ライフサイエンスコーパス: phosphoinositide

1 ic binding to acidic phospholipids including phosphoinositides.

2 macological targeting of membrane-associated phosphoinositides.

3 CB is tethered to the membrane via phosphoinositides.

4 ion of its headgroup produces seven distinct phosphoinositides.

5 Phosphoinositide 3 kinase (PI3K) is a direct upstream ac

6 requires the multimodular B-cell adaptor for phosphoinositide 3-kinase (BCAP).

7 oughput virtual screening (HTVS) study using phosphoinositide 3-kinase (both PI3Kgamma and PI3Kdelta)

8 Phosphoinositide 3-kinase (PI3-K) is involved in both In

9 rain neuroblasts (NBs) in Drosophila utilize Phosphoinositide 3-kinase (PI3-kinase) and DE-cadherin t

10 RAS signalling through phosphoinositide 3-kinase (PI3-Kinase) has been shown to

11 led that platelet DREAM positively regulates phosphoinositide 3-kinase (PI3K) activity during platele

12 Phosphoinositide 3-kinase (PI3K) activity is stimulated

13 evels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased

14 (PTEN), a tumor suppressor that counteracts phosphoinositide 3-kinase (PI3K) activity, is one of the

15 fication or ligand overexpression maintained phosphoinositide 3-kinase (PI3K) and MEK/ERK signaling e

16 )/LYN complexes, which allows recruitment of phosphoinositide 3-kinase (PI3K) and phosphorylation of

17 Phosphoinositide 3-kinase (PI3K) and the proteasome path

18 Phosphoinositide 3-kinase (PI3K) beta signaling is requi

19 ficient of SHP2 binding (PDGFRalpha-F720) or phosphoinositide 3-kinase (PI3K) binding (PDGFRalpha-F73

20 Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)

21 120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the trea

22 Phosphoinositide 3-kinase (PI3K) is deregulated in a wid

23 Inhibitors of the class I phosphoinositide 3-kinase (PI3K) isoform PI3Kalpha have

24 to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110alpha and

25 but not by AG1478, indicating that Gi/o and phosphoinositide 3-kinase (PI3K) mediate the increase in

26 Because regulation of the phosphoinositide 3-kinase (PI3K) pathway is critical for

27 Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely i

28 The phosphoinositide 3-kinase (PI3K) pathway plays an integr

29 The phosphoinositide 3-kinase (PI3K) pathway regulates multi

30 ubtype frequently harbors aberrations in the phosphoinositide 3-kinase (PI3K) pathway, raising the po

31 Effectors of the phosphoinositide 3-kinase (PI3K) signal transduction pat

32 Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are f

33 hanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (PI3K) signaling.

34 of insulin-like growth factor-1R/INSR-driven phosphoinositide 3-kinase (PI3K) signaling.

35 Ralpha), produced in tumour cells, activates phosphoinositide 3-kinase (PI3K) signalling by binding t

36 d mGluR I subsequently induces activation of phosphoinositide 3-kinase (PI3K) through phosphorylation

37 Both myosin II and phosphoinositide 3-kinase (PI3K) were found to hold stri

38 tic signaling by the pre-TCR/Notch effector, phosphoinositide 3-kinase (PI3K), and by inositol-trisph

39 of mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulat

40 ncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs

41 The phosphoinositide 3-kinase (PI3K), which phosphorylates p

42 inase 1 (PDK1) is a pivotal regulator in the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway t

43 bly, nearly all KRAS deficient cells exhibit phosphoinositide 3-kinase (PI3K)-dependent mitogen-activ

44 We hypothesized that a phosphoinositide 3-kinase (PI3K)-dependent signaling pat

45 iphosphate at the plasma membrane to enhance phosphoinositide 3-kinase (PI3K)-dependent tumor cell in

46 red systolic contractility and activated the phosphoinositide 3-kinase (PI3K)-pathway in the heart.

47 Genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway are the mos

48 tly contributes to activating the consequent phosphoinositide 3-kinase (PI3K)/Akt signaling pathway.

49 w that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, r

50 n the liver, a process mediated by the IL-23/phosphoinositide 3-kinase (PI3K)/mammalian target of rap

51 activities of bone morphogenetic protein and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)

52 Moreover, a Phosphoinositide 3-kinase (PI3K)alpha inhibitor disrupte

53 Classically Class IB phosphoinositide 3-kinase (PI3Kgamma) plays a role in ex

54 rmacologic targeting of the gamma isoform of phosphoinositide 3-kinase (PI3Kgamma), highly expressed

55 Mutations in the catalytic subunit of phosphoinositide 3-kinase (PIK3CA) and other PI3K-AKT pa

56 Our findings suggest that phosphoinositide 3-kinase activation promotes PKM2 phosp

57 subtype that showed increased sensitivity to phosphoinositide 3-kinase and fibroblast growth factor r

58 ifloxacin, an IKr blocker with no effects on phosphoinositide 3-kinase and INa-L prolonged APD acutel

59 ics of chemoattractant-induced activation of phosphoinositide 3-kinase and Rac effectors.

60 Also, inhibition of phosphoinositide 3-kinase but not NF-kappaB had a simila

61 The protein expression of phosphoinositide 3-kinase catalytic subunit PI3K(p110alp

62 Aberrant signaling of phosphoinositide 3-kinase delta (PI3Kdelta) has been imp

63 Inhibition of phosphoinositide 3-kinase delta (PI3Kdelta) is an appeal

64 n-of-function variants in the genes encoding phosphoinositide 3-kinase delta (PI3Kdelta) lead to accu

65 Phosphoinositide 3-kinase enhancer (PIKE) is a group of

66 Phosphoinositide 3-kinase gamma (PI3Kgamma) is an attrac

67 Using an established enzyme phosphoinositide 3-kinase gamma, we discuss the insights

68 as independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic act

69 cted findings cast doubt over the utility of phosphoinositide 3-kinase inhibition in acute respirator

70 to include time and INa-L in evaluating the phosphoinositide 3-kinase inhibition-derived proarrhythm

71 phenotype of patient cells was resistant to phosphoinositide 3-kinase inhibition.

72 nal phenotype, and this could be reversed by phosphoinositide 3-kinase inhibitors.

73 location biosensor for signaling through the phosphoinositide 3-kinase pathway, along with a cytosoli

74 either mitogen-activated protein kinases or phosphoinositide 3-kinase prevented the MP-induced endot

75 sely to sepsis and burns datasets but not to phosphoinositide 3-kinase signatures.

76 For example, the PI3K (phosphoinositide 3-kinase) pathway connected to the prod

77 PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-act

78 e findings further support engagement of the phosphoinositide 3-kinase-AKT signaling axis by H-Ras.

79 is response was mediated in part through the phosphoinositide 3-kinase-AKT signaling pathway.

80 Here, we studied the function of class II phosphoinositide 3-kinase-C2alpha (PI3K-C2alpha) in rena

81 Duvelisib is an oral dual inhibitor of phosphoinositide 3-kinase-delta (PI3K-delta) and PI3K-ga

82 estin-1 to the plasma membrane, and promoted phosphoinositide 3-kinase-dependent activation of protei

83 The enhanced respiratory burst was phosphoinositide 3-kinase-dependent but delayed apoptosi

84 enhances the glycine-activated current in a phosphoinositide 3-kinase-dependent manner, a positive f

85 tion of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like kinases ATM (ataxia telan

86 ghly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family a

87 pression of insulin receptor substrate 1 and phosphoinositide 3-kinase.

88 utation in p110alpha, a catalytic subunit of phosphoinositide 3-kinase.

89 ate sodium current (INa-L) via inhibition of phosphoinositide 3-kinase.

90 ity, but this was not mediated by inhibiting phosphoinositide 3-kinase.

91 s/extracellular signal-regulated kinase 1/2, phosphoinositide 3-kinase/AKT and signal transducer and

92 ha (HIF-1alpha) stabilization, including the phosphoinositide 3-kinase/Akt pathway, Siah1, and Siah2,

93 First, phosphoinositide 3-kinase/Akt signaling is hyperactivate

94 n through phosphatase and tensin homolog and phosphoinositide 3-kinase/Akt signaling pathways.

95 of HCK reduced survival and attenuated BTK, phosphoinositide 3-kinase/AKT, and mitogen-activated pro

96 Rac1 and downregulating p22(phox) through a phosphoinositide 3-kinase/Akt-mediated mechanism.

97 ion of mitogen-activated protein kinases and phosphoinositide 3-kinase/Akt.

98 In this study, we tested whether the dual phosphoinositide 3-kinase/mechanistic target of rapamyci

99 resulted in dose-dependent inhibition of the phosphoinositide 3-kinase/mechanistic target of rapamyci

100 Phosphoinositide 3-kinase/PI3K functioned as an essentia

101 Furthermore, LMP1 activated and triggered phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pa

102 ion, and invasion of Huh-7 cells through the phosphoinositide 3-kinase/protein kinase B pathway and i

103 through the aberrant expression of the TYRO3/phosphoinositide 3-kinase/protein kinase B signal transd

104 everal signal transduction pathways, such as phosphoinositide 3-kinase/protein kinase B, which are cr

105 inflammatory molecules and the activation of phosphoinositide 3-kinases (PI3K) in a process that requ

106 e elucidation of the biological functions of phosphoinositide 3-kinases (PI3K) was realized years ago

107 The physiologic roles of the class II phosphoinositide 3-kinases (PI3Ks) and their contributio

108 Phosphoinositide 3-kinases (PI3Ks) are a family of lipid

109 The phosphoinositide 3-kinases (PI3Ks) are a family of lipid

110 Phosphoinositide 3-kinases (PI3Ks) are ubiquitous lipid

111 Phosphoinositide 3-kinases (PI3Ks) regulate several cell

112 lpha regulatory (PIK3R1) subunit of class IA phosphoinositide 3-kinases (PI3Ks).

113 implications for cancer treatments targeting phosphoinositide 3-kinases and Akt because they may impa

114 Inhibition of phosphoinositide 3-kinases, responsible for the synthesi

115 fy a kinase-independent function of class II phosphoinositide 3-OH kinase alpha (PI3K-C2alpha) acting

116 Mutations in the gene encoding the phosphoinositide 3-phosphatase myotubularin (MTM1) are r

117 e expansion phenotypes, and mutations in the phosphoinositide (3) phosphate kinase Fab1 that performs

118 In PC12 cells, inhibition of phosphoinositide-3 kinase (PI3K) activity blocked export

119 Phosphoinositide-3 kinase (PI3K) generates PtdIns(3,4,5)

120 SMG-1 is a phosphoinositide-3 kinase (PI3K) involved in mediating n

121 f activated AKT owing to the deregulation of phosphoinositide-3 kinase (PI3K) signaling, and depletio

122 Depletion of class II phosphoinositide-3 kinase alpha (PI3K C2A), but not inhi

123 racellular signal-regulated kinase 1/2, p38, phosphoinositide-3 kinase signaling pathways.

124 lated GRP78 then bound to VPS34, a class III phosphoinositide-3 kinase, consequently preventing the s

125 3-RAF1 aberrantly activate both the MAPK and phosphoinositide-3 kinase/mammalian target of rapamycin

126 tracellular signal-regulated kinase/RSK1 and phosphoinositide-3 kinase/mTOR pathway, which synergizes

127 Specifically, phosphoinositide-3 kinases (class I PI3Ks, beta and gamm

128 Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha

129 a fly-human cross-species comparison of the phosphoinositide-3-kinase (PI3K) interactome in a drosop

130 a clear degenerating axons slowly due to low phosphoinositide-3-kinase (PI3K) signalling and, subsequ

131 holipase C (PLC), protein kinase C (PKC) and phosphoinositide-3-kinase (PI3K), and subsequently to ph

132 4,5-trisphosphate (PIP3) by the lipid kinase phosphoinositide-3-kinase (PI3K).

133 s in PIK3R1 encoding a regulatory subunit of phosphoinositide-3-kinase (PI3K).

134 lls from patients treated with idelalisib, a phosphoinositide-3-kinase delta inhibitor recently appro

135 adding idelalisib, a first-in-class targeted phosphoinositide-3-kinase delta inhibitor, to bendamusti

136 Treatment with either the phosphoinositide-3-kinase inhibitor, LY294002 and pan-mT

137 on of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a

138 ve been proposed, such as activations of the phosphoinositide-3-kinase/Akt pathway and p38 mitogen-ac

139 ating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase alpha (PI3Kalpha), are frequ

140 allografts (Fib-MCs) demonstrated increased phosphoinositide-3kinase (PI3K) dependent activation of

141 erse membrane cargo by the tubby domain in a phosphoinositide 4,5-bisphosphate (PI(4,5)P2)-dependent

142 congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity that is becoming

143 ynamics is established by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e.

144 distribution is created by Inpp5e, a ciliary phosphoinositide 5-phosphatase.

145 ivity that phosphorylates the 3'-hydroxyl of phosphoinositides and a protein-kinase activity that inc

146 regulate the localization of PIP3 and PI(3)P phosphoinositides and Akt activation.

147 latelets have reduced intracellular pools of phosphoinositides and an 80% reduction in IP3 generation

148 The cleaved N-terminal domain binds phosphoinositides and cardiolipin, forms membrane-disrup

149 The orchestrated recognition of phosphoinositides and concomitant intracellular release

150 Two important identifiers are phosphoinositides and GTP-bound GTPases, which provide w

151 Phosphoinositides and phosphoinositide binding proteins

152 Phosphoinositides and phosphoinositide binding proteins

153 ors to obtain complexes of ion channels with phosphoinositides and to use computational and experimen

154 Phosphoinositides are small phospholipids that control d

155 demonstrate that phospholipids, specifically phosphoinositides, are important regulators of TRPV1 and

156 ion of the primary cilium and maintenance of phosphoinositide balance in nondividing cells.

157 Our study highlights a phosphoinositide-based mechanism for control of choleste

158 Phosphoinositides and phosphoinositide binding proteins play a critical role i

159 Phosphoinositides and phosphoinositide binding proteins play critical roles in

160 rates that VACV H7 displays a novel fold for phosphoinositide binding, which is essential for poxviru

161 pamycin-resistant mutants, we identify Pib2 (PhosphoInositide-Binding 2) as a master regulator of TOR

162 t P4-ATPase Drs2, ATP8A2 is not regulated by phosphoinositides but undergoes phosphorylation on the s

163 Although Ca(2+) is known to directly impact phosphoinositide clustering, little is known about the m

164 tecting' sensors that selectively report the phosphoinositide composition of clathrin-associated stru

165 s a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane.

166 senger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology.

167 demonstrate the possibility that switchable phosphoinositide conformational states can serve as lipi

168 Luminal pH and phosphoinositide content are fundamental features of org

169 Direct phosphoinositide control of the activity of ion channels

170 e of these sensors to follow the dynamics of phosphoinositide conversion during endocytosis.

171 ol 4,5-biphosphate (PIP2) is a cell membrane phosphoinositide crucial for cell signaling and activati

172 In summary, ebselen affects the phosphoinositide cycle and has CNS effects on surrogate

173 f membrane interactions and in the ranges of phosphoinositide densities that they sense.

174 ey do not require high "stimulus-responsive" phosphoinositide density for membrane binding.

175 of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and m

176 olipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and m

177 rturb multiple signalling pathways including phosphoinositide-dependent cytosolic calcium ([Ca(2+) ]i

178 The PI3K/phosphoinositide-dependent kinase (PDK) 1 pathway repres

179 and the phosphatidylinositol 3-kinase (PI3K)/phosphoinositide-dependent kinase 1 (PDK1) pathway.

180 Src signaling, leading to PI3K activation of phosphoinositide-dependent kinase 1 (PDK1).

181 We found that mice lacking the kinase phosphoinositide-dependent kinase 1 selectively lack LC.

182 5 min of training, in which phosphorylated 3-phosphoinositide-dependent kinase-1 (p-PDK1) is increase

183 Key steps of this process are (i) phosphoinositide-dependent membrane recruitment, (ii) FG

184 n of PIK3CA-driven HNSCC is facilitated by 3-phosphoinositide-dependent protein kinase (PDK1) and enh

185 In this manner, we identified 3-phosphoinositide-dependent protein kinase 1 (PDK1) as a

186 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a

187 volves formation of a protein complex with 3-phosphoinositide-dependent protein kinase 1 (PDK1).

188 sis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented

189 ith alpha2M*, CS-GRP78 signaling activates 3-phosphoinositide-dependent protein kinase-1 (PDK1) to in

190 TIPE2 functioned as a local enhancer of phosphoinositide-dependent signaling and cytoskeleton re

191 Membrane phosphoinositides, especially phosphatidylinositol 4,5-b

192 comparison, CID spectra of {LGa2}(5+)-bound phosphoinositides generally resulted in fragment ions co

193 This demonstrates a mechanism where a phosphoinositide-generating enzyme PIPKIgamma couples wi

194 Here, we show that phosphoinositide-generating enzyme, PIPKIgamma, expressi

195 sed of kinases, GTPases, and lipids, such as phosphoinositides, helps to coordinate all of these proc

196 Here, Sac1 participates in phosphoinositide homeostasis by limiting PM phosphatidyl

197 nthesis as a major regulatory junction in PM phosphoinositide homeostasis.

198 AR1 expression also enhanced agonist-induced phosphoinositide hydrolysis and endothelial barrier perm

199 4,5-bisphosphate, mimicking presence of this phosphoinositide in the prospore membrane.

200 In agreement, SEC3a-N interacted with phosphoinositides in vitro and colocalized with a phosph

201 keratinocytes depleted from WD repeat domain phosphoinositide interacting 1 or Unc-51 like autophagy

202 Genetic ablation of WD repeat domain, phosphoinositide-interacting protein 2 in B cells alone

203 Myo-inositol is the precursor of phosphoinositides, key signaling lipids including phosph

204 Here we report that PI5P4Kbeta, a phosphoinositide kinase that regulates PI(5)P levels, de

205 so caused a dramatic generalized decrease in phosphoinositide levels that was rescued by inositol sup

206 is gain-of-function activity shifts cellular phosphoinositide levels, hyperactivates the PI3K/Akt cel

207 Phosphatase and tensin homolog (PTEN) is a phosphoinositide lipid phosphatase and one of the most f

208 y of enzymes constituting a junction between phosphoinositide lipid signaling and the trans-membrane

209 cell-free system, we recently identified the phosphoinositide lipids (PIPs) phosphatidylinositol 3-ph

210 Phosphoinositide lipids (PPIs) are enriched in the nucle

211 Phosphorylated phosphoinositide lipids (PPIs) are low-abundance signali

212 ne trafficking requires coordination between phosphoinositide lipids, Rab GTPases, and microtubule-ba

213 However, the dynamics of phosphoinositide metabolism have not been analyzed in ne

214 We studied the dynamics of phosphoinositide metabolism in sympathetic neurons upon

215 velop a quantitative description of neuronal phosphoinositide metabolism.

216 velop a quantitative description of neuronal phosphoinositide metabolism.

217 hosphocholine membranes doped with different phosphoinositides on silicon/silicon dioxide substrates

218 to nitrocellulose membranes immobilized with phosphoinositides or sulfatide, but not with cardiolipin

219 ng a new perspective on the function of this phosphoinositide phosphatase in health and development.

220 FIG4 is a phosphoinositide phosphatase that is mutated in several

221 Synaptojanin (Synj), a phosphoinositide phosphatase, is known to play an import

222 The biological relevance of most of these phosphoinositide phosphatases in acute myeloid leukemia

223 Three different phosphoinositide phosphates (mono-, di-, and triphosphor

224 intensities obtained in positive ion-mode of phosphoinositide phosphates and phosphatidic acid bound

225 ons impaired phosphatase activity toward the phosphoinositide phosphatidylinositol (4,5)-bisphosphate

226 The membrane phosphoinositide phosphatidylinositol (PI) 4,5-bisphosph

227 naling that functions to dephosphorylate the phosphoinositide phosphatidylinositol 3,4,5-trisphosphat

228 es the integral membrane protein ATP1A1, the phosphoinositide phosphatidylinositol-4,5-bisphosphate (

229 teracts with a plasma membrane (PM)-specific phosphoinositide, phosphatidylinositol-(4,5)-bisphosphat

230 i trigger a signaling cascade culminating in phosphoinositide-phospholipase C (PLC) activation, which

231 mobile G-actin pool in spines depends on the phosphoinositide PI(3,4,5)P3 and involves the actin mono

232 Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger al

233 functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of p

234 mpared to serotonin in both calcium flux and phosphoinositide (PI) hydrolysis assays.

235 We find that phosphoinositide (PI) kinase signaling controls a conser

236 rane recruitment of TIRAP is mediated by its phosphoinositide (PI)-binding motif (PBM).

237 By phosphorylating the phosphoinositide- (PI) binding domain of Daple, Akt abol

238 astating pediatric neuromuscular disorder of phosphoinositide (PIP) metabolism resulting from mutatio

239 Although various phosphoinositides (PIPs) have been detected on phagosome

240 Phosphoinositides (PIs) are phospholipids that perform c

241 Plasma membrane (PM) phosphoinositides play essential roles in cell physiolog

242 Phosphoinositides play important roles in numerous intra

243 s4P during phagocytosis and suggest that the phosphoinositide plays important roles during the matura

244 SopE and SopB target MYO6 to coordinate phosphoinositide production at invasion foci, facilitati

245 Limiting phosphoinositide production leads to a blockage of the a

246 eclin 1-Vps34 complex and thereby inhibiting phosphoinositide production.

247 pids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of

248 tic variation affects expression of VAC14, a phosphoinositide-regulating protein, to influence suscep

249 rther exploring the mechanisms underlying PM phosphoinositide regulation.

250 n assembly factors Dia2 and N-WASP reside on phosphoinositide-rich membranes for longer periods to pe

251 ay transient, low-affinity interactions with phosphoinositide-rich membranes, whereas F-actin assembl

252 cular principles by which ABPs interact with phosphoinositide-rich membranes.

253 Studies have also shown that nuclear phosphoinositide(s) regulates processes such as mRNA exp

254 tion are currently known: (i) binding of the phosphoinositide second messenger PIP3, (ii) binding of

255 by TIPE2 (TNFAIP8L2), a transfer protein for phosphoinositide second messengers.

256 Phosphoinositides serve as key membrane determinants for

257 nally, in eukaryotes, the negatively charged phosphoinositides serve as key signals not only through

258 al point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains TZ fu

259 and PIP kinases serve as a proximal node in phosphoinositide signaling axis and how its interaction

260 des (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research.

261 Here, we review the phosphoinositide signaling axis in cancer, giving due we

262 The partially understood phosphoinositide signaling cascade regulates multiple as

263 d PI(4,5)P2, a technical issue hindering the phosphoinositide signaling field.

264 Phosphoinositide signaling has been implicated in the re

265 linositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells.

266 demonstrate that platelet PITPalpha-mediated phosphoinositide signaling is inconsequential for in viv

267 data suggest a general principle for how the phosphoinositide signaling landscape is physically bit m

268 Here, we show that the phosphoinositide signaling modulated by phosphatidylinos

269 Calcium and phosphoinositide signaling regulate cell division in mod

270 and talin together control the adhesion and phosphoinositide signaling that regulates conversion to

271 that hijack the host actin cytoskeleton and phosphoinositide signaling to drive pathogen invasion.

272 microtubule and actin cytoskeletal dynamics, phosphoinositide signaling, clathrin-mediated endocytosi

273 Lipid signaling, particularly phosphoinositide signaling, plays a key role in regulati

274 duction is a model system for the ubiquitous phosphoinositide signaling.

275 eta cells in pulses regulated by calcium and phosphoinositide signaling.

276 w that FplA binds with high affinity to host phosphoinositide-signaling lipids, revealing a potential

277 to and from the plasma membrane, as well as phosphoinositide signalling and cholesterol homeostasis.

278 l(-) regulates the organization of the major phosphoinositide species PtdIns(4,5)P2 into microdomains

279 ain to properly bind lipids depending on the phosphoinositide species with a preference for phosphati

280 The activation of phosphoinositide-specific phospholipase C (PI-PLC) is on

281 when spheroplast lysates are incubated with phosphoinositide-specific phospholipase C (PI-PLC).

282 Phosphoinositide-specific phospholipase C (PLC) is an im

283 V120027 promotes the recruitment of TRPC3 or phosphoinositide-specific phospholipase C (PLCgamma) to

284 ng differentiation in the cellular levels of phosphoinositide-specific phospholipase Cbeta (PLCbeta)

285 , the pleckstrin homology domain of Cb binds phosphoinositides, specifically phosphatidylinositol 3-p

286 nd plasma membrane lipids and many have high phosphoinositide specificity.

287 INPP5E's phosphoinositide substrates PI(4,5)P2 and PI(3,4,5)P3 ac

288 -bisphosphate (PtdIns(3,5)P2), whereas other phosphoinositides such as PtdIns(4,5)P2, which is enrich

289 The first step in PM phosphoinositide synthesis is the conversion of phosphat

290 odia typically harbor higher densities of 3' phosphoinositides than adjacent regions at the cell peri

291 There are seven species of phosphoinositides that are interconverted by lipid kinas

292 mino acid residues and acidic lipids such as phosphoinositides that play a primary role in these inte

293 E complex formation and its interaction with phosphoinositides, the function of Syx's polybasic juxta

294 ct as a cellular sensor and controller of PM phosphoinositides, thereby influencing many PM processes

295 on the membrane phospholipids, including the phosphoinositides, to form the proinflammatory arachidon

296 Thus, the leukocyte polarizer is a dual-role phosphoinositide-transfer protein and represents a poten

297 ar3 silencing causes apoptosis, triggered by phosphoinositide trisphosphate depletion and decreased A

298 bition by muscarinic receptors that increase phosphoinositide turnover in neurons is enhanced in Kcnq

299 The phosphoinositide, which is present in the plasmalemma be

300 They generate 3-phosphoinositides, which are known to function as import