ライフサイエンスコーパス: paracrine

1 lism of APP results in possible autocrine or paracrine Abeta production to drive the microgliosis ass

2 Several potential estrogen-induced paracrine-acting factors were identified in the expressi

3 FBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matri

4 Thus, S100A4 is one effector of the paracrine action of E2 in brain metastatic cells.

5 promotes myocardial hypertrophy through the paracrine action of endothelium-derived NO, which trigge

6 pathogens in part through the autocrine and paracrine actions of alpha/beta interferon (IFN-alpha/be

7 ver and support a model in which EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate

8 nal differentiation of histamine neurons via paracrine actions or direct synaptic neurotransmission.

9 ation alone, but also due to their transient paracrine actions.

10 their major mechanism of action must involve paracrine actions.

11 s force them to work mainly via time-limited paracrine actions.

12 ought to occur via transmitter spillover and paracrine activation of extrasynaptic receptors.

13 Hedgehog ligand SHH, which regulate CAFs via paracrine activation of Hedgehog signaling.

14 EN-null fibroblasts leading to a loss in the paracrine activation of NOTCH signaling from the surroun

15 This role of midkine was linked to a paracrine activation of the mTOR pathway in lymphatic en

16 As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as a

17 The paracrine activity of regulatory T cell-derived TGF-beta

18 the different adipose depots; however, their paracrine and autocrine effects on de novo adipocyte for

19 iously implicated pathways and predict novel paracrine and autocrine loops involving cytokines, chemo

20 (IFN) IFNlambda1, which functions in both a paracrine and autocrine manner to protect trophoblast an

21 -6 activates a NF-kappaB signaling axis in a paracrine and autocrine manner, leading to bromodomain p

22 ct as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem

23 ential cell-specific regulation of autocrine/paracrine and juxtacrine signaling accounted for the dif

24 Soluble (autocrine/paracrine) and contact-mediated (juxtacrine) signaling m

25 gans and its ability to act as an autocrine, paracrine, and endocrine factor.

26 l to various target tissues in an autocrine, paracrine, and endocrine manner, thereby determining org

27 er, these results demonstrate that NPNT is a paracrine angiogenic factor and may play a role in patho

28 , whose mechanism of action is predominantly paracrine, are being widely tested for the treatment of

29 thway, we describe a mechanism through which paracrine ATP signalling enhances firing in a cell-speci

30 central auditory neurons can be modulated by paracrine ATP signalling, as shown for the cochlear nucl

31 c neuropeptide that has been shown to act as paracrine/autocrine factor in various malignancies inclu

32 The medulloblastoma-endothelial cell paracrine axis can be manipulated in vivo, altering chem

33 and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity ag

34 Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS.

35 duced guanylin loss silences the GUCY2C-cGMP paracrine axis underlying obesity-induced epithelial dys

36 ons result from primary or secondary loss of paracrine BMP signaling from preosteoblasts and dura, hi

37 umption is controlled by endothelial NO in a paracrine, but not intracrine, fashion.

38 -derived complement production and autocrine/paracrine C3ar1/C5ar1 signaling as crucial intermediary

39 ematopoietic cells initiates IL-1beta-driven paracrine cascades, which promote abnormal growth plate

40 We identified a paracrine cell communication network between infected an

41 the JCI, Peteranderl and colleagues define a paracrine communication between macrophages and type II

42 To assess the paracrine contributions, we employed a Transwell system

43 lary thyroid cancer tumors and the autocrine-paracrine conversion of SOD3 expression, which was enhan

44 Therefore, we tested the hypothesis that paracrine Cox-2-mediated signalling from macrophages dri

45 f hematopoietic regeneration and demonstrate paracrine cross-talk between BM osteolineage cells and e

46 a-analytic database analyses, we developed a paracrine cross-talk-based biological mechanism of DCIS

47 les (EVs) released by MSCs contribute to the paracrine crosstalk that shapes hematopoietic function.

48 vironmental cues by modulating autocrine and paracrine DAF-2 ILS.

49 t combines accelerated perfusion with direct paracrine delivery of a bioactive payload to transplante

50 Many beneficial effects of MSCs are paracrine, dependent on extracellular vesicles (EVs).

51 ist of Nodal signalling LEFTY1 and CER1, are paracrine determinants restricting PS progression.

52 In this study, we focused on the paracrine effect of MSCs on macrophage polarization and

53 One facet of their mechanism is the paracrine effect of the transplanted cells.

54 r 11 (TNFSF11; also known as RANKL) is a key paracrine effector of progesterone signaling and that RA

55 o nonplacental cells through the activity of paracrine effectors, including the constitutive release

56 injury and aids muscle regeneration through paracrine effects and as a multipotent cell source, and

57 Evidence for paracrine effects from the tumor microenvironment were r

58 evelop an innovative strategy to enhance the paracrine effects of hMSCs.

59 Promoting the paracrine effects of human mesenchymal stem cell (hMSC)

60 lationship with insulin sensitivity, and the paracrine effects of incretins.

61 ponectin expression in EpAT is controlled by paracrine effects of oxidation products released from th

62 Finally, to study the nature of the hMSC paracrine effects on contractility, proteomic analysis o

63 Cs give rise to most cranial bones and exert paracrine effects on the developing brain.

64 (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium.

65 s in young, pre-menopausal women could exert paracrine effects through the highly estrogen-responsive

66 ), and serum amyloid A2 (SAA2), which elicit paracrine effects to stimulate migration, invasion, and

67 To dissect the relative contributions of the paracrine effects, we first established a liver organoid

68 phosphate oxidase activity via endocrine or paracrine effects.

69 s of cytokines contributing to proangiogenic paracrine effects.

70 sm, and contribute to insulin resistance via paracrine effects.

71 s, which allows the MAPK cascade to transmit paracrine EGF signals into spatially non-uniform ERK act

72 DE2 can mediate hyperpermeability effects of paracrine endothelial NP/GC-A/cGMP signaling and facilit

73 rowth factor (PDGF)/FGF receptor inhibitors, paracrine ERK activation in fibroblasts was blocked in o

74 only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor nich

75 RCC induced paracrine extracellular signal-regulated kinase (ERK) ac

76 Mechanistically, we found that the paracrine factor FGF16 was significantly reduced in the

77 impaired ability to upregulate expression of paracrine factor genes and the conditioned media from th

78 VEGF likely functions as a paracrine factor in this process because deletion of Veg

79 monstrates the power of modified mRNA -based paracrine factor library screening to dissect signaling

80 ther, these results show that miR-9 is a key paracrine factor of BMSCs attenuating SAP targeting the

81 ue to RSV infection appears to function as a paracrine factor priming epithelial cells and monocytes

82 results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with chol

83 ein alpha-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly unde

84 through regulation of Fgf16, suggesting that paracrine factors could be of potential use in promoting

85 nder cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis.

86 support metabolism and express regenerative paracrine factors is a strategy to treat vasculopathies

87 g approach to probe the effect of individual paracrine factors on epicardial progenitors in the adult

88 Paracrine factors secreted by PPM1A-depleted epithelial

89 st that these cells release cardioprotective paracrine factors that activate endogenous pathways, lea

90 Aged CPCs fail to upregulate paracrine factors that are potentially important for pro

91 ablishing this microenvironment by releasing paracrine factors that control the functions of surround

92 iate upon exposure to blue light and release paracrine factors that modulate nearby cells.

93 exert their beneficial effects by release of paracrine factors, microvesicles, and transfer of mitoch

94 doislets depends upon the combined action of paracrine factors, such as insulin and somatostatin, and

95 ate haematopoiesis through the expression of paracrine factors.

96 mportantly, while SHH acted exclusively in a paracrine fashion on PSCs and influenced the growth of P

97 of biologically active molecules acting in a paracrine fashion on resident cells.

98 mokine, CCL5, from ECs, which then acts in a paracrine fashion on TNBC cells to enhance their migrati

99 CCL21 acted in a paracrine fashion to mediate chemotactic migration of EM

100 owards the primary chemoattractant, and in a paracrine fashion to mediate the recruitment of neighbor

101 by immune cells and acts as an autocrine or paracrine fashion to regulate the function of immune cel

102 pable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors, i

103 pable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors.

104 ta-catenin wild-type colon cancer cells in a paracrine fashion, whereas no hyperactivation was detect

105 the T cell response only when delivered in a paracrine fashion.

106 eased the angiogenic potential of HUVEC in a paracrine fashion; conversely, knockdown of RPS15A in He

107 EGF, SEMA3A, TGF-beta, and CXCL12 signal in paracrine fashions between the podocytes, endothelium, a

108 uced within tissues to act in intracrine and paracrine fashions.

109 diovascular effects appear to be mediated by paracrine FGF control of kidney FGFR1 and subsequent reg

110 fore, may have a more important autocrine or paracrine function that is confined within the adipose t

111 tor (TGF)-beta1 contributes to autocrine and paracrine functions in the tumor microenvironment (TME).

112 Moreover, paracrine Hedgehog secretion by MM cells upregulated str

113 Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smo

114 These studies reveal a role for the GUCY2C paracrine hormone axis as a novel compensatory mechanism

115 se C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universall

116 eurotransmitter and endocrine, autocrine and paracrine hormone.

117 eurotransmitter and endocrine, autocrine and paracrine hormone.

118 ed in intestinal epithelial cells, binds the paracrine hormones guanylin and uroguanylin, inducing cG

119 hich are peptides structurally homologous to paracrine hormones of the intestinal guanylate cyclase C

120 n together, our data support the notion that paracrine IGF1/IGF1R signaling initiated by RT-activated

121 val.Significance: These findings reveal that paracrine IGF1/IGF1R signaling promotes colorectal cance

122 ence spontaneous inflammasome activation and paracrine IL-1 signaling, which is sufficient to cause s

123 eased response to and secretion of autocrine/paracrine IL-10, IL-4, IL-22 and thymic stromal lymphopo

124 the spleen compete for a limiting supply of paracrine IL-2 generated by autoreactive CD4(+) T cells

125 ary lymphoid organs are largely supported by paracrine IL-2 signaling.

126 Blocking autocrine and paracrine IL4 signaling with the IL4Ralpha antagonist IL

127 ain vesicles but transmitter release appears paracrine in nature, due to the apparent lack of synapti

128 und is both necessary and sufficient for the paracrine induction of HIF1alpha in such cells under nor

129 endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesti

130 One gene that experiences LOI is the paracrine insulin-like growth factor IGF2, which occurs

131 igodendrogenesis through a cytokine-mediated paracrine interaction.

132 teolytic bone responses that involve complex paracrine interactions between tumor cells, osteoblasts,

133 tumor's genetic profile but also by complex paracrine interactions within the tumor microenvironment

134 of SS18-SSX2-transformed cells, indicating a paracrine link between the bone and synovial sarcomagene

135 findings suggest that an IL-1beta-dependent paracrine loop between infiltrated neutrophils/MDMs and

136 Secreted LEP activates an autocrine/paracrine loop through binding to the LEP receptor (LEPR

137 ions meclofenamate and tonabersat break this paracrine loop, and we provide proof-of-principle that t

138 keratinocyte proliferation through a double paracrine loop.

139 secreted inflammatory signals, which through paracrine macrophage activation regulates the migratory

140 Paracrine macrophage Cox-2 activity drives growth and pr

141 In vitro studies confirmed that paracrine macrophage Cox-2 signalling drives catenin-rel

142 factor 1 (IGF1) is secreted in an autocrine/paracrine manner by GCs and activates the IGF1 receptor

143 1 by NK cells, which participated in an auto/paracrine manner in the suppressive activity of polymorp

144 We show that TNFalpha acts in a paracrine manner on epithelial cells via a TNFR1-PI3K-PK

145 gnal through endothelial CXCR2 receptor in a paracrine manner to promote endothelial tube formation,

146 retion of IL-2 that normally feeds back in a paracrine manner to promote STAT5 activation and IL-9 pr

147 irect targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences

148 weakly metastatic, non-EMT tumour cells in a paracrine manner, in part by non-cell autonomous activat

149 that mesenchymal stem cells (MSCs) act in a paracrine manner, the mechanisms are still not fully und

150 The induction of DOX-MDSC is regulated in a paracrine manner.

151 sting that it may act in an autocrine and/or paracrine manner.

152 yngioma (ACP), derived from Sox2- cells in a paracrine manner.

153 n increases beta cell mass and function in a paracrine manner.

154 itment and activation in an autocrine and/or paracrine manner.

155 nforce the arrest and induce senescence in a paracrine manner.

156 host regeneration and muscle mass gain in a paracrine manner.

157 ld modulate key renal tubular functions in a paracrine manner.

158 gulate cellular processes in an autocrine or paracrine manner.

159 feration of alpha-SMA(+) myofibroblasts in a paracrine manner.

160 III IFNs and use these IFNs in autocrine and paracrine manners to restrict ZIKV infection.

161 ese models revealed that this gap junctional/paracrine mechanism accounts for up to 23% of the suppre

162 Our data reveal a paracrine mechanism by which angiogenic endothelial cell

163 s CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulate

164 igrating cells revealed a possible SCF/c-Kit paracrine mechanism contributing to migration via a subp

165 se is regulated by cardiac fibroblasts via a paracrine mechanism involving plasma membrane calcium AT

166 t of SA CMCs was negligible, which implies a paracrine mechanism of action.

167 Together, these results identify a potential paracrine mechanism that coordinates neuronal homeostasi

168 cuit formation, but they also reveal a novel paracrine mechanism that regulates the assembly of these

169 We suggest that besides the classic paracrine mechanism, cell-autonomous mechanisms that inv

170 al epithelial cells following injury through paracrine mechanism.

171 d proliferation of myeloid progenitors via a paracrine mechanism.

172 inhibits alpha-cell electrical activity by a paracrine mechanism.

173 PGE2 onto its target neurons, possibly by a paracrine mechanism.

174 These paracrine mechanisms could be very prolonged because som

175 ric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replic

176 de arterial PCO2 /pH via cell-autonomous and paracrine mechanisms, and via input from other CO2 -resp

177 ntrol breast cell fate through intrinsic and paracrine mechanisms.

178 growth and progression by both autocrine and paracrine mechanisms.

179 r via point-to-point synapses rather than by paracrine mechanisms.

180 are immunosuppressive and protumorigenic by paracrine mechanisms.

181 ver regeneration after extended resection by paracrine mechanisms.

182 onses to disease states through autocrine or paracrine mechanisms.

183 gen consumption in the working heart through paracrine mechanisms.

184 el insight into the role of exosomes in hMSC paracrine-mediated effects on contractility.

185 Given that RANKL is an important paracrine mediator of hormonal signaling in breast tissu

186 ng the secretion of extracellular, autocrine/paracrine mediators of glioma stem-like cell self-renewa

187 ivation, cell-cycle arrest, and secretion of paracrine mediators, including insulin-like growth facto

188 hway activator CHIR99021 results in distinct paracrine microenvironments codifying hPSCs towards defi

189 ulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous mali

190 f chemokines and growth factors, acting in a paracrine mode.

191 thought to depend on endocrine and autocrine/paracrine modulators.

192 te that the mechanism is through overlapping paracrine or autocrine canonical WNT-beta-catenin signal

193 Inhibition of paracrine or autocrine VEGF signaling had no effect on p

194 protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide hormones involved in cont

195 ulin target cell types through mechanisms of paracrine or endocrine regulation with robust effects on

196 s where they signal via ErbB3/4 receptors in paracrine or juxtacrine mode.

197 an produce signals that act in an autocrine, paracrine, or endocrine manner.

198 s in Hyp mice, its putative role as an auto-/paracrine osteomalacia-causing factor has not been explo

199 tion, and angiogenesis through autocrine and paracrine PDGFRbeta signaling.

200 Here we describe an auto-/paracrine physiologic circuit that controls quiescence o

201 (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the progressio

202 Our findings unveil a novel autocrine/paracrine pro-homeostatic RPE cell signaling that aims t

203 AC) and demonstrate its role as an autocrine/paracrine pro-survival factor.

204 gered the expression of a specific subset of paracrine profibrotic factors, including Lcn2, Pdgfb, an

205 ) therapy in heart failure may be related to paracrine properties and systemic effects, including ant

206 In this study, we explored the importance of paracrine regulation by using an optogenetic strategy.

207 ted by lipotoxicity and were associated with paracrine regulation of glucocorticoid activity because

208 reted by neighbouring beta- and delta-cells (paracrine regulation) have been proposed to be important

209 ic intermediate of the BCAA valine, as a new paracrine regulator of trans-endothelial fatty acid tran

210 ta suggested that osteoclast-derived EVs are paracrine regulators of osteoclastogenesis.

211 but also the heart affects EpAT biology via paracrine 'reverse' signalling.

212 liferation, suggesting a potential endocrine/paracrine role for BMPs, but some of the mechanisms are

213 To understand the autocrine and paracrine roles that amino acids play in islet physiolog

214 Earlier, we had discovered that paracrine secretion from human CD34(+) cells contains pr

215 lating monocytes, augment vascular repair by paracrine secretion of pro-angiogenic factors.

216 RATIONALE: Paracrine secretions seem to mediate therapeutic effects

217 cribe a mechanism by which damage-associated paracrine secretory responses are restrained to preserve

218 e GPR91, which functions as an autocrine and paracrine sensor for extracellular succinate to enhance

219 rabasal daughters become SCs that respond to paracrine SHH and symmetrically expand.

220 PCa bone and visceral metastases, activating paracrine Shh signaling in tumor-stromal interactions.

221 ntiation through triggering the release of a paracrine signal from persistently activated beta-cells.

222 This paracrine signal may ensure thalamocortical connectivity

223 n receptor signalling nexus may operate as a paracrine signal that sustains tumour cell expansion and

224 SC-mediated heterocellular coupling (HC) and paracrine signaling (PS) on human cardiac contractility

225 s animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact reg

226 icroColonies') to quantitatively investigate paracrine signaling and the response to external stimuli

227 y recruited inflammatory cells, allowing for paracrine signaling at the site of an infection.

228 These changes occur via paracrine signaling between the uterine epithelium and s

229 Autocrine or paracrine signaling by beta interferon (IFN-beta) is ess

230 more slowly developing mechanisms involving paracrine signaling by extracellular peptides (C-type na

231 Our findings help elucidate the paracrine signaling events activated by a compromised mu

232 as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors.

233 l breast cancer: TGFbeta is an autocrine and paracrine signaling factor that drives cell invasion and

234 zation are coupled by localized secretion of paracrine signaling factors by the differentiating hMSCs

235 occurred in hepatocytes and was mediated by paracrine signaling from Kupffer cells.

236 s then applied to HMECs to determine whether paracrine signaling from PELP1-cyto-activated macrophage

237 CFB mechanical activation and found that 1) paracrine signaling from stretched cardiomyocytes induce

238 ata suggest that inhibition of Ezh2 promotes paracrine signaling in osteoblasts and has bone-anabolic

239 growth factor-1 receptor (IGF-1R) autocrine/paracrine signaling in patients with renal cell carcinom

240 ctivity not only disrupts IL-1 autocrine and paracrine signaling loops that can alert effector cells

241 However, whether the paracrine signaling mediated by angiogenin secretion is

242 minobutyric acid, an important autocrine and paracrine signaling molecule and a survival factor in is

243 hophysiological significance, the origin and paracrine signaling pathways that regulate epicardial ad

244 duction of an alpha-ketoglutarate (alpha-KG) paracrine signaling system.

245 Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT pathway, leadin

246 n interstitial fibrosis, and through altered paracrine signaling to cardiomyocytes, which become hype

247 These results suggest that autocrine and/or paracrine signaling via locally generated SPMs in the va

248 ation through inhibition of cell activation, paracrine signaling, and dampened cellular proinflammato

249 enous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and trig

250 ted therapy-induced stromal ELR(+) chemokine paracrine signaling, thus enhancing treatment response a

251 To determine role of paracrine signaling, we cultured pure mESC-CMs within mi

252 on of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellu

253 ing both hypertrophic and hypoxia-stimulated paracrine signaling.

254 implicated in metastatic progression through paracrine signaling.

255 rstood as an ATP release channel involved in paracrine signaling.

256 involvement of stem cell differentiation and paracrine signaling.

257 roles in regulating cardiac development via paracrine signaling.

258 dentifies two precocious cells in a study of paracrine signalling in mouse dendritic cells.

259 Paracrine signalling mediated by cytokine secretion is e

260 We propose a model based on paracrine signalling to account for the separation of th

261 between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, in

262 daptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by c

263 ting GBM malignant growth through PTN-PTPRZ1 paracrine signalling.

264 fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulato

265 hed soluble chemokines can generate auto- or paracrine signals by binding and activating their transm

266 Here, we show that paracrine signals driven by mutant beta-catenin in WNT-m

267 ptome, metabolome, and kinome in response to paracrine signals emerging from irradiated CAF.

268 BB receive brain iron status information via paracrine signals from ensheathing astrocytes.

269 early in a physiological response invoked by paracrine signals from iron-starved astrocytes.

270 r, these studies highlight the importance of paracrine signals from the airway epithelium to the unde

271 GP signaling was impaired by altered paracrine signals from the knee joint, including activat

272 Paracrine signals maintain developmental states and crea

273 In conclusion, the mesoderm-derived paracrine signals promote hepatocyte maturation in liver

274 s a novel approach to identify developmental paracrine signals regulating the differentiation of huma

275 Paracrine signals released by AKR1B10-overexpressing ker

276 n, including profibrotic and proinflammatory paracrine signals secreted by epithelial cells after eit

277 artment resulted from loss of stroma-derived paracrine signals that activate Yap1 and the Hedgehog pa

278 infiltration to the injured nerve, and sends paracrine signals to activate TRPA1 of ensheathed nocice

279 ly integrate fluctuating ionic, hormonal and paracrine signals to control the synthesis and secretion

280 As paracrine signals, these factors activate the STAT1 and

281 fibroblast lineages responding to different paracrine signals.

282 lly, dampening a positive EGF-EGFR autocrine/paracrine stimulation loop induced by the post-surgical

283 a1, alpha3-null keratinocytes showed reduced paracrine stimulation of endothelial cell migration and

284 accumulation of pyrophosphate through auto-/paracrine suppression of TNAP.

285 n vivo models, we identify the Hedgehog (HH) paracrine system as a candidate signaling cascade.

286 Similarly, restoring paracrine TGF-beta-Slug-EMT signaling reactivated the tr

287 ilan-infected cells established an autocrine/paracrine TLR5 signaling loop resulting in constitutive

288 nsing of cytokine production was mediated by paracrine TNF-alpha-TNFR1 signaling rather than direct l

289 Moreover, AGR2 expression was inducible by paracrine transfer of ER stress and pro-inflammation bet

290 er damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells

291 e, we uncover the mechanisms underlying this paracrine tumourigenesis.

292 rsors also results in stem cell clusters and paracrine tumours.

293 by LPA1-, Gi-, and COX1-dependent autocrine/paracrine TXA2 release and consequent TP activation.

294 ntrols cardiac oxygen (O2 ) consumption in a paracrine way by slowing respiration at the mitochondria

295 ut hair cycle quiescence and growth, whereas paracrine Wnt inhibition of inner bulge cells reinforces

296 decan-1 and that this binding contributes to paracrine Wnt pathway activation through the Wnt recepto

297 ESCs secrete Wnts that activate autocrine or paracrine Wnt/beta-catenin signaling to promote efficien

298 g activation by autocrine Wnt ligands and/or paracrine Wnts emanating from the bone marrow (BM) niche

299 g activation by autocrine Wnt ligands and/or paracrine Wnts from the BM microenvironment.

300 matically increased sensitivity to auto- and paracrine Wnts.