ライフサイエンスコーパス: pathophysiologic

1 ive prognostic significance of each of these pathophysiologic abnormalities in HFpEF is unknown.

2 agnosis of schizophrenia among glutamatergic pathophysiologic abnormalities in psychiatric disorders.

3 a tool for evaluating one of the fundamental pathophysiologic abnormalities seen in heart failure (HF

4 erogeneous syndrome associated with multiple pathophysiologic abnormalities, including left ventricul

5 in HFpEF, reduced (worse) LA strain is a key pathophysiologic abnormality and is a stronger correlate

6 Specifically, pathophysiologic acidification inhibits CaR activity, th

7 Syt10 underlying the response of neurons to pathophysiologic activity and provide new therapeutic pe

8 Intriguingly, pathophysiologic activity can also trigger signaling cas

9 ia, promoting production of IL-1beta and the pathophysiologic activity of the NLRP3 inflammasome in v

10 the Syt10 gene, which is strongly induced by pathophysiologic activity.

11 apamycin (mTOR) complexes by physiologic and pathophysiologic albumin concentrations in proximal tubu

12 kdown of megalin mimicked all the effects of pathophysiologic albumin concentrations, which disrupt n

13 Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occu

14 The conflict between pathophysiologic and pragmatic feeding strategies remain

15 low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum.

16 n may lead to important understanding of the pathophysiologic and therapeutic management in these dis

17 these neuroimaging markers reflect distinct pathophysiologic aspects in CAA, no studies to date have

18 izures by (18)F-FET PET and to elucidate the pathophysiologic background.

19 dosteronism, in HF and RHT, has provided the pathophysiologic basis for the inclusion of MRA in the o

20 first step towards better understanding the pathophysiologic basis of chronic antibody-mediated allo

21 presents mechanistic evidence related to the pathophysiologic basis of neonatal dysphagia as well as

22 We aimed to determine the pathophysiologic basis of the ST-segment in the BrS-ECG

23 ey have provided important insights into the pathophysiologic basis of these disorders and potential

24 The pathophysiologic basis of V2R-dependent cyst proliferati

25 te a key component of the chronic bronchitis pathophysiologic cascade that produces sputum and mediat

26 In this review, we define different pathophysiologic categories of AP dysfunction.

27 istinctly altered local environment, several pathophysiologic changes are found that may promote brea

28 ysfunction grading system and understand the pathophysiologic changes associated with various grades

29 r extremity ischemia is also associated with pathophysiologic changes in calf skeletal muscle, includ

30 ne alterations with implications for chronic pathophysiologic changes in gastrointestinal tract.

31 The degree of ischemia-related pathophysiologic changes in lower extremity muscles and

32 one for use in future studies interrogating pathophysiologic changes in neuropsychiatric disorders a

33 d PTH secretion in vivo, we examined whether pathophysiologic changes in pHo can significantly alter

34 In this article, the pathophysiologic changes of the arterial vessel wall und

35 Understanding the circulatory and pathophysiologic changes that occur within the uteroplac

36 o date there is almost no information on the pathophysiologic changes within the cerebral spinal flui

37 a discrete illness subtype, but to date its pathophysiologic characteristics are undetermined.

38 , remodel abnormal circuitry relevant to the pathophysiologic characteristics of cocaine addiction.

39 We discuss the pathophysiologic characteristics of isotretinoin therapy

40 scular smooth muscle cells (PAVSMCs) are key pathophysiologic components of pulmonary vascular remode

41 vel mechanism for triggering angiogenesis in pathophysiologic conditions characterized by prothrombin

42 PARs and their cofactors in physiologic and pathophysiologic conditions have the potential to influe

43 es of the role of PXR in the physiologic and pathophysiologic conditions of other cellular processes

44 standing of the role of the venous system in pathophysiologic conditions will allow intensivists to b

45 etachment from the GBM under physiologic and pathophysiologic conditions, including glomerular hypert

46 ream of growth factors in a diverse array of pathophysiologic conditions.

47 lating a number of physiologic processes and pathophysiologic conditions.

48 fected sites, thereby mediating a variety of pathophysiologic conditions.

49 ven macrophage-mediated inflammation and its pathophysiologic consequences in sickle cell disease.

50 little is known regarding the molecular and pathophysiologic consequences of altered GSL biosynthesi

51 ing persistent overproduction of ROS and its pathophysiologic consequences.

52 specificity of S1P1 activation in normal and pathophysiologic contexts in vivo and can be applied to

53 tional cell biological systems in normal and pathophysiologic contexts remain poorly understood.

54 hich altered vasoreactivity is a significant pathophysiologic contributor.

55 (BMI) and the risk of stillbirth defined by pathophysiologic contributors or causes.

56 Pathophysiologic correlates of RV EF were left ventricul

57 1 pathways selectively in podocytes mediates pathophysiologic crosstalk that influences mesangial arc

58 lucose tolerance, in order to identify early pathophysiologic defects.

59 in biochemical pathways and how they promote pathophysiologic developments involving proinflammatory

60 from a diagnosis of exclusion into a direct pathophysiologic diagnosis.

61 ar vesicles will provide insights into their pathophysiologic, diagnostic, and therapeutic roles.

62 g body of literature demonstrating important pathophysiologic differences between ALI caused by diffe

63 ocusing especially on possible etiologic and pathophysiologic differences.

64 This review focuses on recent genetic and pathophysiologic discoveries in the disease process.

65 cardiac and noncardiac comorbidities, valve pathophysiologic disorders, and echocardiographic measur

66 This work strongly supports the notion of pathophysiologic divergence between individuals with sch

67 Thirteen biomarkers reflecting diverse pathophysiologic domains were examined in 8569 HF-free p

68 ured a panel of biomarkers representing four pathophysiologic domains: "inflammation" (tumor necrosis

69 rexinoids would more effectively reverse the pathophysiologic effects of angiotensin II than an indiv

70 and function of ovarian theca cells and the pathophysiologic effects of hyperinsulinism on ovarian f

71 n linked to cancer, neurotoxicity, and other pathophysiologic effects.

72 No distinct pathophysiologic elements or specific biomarkers have be

73 HD and may have value in further elucidating pathophysiologic events and therapeutic strategies.

74 We demonstrate that central pathophysiologic events in ALI (inflammation, IL-1beta l

75 se results begin to describe an order of the pathophysiologic events in ALS.

76 ations in pH elicited by neural activity and pathophysiologic events such as hypoxia-ischemia and sei

77 m of miRNA-mediated integration of the early pathophysiologic events that facilitate tissue remodelli

78 Three major pathophysiologic events were considered to constitute CI

79 2 or HIF-1alpha can prevent or reverse these pathophysiologic events, restoring a state of insulin se

80 ng mechanistic insights into a wide range of pathophysiologic events.

81 nfluence a wide range of seemingly unrelated pathophysiologic events.

82 omerular hyperfiltration as a prognostic and pathophysiologic factor in diabetes may lead to improved

83 ferences may be the basis for the underlying pathophysiologic factors contributing to the development

84 of risk factors for MH may help clarify the pathophysiologic factors of MH and identify potential ne

85 ortical (CSTC) circuit dysfunction is a core pathophysiologic feature of obsessive-compulsive disorde

86 Therapies based on pathophysiologic features have changed the paradigm for

87 asthma that can induce several clinical and pathophysiologic features of asthma in sensitized subjec

88 f TLR7(-/-) mice induced all of the cardinal pathophysiologic features of asthma, including tissue eo

89 cell arteritis, and 1 of 193 (0.5%) for the pathophysiologic features of central retinal artery occl

90 Pathophysiologic features of CUNV were observed to be si

91 volume (ECV) accumulation is one of the key pathophysiologic features of heart failure with preserve

92 This mouse model mimics the pathology and pathophysiologic features of human adult-onset branching

93 geable ranged from 29 of 199 (14.6%) for the pathophysiologic features of retinal detachment, 1 of 20

94 model of HCDD efficiently recapitulates the pathophysiologic features of the disease and demonstrate

95 yositis have unique clinical, pathologic and pathophysiologic features when compared with those with

96 ch disease, including 1 question about basic pathophysiologic features, 1 question about basic sympto

97 Th2-polarized inflammatory response may have pathophysiologic features, they are also efficient and e

98 troparesis, therefore the diseases may share pathophysiologic features.

99 underlying dimensional vs disorder-specific pathophysiologic features.

100 also several other regions implicated in ALS pathophysiologic findings.

101 hy and may represent an important underlying pathophysiologic foundation for cystoid macular edema in

102 ated methylation signatures discriminate HIV pathophysiologic frailty.

103 However, little is known about the pathophysiologic functions of kidney DN T cells.

104 Aside from pathophysiologic imaging studies, an mGluR2 PET tracer w

105 onary disease (COPD), but their clinical and pathophysiologic implications have not been defined.

106 Developmental and pathophysiologic implications of prenatal infection were

107 and should stimulate further studies on the pathophysiologic implications of RAGE axis in the mechan

108 rapeutics, have now clearly demonstrated the pathophysiologic importance of the complement system in

109 On the basis of recently obtained pathophysiologic insights, we postulated that measuring

110 possible mechanism, we found that a chronic pathophysiologic insulin concentration (1 nM) caused abn

111 We hypothesized that different pathophysiologic insults would produce characteristic pa

112 Understanding the pathophysiologic interactions between renal impairment a

113 ory systems in isolation, ignoring the major pathophysiologic interactions between the systems in man

114 ted by the inability to accurately replicate pathophysiologic interactions of GBM cells with unique a

115 conflicting data exist on the expression and pathophysiologic involvement of the bone remodeling liga

116 ll-restricted IR/IGF-1R signaling provides a pathophysiologic link between systemic insulin resistanc

117 nal CNM-associated gene provide a definitive pathophysiologic link with these disorders, confirm that

118 fusogenicity, replicative fitness, and other pathophysiologic manifestations.

119 e used to determine the associations between pathophysiologic markers and outcomes.

120 d by increased RV wall thickness, were the 2 pathophysiologic markers most predictive of worse outcom

121 improve care and should be guided by direct pathophysiologic markers of arrhythmic substrate, such a

122 ASD) (PTEN-ASD), with the aim of identifying pathophysiologic markers that specifically associate wit

123 ography and sphygmomanometry to assess HFpEF pathophysiologic markers.

124 Future studies may examine the pathophysiologic meaning of the finding.

125 notype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C varian

126 Disruption of such connectivity is a key pathophysiologic mechanism for ADHD, and identifying her

127 ransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia.

128 However, the underlying pathophysiologic mechanism is still poorly understood.

129 the effects of dopamine dysregulation on the pathophysiologic mechanism of psychotic symptoms.

130 f PRDM13 in macular development, whereas the pathophysiologic mechanism of the fifth remains unknown

131 The anatomical origin and pathophysiologic mechanism of tremorogenic oscillation a

132 penetrant CID phenotype through a different pathophysiologic mechanism than previously described for

133 made in our understanding of the genetic and pathophysiologic mechanism underlying the development an

134 Orthostatic tremor has an unknown pathophysiologic mechanism.

135 rologic consequences might reveal underlying pathophysiologic mechanisms and clinical implications of

136 riants will provide insights into underlying pathophysiologic mechanisms and facilitate the developme

137 risk factor for disease progression, but the pathophysiologic mechanisms are only incompletely unders

138 ure of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.

139 ew, we summarize the functional outcomes and pathophysiologic mechanisms attributed to progesterone t

140 Although the pathophysiologic mechanisms behind cardiac toxicity have

141 We suspect that the pathophysiologic mechanisms by which HS virus infects ne

142 ity observed in HX and indicate that various pathophysiologic mechanisms contribute to the HX phenoty

143 rcise impairment, indicating that additional pathophysiologic mechanisms contribute to the limb manif

144 Pathophysiologic mechanisms could involve not only subop

145 complement cascade, led us to consider other pathophysiologic mechanisms for this disease.

146 obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD.

147 Because dietary intake may influence pathophysiologic mechanisms in sporadic amyotrophic late

148 Common pathophysiologic mechanisms include systemic and endomyo

149 , there is still very little known about the pathophysiologic mechanisms involved.

150 minophen-induced hypotension, and assess the pathophysiologic mechanisms involved.

151 Pathophysiologic mechanisms leading to loss of white mat

152 Various pathophysiologic mechanisms leading to sickness behavior

153 However, elucidation of the multiple pathophysiologic mechanisms leading to vaso-occlusion an

154 date our findings and to delineate the exact pathophysiologic mechanisms linking migraine and OMCNP.

155 Biomarkers of diverse pathophysiologic mechanisms may improve risk stratificat

156 t into all underlying cellular and molecular pathophysiologic mechanisms of CRS.

157 y of research has begun to shed light on the pathophysiologic mechanisms of CSA.

158 flammatory response to surgery are potential pathophysiologic mechanisms of delirium.

159 Recent advances in the understanding of the pathophysiologic mechanisms of strokelike episodes in ME

160 evidence suggests that age affects the main pathophysiologic mechanisms of the acute respiratory dis

161 d risk of ischemic heart disease, though the pathophysiologic mechanisms remain unclear.

162 ial) function is important to understand the pathophysiologic mechanisms that contribute to MVD and t

163 r "endotypes," which are defined by distinct pathophysiologic mechanisms that might be identified by

164 Details of the pathophysiologic mechanisms that underlie complex disord

165 Recent progress in the understanding of pathophysiologic mechanisms underlying IgE-associated al

166 Furthermore, better delineation of the pathophysiologic mechanisms underlying the development o

167 A greater understanding of the genetic and pathophysiologic mechanisms underlying the disease may l

168 This review will evaluate the multiple pathophysiologic mechanisms underlying the exercise impa

169 Endotypes further describe the functional or pathophysiologic mechanisms underlying the patient's dis

170 us HFrEF, emphasizing prevalence, underlying pathophysiologic mechanisms, and outcomes.

171 g with PET may offer important insights into pathophysiologic mechanisms, diagnosis, and disease prog

172 Insulin resistance results from several pathophysiologic mechanisms, including chronic tissue in

173 h animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of

174 To evaluate pathophysiologic mechanisms, we explored the relationshi

175 d cellular phenotypes suggesting overlapping pathophysiologic mechanisms.

176 TR should contribute to the understanding of pathophysiologic mechanisms.

177 s and prostate cancer appear to share common pathophysiologic mechanisms.

178 ancer and supports the possibility of common pathophysiologic mechanisms.

179 of RPD with other diseases that have defined pathophysiologic mechanisms.

180 accounted for otherwise by previously known pathophysiologic mechanisms.

181 t disease entities characterized by specific pathophysiologic mechanisms.

182 h medical diseases that involve inflammatory pathophysiologic mechanisms.

183 tolic dysfunction is widely considered a key pathophysiologic mediator of HFpEF, the prevalence of co

184 Pathophysiologic models of gSP implicate exaggerated rea

185 A better understanding of the pathophysiologic nature of HIV reservoirs and the impact

186 study provides insight into the mechanism of pathophysiologic occurrence of diarrhea in UC and sugges

187 c state of the diaphragm, which might be one pathophysiologic origin of ventilator-induced diaphragma

188 s in ARMS2 and CFH, indicating a genetic and pathophysiologic overlap between cCSC and AMD.

189 ng similar stimulation paradigms, suggesting pathophysiologic overlap.

190 This finding reveals a potential pathophysiologic pathway involved in the intergeneration

191 One pathophysiologic pathway that may drive changes in DAerg

192 lygenic autoimmune disorders, as well as the pathophysiologic pathways and clinical features of monog

193 dinal investigations are needed to elucidate pathophysiologic pathways and target modifiable mechanis

194 gic agents that target specific and critical pathophysiologic pathways have been developed to better

195 enotypic difference strongly suggests unique pathophysiologic pathways involved in the pathogenesis o

196 or endotypes, which arise through different pathophysiologic pathways.

197 (i.e., quantifiably infer the magnitude of a pathophysiologic perturbation), and helps explain comple

198 s has bearing on a number of physiologic and pathophysiologic phenomena.

199 , little is known about what regulates their pathophysiologic phenotype.

200 Therefore, pathophysiologic pHo changes can modulate CaR responsive

201 Finally, pathophysiologic pHo elevation reversibly suppressed PTH

202 mpliance and RV remodeling are the strongest pathophysiologic predictors of adverse outcomes.

203 ally could be related to the same underlying pathophysiologic process as their renal disease, and nei

204 t likely were related to the same underlying pathophysiologic process as their renal disease.

205 Atherosclerosis is the pathophysiologic process behind lethal cardiovascular di

206 intestinal ischemia/reperfusion is a leading pathophysiologic process in a rat model of deep hypother

207 reinforced behaviors and not the result of a pathophysiologic process.

208 probable AD dementia with evidence of the AD pathophysiologic process: 24 patients with age at onset

209 d biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical

210 ce: Cardiac biomarkers provide insights into pathophysiologic processes and offer an attractive strat

211 It is unclear which pathophysiologic processes are responsible for this diff

212 networks may reveal the impact of underlying pathophysiologic processes as assessed with cerebrospina

213 wn to have a long preclinical phase in which pathophysiologic processes develop many years, even deca

214 peptides allows insight into various ongoing pathophysiologic processes in CKD.

215 iques can identify biomarkers reflecting key pathophysiologic processes in depression and whether suc

216 c value of biomarkers that reflect different pathophysiologic processes in patients with type 2 diabe

217 een shown to play a crucial role in multiple pathophysiologic processes like sepsis, inflammation, va

218 Distinct pathophysiologic processes may underlie the structural i

219 of therapy that can be targeted against the pathophysiologic processes of a patient's endotype, with

220 s) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disor

221 ation of objective biomarkers that represent pathophysiologic processes that differ between bipolar d

222 ward a diagnostic system based on underlying pathophysiologic processes that may cut across conventio

223 The present review seeks to review the pathophysiologic processes that underlie the development

224 omorbidity, and may provide insight into the pathophysiologic processes underlying IOP.

225 y a significant role in many physiologic and pathophysiologic processes, including synaptic transmiss

226 70s as an in vivo method to measure regional pathophysiologic processes.

227 heir central role in a wide variety of human pathophysiologic processes.

228 sion is critical for diverse physiologic and pathophysiologic processes.

229 r disorder (BD), that may reflect underlying pathophysiologic processes.

230 simultaneous presence of multiple coexisting pathophysiologic processes.

231 lcium waves (ICWs) in various physiologic or pathophysiologic processes.

232 of patient-derived GBM cells, with improved pathophysiologic properties as an experimental model.

233 reatment with trypsin; this finding may have pathophysiologic relevance by suggesting that, like beta

234 To examine the pathophysiologic relevance of Gal1 in breast cancer, we

235 ese data provide preliminary support for the pathophysiologic relevance of neurosteroids in this cond

236 in more than 40% of breast cancers, but its pathophysiologic relevance to tumorigenesis has not been

237 lso provide insight into how physiologic and pathophysiologic remodeling differs in adipose tissue an

238 The fundamental pathophysiologic response for the survival of all organi

239 Our goal was to characterize the pathophysiologic response to damage-associated molecular

240 mice display a significant reduction in the pathophysiologic responses seen in asthmatic wild-type l

241 F expression resulted in amelioration of the pathophysiologic responses seen in children with allergi

242 These rapid molecular changes potentiate pathophysiologic responses throughout the body, resultin

243 y nucleotides released during physiologic or pathophysiologic responses.

244 The former is pathophysiologic resulting in intimal hyperplasia, where

245 2-part review, we discuss the epidemiologic, pathophysiologic, risk factors, and imaging aspects of c

246 2-part review, we discuss the epidemiologic, pathophysiologic, risk factors, and imaging aspects of c

247 Taken together, our findings established a pathophysiologic role and new function for LOXL2 in brea

248 A key pathophysiologic role for activated T-cells in mediating

249 ed ejection fraction, suggesting a different pathophysiologic role for both entities.

250 atic cancer, revealing a dual and contextual pathophysiologic role for REG3beta during pancreatitis a

251 These observations underscore an important pathophysiologic role for severely defective metabolism

252 he nitric oxide pathway playing an important pathophysiologic role in its development.

253 th a worse prognosis, and plays an important pathophysiologic role in PCa, which suggesting its poten

254 tivated by human anti-Gal IgM and may play a pathophysiologic role in pig-to-human xenotransplantatio

255 Platelets have a pathophysiologic role in the ischemic microvascular envi

256 n that vascular wall-derived Gas6 may play a pathophysiologic role in venous thromboembolism.

257 Further studies to delineate the underlying pathophysiologic role of elevated WBC across a spectrum

258 m of GN with monoclonal IgG deposits and the pathophysiologic role of granulocyte colony-stimulating

259 related to renal and heart diseases, but the pathophysiologic role of homoarginine and the genetic re

260 droplet-induced oxidative mechanisms and the pathophysiologic role of macrophages in diabetic kidneys

261 6a levels and clinical parameters suggests a pathophysiologic role of miR-146a in CP.

262 activity and, while much is known about the pathophysiologic role of NHE1 in tumor progression with

263 To further evaluate the specific pathophysiologic role of T cells in ectopic calcificatio

264 A pathophysiologic role of the enterohormones peptide YY a

265 T receptor, and its physiologic and possible pathophysiologic roles are not fully elucidated.

266 ed to determine whether these processes have pathophysiologic roles in delirium and whether therapies

267 in meta-inflammation, with a focus on their pathophysiologic roles in obesity, type 2 diabetes, dysl

268 h has been learned about the physiologic and pathophysiologic roles of the ECS.

269 y, and discuss the potential physiologic and pathophysiologic roles thereof in kidney.

270 part fundamentally different physiologic and pathophysiologic roles to these two endocannabinoids.

271 ating a variety of important physiologic and pathophysiologic roles.

272 elial cell fusion, an effect that may reduce pathophysiologic sequelae of NiV infection.

273 In the pathophysiologic setting of cerebral ischemia, excitotox

274 and/or function of these cells in different pathophysiologic settings.

275 ncers and we provide genetic evidence of the pathophysiologic significance of FABP5 in mammary tumori

276 ture longitudinal studies should examine the pathophysiologic significance of the shift from MTL hype

277 ary atrial fibrillation), and intensity of a pathophysiologic state (i.e., quantifiably infer the mag

278 ory properties of IFNbeta that modulated the pathophysiologic state, consistent with the observed pro

279 to modulate the emergence of MDSCs in those pathophysiologic states in which these cells play an imm

280 of the tissue microenvironment in a range of pathophysiologic states, including acute and chronic res

281 n the role of the venous system in different pathophysiologic states, particularly shock.

282 emand across a wide range of physiologic and pathophysiologic states, yet, when compared with other o

283 ene expression in a range of physiologic and pathophysiologic states.

284 pe across a network of human physiologic and pathophysiologic states.

285 by GIV during diverse cellular processes and pathophysiologic states.

286 rnate scaffold protein, SHPS-1, resulting in pathophysiologic stimulation of vascular smooth muscle c

287 uences cellular responses to physiologic and pathophysiologic stresses.

288 tion of results from these correlational and pathophysiologic studies supports the hypothesis that ga

289 ence and focusing on human epidemiologic and pathophysiologic studies.

290 ion, abnormalities of which form the direct, pathophysiologic substrate for SCD.

291 pression of Syt10 is strongly upregulated by pathophysiologic synaptic activity after kainic acid (KA

292 Excessive release of glutamate triggered by pathophysiologic synaptic activity has been put forward

293 In response to pathophysiologic synaptic activity, multiple signaling c

294 Although both pathophysiologic tissue classes were present within inju

295 Pathophysiologic traits varied substantially among parti

296 ylinositol 4,5-bisphosphate [PI(4,5)P2], but pathophysiologic triggers for NHE1 inactivation are unkn

297 ises to transform clinical care by advancing pathophysiologic understanding and fostering novel thera

298 ion; use of biomarkers may provide important pathophysiologic understanding beyond risk prediction.

299 A better pathophysiologic understanding of the neurodevelopmental

300 m)Tc-NTP 15-5) targeting proteoglycans has a pathophysiologic validity for in vivo imaging of rheumat