ライフサイエンスコーパス: pathogenesis

1 rtant part of the mechanism underlying ADPKD pathogenesis.

2 , a critical step in HTLV-1 transmission and pathogenesis.

3 dysplasia, a skeletal disorder with unknown pathogenesis.

4 ial role for the IL-17A signaling axis in AD pathogenesis.

5 ontributions to islet (dys)function and T2DM pathogenesis.

6 Barrett's esophagus hints to a partly common pathogenesis.

7 onhuman primate models of ZIKV infection and pathogenesis.

8 ways were found to have a crucial role in AD pathogenesis.

9 ostasis constitute a cornerstone of ALS/FTLD pathogenesis.

10 translate risk into potential mechanisms of pathogenesis.

11 ontrols biofilm development and pneumococcal pathogenesis.

12 anola oil intake on Alzheimer's disease (AD) pathogenesis.

13 on guidance also suggested a role in disease pathogenesis.

14 , it is unclear how Ox40L contributes to SLE pathogenesis.

15 altered environmental conditions and disease pathogenesis.

16 e mutants) provide a model for investigating pathogenesis.

17 ms have been suggested to play a role in CMA pathogenesis.

18 is thought to play a crucial role in disease pathogenesis.

19 and contributes to defining subsequent AIDS pathogenesis.

20 of neurodegeneration that contribute to ALS pathogenesis.

21 forms, suggesting independent mechanisms of pathogenesis.

22 um is therefore a pivotal event in influenza pathogenesis.

23 e functions of PPP1R1A in Ewing sarcoma (ES) pathogenesis.

24 to dissect the complex mechanisms of disease pathogenesis.

25 arly macrophage-derived proteinases, in COPD pathogenesis.

26 ory bowel diseases (IBD) to learn more about pathogenesis.

27 ifying role of Th17-derived IFN-gamma in DED pathogenesis.

28 al physiology and Mycobacterium tuberculosis pathogenesis.

29 rstanding its impact on skin homeostasis and pathogenesis.

30 olecular mimicry as the key mechanism of RHD pathogenesis.

31 of RNA metabolism and SG dynamics in ALS/FTD pathogenesis.

32 involvement of the non-coding genome in its pathogenesis.

33 y compartmentalization might play in disease pathogenesis.

34 tly during infection and is critical for GAS pathogenesis.

35 aHUS recurrence, yet may not fully block AMR pathogenesis.

36 and likely cooperate with BRAF-V600E in HCL pathogenesis.

37 in their conclusions regarding its impact on pathogenesis.

38 espiratory viruses and S. pneumoniae in CAAP pathogenesis.

39 alcium uptake protein 1, is central to PAH's pathogenesis.

40 rvous system plays a substantial role in HSV pathogenesis.

41 utors beyond B cells are important for lupus pathogenesis.

42 tive study of biotoxins, quorum sensing, and pathogenesis.

43 enes might be critical in systemic sclerosis pathogenesis.

44 ction and the molecular mechanisms mediating pathogenesis.

45 sh DZIP1L as a second gene involved in ARPKD pathogenesis.

46 itical gene regulatory networks that promote pathogenesis.

47 elevance of this protease in human influenza pathogenesis.

48 bout physiological function or mechanisms of pathogenesis.

49 ylori-host interaction with links on gastric pathogenesis.

50 in formation of sebum, a key factor in acne pathogenesis.

51 translocation appear to be important in IRIS pathogenesis.

52 RV) has been suggested to play a role in the pathogenesis.

53 tibodies (Abs) could potentially affect ZIKV pathogenesis.

54 RPK2 plays a critical role in aggravating AD pathogenesis.

55 rimate immune systems that may contribute to pathogenesis.

56 sting that IP hydrolysis has a role in plant pathogenesis.

57 multiple signaling pathways are involved DKD pathogenesis.

58 pecific contribution of oncogenic RAS to LCH pathogenesis.

59 anscriptional functions, work to drive viral pathogenesis.

60 by both somatic and viral events during NPC pathogenesis.

61 derstanding determinants of transmission and pathogenesis.

62 is a central molecule in Parkinson's disease pathogenesis.

63 nd investigate their contribution in disease pathogenesis.

64 function may contribute to understanding AMD pathogenesis.

65 the results are providing insights into IBD pathogenesis and additional strategies for modulating th

66 er, FgSRP1 is important for conidiation, and pathogenesis and alternative splicing is important for i

67 ilitate and accelerate research into Candida pathogenesis and biology, by curating the scientific lit

68 l microRNA (miRNA) expression can affect CRC pathogenesis and development through targeting critical

69 his review summarizes key components of NASH pathogenesis and discusses how inherent and acquired var

70 f dental disease and tooth extraction in ONJ pathogenesis and help delineate an altered profile in wo

71 aine's contribution to key components in HIV pathogenesis and highlights novel targets for interrupti

72 homeostasis, and is implicated in bacterial pathogenesis and human disease.

73 ans of revealing the underlying mechanism of pathogenesis and identifying clinical biomarkers for dis

74 ese findings deepen our understanding of PNI pathogenesis and illuminate how PNI is driven in part by

75 on, supporting their potential role in HHV-8 pathogenesis and KS.IMPORTANCE Here we show that HHV-8,

76 In less than a decade, understanding of the pathogenesis and management of this disease has been tra

77 ion are tightly regulated due to its role in pathogenesis and motility.

78 s in genes such as GRN contribute to disease pathogenesis and neurodegeneration.

79 systemic sclerosis that provide insight into pathogenesis and potential targets for therapeutic inter

80 of CMR in determining sudden cardiac arrest pathogenesis and prognosis in survivors.

81 significant advances in understanding of the pathogenesis and progression of lung disease in cystic f

82 dysfunction of TDP-43 contributes to disease pathogenesis and progression remain unclear.

83 l role in inflammatory bowel diseases (IBDs) pathogenesis and propagation.

84 etween the number of circulating PCs and the pathogenesis and severity of HF and their impact on inci

85 ntrinsic kidney injury (iAKI) actually share pathogenesis and should be aggregated in the same diagno

86 is critical to advancing knowledge on asthma pathogenesis and the development of new therapeutic appr

87 ion has greatly hindered the study of dengue pathogenesis and the development of therapeutics.

88 To better understand HIV-1 pathogenesis and the evolution of the viral population,

89 isease may lead to improved insight into CCC pathogenesis and the identification of prognostic factor

90 suggest that SERPINA3 may be involved in the pathogenesis and the progression of prion diseases, repr

91 may relate to viral fitness, we compared the pathogenesis and transmission in pigs of six representat

92 ture female parasite are responsible for the pathogenesis and transmission of schistosomiasis.

93 motional regulation and is implicated in the pathogenesis and treatment of affective disorders.

94 suggesting potential differences in disease pathogenesis and/or disease characteristics.

95 ection is critical for amyloidogenesis in AD pathogenesis, and implicate a pharmaceutical potential f

96 as the primary macrophage defect driving PAP pathogenesis, and support the feasibility of translating

97 necessary to rethink the dogma involving GAS pathogenesis, and that the most productive avenues for r

98 ts into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding n

99 activation of latent HSV1 in the brain in AD pathogenesis are also discussed.

100 of humans, the roles of these regulators in pathogenesis are less known.

101 gBcyt regulation is necessary for VZV pathogenesis, as the hyperfusogenic mutant gB[Y881F] is

102 tant contributor to Alzheimer's disease (AD) pathogenesis, as underscored by the recent identificatio

103 isorders and in particular the breast growth pathogenesis associated with combined pituitary hormone

104 ificance in global health, the mechanisms of pathogenesis associated with giardiasis remain unclear,

105 Adaptive mutations in pathogenesis-associated genes were 3.1-fold enriched in

106 fection and contributes significantly to GAS pathogenesis at multiple host anatomic sites.

107 information to explore shared mechanisms of pathogenesis between disorders.

108 nflammation-related models for schizophrenia pathogenesis, but also in neurodevelopmental theories, b

109 xpressed in motor neurons is involved in SMA pathogenesis, but increasing evidence indicates that pat

110 nses of allergen-specific T cells and asthma pathogenesis by activating Treg cells.

111 proteins may have a critical role in asthma pathogenesis by altering type 17 inflammation, and thus

112 roups present different approaches to reduce pathogenesis by targeting deactivated Cas9 to either the

113 poliomyelitis, it can be used to study polio pathogenesis, candidate antiviral drugs, and the efficac

114 We propose a pathogenesis cascade that may be relevant to understandi

115 new genes and signaling pathways involved in pathogenesis continue to be discovered.

116 This may provide insight into disease pathogenesis, diagnosis, and therapeutic intervention in

117 two Mn(II) proteins important for bacterial pathogenesis, direct observation of Mn(II) sequestration

118 V) provide an increasingly utilized model of pathogenesis due to clinical manifestations similar to t

119 ular function and plays an important role in pathogenesis during infection in vivo Macrophages are a

120 adaptive immune cells modulate heart failure pathogenesis during viral myocarditis, yet their identit

121 showing that interference with BRD4-mediated pathogenesis, either by restoring miR-29b levels via bor

122 ely to develop through similar mechanisms of pathogenesis, either MCPyV-mediated or ultraviolet light

123 mitations, advances in understanding disease pathogenesis, emerging targeted treatments, and strategi

124 pth investigations towards understanding its pathogenesis, epidemiology and possible zoonotic potenti

125 toma tumor microenvironment in neuroblastoma pathogenesis.-Gaviglio, A.

126 ency virus (HIV) intrahost evolution in AIDS pathogenesis has been limited by the need for longitudin

127 potential role of these alkaloids in animal pathogenesis has not been studied extensively.

128 and molecular mechanisms responsible for ASD pathogenesis have been proposed based on genetic studies

129 How ApoE isoforms influence AD pathogenesis, however, remains unclear.

130 isition of antibiotic resistance exacerbates pathogenesis; however, the survival strategy of C. diffi

131 macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persis

132 d by tetherin and is required for full MoMLV pathogenesis.IMPORTANCE Retroviruses are thought to spre

133 integrated stress response may contribute to pathogenesis in a subset of neurodegenerative disorders.

134 of the primary isolate and displayed similar pathogenesis in AG129 mice.

135 , and strengthen the evidence for a unifying pathogenesis in CNMs via defective membrane trafficking

136 s an endophenotype with differing underlying pathogenesis in different subjects.

137 -1 PRF attenuation strongly inhibited VEEV pathogenesis in mice, and viral replication analyses sug

138 We found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by

139 ying host-microbe interactions and bacterial pathogenesis in the upper FRT.

140 We sought to identify the genetic pathogenesis in this family using a next generation sequ

141 inflammatory response in regulating MERS-CoV pathogenesis in vivo The Middle East respiratory syndrom

142 f this molecular chaperone accelerates prion pathogenesis in vivo.

143 ulent phages in two animal models of cholera pathogenesis (infant mouse and rabbit models).

144 Population data are scant and pathogenesis is incompletely understood, but enteral fee

145 ies seem to protect against reinfection, its pathogenesis is not well established.

146 f genetic factors that regulate glioblastoma pathogenesis is of central importance.

147 A central feature of HSV pathogenesis is the ability to periodically reactivate i

148 ongenital hydronephrosis, yet the underlying pathogenesis is undefined.

149 The role of Hap10 in BD pathogenesis is unknown.

150 iae global virulence regulator, CovR, in UTI pathogenesis is unknown.

151 Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs)

152 laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for furt

153 Stroke risk pathogenesis may include factors that are proximately ca

154 ere, we review the progress on understanding pathogenesis mechanisms of "Ca.

155 ng thrombophilia in perinatal stroke informs pathogenesis models and clinical management.

156 nding of the molecular basis of SMA, disease pathogenesis, natural history, and recognition of the im

157 This study implicates microRNAs in the pathogenesis of AA.

158 ) mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and assoc

159 tion is one of the prominent features in the pathogenesis of acute lung injury (ALI).

160 ite remarkable advances in understanding the pathogenesis of AD, the development of palliative therap

161 the role of impaired mucus clearance in the pathogenesis of allergen-induced type 2 airway inflammat

162 cules and pathways are most important in the pathogenesis of allergic diseases and in the development

163 ndings provide fundamental insights into the pathogenesis of allergies, and on the mechanisms of anti

164 Amyloid-beta (Abeta) plays a key role in the pathogenesis of Alzheimer's disease (AD), but little is

165 rotein E (apoE) has an important role in the pathogenesis of Alzheimer's disease with its three isofo

166 ll known RNA binding protein involved in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS) and

167 nthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and

168 ed by other B. cereus strains and enable the pathogenesis of anthrax-like diseases.

169 ruses, which also provides insights into the pathogenesis of arenaviruses and may facilitate the desi

170 innate immune responses to infection in the pathogenesis of at least some cases of ASD.

171 nt and behavior and provide insight into the pathogenesis of autism spectrum disorder and intellectua

172 ses and have recently been implicated in the pathogenesis of autoimmune diseases by various mechanism

173 A methylation, play an important role in the pathogenesis of autoimmune diseases.

174 IgG populations, FcRn can contribute to the pathogenesis of autoimmune disorders when an abnormal im

175 might reflect fundamental differences in the pathogenesis of B-cell lymphoproliferative disorders.

176 RATIONALE: The pathogenesis of bicuspid aortic valve (BAV)-associated a

177 em cells (MSCs) derived from human MT in the pathogenesis of bone outgrowth.

178 might have implications in understanding the pathogenesis of both conditions and the complex relation

179 methylation pattern could contribute to the pathogenesis of cancer either by silencing key tumor sup

180 t transformation, occurring early during the pathogenesis of cancers such as lung and pancreatic aden

181 Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the p

182 e, thereby suggesting differing roles in the pathogenesis of cardiovascular and cerebral large-vessel

183 le for the mineralocorticoid receptor in the pathogenesis of cCSC.

184 ion are regarded as important factors in the pathogenesis of chronic inflammation, cancer, and wound

185 as long been recognised as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however

186 ndings suggest that IL-22 is involved in the pathogenesis of CM.

187 These findings offer new insights into the pathogenesis of CNS disease in MPS patients, and support

188 ave provided evidence for their roles in the pathogenesis of colitis-associated cancer and sporadic c

189 se) genetic factors likely contribute to the pathogenesis of congenital heart defects, but it is uncl

190 etween the neural vascular structure and the pathogenesis of congenital optic disc anomalies.

191 Pathogenesis of Crohn's disease (CD) involves immune and

192 ukin 23 (IL23), a cytokine implicated in the pathogenesis of Crohn's disease (CD).

193 Thus, the pathogenesis of cryptosporidiosis remains poorly charact

194 domain containing 3) is of importance in the pathogenesis of CVB3-induced myocarditis, we aimed to un

195 evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe

196 ctionally impaired and may contribute to the pathogenesis of DBDC.

197 plicate the Asn396Ser variant of LIPG in the pathogenesis of depressive symptoms in the general popul

198 ucuronate interconversions (P=3.0x10(-6)) in pathogenesis of diabetic kidney disease.

199 They have shed light on the pathogenesis of different amyloid types and have led to

200 ements enable a greater understanding of the pathogenesis of disease and the realization of precision

201 We suggest that C1-Ten contributes to the pathogenesis of DKD by inducing podocyte hypertrophy und

202 ering a positive feedback that resembles the pathogenesis of DR.

203 Advances in understanding the pathogenesis of dry eye disease has revealed that inflam

204 almost nothing was known about the molecular pathogenesis of either illness.

205 been portrayed as a critical cytokine in the pathogenesis of experimental autoimmune encephalomyeliti

206 To better understand the pathogenesis of HD, we analyzed proteasome activity and

207 normal cells, and has been implicated in the pathogenesis of HIV disease.

208 ry B cell subsets point to their role in the pathogenesis of HIV/SIV infections and suggest that moni

209 proteasome dysfunction may contribute to the pathogenesis of Huntington's disease (HD), a devastating

210 utant huntingtin plays a central role in the pathogenesis of Huntington's disease.

211 ion, as well as their potential roles in the pathogenesis of IE.

212 he alternative pathway has a key role in the pathogenesis of IgA nephropathy (IgAN).

213 epresent prime candidates that impact on the pathogenesis of immune-mediated diseases and are known t

214 ype 2 cytokines thereby participating in the pathogenesis of immune-mediated hepatitis.

215 We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibit

216 believed to contribute to the incidence and pathogenesis of inflammatory bowel disease (IBD).

217 at have been found to have a key role in the pathogenesis of inflammatory bowel disease (IBD).

218 intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease.

219 key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacolo

220 are important effector cells involved in the pathogenesis of inflammatory skin diseases including chr

221 her than rearranged JCPyV seems to drive the pathogenesis of JCPyVAN.

222 the role of the virus in parasitemia and the pathogenesis of leishmaniasis.

223 anding of intercellular communication in the pathogenesis of liver disease during HCV infection.

224 le of leukotriene B4 (LTB4) in the molecular pathogenesis of lymphedema.

225 mone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also l

226 relevant molecular mechanisms underlying the pathogenesis of most monogenic forms of NS, and to effic

227 ain aging, may play an important role in the pathogenesis of multiple neurodegenerative disorders, in

228 B cells influence the pathogenesis of multiple sclerosis.

229 ysregulation of microglia contributes to the pathogenesis of neurodegenerative and behavioral disease

230 the adult hypothalamus may contribute to the pathogenesis of obesity.

231 gy of her lens changes is known, whereas the pathogenesis of ONHD is not clear.

232 ategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy.

233 A key feature in the pathogenesis of OSCC is genetic instability, which resul

234 encephalomyelitis; however, its role in the pathogenesis of osteoporosis remains to be determined.

235 While the pathogenesis of Parkinson's disease (PD) is incompletely

236 re involved in mitochondrial dysfunction and pathogenesis of Parkinson's disease (PD).

237 r processes, but deciphering its role in the pathogenesis of PD has been difficult.

238 crevicular fluid (GCF) endocan levels in the pathogenesis of periodontal diseases, supported with vas

239 In an attempt to shed more light onto the pathogenesis of PTFL, an integrative analysis of these m

240 aging technique that could shed light on the pathogenesis of rare diseases of the optic disc.

241 e implicating CD4(+) T-cell cytokines in the pathogenesis of RCDII.

242 t malaria parasitemia does contribute to the pathogenesis of retinopathy-negative CM.

243 en our increasing knowledge of the molecular pathogenesis of S. aureus disease, we suggest that the a

244 the kidney defect in sodium handling and the pathogenesis of salt-sensitive hypertension.

245 Although the pathogenesis of schizophrenia (SCZ) is proposed to invol

246 The pathogenesis of schizophrenia is considered to be multi-

247 tion of these pathways may contribute to the pathogenesis of schizophrenia, highlighting metabolic sy

248 dogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of se

249 nce to cholangiocytes and is relevant to the pathogenesis of several human cholangiopathies.

250 y a role in cancer biology as well as in the pathogenesis of several neurological disorders such as s

251 mucus viscosity play a critical role in the pathogenesis of several respiratory diseases, including

252 The pathogenesis of severe asthma in childhood remains poorl

253 results provide additional insights into the pathogenesis of SFTSV infection and support the use of t

254 plausible that OSA could play a role in the pathogenesis of sight-threatening DR (STDR).

255 a role for monocytes and macrophages in the pathogenesis of SIV/HIV and begin to explain why infants

256 nveil a role for mTORC1 and autophagy in the pathogenesis of skeletal disorders and suggest potential

257 actors and treatment depends on the specific pathogenesis of stroke.

258 generative diseases may help to describe the pathogenesis of such diseases and establish important bi

259 that has been independently involved in the pathogenesis of systemic inflammatory rheumatoid arthrit

260 uggesting a novel class of genes involved in pathogenesis of systemic sclerosis.

261 cell function plays an important role in the pathogenesis of T2D, especially in nonobese individuals

262 indeed, is a factor that contributes to the pathogenesis of the disease remains to be investigated.

263 on primary response gene 88 in the molecular pathogenesis of the disease.

264 egative RA and provide new insights into the pathogenesis of the disorder.

265 However, the molecular pathogenesis of these complications remains poorly under

266 ough some insights have been gained into the pathogenesis of these diseases, it is not fully understo

267 ology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and

268 indings have implications with regard to the pathogenesis of this enigmatic disease and raise the pos

269 veractive innate immune response play in the pathogenesis of this form of hepatic injury.

270 YH11) and RUNX1 plays a critical role in the pathogenesis of this leukemia.

271 rway to understand the spread and the unique pathogenesis of this virus; with the intent to rapidly d

272 eral opportunities for future studies of the pathogenesis of thyroid cancer.

273 findings have important implications for the pathogenesis of TNF-mediated enteropathies and chronic i

274 dentity and advance knowledge related to the pathogenesis of triple-negative breast cancer.

275 acrophage activity are early features in the pathogenesis of type 1 diabetes (T1D).

276 g CD8(+) T cells have been implicated in the pathogenesis of type 2-driven inflammatory human conditi

277 , our findings provide new insights into the pathogenesis of Ube3A/E6AP-dependent ASD.SIGNIFICANCE ST

278 We conclude that the pathogenesis of vascular remodeling in hypoxic PH involv

279 s are important for the understanding of the pathogenesis of VTE.

280 s that these neurons are not involved in the pathogenesis or the gastrointestinal symptoms of PD.

281 ust be understood to better comprehend virus pathogenesis or to manipulate viruses for use as vaccine

282 - to identify so far uncharacterized asthma pathogenesis pathways.

283 to mechanisms underlying disease prevention, pathogenesis, progression, and therapeutic intervention.

284 nockdown plants show decreased expression of PATHOGENESIS-RELATED GENE1 (PR1) and the plants are susc

285 er, the precise role of FLG deficiency in AE pathogenesis remains incompletely understood.

286 onse to enteric pathogens, but its impact on pathogenesis remains poorly defined.

287 ins critical for the viral life cycle and/or pathogenesis represents a useful strategy to uncover new

288 Common for the pathogenesis seems to be the vicious cycle of complement

289 over a novel role of GRP78 in reducing prion pathogenesis, suggesting that modulating its levels/acti

290 have implicated a role for exosomes in HIV-1 pathogenesis, their mechanisms are not well defined.

291 RSV binding to CX3CR1 contributes to disease pathogenesis; therefore, we investigated whether a mutat

292 dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation respo

293 utophagy by expressing three determinants of pathogenesis: two secreted phospholipases C (PLCs; PlcA

294 ther this phenomenon plays a role in disease pathogenesis, we generated a knock-in mouse model with N

295 Using mouse models of SARS-CoV pathogenesis, we have identified that the wound repair p

296 (median age 64 years, 73% male, 30% ischemic pathogenesis) were enrolled.

297 T1 or KIT has been implicated in lung cancer pathogenesis, whether and how DNMT1 and KIT orchestrate

298 cidation of the mechanistic basis of disease pathogenesis will depend on an increased basic understan

299 eural perineuriomas and an unexpected shared pathogenesis with intracranial meningiomas.

300 eumoniae as a key first step in pneumococcal pathogenesis within the heart.