the propeller-shaped HPB with tert-but

83 rawing substituents such as fluorides in the para positions of the pyridine rings can reduce the pote

84 oth at the phenoxide oxygen and on ortho and para positions of the ring.

85 ely charged trimethylanilinium groups at the para positions of the tetraphenylporphyrin (TPP) phenyls

86 ne by sulfonate groups also installed in the para positions of the TPP phenyls.

87 emarkably, magnesiation of IPr occurs at the para-position of an aryl substituent, sodiation occurs a

88 henomenon that a subtle ligand effect in the para-position of benzenethiolate can significantly affec

89 stal imide group of one PDI is linked to the para-position of one ZnTPP phenyl group to yield ZnTPP-P

90 A fluorine atom introduced in the para-position of phenylalanine enhanced the binding affi

91 The para-position of the 4-phenoxy group of the thieno[2,3-c

92 hydrophilic electron-donating groups at the para-position of the anilino ring enhance or maintain in

93 electronegative aromatic substituents in the para-position of the benzamide moiety of CDPPB increase

94 ing hydrophilic group (OH, NH2, COOH) at the para-position of the pendent 2-phenyl ring (8-16) or dif

95 to install a water-solubilizing group at the para-position of the phenoxy group to increase the aqueo

96 he phenylamine moieties were modified at the para-position of the two external rings by electron-with

97 hdrawing and donating functionalities in the para-position of their pyridine nitrogen were synthesize

98 hain, alongside substituents at the meta- or para-positions of the phenylurea, increases ligand affin

99 substituents are placed at the ortho versus para position on the pyrylium cyclohexane ring.

100 signated mpAbc, has substituents at meta and para positions on the inner (azo-linked) and outer rings

101 Additionally, the para-position on the phenyl ring of several substrates w

102 stitution of electron donating groups at the para-position on the phenyl ring was the most favorable

103 ated by reducing the electron density at the para position or by placing substituents bearing lone pa

104 dine units linked to the core either at para-para positions (para series 1-5) or meta-meta positions

105 rgies and that amino acids juxtaposed to the para position play a significant but not dominant role i

106 ship studies showed that substitution at the para position plays a crucial role.

107 idines suggested that a methoxy group in the para position relative to the amino group in aminopyridi

108 ition relative to one acetylene linker and a para position relative to the other, destructive QI is a

109 A chloro and ethoxy group at the meta- and para-positions, respectively, produced the most active c

110 tain strong pi-acceptors in the ortho and/or para position(s).

111 ups, namely -NMe(2), -NH(2), and -SMe in the para position, strongly favors the triplet state.

112 When substituted in the para-position, the 1,4 and the 2,4-triazoles are cation-

113 Conversely, at the farther para-position, the larger alkyl groups were systematical

114 ith aryl boronic acids containing EWG at the para position, there are two competing forces: one direc

115 CoA, hydrolytic removal of chlorine from the para position to generate 4-hydroxybenzoyl-CoA, hydrolys

116 henyl PDI chromophores are attached at their para positions to both nitrogens and the 1 and 7 carbons

117 henyl PDI chromophores are attached at their para positions to both nitrogens and the 3 and 6 carbons

118 t the substrate requires a hydroxyl group in para-position to the acetate moiety.

119 samine rhodamine B fluorophore (in ortho and para positions) to AC42-NH(2).

120 With monosubstitution, the para position was most useful in increasing potency, wit

121 derivative lacking the chlorine atom in the para-position was found to enhance enzyme activity in li

122 ubstrates with different substituents at the para position were studied by molecular modeling using M

123 arious substituted (hetero)aryl rings in the para-position were prepared by palladium nanoparticle-ca

124 Substitution of the aromatic ring at the para position with methyl or NO2 groups abolished this e

125 enesulfonamide inhibitors substituted at the para position with positively charged, negatively charge

126 with -OMe substituents in the meta or ortho/para positions with respect to the C-F bonds.

127 lides, particularly those substituted in the para-position with electron-withdrawing groups, such as

128 ependently substituted at ortho-, meta-, and para-positions with 11 different groups common to inhibi

129 ution strategy, of pi-acceptors in ortho and para positions, works in both cases to planarize and sta