ライフサイエンスコーパス: pathologically

1 ther biopsy results are negative or positive pathologically.

2 were evenly matched both demographically and pathologically.

3 disease not removed surgically or identified pathologically.

4 s, ECs, and fibroblasts, physiologically and pathologically.

5 eaved to a smaller fragment that accumulates pathologically.

6 dence suggest that alpha-Syn and tau overlap pathologically.

7 henotypic heterogeneity, both clinically and pathologically.

8 n 167 women (75%), 56 of which were verified pathologically, 111 by cytology and/or during follow-up

9 re it stabilizes active GTP-rab5, leading to pathologically accelerated endocytosis, endosome swellin

10 uishing them from their normal counterparts: pathologically activated Akt signaling axis, increased c

11 better understand how these pathways become pathologically activated and to potentially identify new

12 Accumulation of pathologically activated immature myeloid cells with pot

13 efinition of the molecular pathways that are pathologically activated in the disease.

14 diovascular diseases and a characteristic of pathologically activated vascular endothelium.

15 -fixed thin sections of clinically acute and pathologically active cases of MS.

16 aemorrhage particularly when the placenta is pathologically adherent (accreta) or for postpartum haem

17 The ability of C4F6 to differentiate pathologically affected tissue in mutant SOD1 ALS rodent

18 n tau, which becomes hyperphosphorylated and pathologically aggregates in a number of these diseases,

19 C T-stage, locally invasive tumors, and more pathologically aggressive tumors were at higher risk for

20 Pathologically, alpha-synuclein mutations and alpha-synu

21 The IPF fibroblast, however, is a pathologically altered cell that has acquired the capaci

22 ply for metabolism under physiologically and pathologically altered conditions.

23 blood pressure and organ blood flow and are pathologically altered in vascular diseases, which modif

24 study was to focus on the interaction of the pathologically altered right heart with the anatomically

25 In ALS, pathologically altered TDP-43 is believed to lead to dis

26 of implantation >30 days and </=3 years were pathologically analyzed, and comparison of vascular resp

27 Dual-tracer PET/CT was performed on 35 pathologically and clinically confirmed and untreated pa

28 al dementia form two poles of a genetically, pathologically and clinically-related disease continuum.

29 ontotemporal dementia (FTD) is a clinically, pathologically and genetically heterogeneous disorder.

30 ible explanations is that FTD is clinically, pathologically, and genetically heterogeneous.

31 Relative to healthy control subjects, pathologically anxious participants exhibited enhanced r

32 sarcomas; it was the first to be recognized pathologically as a singular entity and to have its sign

33 ssion, and had been diagnosed clinically and pathologically as AD.

34 ent subsolid nodules (SSN) <==3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate

35 growth and differentiation but also function pathologically as cancer genes that contribute to tumori

36 Such cases are generally referred to pathologically as encephalitis, not otherwise specified

37 Over half of all FTD cases are classified pathologically as frontotemporal lobar degeneration (FTL

38 esponse to sustained overload but progresses pathologically as heart failure ensues.

39 and voxel-based morphometric) features in a pathologically ascertained cohort of 95 cases of frontot

40 ATA4 represses ms1/STARS expression with the pathologically associated depletion of GATA4 (type 1/typ

41 dogenic proteins is that the majority of the pathologically associated proteins are involved in lipid

42 ve recently been shown to be genetically and pathologically associated with familial forms of ALS and

43 dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DN

44 some of which target known genes or pathways pathologically associated with retinitis pigmentosa.

45 Pathologically, at this time point, mice exhibited a los

46 s were extinguished in 50% of patients, were pathologically attenuated without a documented rod or co

47 Most meningiomas are pathologically benign or atypical, but 3-5% display mali

48 Pathologically, BET proteins are frequently overexpresse

49 Alzheimer's disease, which is defined pathologically by abundant amyloid plaques and neurofibr

50 neurodegenerative diseases are characterized pathologically by accumulation of misfolded proteins as

51 The disease is characterised pathologically by an early and progressive striatal neur

52 ARVC is characterized pathologically by fibrofatty infiltration and clinically

53 g autoimmune myopathy (NAM) is characterized pathologically by necrotic muscle fibers with absent or

54 ve neurodegenerative condition characterised pathologically by neuronal cell loss due to abnormal tau

55 s a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellul

56 Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and alpha-s

57 the huntingtin gene (HTT) and characterized pathologically by the loss of pyramidal neurons in sever

58 are neurodegenerative disorder characterized pathologically by the presence of eosinophilic inclusion

59 Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia nigra

60 y by symptoms of esophageal dysfunction and, pathologically, by an eosinophil-predominant tissue infi

61 uman cardiac progenitor cells (hCPCs) into a pathologically challenged heart.

62 essure and topographic relationships between pathologically changed vessels and particular cerebral s

63 ers, including Alzheimer's disease, that are pathologically characterized by aggregates of phosphoryl

64 disease (AD) is a neurodegenerative disease pathologically characterized by amyloid plaques and neur

65 Malin deficiency causes Lafora disease, pathologically characterized by neurodegeneration and ac

66 disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine n

67 Microsatellite expansion disorders are pathologically characterized by RNA foci formation and r

68 Alzheimer's disease (AD) is pathologically characterized by tau-laden neurofibrillar

69 Alzheimer's disease (AD) is pathologically characterized by the deposition of extrac

70 is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic

71 f ventricular MF have never been extensively pathologically characterized.

72 Pathologically classified resected lung adenocarcinomas

73 carcinomas and 23% of adenocarcinomas had a pathologically complete response (pCR) in the resection

74 We identified all cases with pathologically confirmed AD (NIA-Reagan intermediate-hig

75 brains of six cases with severe dementia and pathologically confirmed AD.

76 wing the initial FL diagnosis, including 147 pathologically confirmed and 232 clinically suspected ca

77 Ten consecutive patients with pathologically confirmed ATL treated with radiotherapy w

78 gional Veterans Affairs Medical Center and a pathologically confirmed Barrett's esophagus registry.

79 This study included 277 pathologically confirmed breast lesions.

80 1, participants included 17 individuals with pathologically confirmed CAA-ri and 37 control group mem

81 Studies of pathologically confirmed cancer patients were included i

82 e Childhood Cancer Survivor Study cohort, 13 pathologically confirmed cases of subsequent leukemia oc

83 A post-mortem cohort of pathologically confirmed cases with multiple sclerosis (

84 In patients with pathologically confirmed CBD, accuracy of diagnosis was

85 al tissue samples derived from patients with pathologically confirmed central nervous system inflamma

86 -1, and 2 of 3 IRSS stage IIIB patients with pathologically confirmed cervical lymph node involvement

87 spective chart reviews of genetically and/or pathologically confirmed collagen VI-related myopathy pa

88 in RAB39B cause intellectual disability and pathologically confirmed early-onset Parkinson disease.

89 We sought to determine the incidence of pathologically confirmed EGLs, by lesion type, among men

90 an HPV line-probe assay was performed on all pathologically confirmed EGLs.

91 nd a significant linear dose response for 38 pathologically confirmed follicular adenoma cases.

92 mean age, 55 years; range, 19-94 years) with pathologically confirmed GIST who were identified with a

93 ter hippocampectomy due to seizures, who had pathologically confirmed hippocampal sclerosis.

94 tients newly diagnosed as having cT1-2 N1-2b pathologically confirmed HPV-negative OPSCC in 2010 to 2

95 EGLs (n = 377) were pathologically confirmed in 228 men, 198 of whom had inc

96 Patients aged 18 years or older who had pathologically confirmed mesothelioma and were deemed fi

97 A postmortem cohort of pathologically confirmed MS (n = 47) and control (n = 10

98 83(+/-) mice with brain homogenates from two pathologically confirmed MSA cases.

99 We prospectively enrolled 112 patients with pathologically confirmed NETs of gastroenteropancreatic

100 med CAA-ri and 37 control group members with pathologically confirmed noninflammatory CAA.

101 Thirty patients with pathologically confirmed NSCLC were included.

102 Eligibility criteria were newly diagnosed, pathologically confirmed NSCLC; stage IIIb or IV; chemot

103 demonstrated that loss of RAB39B resulted in pathologically confirmed Parkinson disease.

104 ition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate beni

105 es of parkin disease and compare them with 5 pathologically confirmed PD cases and 4 control subjects

106 and were at least 10 years post-diagnosis of pathologically confirmed primary Hodgkin's lymphoma.

107 Two of the patients had pathologically confirmed RCC in further evaluation.

108 ), 80 healthy controls, and 19 patients with pathologically confirmed RCC.

109 o identify patients 66 years or older with a pathologically confirmed small kidney cancer (<4 cm) dia

110 d 18 years or older and had treatment-naive, pathologically confirmed stage IIIB or stage IV lung ade

111 er undertaken on brain samples from patients pathologically confirmed to have suffered from AD, and t

112 ars) were eligible for the study if they had pathologically confirmed, advanced (unresectable or meta

113 noglobulin G, and all sarcoidosis cases were pathologically confirmed.

114 NAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of

115 be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fi

116 n in Alzheimer's disease (AD) differs across pathologically defined AD subtypes (hippocampal sparing

117 In total, 105 patients with pathologically defined CAA were included: 52 with autops

118 btypes of Alzheimer's disease (AD) have been pathologically defined on the basis of the distribution

119 Recent genomic analyses of pathologically defined tumor types identify "within-a-ti

120 nic progenitor cell preferentially generates pathologically deleterious myofibroblasts after injury.

121 rison with a library of DESI mass spectra of pathologically determined tissue types.

122 Pathologically diagnosed human cases ranging from no lik

123 rom ageing controls and similar age subjects pathologically diagnosed with Alzheimer's disease, mixed

124 Thirty-three patients who were pathologically diagnosed with the presence of peritoneal

125 Thirty-three patients who were pathologically diagnosed with the presence of peritoneal

126 ated uterine sarcomas which may be useful in pathologically difficult cases.

127 g function and the auditory tubes can become pathologically dilated.

128 Pathologically distinct dementias exhibit characteristic

129 were previously associated with modifying a pathologically distinct form of muscular dystrophy and i

130 can also predispose individuals to develop a pathologically distinct form of tauopathy-related dement

131 In pathologically distinct neuromuscular disorders, we aime

132 significant reduction in portal pressure in pathologically distinct PHT models, through augmentation

133 Pathologically diverse forms of HCC are observed, and re

134 s, after injury to clear damaged neurons, or pathologically during disease.

135 loss occurs normally during development and pathologically during neurodegenerative disease.

136 Complete removal of gravity does not pathologically elevate ICP but does prevent the normal l

137 Pathologically elevated 1-deoxySL concentrations cause h

138 DPc10 binding to RyR2 results in a pathologically elevated Ca(2+) leak by destabilizing key

139 ore, we found that obese humans and mice had pathologically elevated concentrations of circulating as

140 c mice simulate key aspects of AD, including pathologically elevated levels of amyloid-beta peptides

141 activity of the amygdala and, consequently, pathologically elevated levels of negative affect.

142 The pathologically elevated mutant dynorphin A levels in the

143 Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of

144 Electrophysiological analysis revealed a pathologically elevated synaptic activity in ChAc MSNs.

145 that high frequency stimulation may suppress pathologically enhanced low frequency activity in patien

146 patch-clamp electrophysiology, we detected a pathologically enhanced synaptic activity in ChAc neuron

147 requency (15-30 Hz) oscillations that become pathologically exaggerated throughout basal ganglia circ

148 The median total inguinal lymph nodes pathologically examined (SLN + MILND) was 12.0 (interqua

149 9)Zr-trastuzumab by PET/CT were biopsied and pathologically examined to define HER2 status.

150 Pathologically, FXTAS is characterized by ubiquitin-posi

151 NSCLC is a genetically and pathologically heterogeneous disease, giving rise to lun

152 Blue nevi are a clinically and pathologically heterogeneous group of benign pigmented d

153 vioural variant frontotemporal dementia) was pathologically heterogeneous; while pathologically prove

154 croglial P2X7Rs being the primary targets of pathologically high extracellular ATP concentrations, al

155 Stimulation with pathologically high levels of Vegf, or overexpression of

156 A rat model with pathologically high lipid levels in pregnancy showed sym

157 de ((18)F-NaF) has the potential to identify pathologically high-risk nascent microcalcification.

158 eart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regu

159 Pathologically, high levels of aldosterone are associate

160 Pathologically, HP is characterized by a bronchiolocentr

161 Pathologically, human breast cancers with Snail1(+) CAF

162 y in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated

163 s of liver cysts that are radiologically and pathologically identical to those seen in autosomal domi

164 physiological malfunction are believed to be pathologically implicated in considerable neurological d

165 and was also found to cleave aggrecan at the pathologically important Glu(373 downward arrow374) Ala

166 ions for a diverse range of functionally and pathologically important intrinsically disordered protei

167 (ADP)-ribosylation is a physiologically and pathologically important post-translational modification

168 complications to be recognized and explained pathologically in patients with CKD.

169 in normal circumstances but levels increase pathologically in the injured somatosensory system.

170 logically during development or exercise and pathologically in vascular disease, tumorigenesis, and i

171 sembly and may also perform other functions; pathologically, in contrast, alpha-synuclein misfolds in

172 al cardiac slow-twitch myofiber proteins and pathologically increased expression of genes encoding sk

173 of Parkinson's disease (PD), clinically and pathologically indistinguishable from idiopathic PD.

174 Mifepristone treatment rescues the pathologically induced cognitive impairments and markedl

175 teinase involvement in normal (as opposed to pathologically-induced) brain plasticity by surveying fo

176 ell responses and antibody production within pathologically inflamed non-lymphoid tissues.

177 berrant function of these systems, including pathologically inhibited superior colliculus activity, d

178 ease feature that, while strongly associated pathologically, is poorly understood functionally.

179 Pathologically, JEV infection causes an acute encephalop

180 vity of glycine at the NMDAR, giving rise to pathologically large nondesensitizing steady-state NMDAR

181 re of ENaC is yet undetermined, the bases of pathologically linked mutations in ENaC subunits alpha,

182 eover, we demonstrate that TDP-43, a protein pathologically linked to amyotrophic lateral sclerosis a

183 a(1) integrin, a major collagen receptor, is pathologically low in IPF fibroblasts interacting with p

184 ate NPY neurons leading to weight loss and a pathologically low leptin state early in the disease pro

185 Furthermore, cells with pathologically low levels of cytoplasmic RNA are detecte

186 ive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN)

187 Clinically and pathologically, MAS bears strong similarity to hemophago

188 howed a significantly lower discrepancy with pathologically measured necrosis (residual standard erro

189 itative MR imaging techniques in identifying pathologically measured tumor necrosis in HCC hepatocell

190 es SNARE-complex assembly at the synapse but pathologically misfolds into neurotoxic aggregates that

191 However, such herd behavior can also be pathologically misleading by coaxing individuals into be

192 and human DMD tissues, Cx43 was found to be pathologically mislocalized to lateral sides of cardiomy

193 essively transdifferentiates into SCC, via a pathologically mixed mAd-SCC intermediate.

194 Pathologically, multiple system atrophy is characterized

195 overexpression of fluorescently tagged WT or pathologically mutant aSyn constructs.

196 LN status in VC, allowing the prediction of pathologically negative groins and thus the selection of

197 es are uncommon following wide excision with pathologically negative margins, surgery remains the bac

198 inel lymph nodes obtained from patients with pathologically negative sentinel lymph nodes were centra

199 omote tumor progression along with many more pathologically neutral "passenger" events.

200 reased in both black and white patients with pathologically node-negative breast cancer from 2002 thr

201 o identify cases of incident, nonmetastatic, pathologically node-negative breast cancer in women aged

202 rocess that uses averaging to regularize the pathologically noisy representation of letter feature po

203 water, which is commonly observed in MS but pathologically nonspecific.

204 proteoglycan, dcn Clinically, compared with pathologically normal human subjects, patients with IPF

205 disposition may be more likely to experience pathologically obsessive creativity.

206 arie-Tooth disease 1A, and classification as pathologically or clinically definite by MRC criteria wa

207 therapeutics effective for newly identified pathologically or molecularly defined subgroups.

208 tage-sensing domains (VSDs) are perturbed to pathologically or therapeutically modulate Na(+) current

209 at because the left hemisphere in neglect is pathologically over-excited it ought to be suppressed.

210 In those with T1R, the host immune response pathologically overcompensates for the actual infectious

211 cted individuals but also in individuals who pathologically overeat.

212 t cell activation occurs when mast cells are pathologically overproduced or if their activation is ou

213 EGF) drugs might actively close the involved pathologically permeabilized retinal artery and normaliz

214 The atrophic tubules display pathologically persistent signaling increases that trigg

215 Pathologically, persistent rims corresponded to an iron-

216 TDP-43 becomes insoluble, ubiquitinated, and pathologically phosphorylated and accumulates in cytopla

217 predictor of recurrence after cystectomy is pathologically positive nodes, our aim was to assess tec

218 ory symptoms are hypothesized to arise when 'pathologically precise prior beliefs' mediated by attent

219 the congenital disorder Noonan syndrome and pathologically promote human leukemias.

220 Pathologically, prostate cancer-associated SPOP mutants

221 Thirty (37%) patients had pathologically proved acute appendicitis.

222 e 4D CT and parathyroid surgery resulting in pathologically proved removal of adenoma from July 2010

223 MR images from 108 pathologically proved renal masses (88 clear cell RCCs a

224 of the 53 patients who were operated on had pathologically proven acute appendicitis.

225 nsent included 186 consecutive patients with pathologically proven advanced HGSC after primary cytore

226 Of 21 patients with pathologically proven axillary nodal metastases, (18)F-f

227 hip of antiphospholipid antibodies (aPLs) to pathologically proven brain infarcts.

228 We present a very unusual, pathologically proven case of clear cell variety of pedi

229 A total of 208 pathologically proven colon cancer hepatic metastases la

230 s retrospectively reviewed for patients with pathologically proven ECD.

231 (18)F-fluciclovine detected pathologically proven extraaxillary nodal metastases in

232 eration and progressive supranuclear palsy-a pathologically proven feature of these conditions--in si

233 lyse CHCHD10 in a cohort of 21 families with pathologically proven frontotemporal dementia-amyotrophi

234 r a significant proportion of clinically and pathologically proven HDLS.

235 Patients with pathologically proven HER2-positive metastases subsequen

236 Retrospective study of 2840 patients with pathologically proven HNSCC undergoing curative RT at a

237 n1, according to the absence or presence of pathologically proven lymph node metastasis.

238 The prevalence of pathologically proven malignancy was 0.1% (3 of 1,597).

239 A benign IMLN was pathologically proven or defined as showing 1 year of im

240 vember 2012 to June 2014 in 94 patients with pathologically proven parathyroid adenomas or hyperplasi

241 ogical specimens were obtained from cases of pathologically proven Parkinson's disease and a retrospe

242 tia) was pathologically heterogeneous; while pathologically proven Pick's disease and corticobasal de

243 informed consent, included 244 patients with pathologically proven serous ovarian cancer (mean age +/

244 The two LST lesions with BRAF mutation were pathologically proven to be serrated adenoma.

245 nalysis focused on patients with HCC who had pathologically proven vascular invasion (VI) because of

246 tified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb

247 Malignant IMLNs were pathologically proven.

248 signaling in pyramidal neurons that in turn pathologically recruits l-type Ca(2+) channels to facili

249 e signaling in pyramidal neurons, which then pathologically recruits voltage-gated l-type Ca(2+) chan

250 Intracellular sensing of pathologically relevant biomolecules could provide essen

251 f infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we con

252 tivation mediates EC permeability induced by pathologically relevant cyclic stretch.

253 of active fibrogenesis, thus representing a pathologically relevant fibroblast subpopulation.

254 , and alphaS oligomer-dependent ER stress is pathologically relevant for PD.

255 nistration of NPs containing siRNA against a pathologically relevant host cell target can knockdown t

256 Here, we report that exposure to pathologically relevant levels of Abeta induces Abeta fo

257 ation and tumor cell invasion into different pathologically relevant matrix environments.

258 s, this strain warrants evaluation as a more pathologically relevant model for preclinical studies.

259 h was found to be reduced in the case of the pathologically relevant mutant VWF-IIC.

260 rophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy'

261 e inclusion of exon 17b in the SORT1 mRNA, a pathologically relevant splicing event known to be regul

262 abolished are not always physiologically or pathologically relevant to human IR, in which small meta

263 Induction of this ligand/receptor system is pathologically relevant, as a decrease in apoptosis, aft

264 yer at which FLG deficiency is thought to be pathologically relevant.

265 a pressing need to identify the few that are pathologically relevant.

266 intact human prostate surface obtained with pathologically-relevant contrast and subcellular detail,

267 Because many metabolically and pathologically-relevant genes are highly expressed, our

268 model in which fibroblasts are activated to pathologically remodel the ECM in IPF via a positive fee

269 We find that AP propagation into the pathologically remodeled TATS frequently fails and may b

270 oietin-like protein 2 (ANGPTL2) increases in pathologically-remodeled hearts of mice and humans, whil

271 Mucin-producing sweat gland carcinoma pathologically represents a continuum, from an in situ l

272 QAT scores were continuously distributed and pathologically shifted; 13.2% (95% CI, 10.3%-16.1%) of i

273 loprotease responsible for solubilizing many pathologically significant membrane substrates and is an

274 se is responsible for ectodomain shedding of pathologically significant substrates including TNF-alph

275 on of transcriptomic and proteomic data from pathologically similar multiple sclerosis (MS) lesions r

276 Pathologically, SMA is characterized by motor neuron los

277 small-for-gestational-age (SGA) infants from pathologically small infants in a human cohort.

278 en those that are healthy and those that are pathologically small.

279 A diagnostic biomarker that is pathologically specific for the inflammatory demyelinati

280 on of multiple sclerosis (MS) and may mark a pathologically specific proinflammatory component of the

281 hepcidin suppression in physiologically and pathologically stimulated erythropoiesis.

282 thin cardiac (coronary) endothelial cells of pathologically stressed hearts to trigger the Ace2-to-Ac

283 itial fibrosis and mechanical dysfunction of pathologically stressed hearts.

284 Pathologically swollen lymph nodes (LNs), or buboes, cha

285 Pathologically, the amplification or activation of AURKA

286 Pathologically, the disease is defined by selective loss

287 Pathologically, the expression of EphA4 was detected in

288 of patients with AFP-producing tumors, but, pathologically, they had fewer lesions (25% vs 35% with

289 ion event during development and contributes pathologically to carcinoma and fibrosis progression.

290 dinarily close resemblance the disease shows pathologically to neuromyelitis optica (NMO), including

291 as foot lesions similar both clinically and pathologically to those seen in digital dermatitis (DD)

292 Compared with pathologically typical cases, svPPA-tau showed significa

293 Pathologically, valvular incompetence or absence of valv

294 data sets for this highly surface-sensitive pathologically variable [Fe(CN)6](3-/4-) process, but re

295 eria in a multi-site sample of patients with pathologically verified frontotemporal lobar degeneratio

296 entified VZV antigen in 11 of 11 aortas with pathologically verified granulomatous arteritis, in 1 of

297 S: The study included 19 adult patients with pathologically verified renal tumors: 9 patients with cl

298 ,708 injection also restored the strength of pathologically weakened excitatory synaptic transmission

299 fts (VCA) can undergo rejection, manifesting pathologically with skin changes that form the basis of

300 y, with mice showing early onset ataxia, and pathologically, with progressive histologic evidence of