ライフサイエンスコーパス: paramyxovirus

1 Nipah virus (NiV) is the deadliest known paramyxovirus.

2 ) is a highly pathogenic and deadly zoonotic paramyxovirus.

3 attenuated vaccines for hMPV and other human paramyxoviruses.

4 bone" appearance of helical nucleocapsids in paramyxoviruses.

5 he most promising vaccine strategy for human paramyxoviruses.

6 be possible to apply these findings to other paramyxoviruses.

7 ds with diameters of 10 to 14 nm, typical of paramyxoviruses.

8 osure model of membrane fusion triggering by paramyxoviruses.

9 tenuated vaccines for aMPV and perhaps other paramyxoviruses.

10 nal receipt mechanism may be conserved among paramyxoviruses.

11 sm for the targeting of the RIG-I pathway by paramyxoviruses.

12 d is understood neither for MV nor for other paramyxoviruses.

13 membrane fusion triggering and cell entry by Paramyxoviruses.

14 t Sendai virus or human metapneumovirus, two paramyxoviruses.

15 potential utility of inhibitory peptides for paramyxoviruses.

16 a new structural-biological finding for the paramyxoviruses.

17 may be involved in the replication of these paramyxoviruses.

18 ering broad spectrum antivirals for emerging paramyxoviruses.

19 of F, which has not been reported for other paramyxoviruses.

20 ng mechanism(s) of the henipaviruses and the paramyxoviruses.

21 se are poorly understood compared with other paramyxoviruses.

22 rix gene assay, designed to detect all avian paramyxovirus 1, did not detect four of the isolates.

23 This review focuses on paramyxovirus activation of innate immune pathways, the

24 Unlike that for most paramyxoviruses, activation of the henipavirus fusion pr

25 The V proteins from other paramyxoviruses also bind LGP2 and demonstrate LGP2-depe

26 In fact, the analogous mechanisms in other paramyxoviruses also remain undetermined.

27 matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimer

28 that is a highly effective inhibitor of both paramyxoviruses and a set of criteria to be used for eng

29 ld enhance intrinsic cross-immunity to these paramyxoviruses and approaches to controlling recurring

30 f these findings extends beyond NiV to other paramyxoviruses and enveloped viruses.

31 iral entry field extends beyond NiV to other paramyxoviruses and enveloped viruses.

32 s a restriction factor in the replication of paramyxoviruses and orthomyxoviruses.

33 Paramyxoviruses and other negative-strand RNA viruses en

34 tly proposed "stalk exposure model" to other paramyxoviruses and propose an "induced fit" hypothesis

35 proposed for parainfluenza virus 5 to other paramyxoviruses and propose an "induced fit" hypothesis

36 shares sequence homology with members of the paramyxoviruses and the filoviruses.

37 ajor animal populations capable of harboring paramyxoviruses, and host shifting between these animals

38 sted that this virus represented a new avian paramyxovirus (APMV) group, APMV10.

39 rus (NDV) belongs to serotype 1 of the avian paramyxoviruses (APMV-1) and causes severe disease in ch

40 n the replication and pathogenicity of avian paramyxoviruses (APMVs), we constructed a reverse geneti

41 Paramyxoviruses are a large family of membrane-enveloped

42 Paramyxoviruses are enveloped negative-strand RNA viruse

43 Paramyxoviruses are potent activators of extracellular c

44 Paramyxoviruses are responsible for a wide range of dise

45 terplay between glycoprotein trafficking and paramyxovirus assembly.

46 Nipah virus and Hendra virus are two paramyxoviruses associated with high mortality rates in

47 Paramyxovirus attachment and fusion (F) envelope glycopr

48 amental architecture appears conserved among paramyxovirus attachment protein stalk domains, we predi

49 It is unknown how receptor binding by the paramyxovirus attachment proteins (HN, H, or G) triggers

50 The multifunctional HN protein of some paramyxoviruses, besides functioning as the receptor (si

51 genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are uncle

52 gglutinin (HA)-neuraminidase protein (HN) of paramyxoviruses carries out three discrete activities, e

53 hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three distinct activities co

54 VI) of the large (L) polymerase proteins of paramyxoviruses catalyzes methyltransferase (MTase) acti

55 VI) of the large (L) polymerase proteins of paramyxoviruses catalyzes methyltransferase (MTase) acti

56 Paramyxoviruses cause a wide variety of diseases, and ye

57 ion that determines the type of disease that paramyxoviruses cause is relatively small.

58 Infection of cultured cells by paramyxoviruses causes cell death, mediated by a newly d

59 Paramyxovirus cell entry is mediated by the fusion prote

60 Here, we have studied paramyxovirus circulation within populations of endemic

61 Hendra virus is a highly pathogenic paramyxovirus classified as a biosafety level four agent

62 iral RNA-dependent RNA polymerase (vRdRp) of paramyxovirus consists of the large (L) protein and the

63 The fusion apparatus of paramyxoviruses consists of a receptor binding tetramer

64 Paramyxoviruses contain glycoprotein fusion machineries

65 Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented R

66 ruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses and flaviviruses.

67 ignificant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Afric

68 ious RNA viruses, including influenza virus, paramyxovirus, dengue virus, and picornavirus.

69 endra virus (HeV) and Nipah virus (NiV), are paramyxoviruses discovered in the mid- to late 1990s tha

70 vated infection levels as well as widespread paramyxovirus dispersal and frequent host exchange of a

71 parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, encodes a V protein that inhibits viral R

72 Paramyxoviruses enter host cells by fusing the viral env

73 fects the design of effective broad-spectrum paramyxovirus entry inhibitors.

74 During paramyxovirus entry into a host cell, receptor engagemen

75 Paramyxovirus entry into cells requires the fusion prote

76 Membrane fusion is essential for paramyxovirus entry into target cells and for the cell-c

77 We identified a small molecule that inhibits paramyxovirus entry into target cells and prevents infec

78 te closure of the fusion core does not drive paramyxovirus entry may aid the design of strategies for

79 unctionally varies conserved elements of the paramyxovirus entry pathway, providing a possible explan

80 Paramyxovirus entry requires the coordinated action of t

81 This first evidence that activation of a paramyxovirus F can be specifically induced before the v

82 ship between enhanced fusion activity in the paramyxovirus F protein and increased susceptibility to

83 ermine factors driving this association, 140 paramyxovirus F protein TM domain sequences were analyze

84 brane-proximal external region (MPER) of the paramyxovirus F protein.

85 protein linked to the TM segments from three paramyxovirus F proteins was analyzed by sedimentation e

86 The structure shares a common core with paramyxovirus F proteins, implicating mechanistic simila

87 nding to just the TM region of two different paramyxovirus F proteins.

88 ilarity between postfusion coronavirus S and paramyxovirus F structures demonstrates that a conserved

89 ding of the mechanism(s) of receptor-induced paramyxovirus F triggering during viral entry and cell-c

90 terminal helix is a necessary early step for paramyxovirus F-protein refolding and presents a novel t

91 ct that these motions may act as a universal paramyxovirus F-triggering mechanism.

92 Importance: The paramyxovirus family of negative-strand RNA viruses caus

93 loped viruses such as HIV and members of the paramyxovirus family use metastable, proteinaceous fusio

94 exes may differ among diverse members of the paramyxovirus family, central elements of the triggering

95 sles virus (MeV), a morbillivirus within the paramyxovirus family, expresses two envelope glycoprotei

96 The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric

97 ed stabilizing structural element within the paramyxovirus family.

98 G interact with NiV F, a new finding for the paramyxovirus family.

99 tic distance in the phylogenetic tree of the paramyxovirus family.

100 ent fusion protein classes by example of the paramyxovirus, flavivirus and rhabdovirus families.

101 ses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1.

102 es PP1 antagonism as a mechanism employed by paramyxoviruses for evading innate immune recognition.

103 can be applicable to other animal and human paramyxoviruses for rationally designing live attenuated

104 Many paramyxoviruses for which bats and rodents serve as majo

105 nsive structure-function relationship of any paramyxovirus FP and demonstrate that the HeV F FP and p

106 rate that the HeV F FP and potentially other paramyxovirus FPs likely require an alpha-helical struct

107 The paramyxovirus fusion (F) glycoprotein is anchored in the

108 Using a paramyxovirus fusion (F) protein, we tested this paradig

109 recently shown that isolated TMDs from three paramyxovirus fusion (F) proteins interact as trimers us

110 Paramyxovirus fusion (F) proteins promote membrane fusio

111 We suggest a general model for paramyxovirus fusion activation in which receptor engage

112 We suggest a general model for paramyxovirus fusion activation in which receptor engage

113 has broad implications for the mechanism of paramyxovirus fusion and for strategies to prevent viral

114 multiple critical parameters that govern the paramyxovirus fusion cascade, and our assays should help

115 Moreover, F(RSV) is unique among paramyxovirus fusion proteins since F(RSV) possesses two

116 Paramyxovirus fusion with the host cell plasma membrane

117 propose a simple model for the activation of paramyxovirus fusion.

118 with the stalk-mediated activation model of paramyxovirus fusion.

119 favor of the HN stalk-mediated activation of paramyxovirus fusion.

120 In common with most paramyxoviruses, fusion mediated by Sendai virus F prote

121 Receptor binding by members of related paramyxovirus genera rearranges the head domains of the

122 To study the function of novel paramyxovirus genes in JPV, a plasmid containing a full-

123 e results advance our basic understanding of paramyxovirus genome packaging interactions and also hav

124 Paramyxovirus genomes are ribonucleoprotein (RNP) comple

125 N-glycans on paramyxovirus glycoproteins are generally required for p

126 iC) reveals that a high-affinity receptor-to-paramyxovirus H monomer stoichiometry below parity is su

127 phosphorylation site within the P protein in paramyxovirus has been found to play a positive role in

128 phosphorylation site within the P protein in paramyxovirus has been identified as playing a positive

129 is is the first time that the P protein of a paramyxovirus has been systematically analyzed for S/T r

130 he small hydrophobic (SH) protein of certain paramyxoviruses has been found to result in attenuation,

131 redness, because non-human coronaviruses and paramyxoviruses have been listed as priority concerns in

132 In addition, paramyxoviruses have evolved diverse mechanisms to disru

133 Paramyxoviruses have previously been shown to block prod

134 Most paramyxoviruses have two integral membrane proteins: fus

135 Negative-strand RNA viruses, including paramyxoviruses, have been shown to alter autophagy, but

136 The paramyxovirus hemagglutinin-neuraminidase (HN) protein p

137 N stalk domain, and properties of a chimeric paramyxovirus HN protein, we propose a simple model for

138 By extensive study of properties of multiple paramyxovirus HN proteins, we show that key features of

139 Paramyxovirus HN, H, and G form a dimer-of-dimers consis

140 targeting, and broaden our understanding of paramyxovirus-host interactions.

141 The paramyxoviruses human respiratory syncytial virus (hRSV)

142 he HN protein, which is conserved in several paramyxoviruses.IMPORTANCE Oncolytic Newcastle disease v

143 nd mRNA editing experiments revealed a novel paramyxovirus in the genus Ferlavirus, named anaconda pa

144 Nipah virus (NiV), a paramyxovirus in the genus Henipavirus, has a mortality

145 cent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw

146 Entry of hMPV is unusual among the paramyxoviruses, in that fusion is accomplished by the f

147 Human paramyxoviruses include global causes of lower respirato

148 Paramyxoviruses include many economically and agricultur

149 Paramyxoviruses include many important animal and human

150 Paramyxoviruses include several insidious and ubiquitous

151 Human paramyxoviruses, including hRSV, hMPV, and hPIV3, cause

152 Paramyxoviruses, including human metapneumovirus (HMPV),

153 The paramyxoviruses, including human parainfluenza viruses (

154 aturally occurring cleavage sites of several paramyxoviruses, including neurovirulent and avirulent s

155 Paramyxoviruses, including the childhood pathogen human

156 Most paramyxoviruses infect host cells via the concerted acti

157 Phylogenetic analyses revealed that all paramyxoviruses infecting Malagasy bats are UMRVs and sh

158 Paramyxovirus infection also gives rise to the formation

159 portance of innate responses in DC following paramyxovirus infection and their consequences for the a

160 ation that H2S also has a protective role in paramyxovirus infection by modulating inflammatory respo

161 t these pathways, and the innate response to paramyxovirus infection of dendritic cells (DC).

162 ally varies conserved motifs of the proposed paramyxovirus infection pathway.

163 ay indicate a new paradigm for understanding Paramyxovirus infection.

164 For nearly all paramyxoviruses, infection is initiated by fusion of the

165 otentially be targeted for the inhibition of paramyxovirus infections.

166 uld represent a novel treatment strategy for paramyxovirus infections.

167 ggesting a broad inhibitory effect of H2S on paramyxovirus infections.

168 etapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world populati

169 Paramyxoviruses initiate entry through the concerted act

170 Here we show that different paramyxoviruses interact in distinct ways with cells in

171 The fusion process for nearly all paramyxoviruses involves the mixing of the host cell pla

172 Human parainfluenza virus type 3 (HPIV3), a paramyxovirus, is a major viral cause of severe lower re

173 Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor

174 MuV, a paramyxovirus, is an important human pathogen.

175 Newcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is curr

176 ycoprotein G of Hendra virus (HeV), a deadly paramyxovirus, is N-glycosylated at six sites (G2 to G7)

177 Parainfluenza virus 5 (PIV5), a paramyxovirus, is not known to cause any illness in huma

178 J paramyxovirus (JPV) encodes four integral membrane prote

179 At 18,954 nucleotides, the J paramyxovirus (JPV) genome is one of the largest in the

180 J paramyxovirus (JPV) was first isolated from moribund mic

181 s to Newcastle disease virus (NDV), an avian paramyxovirus known to elicit a strong innate immune res

182 ain organization of phylogenetically diverse Paramyxovirus L proteins derived from measles virus (MeV

183 Here we describe four approaches by which paramyxoviruses limit IFN induction: by limiting synthes

184 The V proteins of paramyxoviruses limit interferon induction by binding md

185 Other paramyxovirus M proteins have been shown to dimerize, an

186 and Hendra virus (recently emerged zoonotic paramyxoviruses) M (matrix) protein-derived virus-like p

187 For many paramyxoviruses, M proteins drive viral assembly and egr

188 Paramyxovirus matrix (M) proteins organize virus assembl

189 e and sequence conservation imply that other paramyxovirus matrix proteins function similarly.

190 he cytoplasmic tail of the F proteins of the paramyxoviruses measles virus, mumps virus, Newcastle di

191 s, including orthomyxoviruses (influenza A), paramyxoviruses (measles), and hepadnaviruses (hepatitis

192 interactions as conserved core mechanisms of paramyxovirus-mediated membrane fusion.

193 interactions as conserved core mechanisms of paramyxovirus-mediated membrane fusion.

194 According to the existing paradigm of paramyxovirus membrane fusion, the initial activation of

195 The deadly paramyxovirus Nipah virus (NiV) contains a fusion glycop

196 V proteins of measles virus and the related paramyxovirus Nipah virus interact with PP1alpha/gamma,

197 g partner for the M proteins of the zoonotic paramyxoviruses Nipah virus and Hendra virus.

198 espiratory syncytial virus, and the zoonotic paramyxoviruses Nipah virus and Hendra virus.

199 In contrast to our findings with other paramyxoviruses, normal human serum (NHS) alone did not

200 defined regions near the C-terminal ends of paramyxovirus nucleocapsid proteins that are important f

201 the F protein of Newcastle disease virus, a paramyxovirus of a different genus, suggesting a conserv

202 uman metapneumovirus (hMPV) is a respiratory paramyxovirus of global clinical relevance.

203 Paramyxoviruses of the morbillivirus genus, such as meas

204 A quantitative approach to paramyxovirus packaging revealed a majority of infectiou

205 odies (sAbs) against multiple domains of the paramyxovirus parainfluenza 5 (PIV5) pre- and postfusion

206 region (MPSR) (HN, residues 37 to 56) of the paramyxovirus parainfluenza virus (PIV5), a region of th

207 We show that Cav-1 colocalizes with the paramyxovirus parainfluenza virus 5 (PIV-5) nucleocapsid

208 The paramyxovirus parainfluenza virus 5 (PIV5) enters cells

209 ure of the F protein (prefusion form) of the paramyxovirus parainfluenza virus 5 (PIV5) WR isolate wa

210 Here, we show that the FP from the paramyxovirus parainfluenza virus 5 fusogenic protein, F

211 receptor-binding globular head domain of the paramyxovirus parainfluenza virus 5 HN protein is entire

212 For the paramyxoviruses parainfluenza virus 5 (PIV5) and mumps v

213 teractions of the FP of the F protein of the paramyxovirus, parainfluenza virus 5 (PIV5).

214 biquitination of the matrix (M) protein of a paramyxovirus, parainfluenza virus 5 (PIV5).

215 Paramyxovirus particles are formed by a budding process

216 Infectivity of paramyxovirus particles depends on matrix-nucleocapsid p

217 Paramyxovirus pathogens include measles virus, mumps vir

218 sion states of the fusion proteins including paramyxovirus PIV5 F and influenza virus hemagglutinin s

219 exploited the well-characterized ability of paramyxovirus (PMV) V proteins to counteract both IFN in

220 The paramyxovirus pneumonia virus of mice (PVM) is a model o

221 The paramyxovirus pneumonia virus of mice (PVM) is a rodent

222 Paramyxovirus polymerases are composed of at least two t

223 During transcription, paramyxoviruses produce capped, methylated, and polyaden

224 Paramyxoviruses produce pleiomorphic particles containin

225 However, other paramyxovirus proteins, including glycoproteins, nucleoc

226 rological, and genomic characterization of a paramyxovirus recently isolated from rockhopper penguins

227 factor may be involved in the regulation of paramyxovirus replication and could be a target for broa

228 highlights a critical role of 2'-O MTase in paramyxovirus replication and pathogenesis and a new ave

229 Understanding the regulation of paramyxovirus replication will enable the rational desig

230 Paramyxoviruses represent a remarkably diverse family of

231 Most paramyxoviruses require the interaction of two viral pro

232 Paramyxoviruses require two viral membrane glycoproteins

233 The promotion of membrane fusion by most paramyxoviruses requires an interaction between the vira

234 Cell entry by paramyxoviruses requires fusion between viral and cellul

235 annual and biennial pattern of three common paramyxoviruses, Respiratory Syncytial Virus (RSV), Huma

236 magglutinin-neuraminidase protein of another Paramyxovirus revealed a four-helix bundle stalk.

237 with the F protein TM domains from two other paramyxoviruses, Sendai virus (SV) and measles virus (MV

238 stle disease virus (NDV), representing avian paramyxovirus serotype 1 (APMV-1), cause respiratory and

239 Avian paramyxovirus serotype 2 (APMV-2) is one of the nine ser

240 structed a reverse genetics system for avian paramyxovirus serotype 7 (APMV-7) to investigate the rol

241 Our data suggest a model in which paramyxoviruses share an overall common strategy for dir

242 simultaneous identification of IAV-specific, paramyxovirus-specific, and broad-spectrum inhibitors.

243 The V protein of the paramyxovirus subfamily Paramyxovirinae is an important

244 Respiratory paramyxoviruses such as respiratory syncytial virus (RSV

245 tenuated vaccines for hMPV and perhaps other paramyxoviruses, such as hRSV and hPIV3.

246 inhibited the synthesis of the RNA of other paramyxoviruses, such as Nipah virus (NiV), human parain

247 ding hemagglutinin-neuraminidases of certain paramyxoviruses suggest that fusion triggering is preced

248 studies of the triggering mechanism of other paramyxoviruses suggest that receptor binding to their h

249 l action of ISG56/IFIT1, while all the other paramyxoviruses tested were resistant.

250 .IMPORTANCE Nipah virus (NiV) is an emerging paramyxovirus that can cause a lethal respiratory and ne

251 Nipah virus (NiV) is a zoonotic emerging paramyxovirus that can cause fatal respiratory illness o

252 Mumps virus (MuV) is a reemerging paramyxovirus that caused large outbreaks in the United

253 s (hMPV) is a relatively recently identified paramyxovirus that causes acute upper and lower respirat

254 Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respir

255 Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and h

256 Nipah virus (NiV) is a zoonotic paramyxovirus that causes high mortality rates in humans

257 Human metapneumovirus (HMPV) is a paramyxovirus that causes respiratory disease worldwide.

258 Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and a

259 uman metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces

260 Nipah is an emerging paramyxovirus that is of serious concern to human health

261 h virus (NiV) is a deadly emerging enveloped paramyxovirus that primarily targets human endothelial c

262 Nipah virus (NiV) is a highly lethal paramyxovirus that recently emerged as a causative agent

263 (HeV) are closely related, recently emerged paramyxoviruses that are capable of causing considerable

264 and Nipah virus (NiV), are emerging zoonotic paramyxoviruses that can cause severe and often lethal n

265 CE Hendra virus and Nipah virus are zoonotic paramyxoviruses that cause lethal infections in humans.

266 (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capa

267 Bats carry a variety of paramyxoviruses that impact human and domestic animal he

268 This is in contrast to other paramyxoviruses that require attachment protein function

269 and fusion could differ mechanistically from paramyxoviruses that use glycan-based receptors.

270 For paramyxoviruses, the activities of two membrane proteins

271 Unlike the case for most paramyxoviruses, the fusion proteins (F) of a number of

272 We have shown that for paramyxoviruses, the inhibitory efficacy of HR peptides

273 Unlike most other paramyxoviruses, the respiratory syncytial virus (RSV) F

274 Across the paramyxoviruses, these domains share little sequence ide

275 In other paramyxoviruses, these residues were shown to affect fus

276 te we measured the interbilayer spacing of a paramyxovirus trapped in the process of fusing with soli

277 We conclude that paramyxoviruses trigger the DNA damage response, a pathw

278 As with other paramyxoviruses, two major RSV surface viral glycoprotei

279 ed by Newcastle disease virus (NDV) or avian paramyxovirus type 1 (APMV-1), a negative-sense single-s

280 Avian paramyxovirus type 1, NDV, has been an attractive oncoly

281 referred to as Unclassified Morbilli-related paramyxoviruses (UMRVs).

282 These findings indicate that paramyxoviruses use a single amino acid to distinguish M

283 Paramyxoviruses use a specialized fusion protein to merg

284 within infected hosts, the vast majority of paramyxoviruses utilize two viral envelope glycoproteins

285 onsequences of MDA5 and LGP2 interference by paramyxovirus V proteins and help resolve the distinct r

286 Paramyxovirus V proteins are interferon antagonists that

287 Paramyxovirus V proteins bind to MDA5 (melanoma differen

288 Importance: Paramyxovirus V proteins interact with two innate immune

289 of generating an experimental Nipah virus (a paramyxovirus) vaccine, we generated two defective VSVDe

290 the crystal structures of HN from different paramyxoviruses, varying energy requirements for fusion

291 Paramyxovirus viral fusion proteins (F) insert into the

292 scription (RT)-PCR results were positive for paramyxovirus (viral loads of 2.33 x 10(4) to 1.05 x 10(

293 In paramyxoviruses, viral attachment and membrane fusion ar

294 For paramyxoviruses, viral matrix (M) proteins are key drive

295 omain of PIV5 F with the C terminus of other paramyxoviruses were unable to cause cell fusion.

296 bserved with parainfluenza virus 5 (PIV5), a paramyxovirus, when neutralizing antibody was used to bl

297 ribed models, including the one proposed for paramyxovirus, where following random movement efficienc

298 otypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4

299 ncing of JPV (JPV-LW) confirms that JPV is a paramyxovirus with several unique features.

300 irus in the genus Ferlavirus, named anaconda paramyxovirus, with a typical Ferlavirus genomic organiz