ライフサイエンスコーパス: parabiosis

1 ads to different outcomes than heterochronic parabiosis.

2 ession patterns, genetic lineage tracing and parabiosis.

3 molecules into the brains of mice following parabiosis.

4 ges, we joined the circulation of mice using parabiosis.

5 uthful systemic milieu through heterochronic parabiosis.

6 s controls were phenotypically unaffected by parabiosis.

7 and Abeta plaques after a 12-month period of parabiosis.

8 T iso-mRNA switching and was not affected by parabiosis.

9 e of circulating factors using heterochronic parabiosis, a surgical technique in which joining of ani

10 However, using parabiosis and fate-mapping approaches in mice, we found

11 Using parabiosis and fate-mapping approaches, we confirmed tha

12 ne translation, we tested their validity via parabiosis and quantitative immunofluorescence microscop

13 youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, reveali

14 SF) and stem cell factor at days 17 to 20 of parabiosis and were studied 3 weeks later; 10.1% of marr

15 he negative effects of B2M and heterochronic parabiosis are, in part, mitigated in the hippocampus of

16 We have used the technique of parabiosis, as a means of adoptive transfer, to demonstr

17 Using a parabiosis-based strategy, we identified and isolated ma

18 In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and

19 established a chimeric blood circulation by parabiosis between fetal chicks and quails to determine

20 in-expressing haematopoietic stem cells, and parabiosis between genetically marked mice, confirmed th

21 Here, we used parabiosis between intact and SCN-lesioned mice to show

22 Parabiosis, bromodoxyuridine (BrdU) pulse-chase analysis

23 ell and tissue transplantation, apheresis or parabiosis.Clarifying the source of proteins in mixed bi

24 Parabiosis-conjoined surgery to provide a shared circula

25 ed a naturally occurring process of vascular parabiosis coupled with intravascular microinjection of

26 Studies of heterochronic parabiosis demonstrated that with age, the composition o

27 poietic and endothelial cell chimerism after parabiosis demonstrates that circulating cells can give

28 Parabiosis experiments confirmed that RIPC in this latte

29 Parabiosis experiments demonstrate that the kidney conta

30 Parabiosis experiments demonstrating that dendritic cell

31 By performing BrdU labeling and parabiosis experiments in adult mice, we found that circ

32 Parabiosis experiments indicate that impaired regenerati

33 In parabiosis experiments, splenic DCs were only partially

34 tivating gene 2 GFP reporter mice along with parabiosis experiments, we demonstrate that the vast maj

35 g lymphocytes into lymph nodes and long-term parabiosis experiments, we have found that, contrary to

36 d not circulate or emigrate from the lung in parabiosis experiments, were protected from in vivo Ab l

37 This protocol describes the use of parabiosis for efficient transplantation of skin from a

38 Here we provide evidence that mice joined by parabiosis gradually recover much physiology relevant to

39 animals using a surgical procedure known as parabiosis has created a wealth of information towards o

40 between mice even after prolonged joining by parabiosis have suggested that DCs are derived from self

41 e conclude that, compared with heterochronic parabiosis, heterochronic blood exchange in small animal

42 Glycemic control was unaffected by parabiosis; however, the distribution of circulating leu

43 able to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor.

44 Experiments using heterochronic parabiosis, in which the circulatory systems of young an

45 Furthermore, heterochronic parabiosis increased aged hepatocyte proliferation and r

46 Parabiosis may also be used, taking advantage of the sha

47 Following parabiosis, memory T cells rapidly equilibrated into the

48 This defect is even more pronounced in a parabiosis model that demonstrates a profound reduction

49 Here, we used a parabiosis model that demonstrates preferential hematoge

50 total body irradiation, we employed a murine parabiosis model with tie-2-LacZ FvB/N mice connected to

51 enhanced ILC2 trafficking to the lungs in a parabiosis mouse model of tissue disruption and repopula

52 ither exogenous or endogenous clusterin, and parabiosis of db clusterin(-/-) double-mutant to WT mice

53 We reconfirmed the lethal effect of parabiosis of db mutant on WT mice and further showed th

54 Parabiosis of db mutant, which overexpress leptin, to wi

55 normally decline with age, by heterochronic parabiosis or systemic delivery of recombinant protein,

56 shared blood circulation between 2 mice (aka parabiosis) or repeated injections of young blood plasma

57 providing a shared blood circulation through parabiosis, or through repeated injections of plasma fro

58 ed with the stress or other aspect(s) of the parabiosis procedure.

59 While quail fetuses were unaffected by parabiosis, quail serum caused premature troponin T iso-

60 equal exchange of DCs between mice joined by parabiosis reflected uneven distribution of DC precursor

61 Heterochronic parabiosis rejuvenates the performance of old tissue ste

62 vironments, such as after transplantation or parabiosis, remains a challenge.

63 Notably, heterochronic parabiosis restored the activation of Notch signalling a

64 Parabiosis revealed that SLO CD69(+) memory CD8 T cells

65 ure to youthful circulation by heterochronic parabiosis reverses the aged fracture repair phenotype a

66 After parabiosis, secreted PCSK9 was transferred to the circul

67 Second, combining parabiosis, single-cell analyses, and gene knockouts, we

68 The initial parabiosis studies were done in 2010, and the final stud

69 dal B cells circulate freely, as revealed by parabiosis studies.

70 6/INK4A mRNA did not change in heterochronic parabiosis, suggesting the involvement of other pathways

71 With the use of parabiosis surgery, this study shows that soluble danger

72 al proteins after exposure to young blood in parabiosis (synaptophysin P = .02; calbindin P = .02) or

73 ues was examined using adoptive transfer and parabiosis systems.

74 Only modestly restored by parabiosis, these features are rooted in elevated cell-i

75 at the appetite suppression in WT mice after parabiosis to db mutants is the result of induced hyperl

76 We used parabiosis to introduce fluorescent-labeled bone marrow-

77 ve to one young mouse and transferred during parabiosis to its old partner.

78 ineage tracing, transplantation studies, and parabiosis to show that most adult cardiac fibroblasts d

79 Here, using heterochronic parabiosis we show that blood-borne factors present in t

80 Using parabiosis, we found that amyloid-associated myeloid cel

81 Using heterochronic parabiosis, we observe that young circulating factors ar

82 set out to explain the differing effects of parabiosis with genetically diabetic (db) mice versus ad

83 is impaired in Chrm1(--) mice and rescued by parabiosis with wild-type mice, suggesting a relay by a