ライフサイエンスコーパス: pathology

1 ut ameliorates the progression of dystrophic pathology.

2 has been measured both at imaging and gross pathology.

3 developmental insult is key to the afferent pathology.

4 n have been conclusively associated with PSP pathology.

5 jor etiologic factor involved in the mucosal pathology.

6 ofessional (101 [86%]) players having severe pathology.

7 KLH) control proteins induced no symptoms or pathology.

8 icity of the new criteria for underlying PSP pathology.

9 has been shown recently to be involved in AD pathology.

10 possible interaction leading to sarcoidosis pathology.

11 on, which is associated with worsened axonal pathology.

12 ntous bacteria (SFB), distantly provoke lung pathology.

13 relationship between DMGV and early hepatic pathology.

14 antibodies have similarly distinct roles in pathology.

15 ed cognitive performance in patients with AD pathology.

16 NCA is of utmost importance to understand PD pathology.

17 cts against the toxic hallmarks of alpha-syn pathology.

18 otor processing at subcortical levels to FXS pathology.

19 romising advances in diagnostic and academic pathology.

20 reducing tissue-associated inflammation and pathology.

21 k of disease models recapitulating the human pathology.

22 to affect immunoregulation, inflammation and pathology.

23 s on the context and type of the stressor or pathology.

24 a prominent role in Parkinson's disease (PD) pathology.

25 ute to the ability of LPS to stimulate liver pathology.

26 event that underpins Alzheimer disease (AD) pathology.

27 nse contributing to prion disease-associated pathology.

28 recapitulates several features of the human pathology.

29 TDP-43 acetylation as a trigger for disease pathology.

30 pregnancy syndrome associated with placental pathology.

31 lities, mitochondrial dysfunction and kidney pathology.

32 nogen genes, which suggest significant liver pathology.

33 emic influences (e.g., serum) on the disease pathology.

34 ic conditions, and in regeneration and liver pathology.

35 without the need for pre-existing or hidden pathology.

36 promising applications in medicine or plant pathology.

37 nested frequencies may correlate better with pathology.

38 variants that can fuel evolution and inflict pathology.

39 al bearings on IAPP glycemic control and T2D pathology.

40 or tau acetylation in the propagation of tau pathology.

41 hy in TREM2-deficient mice with amyloid-beta pathology.

42 s not associated with macrovascular arterial pathology.

43 tal TTP positively correlated with placental pathology.

44 %) did not have knowledge about peri-implant pathology.

45 ally inefficient at seeding alphaS inclusion pathology.

46 before or after establishment of human-like pathology.

47 ted inflammatory response and extensive lung pathology.

48 ly to contain TDP-43 and not significant tau pathology.

49 primary mtDNA abnormality that can result in pathology.

50 ered function as the likely cause of retinal pathology.

51 ion neurons, as a potential locus for autism pathology.

52 gut microbial community leads to intestinal pathology.

53 ted for its role in Alzheimer's disease (AD) pathology.

54 c variants affect a number of phenotypes and pathologies.

55 and complex rearrangements underlying human pathologies.

56 rendering the organism susceptible to these pathologies.

57 of ocular angiogenesis: from development to pathologies.

58 play a crucial role in the treatment of such pathologies.

59 for the treatment of various cardiovascular pathologies.

60 ystem are correlated with a variety of human pathologies.

61 ermined to understanding their role in these pathologies.

62 splantation outcome without signs of adverse pathologies.

63 e littermates, knockout mice showed no gross pathologies.

64 p of inherited disorders resulting in enamel pathologies.

65 gehog pathway activation in cancer and other pathologies.

66 in limiting inflammation in immune-mediated pathologies.

67 heimer and Parkinson disease, and many other pathologies.

68 the development of fear- and stress-related pathologies.

69 ferent forms of infectious and noninfectious pathologies.

70 plicating telomere length in various cardiac pathologies.

71 r perfusion model to patients with different pathologies.

72 hat ameliorate age-related neurodegenerative pathologies.

73 n and underlie a variety of poorly treatable pathologies.

74 t of therapeutic interventions in intestinal pathologies.

75 ess itself could ameliorate many age-related pathologies.

76 mited understanding of the resulting retinal pathologies.

77 rying levels of comorbid Alzheimer's disease pathology according to US National Institute on Aging-Al

78 te mortem CSF tau levels with postmortem tau pathology adjusting for demographics.

79 esis, but increasing evidence indicates that pathologies also exist in other tissues.

80 lesions in Alzheimer's disease (AD) but both pathologies also occur in cognitively normal older peopl

81 F-alpha therapy or RA itself can modulate AD pathology, although the underlying mechanism is unclear.

82 ies have demonstrated considerable dendritic pathologies among persons with schizophrenia and to some

83 es and plays prominent roles in inflammatory pathologies and cancer.

84 ons, and dynamics cell volume in other brain pathologies and normal brain function.

85 for the delta peptide in Ebola virus disease pathology and as a possible target for novel countermeas

86 th wild-type R. typhi and develop comparable pathology and bacterial loads in the organs, demonstrati

87 ty shift within islets in the context of T2D pathology and beta cell health, which may have broad tra

88 a freely available resource for the digital pathology and cancer research communities.

89 e pathologies tended to have cerebrovascular pathology and carry the MCI diagnosis for a longer inter

90 may be a significant contributor to disease pathology and clinical complications.

91 ve revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer'

92 he metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly unders

93 health problem, together with information on pathology and factors that determine individual risk, to

94 erse research disciplines ranging from plant pathology and forest ecology, to carbon sequestration.

95 ociated with amelioration of age-related gut pathology and functional decline, dampened protein synth

96 Based on pathology and gene expression analysis, we report the fi

97 een proposed based on genetic studies, brain pathology and imaging, but a major impediment to testing

98 c virulence genes and how they may influence pathology and immunity in the upper genital tract.

99 This is associated with reduced dendritic pathology and improved axonal and synaptic plasticity on

100 ly reduces SLN expression, attenuates muscle pathology and improves diaphragm, skeletal muscle and ca

101 y using in vivo models of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell

102 rhythm monitoring may clarify the underlying pathology and mechanisms driving mortal events.

103 evidence linking Alzheimer's disease-related pathology and neuronal stem cells suggests that hippocam

104 ever, the mechanistic link between the human pathology and NMDAR dysfunction is poorly understood.

105 tes) indicated that VtE ameliorates podocyte pathology and prevents podocyte loss in the DGKalpha(+/+

106 gene transfer vector significantly prevented pathology and produced significant improvements in life

107 a open new fields of investigation into HSCR pathology and provide novel insights into the developmen

108 ed the effect of synaptic stimulation on Tau pathology and synapses in in vivo and in vitro models of

109 all 3 former high school players having mild pathology and the majority of former college (27 [56%]),

110 ta-analysis to identify the patterns of SERT pathology and the relevance to symptoms.

111 of essential features underlying mechanical pathology and their contribution to Zrs.

112 d be considered in the investigation of FSHD pathology and therapy.

113 significant recovery of function, associated pathology and transcriptomic dysregulation even after su

114 f Abeta at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration.

115 extensible, open-source solution for digital pathology and whole slide image analysis.

116 ility, (2) identifying mechanisms leading to pathology, and (3) informing the development and/or more

117 on of IDO activity reduced bacterial burden, pathology, and clinical signs of TB disease, leading to

118 used multispectral microscopy, quantitative pathology, and gene expression profiling to analyze TLS

119 cific spatial molecular information, patient pathology, and patient treatment options.

120 ationships between age, CSF biomarkers of AD pathology, and quantitative magnetic resonance imaging r

121 rovascular signalling in both physiology and pathology, and the impact of these findings on understan

122 ory responses are a crucial component of WNV pathology, and understanding how they are regulated is i

123 s.SIGNIFICANCE STATEMENT Alzheimer's disease pathology appears earliest in brain regions that overlap

124 c memory and the accumulation of Alzheimer's pathology are common in cognitively normal older adults.

125 yond the reflection of left ventricular (LV) pathology are not well understood.

126 andial sensations of satiation to measurable pathology are scarce.

127 ealed by the worsening of the amyloid plaque pathology arising from JIP3 haploinsufficiency in a mous

128 antitative assessment of blood-brain barrier pathology as a clinically relevant predictive, diagnosti

129 F-alpha can also indirectly modulate amyloid pathology as a regulator of peripheral inflammation.

130 rs, neurodegenerative diseases and metabolic pathologies, as well as in the progression of certain in

131 olysaccharides (LPS), and induces intestinal pathology, as indicated by inflammation, barrier dysfunc

132 viding novel therapeutic avenues for cardiac pathologies associated with dysregulation of these mecha

133 w therapies in the treatment of diseases and pathologies associated with Panx3, such as osteoarthriti

134 ighlighted, emphasizing the spectrum of oral pathology associated with heterogeneous clinical phenoty

135 reatly enhanced the study of the biology and pathology associated with parasites of the phylum Apicom

136 Clenbuterol improved muscle pathology, attenuated the glycolytic-to-oxidative metabo

137 ital histology measurement of postmortem tau pathology averaged from three cerebral regions (angular

138 cell-to-cell communication in physiology and pathology because they represent a new way to convey fun

139 y, and color perception before microvascular pathologies become apparent.

140 an serve as a primary screening tool for TMJ pathology, before proceeding to complicated, time consum

141 logy, genomics, cost-effectiveness modeling, pathology, bioethics, and patient advocacy to identify f

142 n diverse domains of sex-biased behavior and pathology, but we lack a basic understanding of how sex

143 cose regulation, hyperlipidemia, and adipose pathology; but may not be as effective as behavioral mod

144 eurodegenerative diseases, but also that tau pathology can manifest in healthy neural tissue transpla

145 type is linked to severe cerebellar cellular pathology, characterized by nuclear degeneration through

146 e found to be more appropriate for radiology-pathology co-registration.

147 be excluded, however, that extra-cerebellar pathology contributed to the present findings.

148 hanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton,

149 CPO_Abeta17-21 P reduced Abeta-related pathology coupled with cognitive improvements in an AD A

150 spective cohort study using national explant pathology data from 2012 to 2015.

151 We collected demographic, clinical, and pathology data.

152 o unlock phenotypic information from digital pathology datasets to investigate prognostic image bioma

153 Enucleated eyes received at the pathology department of the Retinoblastoma Center of Hou

154 ribute to but may not completely explain the pathology detected in Pabpn1+/A17 mice.

155 disease (PD), it is known that nigrostriatal pathologies do not persist in the acute MPTP mouse model

156 y enters a persistent state without inducing pathology due to loss of the Golgi GDP mannose transport

157 in preventing T-cell- and cytokine-mediated pathology during potentially lethal malaria infections.

158 tic-gut communication is associated with gut pathology, dysbiosis, and inflammation and plays a key r

159 ng that TREM2 deficiency ameliorates amyloid pathology early, but exacerbates it late in disease prog

160 omic development of oral components and oral pathology encountered in the context of various BBS phen

161 stic adjunct for identifying IPMNs and their pathology, especially when incorporated with biomarkers

162 sk factors for HCA, disease progression, and pathology features of tumors.

163 t aripiprazole is increasingly used to treat pathologies for which other antipsychotics are indicated

164 KRP) gene mutations generate a wide range of pathologies from mild limb girdle muscular dystrophy 2I

165 These distinct tau pathologies have different temporal onsets and functiona

166 , and radiologic evidence of cerebrovascular pathology.Higher concentrations of plasma choline were a

167 T cells are central mediators of autoimmune pathology; however, defining their key effector function

168 Pathology Image Informatics Platform (PIIP) is an NCI/NI

169 haring, and quantitatively analyzing digital pathology imaging data.

170 eractive machine-learning system for digital pathology imaging datasets.

171 athology, atrial-specific physiology, atrial pathology, impact on arrhythmia occurrence, imaging, map

172 targeting thrombin or fibrin(ogen) may limit pathologies in obese patients.

173 TLD-tau in 40.5%, and Alzheimer disease (AD) pathology in 19% of cases.

174 t controls and significantly reduced cardiac pathology in a BALB/c mouse model of live Chagas disease

175 Agrin) have been shown to ameliorate disease pathology in a laminin-alpha2 knockout mouse model of mu

176 different rates of cellular intoxication and pathology in a mouse model of botulism.

177 rasts dramatically with observed PT-promoted pathology in adult mice.

178 PET imaging of tau pathology in Alzheimer disease may benefit from the use

179 and tau, mediating the amyloid-beta and tau pathology in Alzheimer's disease (AD).

180 on of alphaS fibrils also induced CNS alphaS pathology in another alphaS transgenic mouse line (M20),

181 vascular homeostasis and contributes to lung pathology in ARDS.

182 hereby IL-17A can contribute to IL-13-driven pathology in asthmatic patients remain unclear.

183 ading is greatest in sulcal locations, where pathology in cases of chronic traumatic encephalopathy i

184 For example, the tau pathology in corticobasal degeneration is distinct from

185 the synaptic phosphorylated alpha-synuclein pathology in dementia with Lewy bodies.

186 sphingolipid accumulating in GD, mediates PD pathology in GBA-associated PD.

187 cumulation of aggregated amylin and vascular pathology in HIP rats.

188 he toxin can be lethal and cause significant pathology in humans.

189 These changes in gut pathology in hypertension were associated with alteratio

190 cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated

191 cantly increase bacterial burdens and kidney pathology in mice infected with MRSA.

192 However, evaluating TMJ pathology in mice using standard histologic methods is t

193 encoded by HTT exon 1) underlies the disease pathology in mouse models and that the HTT exon 1 gene p

194 Here, we investigated skeletal muscle pathology in myofibers and myofibrils isolated from youn

195 Surprisingly, PT inhibited lung inflammatory pathology in neonates, a result which contrasts dramatic

196 Progression of pathology in neurodegenerative diseases is hypothesized

197 naggregated alphaS resulted in paralysis and pathology in only a subset of mice, whereas soluble Delt

198 neurophysiological biomarkers relevant to SZ pathology in order to inform DBS targeting.

199 ed evidence for the key role of serotonergic pathology in patients with Parkinson's disease (PD).

200 TFEB) gene was effective in improving muscle pathology in PD mice injected intramuscularly with an AA

201 of corticobasal degeneration had severe tau pathology in PSP-related brain structures with good corr

202 ge scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is l

203 and atherosclerosis, include characteristic pathology in specific anatomical locations.

204 oligomers and amyloid deposits is a primary pathology in tauopathies, the most common of which is Al

205 Overt tau pathology in the aged mice was accompanied by spatial me

206 ippocampal volume was not related to amyloid pathology in this sample of patients with late-life depr

207 RVX-297 also countered pathology in three rodent models of polyarthritis: rat a

208 specks resulted in spreading of amyloid-beta pathology in transgenic double-mutant APPSwePSEN1dE9 mic

209 Pathology in Zc3h12a(+/-) mice was associated with eleva

210 he development of numerous IL-36gamma-driven pathologies, in addition to psoriasis.

211 P2X7R has also been implicated in neuronal pathologies, in which it may influence neuronal survival

212 Pathologies including diabetes and conditions such as ex

213 contributes to a number of significant human pathologies including respiratory distress syndrome, lun

214 Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration,

215 een implicated in the development of various pathologies, including neurodegeneration.

216 ited to prevent and/or treat T cell-mediated pathologies, including transplant rejection.

217 not only adds to the recent reports that tau pathology is a feature of these neurodegenerative diseas

218 AC pathology is characterized by cardiomyocyte loss and rep

219 A hallmark of RVFV pathology is NSs filament formation in infected cell nuc

220 Together, these results show that tau pathology is related in a region-specific manner to cogn

221 e investigated whether DM1-associated muscle pathology is related to deregulation of central metaboli

222 Astroglial pathology is seen in various neurodegenerative diseases

223 The underlying basis of thalassemia pathology is the premature apoptotic destruction of eryt

224 important manifestations, but the underlying pathology is unknown.

225 duced neuropathies may be a primary cause of pathology, leading to further deficits in the mitochondr

226 Vici syndrome, an early-onset autolysosomal pathology, leads to the activation of alternative cleara

227 stic images of a wide spectrum of congenital pathologies may serve as an example of routine utilizati

228 However, tau pathology may also result in the loss of specific physio

229 here could be substantial effects on chronic pathology, natural immunity, vaccine development strateg

230 r leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents

231 eir value as potential biomarker in selected pathologies of cardiovascular disease.

232 s disease in Was(-/-) mice recapitulates the pathology of a conventional disease model and/or human f

233 ponse DNA-binding protein 43 (TDP-43) in the pathology of ALS and other neurodegenerative diseases.

234 rsus the secreted form of mutant SOD1 in the pathology of ALS.

235 biological organization more relevant to the pathology of complex diseases such as Parkinson's Diseas

236 ental data has suggested that the underlying pathology of DED involves inflammation of the lacrimal f

237 in the intracellular localization of FUS and pathology of FUS-related amyotrophic lateral sclerosis.

238 uction of TBK1 kinase may have a role in the pathology of glaucoma.

239 a murine model that recapitulates the polyQ pathology of HD (R6/2 mice).

240 table levels and damages neurons, explaining pathology of human syndromes caused by betaIII spectrin

241 The likely pathology of identified variants was examined using in s

242 The pathology of inflammatory bowel diseases is driven by th

243 or animal models that accurately reflect the pathology of LAM have been challenging to develop.

244 ndicates that T cells play a key role in the pathology of lymphedema by promoting tissue fibrosis and

245 Epithelial dysfunction is critical in the pathology of many respiratory diseases, including cystic

246 Astrocytes are key players in the pathology of multiple sclerosis and can assume beneficia

247 on of neuronal morphology contributes to the pathology of neurodegenerative disorders such as Alzheim

248 The pathology of ovalbumin-induced acute allergic airway inf

249 tical role for nonclassical monocytes in the pathology of TBI in mice, including important clinical o

250 tween postoperative outcome and preoperative pathology of white matter tracts, which constitute cruci

251 l dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were assessed an

252 ck of understanding of the effect of disease pathology on the function of neural circuits in vivo Thi

253 that feature both gain- and loss-of-function pathologies or have a heterogeneous genetic background.

254 n of such models to investigate other tissue pathologies or test pharmacological treatments.

255 ndidate for studying and monitoring cortical pathology or therapeutic effects in multiple sclerosis.

256 is infection induced reactivation of disease pathology, overriding the protective adaptive immune res

257 uces amyloid-beta levels, amyloid-associated pathology, oxidative stress, as well as mitochondrial an

258 is the primary determinant in heart failure pathology post-MI.

259 platform, we demonstrated that amyloid-beta pathology recapitulates an Alzheimer-like profile of bio

260 Although diverse pathologies reduce quality of life by impacting such spe

261 AD-type pathologies related to the Abeta accumulation including

262 t can be affected by DISC1 in the context of pathology-related phenotypes.

263 rculating Abeta contributes to brain AD-type pathologies remains largely unknown.

264 INTERPRETATION: Underlying pathology, repeated focal seizures, and global insults e

265 Pathology reports of all patients having a second surger

266 ppendicitis and correlated with surgical and pathology reports.

267 hanges are disruptive influences on academic pathology research as we know it, straining limited reso

268 These findings indicate that in hamsters, pathology resulting from intravenous infection with aden

269 endocrine, enteric, and immune systems, with pathology resulting in disruption to neurotransmitter ba

270 local pathologists), included in the central pathology review, have been analyzed in this study.

271 f whom four (5%) were excluded after central pathology review; hence, 71 (95%) patients were included

272 These findings suggest amyloid pathologies significantly influence white matter and tha

273 Each pathology specimen was evaluated by two hepatopathologis

274 ts dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer.

275 ation for an integrated approach to study BG pathologies such as Parkinson's disease in silico.

276 treatment of central nervous system-related pathologies, such as Alzheimer's disease (AD).

277 al positioning contribute to different human pathologies, such as cancer, neurodegeneration, and lyso

278 is, however, becoming clear that significant pathology, such as microglial activation, also takes pla

279 wed spatiotemporal transmission of glial tau pathology, suggesting glial tau transmission contributes

280 ccompanied by only a mild aggravation of tau pathology, suggesting that increased tau burden cannot f

281 sk, including left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal acti

282 ia and were without severe neurodegenerative pathologies tended to have cerebrovascular pathology and

283 This article reviews the spectrum of liver pathologies that can manifest in the first 6 months of l

284 echanisms underlie neurological and muscular pathologies that toxoplasmosis patients present with.

285 rils displayed induction of alphaS inclusion pathology that increased and spread over time.

286 We propose a multistep process for CM pathology that is initiated by cytoadhesion of infected

287 particular risk for developing virus-related pathology; thus, the impact of the virome on health and

288 ures play a key role in human physiology and pathology; thus, the introduction of artificial receptor

289 abolites beyond which the accumulation of AD pathology triggers the expression of clinical symptoms.

290 dies and further suggest that entorhinal tau pathology underlies memory decline in old age even witho

291 Abrogation of disease-related pathology was also evident, with reductions in inflammat

292 etrance of AD dementia with respect to Abeta pathology, we hypothesized that factors present in the C

293 Following standard procedures used in pathology, we selected small fresh frozen uterine tissue

294 Pronounced tau and Abeta pathologies were primarily detected in the subiculum/CA1

295 even after substantial motor dysfunction and pathology were observed.

296 ions result in hearing loss alone or in skin pathologies with comorbid hearing loss.

297 sis lesions and other central nervous system pathologies with prominent myelin injury, namely, progre

298 contribute to the fight against a number of pathologies with unmet needs.

299 The spreading of pathology within and between brain areas is a hallmark o

300 nuclein levels sufficient to induce terminal pathology without significant loss of nigral neurons.