ライフサイエンスコーパス: paracrine signaling

1 roles in regulating cardiac development via paracrine signaling.

2 involvement of stem cell differentiation and paracrine signaling.

3 hat this factor plays in cardiac disease and paracrine signaling.

4 ing both hypertrophic and hypoxia-stimulated paracrine signaling.

5 primed state of DC maturation mediated by DC paracrine signaling.

6 DCs to a panoply of cytokines/chemokines via paracrine signaling.

7 ifferentiated state of mammary epithelia via paracrine signaling.

8 tivation of Smads through TGFbeta1 autocrine/paracrine signaling.

9 e for the increased autocrine endogenous and paracrine signaling.

10 ses secretion of S1P, allowing for autocrine/paracrine signaling.

11 lls, it may be engaged in both autocrine and paracrine signaling.

12 implicated in metastatic progression through paracrine signaling.

13 rstood as an ATP release channel involved in paracrine signaling.

14 al systems may be affected by such limits of paracrine signaling.

15 an promote growth via KITLG autocrine and/or paracrine signaling.

16 organized in a modular network implicated in paracrine signaling.

17 asis, and angiogenesis through autocrine and paracrine signaling.

18 ate stem cell fate outcomes to autocrine and paracrine signaling.

19 liberated during cellular necrosis to effect paracrine signaling.

20 TGF-beta1, which is capable of autocrine and paracrine signaling.

21 n addition to spatial patterns of intratumor paracrine signaling, a possible cell-cycle-associated re

22 This paracrine signaling acts to constrain ISC proliferation

23 omote repair of the infarcted myocardium via paracrine signaling after transplantation.

24 may participate importantly in autocrine and paracrine signaling among leukocytes and vascular endoth

25 s animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact reg

26 mechanisms underlying astrocytic-endothelial paracrine signaling and have found that integrin-mediate

27 creted TGF-beta1 is capable of autocrine and paracrine signaling and is dependent upon expression of

28 rotein also efficiently blocks autocrine and paracrine signaling and reduces the proliferation of MCF

29 icroColonies') to quantitatively investigate paracrine signaling and the response to external stimuli

30 ation through inhibition of cell activation, paracrine signaling, and dampened cellular proinflammato

31 issue formation by neonatal chondrocytes via paracrine signaling, and highlights the importance of co

32 ing environments, regulated by autocrine and paracrine signaling, and modulated by cell organization,

33 ude direct incorporation into blood vessels, paracrine signaling, and tunneling nanotube renewal of m

34 sues did not have similar effects, excluding paracrine signaling as a major mechanism.

35 y recruited inflammatory cells, allowing for paracrine signaling at the site of an infection.

36 s reveal a novel TGF-beta, androgen, and Wnt paracrine signaling axis that enables prostatic regressi

37 hat alphavbeta8 integrin is a component of a paracrine signaling axis that links astrocytes to blood

38 Thus, HIFs mediate complex and bidirectional paracrine signaling between BCCs and MSCs that stimulate

39 idence, however, points to a direct role for paracrine signaling between blood vessel cells and surro

40 We demonstrate that HIFs mediate paracrine signaling between breast cancer cells (BCCs) a

41 ate the latter effect is caused by disturbed paracrine signaling between endothelial and surrounding

42 Paracrine signaling between hepatic stellate cells (HSCs

43 est the hypothesis that sorafenib influences paracrine signaling between HSCs and LECs and thereby re

44 autoreceptor function, provide a pathway for paracrine signaling between NG neurons, and contribute t

45 Paracrine signaling between pancreatic islet beta-cells

46 Paracrine signaling between podocytes and glomerular end

47 lies upon coordination of both autocrine and paracrine signaling between the budding epithelium and a

48 ing on the nutrient type and likely involves paracrine signaling between the differentiated beta-cell

49 riction (IUGR) on pancreatic vascularity and paracrine signaling between the EC and beta-cell.

50 These changes occur via paracrine signaling between the uterine epithelium and s

51 Autocrine or paracrine signaling by beta interferon (IFN-beta) is ess

52 Paracrine signaling by enterochromaffin cells (EC), whic

53 more slowly developing mechanisms involving paracrine signaling by extracellular peptides (C-type na

54 We conclude that HER-mediated autocrine and paracrine signaling by HB-EGF or other EGF family member

55 Survival and proliferation of hHpSCs require paracrine signaling by hepatic stellate cells and/or ang

56 s to a positive feedback loop involving auto/paracrine signaling by IL13 and the IL4/13 receptor.

57 rom of each other, a distance sufficient for paracrine signaling by leukotrienes to operate effective

58 The concept of local paracrine signaling by nitric oxide over subcellular dis

59 Enhancement of Hmga2-induced paracrine signaling by overexpression of androgen recept

60 ngs establish a critical functional role for paracrine signaling by tumor-derived osteopontin in repr

61 Blockade of autocrine/paracrine signaling can aid in dissecting the contributi

62 of how quantitative control of autocrine and paracrine signaling can be integrated with spatial organ

63 While it is well established that paracrine signaling can similarly elicit diverse respons

64 Additionally, ER-stressed astrocytes, via paracrine signaling, can stimulate activation of microgl

65 ix metalloproteinase-1 (MMP1), orchestrate a paracrine signaling cascade to modulate the bone microen

66 Paracrine signaling cascades regulated by hypoxia initia

67 expressing oncogenic mutants of Src, whereas paracrine signaling could stimulate EGFR and ERK signali

68 tion, which effectively blocks all autocrine/paracrine signaling crucial to induction of downstream e

69 ivate valvular interstitial cells and latent paracrine signaling cytokines (eg, transforming growth f

70 Our findings help elucidate the paracrine signaling events activated by a compromised mu

71 rain) can trigger a cascade of autocrine and paracrine signaling events between ECs and SMCs critical

72 These effects occur through autocrine and paracrine signaling events initiated by interactions bet

73 poptosis during cytotoxic treatment activate paracrine signaling events that promote the growth of su

74 as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors.

75 effect on the epithelium through additional paracrine signaling events.

76 gest that suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, in

77 h is a well-established potent autocrine and paracrine signaling factor modulating a variety of cellu

78 l breast cancer: TGFbeta is an autocrine and paracrine signaling factor that drives cell invasion and

79 zation are coupled by localized secretion of paracrine signaling factors by the differentiating hMSCs

80 other nucleotides function as autocrine and paracrine signaling factors in many tissues.

81 for kinins, including those in autocrine and paracrine signaling for skeletal and cardiac muscle ener

82 Mast cells use paracrine signaling for the transfer of chemical informa

83 omatic events may drive tumor growth through paracrine signaling fostering a tumor ecologic niche are

84 results demonstrate a directionally specific paracrine signaling from epithelial FGF9 and stromal FGF

85 This likely resulted from paracrine signaling from hepatocytes in the peritoneal c

86 Paracrine signaling from infected DCs induced an antivir

87 occurred in hepatocytes and was mediated by paracrine signaling from Kupffer cells.

88 Paracrine signaling from lung epithelium to the surround

89 IgG-mediated changes may be a means by which paracrine signaling from neuronal activity influences mi

90 s then applied to HMECs to determine whether paracrine signaling from PELP1-cyto-activated macrophage

91 Paracrine signaling from SCF to KIT, between differentia

92 CFB mechanical activation and found that 1) paracrine signaling from stretched cardiomyocytes induce

93 Moreover, paracrine signaling from the epicardium and endocardium

94 The expression of the paracrine signaling hormone pituitary adenylate cyclase-

95 Cilia are critical mediators of paracrine signaling; however, it is unknown whether prot

96 Paracrine signaling in a bacterial population ensures th

97 Here we present evidence for paracrine signaling in bacterial populations-some cells

98 a general tool for the quantitative study of paracrine signaling in both adherent and nonadherent cel

99 nd provide a quantitative assay for studying paracrine signaling in early development.

100 ata suggest that inhibition of Ezh2 promotes paracrine signaling in osteoblasts and has bone-anabolic

101 growth factor-1 receptor (IGF-1R) autocrine/paracrine signaling in patients with renal cell carcinom

102 ivity is required in Shh-producing cells for paracrine signaling in Shh target fields, we used a ShhG

103 tive oxygen species activate NRG-1beta/erbB4 paracrine signaling in the heart and suggest that this s

104 role of the cardiac myocyte as a mediator of paracrine signaling in the heart has remained unclear.

105 ng the inflammatory and fibrotic response by paracrine signaling inducing the secretion of a variety

106 skeletal muscle hypertrophy alters autocrine/paracrine signaling, intracellular signaling, and transc

107 nterfering with homeostatic VEGFR2-dependent paracrine signaling involving interactions between hepat

108 ls in BCP-ALL cells, but we demonstrate that paracrine signaling involving prostaglandin E2-induced c

109 itive cells but rather in adjacent cells via paracrine signaling involving several local growth facto

110 These data indicate that paracrine signaling is an important mediator of bone mar

111 atical modeling suggests that a high rate of paracrine signaling is likely to occur among DCs located

112 Paracrine signaling is proposed as a link that emphasize

113 We demonstrate that paracrine signaling is sufficient to restore cellular sy

114 Autocrine and paracrine signaling leading to stimulation of tumor cell

115 A BDNF/TrkB autocrine/paracrine signaling loop has additionally been implicate

116 contributes to an active BDNF/TrkB autocrine/paracrine signaling loop in HTLV-1-infected T cells that

117 MCP-1 upregulation is driven by an autocrine/paracrine signaling loop in which interleukin (IL)-1alph

118 s and perivascular fibroblasts, suggesting a paracrine signaling loop.

119 We previously cataloged putative autocrine/paracrine signaling loops in pancreatic islets, includin

120 ctivity not only disrupts IL-1 autocrine and paracrine signaling loops that can alert effector cells

121 blood mononuclear cells upon coculture in a paracrine signaling manner.

122 cinoma cells, suggesting that this autocrine-paracrine signaling may be a common response to Ras/Raf

123 ddition, these findings argue that US28-CCL5 paracrine signaling may contribute to glioma progression

124 t outcome, suggesting that HCMV pp71-induced paracrine signaling may contribute to the aggressive phe

125 ion during mechanotransduction and that VEGF paracrine signaling may provide potent cross-talk among

126 a dual circulation, and that VEGF autocrine/paracrine signaling may regulate these processes.

127 evels, indicating that a TNF-alpha autocrine/paracrine signaling mechanism alone is not sufficient to

128 We describe various paracrine signaling mechanism(s) by which the loss of st

129 ivated in sebocyte progenitors, suggesting a paracrine signaling mechanism.

130 mmune systems, possibly through autocrine or paracrine signaling mechanisms.

131 r growth and survival through autocrine- and paracrine-signaling mechanisms.

132 However, whether the paracrine signaling mediated by angiogenin secretion is

133 Paracrine signaling mediated by FGF-10 and the FGF-R2III

134 enous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and trig

135 and identify fibroblast-derived miR-21* as a paracrine signaling mediator of cardiomyocyte hypertroph

136 ns; however, miRNAs have emerged recently as paracrine signaling mediators.

137 l of peptide growth factors in autocrine and paracrine signaling, mesenchymal-epithelial interactions

138 ignaling components, the logic of this auto-/paracrine signaling module in growth control remains poo

139 minobutyric acid, an important autocrine and paracrine signaling molecule and a survival factor in is

140 The agouti locus encodes a novel paracrine signaling molecule containing a signal sequenc

141 ytryptamine (5-HT) is a neurotransmitter and paracrine signaling molecule in the gut.

142 Agouti protein, a paracrine signaling molecule normally limited to skin, i

143 (eNOS)-derived NO has long been considered a paracrine signaling molecule only capable of affecting n

144 The mouse agouti protein is a paracrine signaling molecule that causes yellow pigment

145 the Agouti coat color gene, which encodes a paracrine signaling molecule that induces a swithc in me

146 ta (LPAAT-beta), is a well-studied autocrine/paracrine signaling molecule that is secreted by ovarian

147 n ATP metabolite, which acts as an autocrine/paracrine signaling molecule through A2b adenosine recep

148 llular ATP represents an important autocrine/paracrine signaling molecule within the liver.

149 roto-oncogene Wnt3, which encodes a secreted paracrine signaling molecule, is expressed in developing

150 ties, such as converting a juxtacrine into a paracrine signaling molecule.

151 ression of agouti-signaling protein (ASP), a paracrine-signaling molecule that regulates pigment-type

152 tor parathyroid hormone-related protein is a paracrine-signaling molecule that regulates the developm

153 the family of prostaglandins (PG), autocrine/paracrine signaling molecules synthesized via the cycloo

154 AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonis

155 This suggested that paracrine signaling molecules that induce PMN degranulat

156 e only member of the WNT family of autocrine/paracrine signaling molecules whose expression in the lu

157 etastatic growth in mice via upregulation of paracrine signaling molecules.

158 rotein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pig

159 Here, we have uncovered a paracrine signaling network between the adaptive and inn

160 rapeutic approaches, namely the miR-mediated paracrine signaling network.

161 tal stress can therefore block autocrine and paracrine signaling of the Wnt/beta-catenin pathway and

162 nomas and other cancers, while autocrine and paracrine signaling of this receptor/ligand pair has bee

163 sent study, we identified ATP-triggered PGE2 paracrine signaling originating from beta-ICs as a mecha

164 Prostaglandins mediate autacrine and paracrine signaling over short distances.

165 over, the evidence provided suggests a novel paracrine signaling pathway for epithelia, which previou

166 These findings imply an important paracrine signaling pathway in the heart.

167 Here we identified a paracrine signaling pathway in the kidney in which high

168 in this pathway, miR-145 seems to suppress a paracrine signaling pathway in the tumor microenvironmen

169 ound that HBZ promotes a BDNF/TrkB autocrine/paracrine signaling pathway that is known to enhance the

170 Collectively, these data identify a paracrine signaling pathway that links the neuroepitheli

171 the differential activation of an autocrine/paracrine signaling pathway.

172 ion of 5'-AMP to adenosine required for this paracrine signaling pathway.

173 at basal body proteasomal regulation governs paracrine signaling pathways and suggest that augmenting

174 Complex autocrine and paracrine signaling pathways control the multiple cycles

175 hophysiological significance, the origin and paracrine signaling pathways that regulate epicardial ad

176 neuropeptides urocortins (Ucns) are ancient paracrine-signaling peptides secreted in both the centra

177 o prostate cancer disease recurrence through paracrine signaling processes.

178 SC-mediated heterocellular coupling (HC) and paracrine signaling (PS) on human cardiac contractility

179 fected DCs and uninfected DCs to investigate paracrine signaling responses.

180 hat Disp1 is not absolutely required for the paracrine signaling role of Ihh in the skeleton.

181 duction of an alpha-ketoglutarate (alpha-KG) paracrine signaling system.

182 Thus, CAMP is a promoter of islet paracrine signaling that enhances islet function and glu

183 The latter involves autocrine/paracrine signaling that enhances the viability and grow

184 tic colonization are most likely mediated by paracrine signaling that enhances tumor/stromal cell int

185 uggest a previously undescribed mechanism of paracrine signaling that in vivo may involve the reversi

186 entiation and behavior mediated by autocrine-paracrine signaling that instructs transcriptional proce

187 may influence PEL through VEGF autocrine and paracrine signaling that promotes PEL cell growth and ex

188 Paracrine signaling through receptor activator of NF-kap

189 suggest that strain may induce autocrine or paracrine signaling through TGFbeta superfamily ligands.

190 Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT pathway, leadin

191 uced progesterone resistance indicating that paracrine signaling through the stroma is essential for

192 ted therapy-induced stromal ELR(+) chemokine paracrine signaling, thus enhancing treatment response a

193 n interstitial fibrosis, and through altered paracrine signaling to cardiomyocytes, which become hype

194 Paracrine signaling to endogenous cells amplifies the ef

195 reveals that cells utilize optimal levels of paracrine signaling to maximize the accuracy of gradient

196 active as shown by its ability to stimulate paracrine signaling via c-Met, the cell surface receptor

197 Paracrine signaling via gamma-aminobutyric acid (GABA) a

198 nstrated Akt1 mediated MEC migration through paracrine signaling via induction of expression and secr

199 These results suggest that autocrine and/or paracrine signaling via locally generated SPMs in the va

200 Paracrine signaling via platelet-derived growth factor B

201 on of ADAM17 by Src(E378G) leads to enhanced paracrine signaling via release of EGFR ligands into the

202 Activation of NRG/erbB paracrine signaling was also seen in the intact heart su

203 To determine role of paracrine signaling, we cultured pure mESC-CMs within mi

204 llus subtilis biofilm formation depends upon paracrine signaling where the signal-producing and targe

205 on of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellu

206 Hence paracrine signaling will generally extend beyond the syn

207 man mammary tumor model is dependent on both paracrine signaling with host macrophages as well as aut

208 onceivable that TrkB also mediates autocrine/paracrine signaling within these structures or anterogra