ライフサイエンスコーパス: pathophysiological

1 nxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorder

2 ectrically excitable cells during normal and pathophysiological activity.

3 Pathophysiological and atrophic changes in the cerebellu

4 fective treatment of a wide range of AD-like pathophysiological and cognitive impairments.

5 the first time characterize the metabolomic, pathophysiological and morphometric changes associated w

6 evere traumatic brain injury may carry novel pathophysiological and predictive information.

7 Here, we discuss the pathophysiological and therapeutic implications of the m

8 ut a finely regulated process with prominent pathophysiological and therapeutic implications.

9 isciplines together to identify its genetic, pathophysiological, and hemodynamic features.

10 king them amenable to investigation of early pathophysiological, and later parkinsonian-like, alterat

11 These novel interactions are critical for pathophysiological angiogenesis, suggesting that these s

12 contribute to impaired blood flow and other pathophysiological aspects of diabetes-related vascular

13 cuss the genetic, structural, substrate, and pathophysiological aspects of neprilysin.

14 (PPV) for non-RRD in MGS, in order to follow pathophysiological aspects of the disease and to underst

15 or example) in the framework of the specific pathophysiological aspects of the diseases caused by the

16 ehensive overview of the epidemiological and pathophysiological aspects of TR, and the current and fu

17 gnificant challenges that are imposed by the pathophysiological barriers that lie between their site

18 as a single or combined test that allows the pathophysiological bases of exercise limitation to be tr

19 diomyopathy and help to define the molecular pathophysiological basis for cardiac remodeling.

20 Our understanding of the pathophysiological basis of chronic thromboembolic pulmo

21 nvolvement provides further insight into the pathophysiological basis of clinical disability in progr

22 ine its diagnostic challenges, summarize its pathophysiological basis, and discuss various therapeuti

23 This review focuses on the pathophysiological basis, mechanisms of action, and clin

24 Our results suggest that the pathophysiological beta generator is altered by DBS, smo

25 ed hemolytic anemia and reticulocytosis, key pathophysiological biomarkers of SCD.

26 d 30 distinct biomarkers representative of 6 pathophysiological categories were evaluated using multi

27 s support our finding of UBA5 mutations as a pathophysiological cause for early-onset encephalopathie

28 ant regulators and fine-tuners of a range of pathophysiological cellular effects and molecular signal

29 mptoms and emphasize the need to clarify the pathophysiological changes associated with distinct tauo

30 arkinson's resting tremor has been linked to pathophysiological changes both in the basal ganglia and

31 The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles.

32 and DTI are sensitive measures for detecting pathophysiological changes in MAP and describe a potenti

33 al stages of tauopathy and define tau-driven pathophysiological changes of potential value to support

34 g from human mutant LRRK2 manifests as early pathophysiological changes to dopamine circuit function

35 votal structure of basal ganglia involved in pathophysiological changes underlying Parkinson's diseas

36 Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic link

37 orms may inform underlying physiological and pathophysiological characteristics.

38 rs; however, recent studies have suggested a pathophysiological component that involves the central n

39 at, even if cochlear synaptopathy is a valid pathophysiological condition in humans, its perceptual s

40 management during exercise, and relevance to pathophysiological conditions (e.g. fatty acid oxidation

41 he CHGA promoter haplotype 2 under basal and pathophysiological conditions (viz.

42 ellular Ca(2+) homeostasis are a hallmark of pathophysiological conditions and a key trigger of cell

43 Under pathophysiological conditions following nerve injury or

44 centrations are altered in physiological and pathophysiological conditions in a tissue- and isomer-sp

45 ctivity has been implicated in several human pathophysiological conditions ranging from cardiovascula

46 A repair mechanisms and modulates many human pathophysiological conditions related to DNA damage.

47 ophysiological role in numerous diseases and pathophysiological conditions with considerable biomedic

48 nd are altered by, physiological challenges, pathophysiological conditions, and pharmacological agent

49 berrant redox signaling in physiological and pathophysiological conditions, and suggest therapeutic t

50 helium are regulated under physiological and pathophysiological conditions, and to suggest possible t

51 tanding of EV signaling in physiological and pathophysiological conditions, highlighting how certain

52 Disruption of SUMO dynamics prompts various pathophysiological conditions, including cancer.

53 is contributes to cellular demise in various pathophysiological conditions, including viral infection

54 Under pathophysiological conditions, nucleotide-scavenging ect

55 neration of persistent neural activity under pathophysiological conditions, opening up new targets fo

56 ct implications in the regulation of various pathophysiological conditions, signaling pathways and di

57 Under pathophysiological conditions, the purinergic A2b recept

58 es vascular function under physiological and pathophysiological conditions.

59 ualize cells in vivo under physiological and pathophysiological conditions.

60 man microcirculation under physiological and pathophysiological conditions.

61 ulator of BA metabolism in physiological and pathophysiological conditions.

62 ely tune their function in physiological and pathophysiological conditions.

63 is activated by a myriad of environmental or pathophysiological conditions.

64 stress are commonly associated with various pathophysiological conditions.

65 how stress regulates exosome secretion under pathophysiological conditions.

66 fetime risk of SUDEP and the lack of a clear pathophysiological connection between epilepsy itself an

67 rdiac output and may not be related to other pathophysiological consequences of HF.

68 Apart from increased bleeding tendency, the pathophysiological consequences of hyperfibrinolysis rem

69 ining PKA is likely to contribute to chronic pathophysiological consequences of SCI, including pain,

70 Understanding the pathophysiological consequences of these associations is

71 pact of this finding embedded in the complex pathophysiological context of BO.

72 attracted intense interest for its role in a pathophysiological context: suppression of anti-tumor im

73 tome, is biologically relevant in normal and pathophysiological contexts, affecting central and perip

74 ell fate decisions in many physiological and pathophysiological contexts, but how these proteins func

75 ntal origin of adipocytic properties and the pathophysiological contributions of visceral fat depots.

76 tegorized according to neuroradiological and pathophysiological criteria.

77 on infrastructure is a potential mediator of pathophysiological damage after demyelination.

78 sleep apnea (OSA) is associated with several pathophysiological deficits found in diabetic retinopath

79 Furthermore, the major pathophysiological derangements of heart failure and a p

80 However, the physiological and pathophysiological effects of high CO2 (hypercapnia) on

81 Histamine has pleiotropic pathophysiological effects, but its role in myocardial i

82 ng pathways, and thus have physiological and pathophysiological effects.

83 Yet, the extent to which normal and pathophysiological energy metabolism depend on the GC re

84 lity transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a vari

85 laucoma mechanisms, detecting and monitoring pathophysiological events and eye-brain-behavior relatio

86 ight the implication of energy metabolism in pathophysiological events associated with p62 deficiency

87 beta in spinal cord neurons might involve in pathophysiological events during the EAE.

88 cell-to-cell transfer, identifying possible pathophysiological events in the PD brain that could be

89 nd modifiable risk factors for AF and of the pathophysiological evidence supporting the mechanistic l

90 g prosthesis dysfunction and could suggest a pathophysiological explanation for acquired bleeding in

91 an increasing scientific effort to find the pathophysiological explanations for the disease, the neu

92 n associated with endothelial dysfunction, a pathophysiological feature of atherosclerosis.

93 d-type mice that recapitulates major retinal pathophysiological features of AMD and will be instrumen

94 one that uses targeted agents, interrogating pathophysiological features of disease.

95 tress, and mitochondrial dysfunction are key pathophysiological features of insulin resistance and ob

96 that are likely to be implicated in the key-pathophysiological features of MPB and may represent pro

97 rovided significant protection from multiple pathophysiological features, and as approved drugs in wi

98 Based on correlation with pathophysiological findings, we conclude that discontinu

99 d clotting within small sample volumes under pathophysiological flow.

100 es the molecular basis for the signaling and pathophysiological functions mediated by 20-HETE in hype

101 ramework for investigating physiological and pathophysiological functions of small transmembrane regu

102 P and G9a possess distinct physiological and pathophysiological functions.

103 The pathophysiological hallmark of DHF and DSS is plasma lea

104 Neurodegenerative diseases share certain pathophysiological hallmarks that represent common targe

105 Future work should test pathophysiological hypotheses and novel interventions ta

106 , that raise motivation for forming a viable pathophysiological hypothesis.

107 , with implications for our understanding of pathophysiological hypoxia.

108 Dysfunctional macrophages have significant pathophysiological impacts on diseases such as cancer, i

109 rough which VWF modulates complement and its pathophysiological implications for human diseases.

110 Although the pathophysiological importance of adiponectin has been th

111 genetic, epidemiological, translational, and pathophysiological insights, have established Lp(a) as a

112 novial fibroblasts are likely to provide new pathophysiological insights.

113 ese cells at steady state and in response to pathophysiological insults.

114 platforms will allow us to gain insight into pathophysiological interactions of metabolites, proteins

115 ning of drugs for transporters of particular pathophysiological interest.

116 n relationships underlying physiological and pathophysiological intracellular calcium handling phenom

117 few years, it has become clear that, at the pathophysiological level, cerebral amyloid angiopathy ap

118 Despite pathophysiological links between endothelin-1 and pulmon

119 The authors review the pathophysiological literature, including animal studies,

120 Detailed pathophysiological manifestations of early disease in th

121 ), disordered erythropoiesis triggers severe pathophysiological manifestations.

122 ase, ameliorating clinical disease signs and pathophysiological markers, even when treatments were in

123 Axonal degeneration is a pathophysiological mechanism common to several neurodege

124 control of pyramidal neuron-PV circuits as a pathophysiological mechanism contributing to cognitive f

125 of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegene

126 T1 (also known as GLAST), but the underlying pathophysiological mechanism for EA6 is not known.

127 ng to structural heterogeneities are a major pathophysiological mechanism in human persistent atrial

128 cium homeostasis in PNs form a common, early pathophysiological mechanism in SCAs.

129 ith human brain aging thus appears to be one pathophysiological mechanism influencing subcortical-cor

130 The exact pathophysiological mechanism is not completely understoo

131 ings may provide a new way to understand the pathophysiological mechanism of CAE.

132 eoclastogenesis, and uncover an unrecognized pathophysiological mechanism of high-bone-mass disorders

133 an play an important role in elucidating the pathophysiological mechanism of IGE from a cerebral haem

134 and point to a difference in the underlying pathophysiological mechanism of illusions and formed hal

135 To elucidate the pathophysiological mechanism of the R1441C mutation in t

136 , a specific infectious agent and underlying pathophysiological mechanism remain elusive.

137 These data suggest a potential pathophysiological mechanism that elevated HB-EGF can el

138 depressed patients, suggesting that a common pathophysiological mechanism underlies these biases.

139 evance of this sequence and uncovers a novel pathophysiological mechanism underlying this class of my

140 iterative arteriopathy induced via a two-hit pathophysiological mechanism without hypoxia provides no

141 The underlying pathophysiological mechanism(s) explaining why motor mem

142 The observations appear relevant to the FRDA pathophysiological mechanism, as FXN-dependent deficienc

143 However, the pathophysiological mechanisms accounting for VIDD are st

144 c Mttp deletion, adding new insight into the pathophysiological mechanisms and consequences of defect

145 nst severe malaria cases, we review here the pathophysiological mechanisms and the immunological aspe

146 or intermittent muscle contractions and its pathophysiological mechanisms are still poorly understoo

147 The pathophysiological mechanisms behind this observation re

148 in athletes indicates potentially different pathophysiological mechanisms for plaque formation in at

149 Multi-modal MRI may help evaluate the pathophysiological mechanisms in CSS and the efficacy of

150 ols for future clinical trials, and to probe pathophysiological mechanisms in vivo.

151 caused by Varicella zoster Nevertheless, the pathophysiological mechanisms involved in herpetic neura

152 This review summarizes the pathophysiological mechanisms involved in the dynamic de

153 Multiple pathophysiological mechanisms involving the hippocampal

154 These pathophysiological mechanisms lead to an array of clinic

155 Linked pathophysiological mechanisms may be involved in some co

156 Common pathophysiological mechanisms may be responsible for imm

157 Common underlying pathophysiological mechanisms may explain the risk of de

158 expression of the MQC and contribute to the pathophysiological mechanisms of cell damage.

159 t diabetes mellitus may favorably affect the pathophysiological mechanisms of heart failure by inhibi

160 The underlying pathophysiological mechanisms of narcotic bowel syndrome

161 Nevertheless, the pathophysiological mechanisms of such epileptogenesis re

162 Progress in monitoring and in understanding pathophysiological mechanisms of TBI could change curren

163 our results provides insights into potential pathophysiological mechanisms of TCF4-associated psychia

164 There are few clinical studies on the pathophysiological mechanisms of very late stent thrombo

165 These findings suggest that the pathophysiological mechanisms of VH in PD may include a

166 Purpose To gain more insight into the pathophysiological mechanisms of visual hallucinations (

167 s to gene loss of function could reveal some pathophysiological mechanisms potentially accessible to

168 llectual disability can generate "secondary" pathophysiological mechanisms prone to become pharmacolo

169 Pathophysiological mechanisms relating sarcopenia and NA

170 on and challenging clinical problem, and its pathophysiological mechanisms remain unclear.

171 rall genetic architecture and the underlying pathophysiological mechanisms remains incomplete.

172 However, even though alpha-Syn is linked to pathophysiological mechanisms similar to those that prod

173 f asthma is complicated by the heterogeneous pathophysiological mechanisms that underlie its clinical

174 powerful tool to further dissect the complex pathophysiological mechanisms that underlie the tissue s

175 Although the pathophysiological mechanisms that underlie this relatio

176 with reduced ejection fraction (HFrEF), the pathophysiological mechanisms underlying deterioration o

177 However, pathophysiological mechanisms underlying knowlesi malari

178 that understanding the dynamic nature of the pathophysiological mechanisms underlying psychiatric dis

179 The pathophysiological mechanisms underlying these abnormali

180 cific differences exist in the presentation, pathophysiological mechanisms, and outcomes in patients

181 We discuss pathophysiological mechanisms, clinical implications, an

182 Through its diverse pathophysiological mechanisms, cocaine exerts various ad

183 munosorbent assays and dissection of various pathophysiological mechanisms, including direct inhibiti

184 multiple sclerosis; however, its underlying pathophysiological mechanisms, including its link to inf

185 r, but sometimes species-dependent different pathophysiological mechanisms, prompting the specific cl

186 ectual disability might generate "secondary" pathophysiological mechanisms, which are prone to become

187 ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heter

188 hare some common risk alleles, and therefore pathophysiological mechanisms, with cases without the sa

189 mechanistic understanding of the underlying pathophysiological mechanisms.

190 r and supports the hypothesis of overlapping pathophysiological mechanisms.

191 rovided valuable insight into the underlying pathophysiological mechanisms.

192 nd warrants investigations of the underlying pathophysiological mechanisms.

193 e that mast cells may represent an important pathophysiological mediator in sleep and energy homeosta

194 In both physiological and pathophysiological microenvironments, the O2 concentrati

195 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission.

196 based on risk factors reflecting a plausible pathophysiological model for VRE BSI in patients with he

197 These findings are interpreted in terms of a pathophysiological model of SDB in which hypoxia-mediate

198 Developmentally sensitive pathophysiological models are needed to guide treatment

199 istic inferences regarding physiological and pathophysiological neural communication may be made from

200 rve modulation to attenuate or reverse these pathophysiological outcomes and restore autonomic homeos

201 Early events initiating the pathophysiological outcomes of IgG binding to astrocytic

202 mood, and the immune system, as well as the pathophysiological outcomes of vagus nerve dysfunction r

203 The pathophysiological overlapping between Sjorgen's Syndrom

204 with drusen area may provide new insights in pathophysiological pathways underlying different stages

205 s in multiple biomarkers reflecting distinct pathophysiological pathways, accounting for differences

206 To determine the underlying pathophysiological pathways, we characterized macrophage

207 A total of 48 biomarkers, assessing multiple pathophysiological pathways, were measured in 2033 patie

208 our multi-parametric analysis defined common pathophysiological patterns linked to clinical outcome o

209 each individual parameter and revealed some pathophysiological patterns that accurately allow defini

210 rapeutic advances specifically targeting the pathophysiological perturbations that develop in this pa

211 we focused on oxidative stress since it is a pathophysiological process commonly occurring in experim

212 lamydial infection are key components of the pathophysiological process of fibrogenesis; these target

213 ive oxygen species (ROS), a hallmark of many pathophysiological process, is imperative to both unders

214 ylases, known to be involved in a variety of pathophysiological processes and thus remain promising t

215 Many pathophysiological processes are associated with prolife

216 aterial and to model human embryogenesis and pathophysiological processes are leading to new insights

217 ine are stratification by risk, detection of pathophysiological processes as early as possible (even

218 ysiological functions of FAO and discuss the pathophysiological processes associated with FAO disorde

219 normalities detected at 7T appear to reflect pathophysiological processes beyond epileptogenesis.

220 Many different genes and pathophysiological processes contribute to the disease,

221 e studies are needed to characterize whether pathophysiological processes delineated by these biomark

222 sults show that zebrafish mimics most of the pathophysiological processes described in humans and mam

223 Whether GPCRs in endosomes control pathophysiological processes in vivo and are therapeutic

224 ies to a number of physiological systems and pathophysiological processes including ischaemia-reperfu

225 elopment of potential targets to control the pathophysiological processes of cell survival.

226 been implicated in the regulation of various pathophysiological processes of the skin that include im

227 rocesses in some cases, it may reflect other pathophysiological processes such as abnormalities in ce

228 ants in a diverse range of physiological and pathophysiological processes such as host defense, regul

229 uggests that miRNAs may be implicated in the pathophysiological processes taking place the hearts of

230 to diastolic dysfunction, functional class, pathophysiological processes, and prognosis.

231 and IGF2 and plays an important role in many pathophysiological processes, including gut mucosal adap

232 nvolved in a wide range of physiological and pathophysiological processes, including pain and anxiety

233 EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascu

234 ogenous RAGE ligands/effectors in normo- and pathophysiological processes, summarizes the current sta

235 crucial roles in mediating physiological and pathophysiological processes, yet Ca(2+) dynamics local

236 s, suggests its potential role in peripheral pathophysiological processes.

237 biological functions, metabolic pathways and pathophysiological processes.

238 ation whose changes reflect different tissue pathophysiological processes.

239 plasticity of HSCs during physiological and pathophysiological processes.

240 are involved in different physiological and pathophysiological processes.

241 lay critical roles in many physiological and pathophysiological processes.

242 tant regulators of diverse physiological and pathophysiological processes.

243 estinal microbiota in many physiological and pathophysiological processes.

244 This ex vivo system recapitulates the pathophysiological progression from APC-mutant neoplasia

245 attern which may suggest specific underlying pathophysiological relationships.

246 essential quality-control (QC) mechanism of pathophysiological relevance in mammals.

247 pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepa

248 colon tissue and whole animal and reveal the pathophysiological relevance of Sam68-dependent NF-kappa

249 tations were associated with autism, but the pathophysiological relevance of these mutations is often

250 The pathophysiological relevance of this observation is sugg

251 Our findings support the potential pathophysiological relevance of TRX in celiac disease an

252 Pathophysiological relevance was demonstrated when the c

253 logical protective response, and when it has pathophysiological relevance.

254 ix metalloproteinases underscores the data's pathophysiological relevance.

255 ity of disease-linked SNPs have unidentified pathophysiological relevance.

256 s system have served as the primary focus of pathophysiological research in the functional gastrointe

257 d highlights potential directions for future pathophysiological research.

258 y review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive v

259 undamental role in several physiological and pathophysiological responses, therefore are attractive d

260 rgic 1 and 2 (P1 and P2)-to modulate crucial pathophysiological responses.

261 re, the trkB.T1 receptor plays a significant pathophysiological role after SCI, and may provide a nov

262 dy is warranted to determine their potential pathophysiological role in cocaine addiction.

263 In conclusion, TRIB3 has a pathophysiological role in diabetes and a physiological

264 Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathoph

265 wn phenotype of CTEPH, including the pivotal pathophysiological role of impaired vascular endothelial

266 lso their main effector target; however, the pathophysiological role of mitochondria in ADPKD remains

267 ions, a function which may contribute to the pathophysiological role of neuroligins in brain disorder

268 However, the pathophysiological role of potassium channel subfamily K

269 ic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear.

270 may therefore allow the investigation of the pathophysiological role of these dimers.

271 The pathophysiological role of this process is unknown.

272 and fMRI, boosting confidence in a possible pathophysiological role.

273 rance of evidence supports developmental and pathophysiological roles for the MET receptor tyrosine k

274 opic physiological roles in normal cells and pathophysiological roles in cancer.

275 ll types are crucial for understanding their pathophysiological roles in human diseases.

276 the gingival tissue with periodontitis, its pathophysiological roles in periodontitis remain unclear

277 ld be a versatile tool for investigating the pathophysiological roles of lymphocytes in various disea

278 study opens new avenues to understanding the pathophysiological roles of mGlu heterodimers.

279 nsidered when analyzing the physiological or pathophysiological roles of serotonin in tissues where 5

280 This pathophysiological sequence of events underscores the ro

281 Angiogenesis in pathophysiological settings reactivates signaling pathwa

282 icles (NPs), which when combined with unique pathophysiological signatures in the tumor microenvironm

283 However, the pathophysiological significance of its activity is not w

284 Despite its pathophysiological significance, the origin and paracrin

285 gy is important in a variety of cellular and pathophysiological situations; however, its role in immu

286 cosylation profiles may be indicative of the pathophysiological state of the patients.

287 (P2X7R) for ATP is a therapeutic target for pathophysiological states including inflammation, pain m

288 in lymphoid organs, which can be altered in pathophysiological states, modulates humoral immunity.

289 scular disease and are associated with other pathophysiological states.

290 hesion of the blood-brain barrier in several pathophysiological states.

291 Evidence suggests that the pathophysiological stress response to severe burn trauma

292 nce of including appropriate controls in all pathophysiological studies using this means of induction

293 arer understanding of true physiological and pathophysiological substrates of GSK3 should provide opp

294 l implications and raise the hypothesis that pathophysiological tau loss-of-function favors brain ins

295 The molecular mechanisms responsible for the pathophysiological traits of type 2 diabetes are incompl

296 However, a pathophysiological transformation of astrocytes does not

297 In addition, proteomic profiling may inform pathophysiological understanding and point to novel ther

298 This model may reveal a better pathophysiological understanding of how PE transitions t

299 port to the community, in aiding the further pathophysiological understanding of P. aeruginosa biofil

300 Ps) has shed light on disease mechanisms and pathophysiological variability in some cases.