ライフサイエンスコーパス: permanently

1 ibers without affecting absolute sensitivity permanently.

2 maculopathies that can reduce central vision permanently.

3 s in which the investigated molecule changes permanently.

4 eficits that affect humans and other mammals permanently.

5 tively repairing or replacing damaged joints permanently.

6 o halt or exit the cell cycle temporarily or permanently.

7 ogies that prevent content from being stored permanently.

8 thyroid function of neonates transiently or permanently.

9 ergoing intubation elected to keep the stent permanently; 34% (n = 22) had an eyelid-tightening proce

10 e classical tumor suppressors that are often permanently abrogated during tumorigenesis.

11 The original data will be easily and permanently accessible via the University of Cambridge d

12 shape change, the CAN structure responds by permanently adjusting its structure through either rever

13 Ischemic injuries permanently affect kidney tissue and challenge cell viab

14 Permanently affecting one in seven adults, tinnitus lack

15 t developmental chronic circadian disruption permanently affects somatic and behavioral development i

16 n, and that a history of stress exposure can permanently alter gene expression patterns in the hippoc

17 rgeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) m

18 anthropogenic inputs to natural systems may permanently alter the natural signatures of REE, motivat

19 ich was found to be the most consistent gene permanently altered by smoking in the three sets.

20 Permanently altered DAergic function as a consequence of

21 Permanently altered tumor endothelial cells may represen

22 terrestrial chemical weathering flux may be permanently altered--contrasting with the conventional v

23 ormation, and a single course of antibiotics permanently alters CCM susceptibility in mice.

24 manipulation of CB(1) cannabinoid receptors permanently alters cholinergic projection neuron identit

25 Pregnancy permanently alters maternal anatomy, physiology and immu

26 ut primary amino groups [R-NH2 ] and becomes permanently anchored via a tetrahedral iminosulfur(VI) l

27 nt protein were microinjected into the PB to permanently and selectively disrupt Vglut2 expression wh

28 her the selfie was shared temporarily versus permanently) and are instead driven by the disinhibition

29 ng a Sericomyrmex fungus-growing ant host, a permanently associated parasitic guest ant of the genus

30 ly, is the only member of this group that is permanently associated with the spliceosome, thus requir

31 All 45 subjects lived permanently at 3200-4000 m.

32 Among ex-smokers who had stopped permanently at ages 25-34 years or at ages 35-44 years,

33 5 and 8.5, but two leaks did not self-repair permanently at pH 11.0 suggesting that water chemistry m

34 aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstr

35 Cells remain permanently attached following mitosis, giving rise to c

36 pe specimens to which the name of a taxon is permanently attached.

37 the Oligocene (27 Mya), all parts of the JMM permanently became part of the Eurasian plate following

38 arctic clam Laternula elliptica lives almost permanently below 0 degrees C and therefore is a valuabl

39 Research in permanently blind individuals has revealed brain reorgan

40 ly to what has been observed in congenitally permanently blind individuals.

41 actions, the unpaired cysteine-34 of HSA was permanently blocked by iodoacetamide and the primary ami

42 promote killing; and 3) surfaces containing permanently bonded agents that generate antimicrobial su

43 f cement proteins (CPs) that organize into a permanently bonded layer displayed as nanoscale fibers.

44 However, permanently bonding some or all of the complementary pai

45 e is typically a monolithic integration that permanently bonds acoustic transducers with microfluidic

46 it functions like a GIRK4 subunit with Na(+) permanently bound.

47 als can temporarily be carried off course or permanently carried away from their preferred habitat by

48 g to secondary interactions of the analytes' permanently charged quaternary ammonium head or hydropho

49 Hofmeister effects in Ca2+/Na+ exchange on a permanently charged surface over a wide range of ionic s

50 DAD is not permanently charged, and the uncharged form enables the

51 Both trials were permanently closed.

52 imonas, are isolated for the first time from permanently cold marine sediments.

53 with systemic pathogens that transiently or permanently colonize the oral environment.

54 Ladahk were among the last habitable places permanently colonized by prehistoric humans due to the c

55 Sensory deprivation during these periods permanently compromises an organism's ability to perceiv

56 he results show that K4Nb6O17 nanolamina can permanently confine the toxic cations within the interla

57 offs evolve, and whether they transiently or permanently constrain virus adaptation.

58 In contrast, EPCS permanently controlled bleeding in 97% and 100% of the p

59 r goal-directed movements, their accuracy is permanently controlled by adaptation mechanisms that, in

60 f this technology is that genome editing can permanently correct disease-causing mutations and circum

61 y and community composition of fungi in five permanently covered lake basins located in the Taylor an

62 Here, we demonstrate that permanently cross-linked hydrogels can be engineered to

63 hese advancements, achieving self-healing in permanently cross-linked hydrogels has remained elusive

64 w their long-term survival can be induced to permanently cure type 1 diabetes.

65 uses of IDA, 64% to 75% of such patients are permanently cured by H pylori eradication.

66 etching across its thickness, resulting in a permanently curved shape.

67 H) can lead to fibrosis and cirrhosis, which permanently damage the liver.

68 or T cell production can be dramatically and permanently damaged after a single relatively low TBI do

69 marrow stroma cells (BMSCs) are severely and permanently damaged by the pre-conditioning irradiation

70 The affected joints are often rapidly and permanently damaged despite antibiotic treatment, indica

71 orter than drought recovery time, leading to permanently damaged ecosystems and widespread degradatio

72 tress by locking damaged exocrine cells in a permanently de-differentiated state.

73 impurities cause these catalyst particles to permanently deactivate.

74 l cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye

75 All patients who were permanently dependent on PN and underwent a SRSB between

76 l bowel transplantation in patients with SBS permanently dependent on PN.

77 ts with short bowel syndrome (SBS) who were "permanently" dependent on parenteral nutrition (PN) and

78 using rhesus macaques (RMs) selectively and permanently depleted of CD4(+) T(N) before SIV infection

79 y and map topology occur normally in animals permanently deprived of mechanosensory activity.

80 currently with peptide self-assembly without permanently destroying the hydrogel's architecture and r

81 Covalent capture of oxidized PTP1B could permanently disable the intracellular pool of enzyme inv

82 emble into large multi-mRNP assemblies or be permanently disassembled and degraded.

83 ial fibrillation patients who temporarily or permanently discontinued anticoagulation, the risk of st

84 brillation (RELY-ABLE) trial if they had not permanently discontinued study medication at the time of

85 No patient permanently discontinued the active drug.

86 One patient permanently discontinued treatment because of an adverse

87 No patient permanently discontinued treatment because of liver abno

88 lated adverse event; of these patients, nine permanently discontinued treatment.

89 onRI complexes, such allergic effector cells permanently display allergen-specific IgE on their surfa

90 ntensity monopolar pulsed electric fields to permanently disrupt cell membranes within a well-defined

91 We find that the binocular matching is permanently disrupted in mice that have a precocious cri

92 We permanently disrupted the below-ground transfer of recen

93 rbing axon projection beyond postnatal day 7 permanently disrupts targeting specificity of the sensor

94 throughout experiments, indicating they were permanently docked dead-end vesicles.

95 oma cells deficient for TF remain viable but permanently dormant at the injection site for nearly a y

96 arget genes independently of HOCl stress and permanently down-regulates intracellular iron levels.

97 ant pairs who migrated out of the study area permanently during the trial period.

98 T cells in which the CCR5 gene was rendered permanently dysfunctional by a zinc-finger nuclease (ZFN

99 ntified multiple pathways which appear to be permanently dysregulated in UC patients at formerly acti

100 the metastatic behavior of primary tumors by permanently 'educating' bone marrow progenitors through

101 We developed a noninvasive method to permanently eliminate circadian rhythms in Siberian hams

102 Finally, mutations that permanently eliminate the pathways leading to alternativ

103 esent strong evidence that WDPS females have permanently emigrated to the East, reproducing at two 'm

104 of triggering unrestrained proliferation of permanently engineered T cells raises safety concerns th

105 ly-life pheromone exposure are sufficient to permanently enhance specific avoidance responses.

106 sponse through various defined mechanisms to permanently eradicate disseminated cancer.

107 ing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues.

108 tion I: the initially formed wrinkles can be permanently erased and never reappear; and (3) irreversi

109 d that sexual phenotypes formed in utero are permanently established and do not require maintenance.

110 The 2.25-m flood height is permanently exceeded by 2280-2300 for scenarios that inc

111 ions wherein the IgM-producing Cmu exons are permanently excised from the B-cell genome.

112 study has data for whether a child has been permanently excluded from school up to the age of 8 year

113 , after which the majority of cardiomyocytes permanently exit cell cycle.

114 any cellular constituents in the human brain permanently exit from the cell cycle during pre- or earl

115 onal nuclei that reside in an aged brain had permanently exited from the cell cycle during prenatal d

116 ess, accumulated irreparable DNA damage, and permanently exited the cell cycle after transient exposu

117 ey then re-enter the cell cycle before later permanently exiting.

118 ding site or a cytosolic tripeptide sequence permanently expose the alpha-arrestin-targeted region so

119 The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is

120 andomly integrate into plant chromosomes and permanently express encoded transgenes, a process known

121 tent retroviruses can be used in axolotls to permanently express markers or genetic elements for func

122 r basal state, recognize transporter regions permanently facing the cytosol or unveiled during transp

123 ross-linking of the B compartments allows to permanently fixate the phase-separated state and dissolu

124 of note was that executive boards may not be permanently fixed as either unsupportive or supportive a

125 hology collections I show that nematodes are permanently fixed in shells for hundreds of years and th

126 nhancement, making PAiRFPs advantageous over permanently fluorescent probes for in vivo imaging condi

127 al and temporal sensitivity in comparison to permanently fluorescent small molecules, represent power

128 Globular proteins are not permanently folded but spontaneously unfold and refold o

129 most common type of DNA damage, as they are permanently formed in living cells due to erroneous inse

130 geographic ranges of arctic megafauna became permanently fragmented after stable, interglacial climat

131 cumulation of fructose 1,6-bisphosphate in a permanently frozen solution as followed over months.

132 e argue that UV(254) treatment of aggregates permanently fused a fraction of viruses, which increased

133 lling the health authorities for action, and permanently generating educational activities.

134 that infection leads to the establishment of permanently growing lymphoblastoid cell lines, whereas C

135 leads to an accumulation of DNA damage that permanently halts beta-cell proliferation and dramatical

136 ugs, which bind with protein targets but not permanently, have been gaining attention because of thei

137 y share an allele at only one locus, or fuse permanently if they share an allele at both genes [5, 9]

138 Permanently immature dendritic cells were generated from

139 es plants to establish a vegetative cover to permanently immobilize contaminants in the rooting zone,

140 elease, a histone H2B-Chk1 chimera, which is permanently immobilized in chromatin, is unable to promo

141 The presence of permanently immobilized ion centers in ICOFs enables the

142 es to sparingly soluble oxides and, thereby, permanently immobilizing them.

143 rbances in this process would be expected to permanently impact lung structure and might predispose t

144 e during adolescence, but not adulthood, may permanently impair cognition and increase the risk for p

145 Since it may permanently impair erectile function, it must be managed

146 an also form debilitating adhesions that may permanently impair hand function.

147 gen-specific antibody responses but does not permanently impair their development or induce tolerance

148 ons and their projections are profoundly and permanently impaired.

149 s; however, the fertility of patients can be permanently impaired.

150 ivation of pattern vision (BD) early in life permanently impairs global motion perception.

151 g System (CardioMEMS, Atlanta, Georgia) is a permanently implantable pressure measurement system desi

152 Here we describe a minimally invasive, permanently implantable window for high-resolution intra

153 electromechanical system pressure sensor was permanently implanted in all participants during right h

154 lled by recordings made from microelectrodes permanently implanted in the brain.

155 wel symptoms during the trial phase and were permanently implanted.

156 other sexual dimorphisms, drug metabolism is permanently imprinted by perinatal hormones, resulting i

157 or Ku expression, we found that cells arrest permanently in G2 phase when Ku expression is turned off

158 Transmural stents were left permanently in situ in DPDS patients from 2008 onwards.

159 xhibited by nonswitching proteins, which are permanently in the on-state; when these bind to DNA nons

160 ereafter (time 3: cardiogenic shock excluded permanently) in New York and compared with Michigan.

161 uorescent protein expression, transiently or permanently, in cells that survive caspase-3 activation

162 ecision medicine strategy to selectively and permanently inactivate only mutant, not normal allele, c

163 me period in wild-type (WT) is sufficient to permanently induce a seizure behavior.

164 gesting that fetal nutritional exposures may permanently influence bone development.

165 Many animals permanently inhabit the marine interstitium, the space b

166 unct PV neurons in the generation of TLE, we permanently inhibited GABA release selectively from PV n

167 It is based on perforated access tubes (ATs) permanently installed in the soil.

168 Highly stable permanently interlocked aryleneethynylene molecular cage

169 Photooxygenation of permanently interlocked squaraine rotaxanes with anthrac

170 d structures by external fields can be bound permanently into stiff chains through electrostatic or v

171 y, we generated GFAP-CreER(TM);tdRFP mice to permanently label reactive astrocytes.

172 ently, transplantation experiments involving permanently labeled cells revealed multipotent neural st

173 progenitors undergoes CRE/lox recombination, permanently labeling their progeny.

174 ombination with a reporter mouse line (Ai9), permanently labels a cell population, termed 'SMA9'.

175 re)R26R(eYFP) mice, the fluorescent reporter permanently labels cells that have switched on Il22 expr

176 Male mice permanently lacking 5-HT2B receptors, even restricted to

177 sociated with individuals who temporarily or permanently left employment because of illness.

178 ay-old rat pups had the right carotid artery permanently ligated followed by 160min of hypoxia (8% ox

179 These metadata are then validated and permanently linked to archived genetic data stored in th

180 for independent movements of the digits was permanently lost after a complete, bilateral lesion of t

181 Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished.

182 a afferent synapses and stretch reflexes are permanently lost, even after regeneration and reinnervat

183 nt hosts and that immunological tolerance is permanently lost.

184 This study investigated the role of a permanently manned Australian Antarctic research station

185 However, not all PAs remain intact permanently; many PAs undergo downgrading, downsizing an

186 we used an inducible Atoh1(CrePR) allele to permanently mark Atoh1-expressing cells at different dev

187 in mice and then bred with reporter lines to permanently mark cell lineage.

188 rowth of 97 199 individual trees within 1070 permanently marked inventory plots as a function of tree

189 facilitates the study of neural circuits by permanently marking cells active during user-specified t

190 facilitates the study of neural circuits by permanently marking cells active during user-specified t

191 itive moiety yields an "ion integrator" that permanently marks cells undergoing high Ca(2+) flux duri

192 glucocorticoid receptor and degradation of a permanently misfolded protein, two previously defined ro

193 pre-1950, most (74%) of the sea floor in the permanently mixed area off East Anglia was within the ph

194 ngs suggest that tumor endothelial cells are permanently modified compared with normal counterparts.

195 ing a stage of development when activity can permanently modify circuit structure and function.

196 posons offer an efficient nonviral method of permanently modifying the genomes of mammalian cells.

197 Therefore, the global SAT will not remain permanently neutral.

198 inding mutants of kinesin-1 as roadblocks to permanently obstruct individual microtubule binding site

199 of control compounds whose PET processes are permanently "on" or "off".

200 state, i.e. in the absence of DctA, DcuS is permanently "on", but its activity is C4-diC-dependent w

201 a drastic gain-of-function effect leading to permanently open channels.

202 to the formation of a channel that is quasi-permanently open.

203 lanted for hereditary HLH (2000-2013) and DC permanently or transiently <75% (overall, CD3(+), CD56(+

204 ay initiate nests, join nests temporarily or permanently, or abandon nests.

205 ental factors, including air pollutants, may permanently organize these systems toward trajectories o

206 d inactivation, whereas a Cys residue can be permanently overoxidized to the sulfinic acid form, and

207 rasting depositional regimes: Zaka Bay, with permanently oxic bottom and station D, where anoxic cond

208 ermediate is stabilized in MauG and does not permanently oxidize its own aromatic residues.

209 Aphids that are anholocyclic (permanently parthenogenetic) or are monoecious (non-host

210 th large three-dimensional channels that are permanently porous and chemically stable offers new oppo

211 The permanently porous crystal architecture is sustained by

212 Zn2(TTFTB) represents the first example of a permanently porous MOF with high charge mobility and may

213 network is stable up to 425 degrees C and is permanently porous to CO(2) with an apparent BET surface

214 These COFs are crystalline, permanently porous, and stable in boiling water, acid (9

215 A permanently porous, three-dimensional metal-organic mate

216 t organic frameworks (COFs) are crystalline, permanently porous, two-dimensional or three-dimensional

217 (i) stable to the removal of solvents, (ii) permanently porous, with surface areas of ~1200 m(2) g(-

218 Patch formation is reversible but can be permanently preserved using a photocrosslinking step.

219 s and then freeze them into solid particles, permanently preserving their shape.

220 ere, we used DcxCreER(T2) transgenic mice to permanently pulse-label age-defined cohorts of granule c

221 the recombinases can be layered and used to permanently record the transient state of a transcriptio

222 of an inactive, dsRNA-binding mutant can be permanently recorded by the input-responsive action of a

223 Certain larval traits of reef fishes are permanently recorded in the rings in their otoliths.

224 We describe a method for permanently recording protein-DNA interactions in mammal

225 te that apartment-level billing and metering permanently reduce EEC by about 25%.

226 ple doses of ivermectin may cumulatively and permanently reduce the fertility and shorten the lifespa

227 gue, and syncope because of a temporarily or permanently reduced heart rate.

228 least 2% of most populations and can lead to permanently reduced vision if not detected and treated w

229 uring pregnancy and lactation in mice, which permanently reduces endocannabinoid levels in the offspr

230 of older people (aged >/=65 years) who were permanently registered with a general practice in three

231 chemotherapeutic, gemcitabine, the treatment permanently remodels the tumor microenvironment and cons

232 The renewed effort to eliminate malaria and permanently remove its tremendous burden highlights ques

233 ecause of a continuous leak, Na(+) has to be permanently removed from the intracellular milieu, a pro

234 licles (FR), a procedure that completely and permanently removes whisker-sensory input.

235 The creation of a transplantable graft to permanently replace kidney function would address donor

236 ed bacterial carbohydrates and phospholipids permanently reprograms the natural antibody repertoire d

237 oper control of vital reactions, NAD must be permanently resynthesized.

238 The shape of uncured gels can be permanently retained by templated UV-curing of the solve

239 mental homologs, stop growing, and are later permanently retracted.

240 ns' normal anterior-posterior pattern can be permanently rewritten by a brief perturbation of endogen

241 al structure to heal and, in many instances, permanently seal the damaged location.

242 cessfully launch polio endgame activities to permanently secure and sustain the enormous gains of pol

243 e, which lack alphaCaMKII or which express a permanently self-inhibited alphaCaMKII (alphaCaMKII(T305

244 bind to a capture or competitor DNA strand, permanently separating it from the BHQ-modified reporter

245 Zealand became the last major landmass to be permanently settled by humans.

246 Measurements of surface reflectance of permanently shadowed areas near Mercury's north pole rev

247 t the lunar volatile inventory in the Cabeus permanently shadowed region includes a water concentrati

248 esigned to search for evidence of water in a permanently shadowed region near the lunar south pole.

249 consistent with the presence of water ice in permanently shadowed regions.

250 tly impacts key developmental processes that permanently shape circuit function and behavior, as well

251 Genome duplication (GD) has permanently shaped the architecture and function of many

252 he importance of early sensory experience in permanently shaping brain function.

253 elopment when activity plays a large role in permanently shaping neural circuits, our data show how t

254 nn widget is incorporated into a website, it permanently shows timely relevant information as if it w

255 egulated subnuclear genome reorganization to permanently silence Hunchback target genes that results

256 K4me3 mark prevents the region from becoming permanently silenced and prepares the domain for activat

257 perfect piRNA target site can be rapidly and permanently silenced via RNAe.

258 NA-induced epigenetic silencing pathway that permanently silences single-copy transgenes.

259 he previously intact side before UL remained permanently silent during natural vestibular stimulation

260 dipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammato

261 We tested this prediction in a permanently social spider, Stegodyphus dumicola that app

262 thetic variants of CX3CL1 that remain either permanently soluble or membrane bound.

263 Here, we permanently stabilize the temperature response of isolat

264 large minority of resilient cooperators can permanently stabilize unravelling among a majority of ra

265 ferroelastic domains can be effectively and permanently stabilized by dislocations at the substrate

266 ion and transcription in the affected region permanently stall, so the failure of R-loop removal in R

267 65% (45 of 69) had a sustained reduction or permanently stopped >/= 1 concomitant treatment.

268 Emergency portacaval shunt permanently stopped variceal bleeding, almost never beca

269 olution depends on the ability to safely and permanently store CO2 This study demonstrates for the fi

270 to the atmosphere of C putatively considered permanently stored, thus challenging current models of l

271 e incremental oil from depleted fields while permanently storing large tonnages of injected CO2.

272 This major hydrothermal activity that permanently stratifies Lake Kivu today was initiated app

273 to long-lived lakes in preglacially formed, permanently subsiding geological basins.

274 anscriptionally silenced in the syncytium to permanently suppress its activity during all nematode pa

275 lation, demonstrating that CD8(+) dT are not permanently suppressed and retain the capacity to respon

276 .0%; PP 22.2%) had their device explanted or permanently switched off before 5 years.

277 disease-associated variant of human MDA5 is permanently switched on.

278 e by using a stable form of GFP (H2B-GFP) to permanently tag neurons that are active during contextua

279 blocks, the PEDOT chains are intimately and permanently tethered on the PbTe nanoparticle surface, t

280 rse ferroelectric nanoparticles directly and permanently tethered with ferroelectric polymers by capi

281 e river water compartment without increasing permanently the pumping losses.

282 ocessable, and have limited ability to alter permanently their stress state, topography, topology, or

283 ycle: when the manipulated host fixes itself permanently to a substrate by its mandibles.

284 nests at the field site and sometimes moving permanently to new nests should that offer better (inclu

285 Polylysine bound permanently to RG-II, precluding electrophoretic analysi

286 virus-based vectors is that they add nothing permanently to the environment.

287 D feeding, inflammation and gliosis returned permanently to the mediobasal hypothalamus.

288 al upward ice transport, which may therefore permanently trap them below the ice surface and explain

289 ation appears to occur through Ede1, because permanently ubiquitinated Ede1 phenocopies deletion of U

290 enotypes could be replicated by expressing a permanently ubiquitinated version of Ede1, the yeast Eps

291 of yield, where a material changes its shape permanently under external deformation, are not yet unde

292 atients who stopped dosing at week 12 either permanently under the original protocol, or temporarily

293 poptotic pathways in effector T cells and by permanently upregulating their IL-7 receptor expression,

294 Twenty patients (9%) became permanently visually impaired or blind in at least 1 eye

295 the minor antenna complexes were present in permanently weakly fluorescent states under most conditi

296 Rigidifying this contact permanently with a disulfide bridge disrupts ligand-indu

297 cated by soft-lithography in PDMS and bonded permanently with an oxygen plasma treatment.

298 Mammalian cardiomyocytes permanently withdraw from the cell cycle shortly after b

299 ill needlessly and potentially harm patients permanently without providing any significant benefit.

300 However, the influence of temperature was permanently written into tree-ring structure only for th