ライフサイエンスコーパス: paralogue

1 able databases) and 49% are gene duplicates (paralogues).

2 protein gene RPL22A, but not its unenriched paralogue.

3 ponds with a key, conserved eukaryotic Rad51 paralogue.

4 nBank and the large number of highly similar paralogues.

5 s, but in S. maritima is encoded by over 100 paralogues.

6 Most teleost fish possess two MSTN paralogues.

7 tic conservation with respect to their human paralogues.

8 n function between the closely related SEC23 paralogues.

9 ects in OXS2 and three of the four OXS2-like paralogues.

10 ncluding RAD51-related proteins termed Rad51 paralogues.

11 on of these non-redundant, tandemly arranged paralogues.

12 rk of vertebrate calpains, including teleost paralogues.

13 PA1 gene but Arabidopsis possesses five RPA1 paralogues.

14 RIM5alpha orthologues and in closely related paralogues.

15 gene duplication and creation of families of paralogues.

16 tional diversity among the 3 Arabidopsis CRT paralogues.

17 ing members of the miR-17-92 cluster and its paralogues.

18 al divergence relative to their SLO1 channel paralogues.

19 B. napus with the participation of ABI1-like paralogues.

20 nce and functional divergence of the BnaABI1 paralogues.

21 The four pathways share MtrA paralogues, a periplasmic electron carrier cytochrome, a

22 Multiple myosin II paralogues accumulate at mammalian epithelial cell-cell

23 Here we show that all four RAD51 paralogues act in DNA repair, recombination and RAD51 su

24 The RAD51 paralogues act in the homologous recombination (HR) path

25 S domain-containing protein ENL, but not its paralogue AF9, is required for disease maintenance in ac

26 rst reported comprehensive analysis of Hsp90 paralogue affinity and selectivity in the clinical Hsp90

27 degree of similarity between the S. gordonii paralogues, analysis of SecA-SecA2 chimeras indicates th

28 s that specifically antagonize each receptor paralogue and yet cross-react with the human and mouse s

29 d the zebrafish genome to identify potential paralogues and confirmed their homology, bringing the to

30 n IPTL, as shown by the accumulation of LC3B paralogues and diminishment of lysosome associated membr

31 , has revealed that these proteins are Rad51 paralogues and mediate DNA binding of this complex.

32 s, which are the most diverged region of the paralogues and probably evolved independently after a ge

33 monstrate correlation between Notch and Mef2 paralogues and support the notion that Notch-MEF2 synerg

34 suggesting functional coupling between Cas6 paralogues and their downstream effector complexes.

35 SM/type III-A and CMR/type III-B), five Cas6 paralogues and two different CRISPR-repeat families (AB

36 a suggest the involvement of two other mak-1 paralogues and two orthologues of p38 MAP kinase.

37 B. subtilis has four ltaS paralogues and we show how their roles are partially dif

38 residues in evolutionarily related proteins (paralogues) and, where appropriate, transfers annotation

39 agonists that selectively target each Jagged paralogue, and determine a crystal structure that explai

40 Rec2, a Rad51 paralogue, and Rad52 are additional components of the ho

41 ed sequence heterogeneity in mammalian Notch paralogues, and should allow the development of paralogu

42 lt of the expression of multiple Kir2 family paralogues, and the inwardly rectifying conductance cont

43 The functionally conserved paralogues appear to target to compartments associated w

44 r because of the observation that various PC paralogues are activated at different organellar pH valu

45 In human and primates, ATAD3 paralogues are encoded by three genes (ATAD3A, 3B and 3C

46 at is found in budding yeast where the RAD51 paralogues are fully dependent on the SRS2 anti-recombin

47 n supernumerary chromosomes and whether EBR1 paralogues are functional is currently unknown.

48 Because the functionally diversifying paralogues are still closely related to and derived from

49 ARID3B has two closely related paralogues, ARID3A and ARID3C.

50 establishes a role for this tissue-specific paralogue as a ribosomal component.

51 an contains approximately the same number of paralogues as found in the two soybean homeologues combi

52 These Acinetobacter baylyi paralogues belong to the largest family of prokaryotic t

53 itration calorimetry studies show that these paralogues bind the product of the methylation reaction,

54 only the major binding modes that relay pan-paralogue binding or, conversely, paralogue selectivity,

55 cking the endogenous bak1 and its functional paralogue, bkk1, produced plants that were viable but ex

56 ession pattern of two evolutionarily distant paralogues, BnaA01.ABI1.a and BnaC07.ABI1.b in B. napus

57 were not compensated by the closely related paralogue Bright-derived protein (Bdp)/Arid3b, suffered

58 ling tight co-expression between the IGF-IRa paralogues, but expression divergence comparing IGF-IRa

59 ared the physical binding properties of each paralogue by surface plasmon resonance and determined th

60 The caspase-8 paralogue c-FLIP is a good candidate for a molecular rhe

61 The conformations of C4b and its paralogue C3b are shown to be remarkably conserved, sugg

62 A TsdA paralogue (C8j_0040), lacking the unusual His-Cys haem l

63 ome duplication, which suggests that ancient paralogues can remain in the same regulatory networks fo

64 uely, C. neoformans has two functional Cdc42 paralogues, Cdc42 and Cdc420.

65 is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission chec

66 that in zebrafish two subfunctionalized cmas paralogues co-exist, we introduce a novel and unique mod

67 that HELQ interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the

68 us proteins, evolved from a more ancient two-paralogue complex because of a gene duplication that was

69 pression of the endogenous MAF2 gene and its paralogues, confounding functional assessment.

70 The transcripts of these clustered paralogues contribute to a large majority of the mRNA po

71 activation are the histone acetyltransferase paralogues CREB-binding protein (CBP) and p300.

72 Finally, we show that Dchs1, and its paralogue Dchs2, function in a partially redundant fashi

73 and HrpS functionalities suggest how partial paralogue degeneration has potentially led to a novel co

74 Relative expression of the EBR1 paralogues depends on growth conditions and on the prese

75 Here we show in mice that different NAIP paralogues determine the specificity of the NLRC4 inflam

76 Spiking experiments with purified SUMO paralogues determined that we could detect as little as

77 aeruginosa genome encodes a closely related paralogue DksA2 that lacks the Zn-finger motif.

78 acking Dcx and/or its structurally conserved paralogue, doublecortin-like kinase 1 (Dclk1), show impa

79 ABI1 gene orthologue and Brassica napus gene paralogues encoding protein phosphatase 2C (PP2C, group

80 Conversely, the ESX-1 paralogue EspG(1) interacted with a PE/PPE couple secret

81 blished with what degree of specificity CheR paralogues exert their activity.

82 These paralogues exhibit sequence and copy number variation am

83 To determine how tissue-specific septin paralogue expression may shape core heteromer repertoire

84 plasmic domain 6 amino acids longer than its paralogue, Fcgr3.

85 indicated that expression of two fibronectin paralogues, fn1 and fn1b, are induced by injury in epica

86 In zebrafish, there are 2 paralogues for adtrp (i.e., adtrp1 and adtrp2).

87 GOLPH3L is a GOLPH3 paralogue found in all vertebrate genomes, although prev

88 l locus shared with the dual TOR1A and TOR1B paralogues found in tertrapods.

89 heniformis and Bacillus pumilus as well as a paralogue from B. subtilis called YweA.

90 ally completely conserved in orthologues and paralogues from invertebrates to humans, and clinical fo

91 the kinetic properties of two different Cas6 paralogues from S. solfataricus.

92 establish that salmonids retain two IGF-IRa paralogues from ssWGD and a single IGF-IRb copy.

93 Individual AdoMetDC-SpdSyn fusion protein paralogues from Tetrahymena exhibit undetectable AdoMetD

94 proteins in Paramecium cells, we found that paralogues from the two most recent whole-genome duplica

95 pressed ubiquitously, suggesting distinctive paralogue functions.

96 and I304N mutant FMRP isoforms and the FMRP paralogues FXR1P and FXR2P (also known as FXR1 and FXR2)

97 et al. investigate the role of Gata6 and its paralogue Gata4 in mouse embryonic pancreas and show tha

98 uivalently, while mutation of only one RAD51 paralogue gene significantly impedes VSG switching.

99 ry microRNAs and temporal divergence of gene paralogues generated in the teleost genome duplication.

100 In T. brucei, four putative RAD51 paralogue genes have been identified by sequence homolog

101 an Golgi reassembly stacking protein (GRASP) paralogues, GRASP55 (GORASP2) and Rab8a.

102 We conclude that it is unlikely that the paralogues have a function in primary myogenesis.

103 Two paralogues have a redundant role in LTA synthesis during

104 Our data demonstrate that Survivin paralogues have different characteristics of phosphospec

105 The two paralogues have distinct inductive properties: Tbx6 indu

106 ic clones showed that the effects that these paralogues have on proliferation serve to promote cell c

107 ound that it includes a cohesive outgroup of paralogues (herein coined LoaP), which are often positio

108 Using zebrafish, we found that the HNF1beta paralogues hnf1ba and hnf1bb, which encode homeodomain t

109 expression assays reveal that Hoxb4 and its paralogue Hoxd4 are necessary and sufficient for cell se

110 l extension (CTE) by contrasting HP1a to its paralogue, HP1b.

111 uctures of tau55-HPD and its closely related paralogue Huf and used in silico docking methods to iden

112 We performed the same experiment for a paralogue human melanocortin receptor (hMC1R) and a mous

113 Different IL-4/13 paralogues (IL-4/13 A and IL-4/13B) exist in teleost fis

114 function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed

115 er, the specific cells expressing this Notch paralogue in the mammary gland remain unknown.

116 switching from the clag 3.2 to the clag 3.1 paralogue in vitro.

117 ssed the in vivo activities of SCCRO and its paralogues in cullin neddylation.

118 or understanding the role of the human RAD51 paralogues in Fanconi anaemia and cancer predisposition.

119 The exclusive presence of highly conserved paralogues in higher organisms led us to assess whether

120 There are 13 confirmed septin paralogues in mammals, which may be ubiquitous or tissue

121 ous to heteromeric complex formation by BRE1 paralogues in other organisms, yBre1 forms a homo-multim

122 .graminearum and other fungi but as multiple paralogues in pathogenic F.oxysporum strains.

123 nt a comprehensive analysis of MtrA and MtrC paralogues in S. oneidensis to define the roles of these

124 demonstrate an unexpected role of the Rad51 paralogues in stabilizing the Rad51 filament against a b

125 ay in dicots may have functionally redundant paralogues in switchgrass and therefore require further

126 trand invasion, however, the function of the paralogues in the process of homologous recombination is

127 that the differential use of duplicated MRF paralogues in this novel two-component myogenic system f

128 tentially broad role for RNase G, an RNase E paralogue, in the trimming of 5'-monophosphorylated ends

129 The conserved budding yeast Rad51 paralogues, including Rad55, Rad57, Csm2 and Psy3 are in

130 We also show that the T. brucei RAD51 paralogues interact, and that the complexes they form ma

131 that requires Arg67, a residue conserved in paralogues, IRAK-1 and 3(M).

132 dies suggest that silencing of either clag 3 paralogue is associated with the enrichment of specific

133 sociated ClpX must recruit ClpP, for which a paralogue is not duplicated within any of the nitrogen f

134 A distinguishing feature of these paralogues is an H-to-R change in an amino acid that int

135 esults show that the presence of these three paralogues is associated with different activities, both

136 Having two FtsK/SpoIIIE paralogues is not conserved among endospore-forming bact

137 The Shu complex, which contains RAD51 paralogues, is involved in the decision between homologo

138 Here we characterise Tbx6r, a unique Tbx6 paralogue isolated from the amphibian Xenopus.

139 vated protein kinase Slt2p, its pseudokinase paralogue, Kdx1p, and an associating transcription facto

140 lso report that a high dose of either of two paralogue kinases, Kin1 and Kin2, overcomes the defectiv

141 esults in an increased reliance on the FabHb paralogue leading to a greater proportion of straight ch

142 ucing a single historical mutation from each paralogue lineage into the resurrected ancestral protein

143 Mammals express three paralogues: lipins 1, 2, and 3.

144 eine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previous

145 Gain/amplification of MIR17HG and its paralogue loci was observed in 50% of adult-mBL.

146 d the possibility that additional JAM family paralogues may also function in muscle development.

147 e amygdala (high Utx), implying that the two paralogues may be differentially regulated.

148 Furthermore, possession of two MoeA paralogues may explain the formation of both molybdopter

149 circle accumulation, suggesting that the two paralogues mediate overlapping and nonredundant function

150 on assays show that CheR2, but not the other paralogues, methylates the McpS and McpT chemotaxis rece

151 ysine-4 (H3K4)-methyltransferase MLL3 or its paralogue MLL4.

152 nnotation errors, nomenclature variation and paralogues; moreover, GenBank's structure and tools are

153 In contrast, TRIM family paralogues most closely related to TRIM5 did not.

154 Vertebrate SoxE paralogues, most notably Sox9/10, are essential for NC i

155 transcription factor FOUR LIPS (FLP) and its paralogue MYB88 regulate terminal divisions during stoma

156 A third paralogue, Mycl1, is dispensable for normal embryonic de

157 RNAi against the NDE1 paralogue NDEL1 has no such effects.

158 Here we show that the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind SA w

159 The transaldolase paralogue NQM1 and the transcription factor VHR1 interac

160 previously reported role of Nup157, and its paralogue Nup170, in chromatin organization.

161 TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been

162 The paralogue of Alx1, Alx4, was not functionally interchang

163 Gene expression studies identified MtLAX2, a paralogue of Arabidopsis (Arabidopsis thaliana) AUX1, as

164 We also show that iBraf, a paralogue of Braf35, forms heterodimers with Braf35.

165 protease 50 (TSP50) and the testis-specific paralogue of CCCTC-binding factor, BORIS (brother of the

166 to suggest that a nitrogen fixation-specific paralogue of ClpX is used to control the accumulation of

167 L3MBTL1, a paralogue of Drosophila tumor suppressor lethal(3)malign

168 efect, is to modulate utrophin, a functional paralogue of dystrophin, able to compensate for the prim

169 nants of PC activation, we analyzed PC1/3, a paralogue of furin that is activated at a pH of approxim

170 However, POLRMT also interacts with the paralogue of h-mtTFB2, h-mtTFB1, which is a 12S ribosoma

171 ein, which suggests that NS1 is a structural paralogue of hRSV matrix (M) protein.

172 L) is a nucleolar protein and the vertebrate paralogue of nucleostemin (NS).

173 ORP4 (OSBP2) is a closely related paralogue of OSBP, but its function is unknown.

174 mature ribosomes, whereas Mrt4 is a nuclear paralogue of P0.

175 and also inhibit the activity of RNase G, a paralogue of RNase E.

176 nt evidence indicating that SlrA, which is a paralogue of SinI, is like SinI, an antirepressor that b

177 protein (TBP)-associated factor 7l (Taf7l; a paralogue of Taf7) and TBP-related factor 2 (Trf2) are c

178 Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocyt

179 ong the regulated genes was Rv0190/MT0200, a paralogue of the copper metalloregulatory repressor CsoR

180 As the endoplasmic reticulum paralogue of the cytosolic HSP90, gp96 (GRP94, HSP90b1)

181 Blo t 21 is a paralogue of the group 5 allergen, Blo t 5, a major alle

182 StpA is a paralogue of the nucleoid-associated protein H-NS that i

183 SYCP2L is a paralogue of the synaptonemal complex protein SYCP2 and

184 The SAS6-like (SAS6L) protein, a truncated paralogue of the ubiquitous basal body/centriole protein

185 hiamin pyrimidine synthase (thiC) revealed a paralogue of thiC (bzaF) clustered with anaerobic vitami

186 The recently identified paralogue of XRCC4 and XLF (PAXX) factor has homology to

187 4(yeast)/Pelota(mammals) and Hbs1, which are paralogues of eRF1 and eRF3, are implicated in these pro

188 iRNA precursors, and previously unrecognized paralogues of functionally important miRNA families (e.g

189 Signatures of subfunctionalisation of paralogues of Hox genes are revealed in the appendages o

190 share 4 unique microRNA families, 15 unique paralogues of more primitive microRNA families, and 22 u

191 Three paralogues of NudC are known in vertebrates: NudC, NudC-

192 ere a comparative analysis of the three CheR paralogues of Pseudomonas putida.

193 oteins of streptococci and staphylococci are paralogues of SecA and are presumed to have an analogous

194 l other adaptin complex subunits, as well as paralogues of the syntaxins and Rabs specific for the ot

195 aricus and related crenarchaea contain three paralogues of the tfb gene.

196 the Tmem16a transcript in addition to other paralogues of the Tmem16a family.

197 Assays with paralogues on chromosomes 18 and 20 (18|20 PRT) and chro

198 coactivator CREB binding protein (CBP), its paralogue p300, and the retinoblastoma protein (pRb; als

199 The histone acetyltransferase paralogues p300 and CREB-binding protein (CBP) are key t

200 roteins interact directly with ATML1 and its paralogue PDF2 and that silencing of both HD-ZIP transcr

201 lino oligonucleotides we show that both Tbx6 paralogues perform essential functions in the developmen

202 B forms homodimers and heterodimers with its paralogue PHOX2A in vitro, we tested the hypothesis that

203 The paralogues play differential roles in actin and septin o

204 istoyl sequence in SCCRO3, one of four SCCRO paralogues present in humans that localizes to the membr

205 r the evolution of complexity in other multi-paralogue protein complexes.

206 ation about the role of QUA2 and its closest paralogues, QUASIMODO2 LIKE1 (QUL1) and QUL2.

207 product of RAD51B interacts with that of its paralogue RAD51, which is associated with congenital mir

208 In yeast the two Rad51 paralogues, Rad55 and Rad57, have been shown to be invol

209 The paralogue ratio test (PRT) is a simple, cost-effective m

210 e methods of copy number typing based on the paralogue ratio test (PRT) to assess beta-defensin copy

211 DEFB copy number was determined by paralogue ratio test.

212 urpose of this study was to evaluate whether paralogue ratio tests (PRT) using real-time PCR can accu

213 Combined paralogue ratio tests (PRTs) were used to distinguish th

214 In this work, we use paralogue ratio tests, microsatellite analysis, read dep

215 he function of OTT3 and compared it with its paralogues RBM15 and SHARP.

216 RNA-binding motif protein 15 (RBM15) and its paralogue RBM15B, which bind the m(6)A-methylation compl

217 Five paralogues (RecQ1, Bloom, Werner, RecQ4, and RecQ5) are

218 ge of protists, demonstrating that the Rad51 paralogue repertoire in T. brucei is unusually large amo

219 g mutants in both ecotypes lacking the DELLA paralogues REPRESSOR OF ga1-3 (RGA) and GA INSENSITIVE (

220 d us to assess whether compensation by SCCRO paralogues rescues lethality in SCCRO(-/-) mice.

221 Variant expression of these paralogues results in the use of alternative invasion pa

222 erized the interaction between NUPR1 and the paralogue RING1B in vitro, in silico, and in cellulo.

223 degrades highly structured RNA, whereas its paralogue, RNase II, is unable to do so.

224 hough the function of RNF114 is unknown, its paralogue RNF125 has been shown to regulate the RIG-I/MD

225 ffects are specific to rhomboid, because its paralogue roughoid is neither required nor sufficient fo

226 thin the genome in a strain lacking the Rpl8 paralogue RPL8A, demonstrating that the gene targeted fo

227 Missense mutations in the human COPII paralogues SEC23A and SEC23B result in craniolenticulosu

228 es and set the ground for the development of paralogue selective inhibitors.

229 analysis that allows for rationalization of paralogue selectivity and defines not only the major bin

230 relay pan-paralogue binding or, conversely, paralogue selectivity, but also identifies molecular cha

231 Apparently, these paralogues share few partners and create new sets of int

232 tion patterns, and that less closely related paralogues showed evidence of both conservation and dive

233 Identical experiments with purified SUMO paralogues showed that SUMO-1 was well digested by our p

234 lear positioning in guard cells, whereas its paralogue SINE2 contributes to innate immunity against a

235 Trypanosoma brucei encodes three paralogue single-protein OSTs called TbSTT3A, TbSTT3B, a

236 Humans have a paralogue, SMN2, whose exon 7 is predominantly skipped,

237 udied the poorly characterized SNX20 and its paralogue SNX21, which contain an N-terminal PX domain a

238 Our studies emphasize the value of paralogue-specific antagonists in dissecting the contrib

239 3% identical in amino acid sequence but have paralogue-specific effects on cell proliferation, metast

240 alogues, and should allow the development of paralogue-specific ligand-blocking antibodies.

241 ar determinants of the bound orientation and paralogue specificity of a SIM are unclear.

242 and the L. monocytogenes genome contains two paralogues, spxA1 and spxA2 Here, we demonstrate that sp

243 xidative stress requires the activity of two paralogues, SpxA1 and SpxA2.

244 The nucleoid-associated protein H-NS and its paralogue StpA are global regulators of gene expression

245 erminal region (RQC) found in the other RecQ paralogues; such a region consists of a zinc domain and

246 Deletion of IscA and its paralogue SufA results in an E. coli mutant that fails t

247 other protists possess highly divergent XPB paralogues suggesting that XPBs specialized in transcrip

248 together with studies on Fur homologues and paralogues, suggests that in fact the Zn2 site is the re

249 Structure-guided mutagenesis of the close paralogue SWEET1 from Arabidopsis identified key residue

250 om other chromatin remodellers including its paralogue SWR1.

251 ed structure is similar to that found in the paralogue Talin head domain.

252 -43, we knocked out zebrafish Tardbp and its paralogue Tardbp (TAR DNA binding protein-like), which l

253 ls in the presence of low levels of the TatA paralogue TatE.

254 f the xenophagy cargo receptor Ndp52 and its paralogue Tax1bp1, which we demonstrate here to be a bon

255 e show that downregulation of TCF7L1 and its paralogue TCF7L2 reduces tumor growth in a xenograft mod

256 CUL3(KBTBD8) monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neu

257 ed by heterodimer formation with an inactive paralogue termed prozyme.

258 that a knockout of the gene for the smaller paralogue, termed XPB-R (R for repair) resulted in viabl

259 T-STAR is a tissue-specific paralogue that regulates the alternative splicing of neu

260 Finally, we document the Rad51 paralogues that are encoded by a wide range of protists,

261 in vivo, which preferred endogenous SUMO-2/3 paralogues that form poly-chains.

262 2 and RING 1A, which are partially redundant paralogues that together account for the E3 ubiquitin li

263 istent with the Shu complex containing Rad51 paralogues, the methyl methanesulphonate sensitivity of

264 mited use for environmental barcoding due to paralogues, the potential for unidentifiable chimaeras a

265 that Csm2 interacts with Rad51 and the Rad51 paralogues, the Rad55-Rad57 heterodimer and that the Shu

266 show that the Saccharomyces cerevisiae Rad51 paralogues, the Rad55-Rad57 heterodimer, counteract the

267 cellular roles for these P. aeruginosa SPase paralogues; the role of PA1303 is integrated with the qu

268 ate cell-specific expression of the teashirt paralogue tiptop, which is not normally expressed in lar

269 intercalating between principal cells, and a paralogue, tiptop, is expressed in forming tubules.

270 Here we investigate the contribution of each paralogue to resistance to host stress.

271 olic enzyme non-quiescent mutant 1 (NQM1), a paralogue to the pentose phosphate pathway enzyme transa

272 For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where

273 ignaling pathways recruit distinct myosin II paralogues to generate the contractile apparatus at apic

274 rsing out the contribution of the four Hsp90 paralogues to the perceived biological activity with the

275 l element that is recognized by TUT7 and its paralogues, TUT4 (ZCCHC11) and TUT2 (GLD2/PAPD4).

276 a showed differences in the induction of the paralogues under dehydration stress.

277 The regional expression of the Y-linked paralogue Uty (ubiquitously transcribed tetratricopeptid

278 We identified wake-up-call (wuc), a lin-52 paralogue, via a physical interaction with the tMAC lin-

279 ma-carboxylation in osteoblasts, whereas its paralogue, VKORC1L1, is dispensable for this function an

280 Two of these paralogues, VPS26A and VPS26B, are expressed in humans.

281 -2/simian immunodeficiency virus (SIV) SIVsm paralogue Vpx, hijack the CRL4(DCAF1) E3 ubiquitin ligas

282 Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-L-galactose phosphorylase

283 In C. elegans, MEC-17 and its paralogue W06B11.1 are redundantly required for acetylat

284 The functional divergence between kindlin paralogues was assessed using the sequence swap (chimera

285 s transcriptional divergence between the two paralogues was associated with high levels of histone H3

286 hat led to the functional diversification of paralogues, we tracked duplicate retention patterns, exp

287 new inhibitors targeting MraY as well as its paralogues, WecA and TarO.

288 omains are extremely similar, WelLFY and its paralogue WelNDLY exhibit distinct DNA-binding specifici

289 the miR-17 approximately 92 cluster and its paralogues were also highly expressed in ALK(+) ALCL and

290 cmas paralogues were maintained in fishes of the Otocephala c

291 In mammals, 13 septin paralogues were recently shown to assemble into core het

292 inding to histone tails of the human class A paralogue, which has a histidine at this position, is se

293 or the potential function of the human RAD51 paralogues, which are known to be involved in cancer pre

294 t nonmammalian vertebrates have two Survivin paralogues, which we name class A and B.

295 Several ribosomal protein families contain paralogues whose roles may be equivalent or specialized

296 Eukaryotes also possess Rad51 paralogues, whose exact role in recombination remains to

297 s, however, possess two highly divergent XPB paralogues with only the larger being identified as a TF

298 This suggests that EB1 paralogues within one species may interact with overlapp

299 We also show that Mdm1 and its paralogue Ydr179w-a (named Nvj3 in this study) localize

300 ector domain of Ptr1, the M. jannaschii Ptr2 paralogue, yields only very weak activation.