ライフサイエンスコーパス: polyol

1 -molecular-weight polyhydroxylated compound (polyol).

2 o either the candidin polyol or the nystatin polyol.

3 y in combination with a caprolactone-derived polyol.

4 ernally by fluorides or a penta-deprotonated polyol.

5 t as a prelude to deoxygenation reactions of polyols.

6 enantioselective propargylation of aliphatic polyols.

7 ts extension to the synthesis of 1,3-related polyols.

8 oride that is unlike that of other sugars or polyols.

9 entable oligo-, di-, and monosaccharides and polyols.

10 ntable oligo-, di-, and mono-saccharides and polyols.

11 her the glycolytic flux the lower the PP and polyols.

12 decrease is due to polymer interaction with polyols.

13 fermentable oligo-, di-, monosaccharides and polyols.

14 or substrate-controlled functionalization of polyols.

15 include significant amounts of sugars and/or polyols.

16 omes to the trace amounts of impurities in a polyol, a major issue for reproducibility and scale up s

17 o determine the in vitro effects of pluronic polyols, a family of widely used surfactants currently u

18 Pluronic polyols, a family of widely used surfactants, in very lo

19 tor (ARI) previously shown to prevent spinal polyol accumulation and formalin-evoked hyperalgesia in

20 -inositol efflux as induced by intracellular polyol accumulation appear to be interactively associate

21 Polyol accumulation easily occurs in pericytes but not i

22 in galactose neuropathy, factors other than polyol accumulation may contribute to the deficit in CNT

23 e-concentrating capability and intracellular polyol accumulation or extracellular hypertonicity.

24 rast, the ARI IDD676 had no effect on spinal polyol accumulation, elevated spinal COX-2, or hyperalge

25 the amelioration of hyperglycemia or retinal polyol accumulation.

26 l transport route for tonicity-activated and polyol- activated myo-inositol release from cell to medi

27 cterization of the role of sugar alcohols in polyol-activated myo-inositol efflux.

28 cantly inhibited both tonicity-activated and polyol-activated myo-inositol release, as did the chlori

29 logenesis, we studied how various sugars and polyols affect the formation and stability of collagen f

30 ux fusion bioreporters, specific for sugars, polyols, amino acids, organic acids, or flavonoids, have

31 code provides a convenient method to catalog polyol analytes.

32 3)) consisted of organic hydroxyl (including polyol and other alcohol) groups characteristic of sacch

33 The polyol and polyenic fragments were coupled using a 1,5-a

34 ces, the overall trend was that the pluronic polyol and the mode of administration did not result in

35 ce to predict the stereochemistry of unknown polyols and (13)C and (1)H chemical shift profiles as th

36 uch higher lactate content compared to other polyols and (ii) high sensor selectivity (Klactate(gluco

37 ogen content of the pyrolysis oil, producing polyols and alcohols.

38 There is significant uptake of several polyols and of mannose across the umbilical circulation

39 p consists of general lyoprotectants such as polyols and polyethylen glycol that apparently preserve

40 ug treatment at 5 mg/kg/d po), it normalizes polyols and reduces the motor nerve conduction velocity

41 In this study, synthetic polyols and surfactants separated by liquid chromatograp

42 However, AQPxlo excluded larger polyols and thiourea.

43 Major volatile compounds, polyols and turbidity were analyzed in fined wines and t

44 Selective degradation allows recovery of the polyols, and direct observation of the soft block oligom

45 tion of osmoprotectants, such as betaine and polyols, and metal-chelating organic acids.

46 The effect of a sugar or a polyol appears to be strongly dependent on the specific

47 Pluronic polyols are a family of non-ionic surfactants currently

48 Pluronic polyols are easily mixed with either DBP or TCP to impro

49 Five of these novel polyols are elaborated to 4-C-alkyl Ins(1,4,5)P(3) and I

50 Furthermore, nonglucose carbohydrates and polyols are found in fetal blood, some in concentrations

51 Polyols are included at very close spacings.

52 Here we report that a variety of polyols are present in, and indigenous to, the Murchison

53 inal spin-coupling constants) for contiguous polyols are reported.

54 ransfer reagent, poly(cyclohexene carbonate) polyols are synthesized with high selectivity.

55 eduction steps to construct the extended 1,3-polyol array present in the natural product.

56 ding biodiesel industry, which produces this polyol as the main waste material.

57 cently identified series of carboxylates and polyols as efficient enhancers for an AFP from the beetl

58 e utility of this method for the analysis of polyols as single-component solutions, as mixtures, or i

59 ofuels--alcohols and hydrocarbon precursors (polyols) as well as gaseous biofuel--hydrogen have been

60 ment of a novel approach to 1, 3, 5.(2n + 1) polyols based on iterative radical homologation as well

61 matrix (polypyrrole) and a dynamic network (polyol-borate), strong and flexible polymer films were d

62 h acetyl-L-carnitine had no effects on nerve polyols, but corrected the Na+/K+ -ATPase defect and was

63 that in solution Sb(III) is recognized as a polyol by the glycerol facilitator.

64 that NO regulates the vascular synthesis of polyols by S-thiolating AR; therefore, increasing NO syn

65 des, phosphorylated and N-acetylated sugars, polyols, carboxylic acids, nucleotides, and amines.

66 Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymmetric Diels-Alder reac

67 nthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides.

68 cyanate, is a viable method for polyurethane polyol characterization.

69 to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplas

70 mechanistic differences in decomposition of polyols compared to that of monoalcohols and hydrocarbon

71 Boron (B) polyol complexes have been isolated and characterized fr

72 Polyol content was elevated (P < 0.001) and motor nerve

73 id cycle, and polyamines and lower levels of polyols, cysteine, and glutathione.

74 is subsequently reduced by a NADPH-dependent polyol dehydrogenase and dephosphorylated by a sugar pho

75 In contrast, the NADPH-dependent polyol dehydrogenase exhibits broad substrate specificit

76 They differ from other alcohol and polyol dehydrogenases because they do not contain a cons

77 The polyol derivatization products are separated by 68 mass

78 pable of transporting xylitol, a five-carbon polyol derived from xylose, the most abundant pentose in

79 s is presented for the de novo production of polyol differentiated hexoses in only two chemical steps

80 followed by directed reductions to build the polyol domain, a Stille cross-coupling reaction to assem

81 Metabolites such as fusel alcohols, polyols, ethyl esters, mono- and di-saccharides were ass

82 d NF-kappaB activation, as well as increased polyol flux.

83 charides, disaccharides, monosaccharides and polyols (FODMAP) in foods reported.

84 harides, disaccharides, monosaccharides, and polyols (FODMAPs) exacerbate symptoms of irritable bowel

85 harides, disaccharides, monosaccharides, and polyols (FODMAPs) often is used to manage functional gas

86 ermentable oligo-, di-, monosaccharides, and polyols [FODMAPs]) has been reported to be effective in

87 rmentable, oligo-, di-, monosaccharides, and polyols [FODMAPs]) in subjects believed to have NCGS.

88 terparts; (b) the optimum ratios of epoxy to polyol for most rapid cure were 50:50 or 60:40 under con

89 tide phosphate (NADPH)-dependent reductases, polyol formation, and flux through the polyol pathway in

90 Polyols formed from isoprene oxidation contribute 8% and

91 absence of symmetry in the final cyclooctane polyols (four shown) generated in this investigation.

92 Control of the stereogenic centers of the polyol fragment was performed by utilizing an Evans aldo

93 ve cleavage sequence to construct the C5-C11 polyol fragment, a diastereoselective aldol reaction to

94 nantioselective monosilylations of diols and polyols furnish valuable alcohol-containing molecules in

95 tions tested; (c) resins containing TONE 305 polyol generally were faster to cure than those containi

96 To understand the role of polyols, genes for bacterial mannitol-1-P dehydrogenase

97 -reducing sugars (sucrose and trehalose) and polyols (glycerol and sorbitol).

98 tose, mannose, raffinose, and sucrose), four polyols (glycerol, mannitol, erythritol, and sorbitol),

99 of water as chain-transfer reagent to afford polyols (HO-(PPC)-OH) with narrow molecular weight distr

100 ion with hydrogen-bond interactions in three polyols (i.e., CF3CH(OH)CH2CH(OH)CF3, 1; (CF3)2C(OH)C(OH

101 rldwide pathogen that finds this four-carbon polyol in genital tissues.

102 saccharides, disaccharides, derivatives, and polyols in (0.05, 0.15, 0.25 and 0.35) mol kg(-1) aqueou

103 no conclusive evidence for the existence of polyols in meteorites, leaving a gap in our understandin

104 The addition of an organocatalyst to these polyols in the presence of lactides produces well-define

105 The distance dependence of polyol inclusion, however, is quite different from nonpo

106 r and electrophoretic mobility shift assays, polyols increased the ORE-dependent expression of MIOX.

107 nations in dimethyl sulfoxide on a series of polyols indicate that multiple hydrogen bonds to a singl

108 For polyol-induced inositol release, hypertonically adapted

109 For example, polyol information related to initiator, identity/relati

110 es the transformation of a four-carbon sugar polyol into an oxygen-reduced compound, providing promis

111 selective modification of glycols and higher polyols is possible, streamlining or eliminating use of

112 ylene-mediated benzylation and allylation of polyols is reported.

113 of WAY-121,509 sufficient to reduce retinal polyol levels by 95% ameliorated the development of gala

114 raised glycated hemoglobin or sciatic nerve polyol levels, confirming that hyperglycemia was unaffec

115 These polyols likely decelerate the rate of water loss during

116 ovide access to other members of the polyene-polyol macrolides, including stereoisomers of RK-397.

117 To investigate the potential role of a polyol, mannitol, in oxidative stress protection, a bact

118 Pluronic polyols may be considered as carriers for osseous graft

119 The accumulation of polyols may have dual functions: facilitating osmotic ad

120 her disorders, including leukodystrophy with polyol metabolism abnormality, demonstrate that an incre

121 lic complications of IDDM and that increased polyol metabolism is involved in this response.

122 ical levels of glucose specifically activate polyol metabolism with a consequent decrease in Na,K-ATP

123 f aldose reductase (AR), a primary enzyme of polyol metabolism, in Capan-1 human pancreatic duct cell

124 metabolism of glucose through glycolysis and polyol metabolism.

125 The Pt/MWCNTs synthesized by polyol method and have been characterized by transmissio

126 We report a polyol method for the facile synthesis of Ag nanocubes h

127 d (reaction time < 15 min), sulfide-mediated polyol method in which Ag(I) is reduced to Ag(0) by ethy

128 composites were synthesized using an in situ polyol method.

129 gy of the conjugate base of a small covalent polyol model compound (i.e., (HOCH2CH2CH(OH)CH2)2CHOH) i

130 olling regioselectivity during the course of polyol modification, we found that histidine-containing

131 upling, and application to the synthesis 1,3-polyol motifs.

132 carnitine administration on peripheral nerve polyols, myoinositol, Na+/K+ -ATPase, vasoactive prostag

133 gle hydroxyl group among many in unprotected polyol natural products.

134 ct of key bulking agents/excipients - sugars/polyols - on the material form, structure, strength, fai

135 reversible processes by adding amino acids, polyol or simple alcohols, or sugars, forming IAA conjug

136 diate to be converted to either the candidin polyol or the nystatin polyol.

137 were faster to cure than those containing no polyol, or TONES 201 or 310; and (d) a resin mixture was

138 Polyols, or polyhydroxy alcohols, are produced by many f

139 conducting) polymers considering sensors for polyols, particularly, saccharides and hydroxy acids.

140 ption is accompanied by aldose reductase and polyol pathway activation in steatotic areas.

141 ients, mice undergoing iAKI show significant polyol pathway activation in the kidney cortex character

142 This suggests that polyol pathway activity in the lens may translate to oxi

143 s and to assess the potential involvement of polyol pathway activity in the pathogenesis of spinally

144 documents discrete cellular consequences of polyol pathway activity in the retina, and it suggests t

145 a short duration of diabetes are mediated by polyol pathway activity.

146 ucose concentrations are known to induce the polyol pathway and increase fructose generation in the l

147 is the first and rate-limiting enzyme of the polyol pathway and is involved in the pathogenesis of di

148 ole of endogenous fructose production by the polyol pathway and its metabolism through fructokinase i

149 may be a useful strategy for inhibiting the polyol pathway and preventing the development of diabete

150 novel mechanism, involving activation of the polyol pathway and repression of microRNA-24 (miR-24), t

151 e idea of activation of aldose reductase and polyol pathway as an important mechanism of hyperglycemi

152 f glucose via several pathways including the polyol pathway causes cellular toxicity.

153 The aldose reductase (AR) polyol pathway contributes to these microvascular compli

154 Herein we report that inhibition of the polyol pathway enzyme aldose reductase (AR) by two struc

155 Increased reduction of glucose via the polyol pathway enzyme aldose reductase (AR) has been lin

156 esent study was to elucidate the role of the polyol pathway enzyme aldose reductase (AR) in the media

157 Herein we report that inhibition of the polyol pathway enzyme aldose reductase (AR) prevents the

158 e of this study was to determine whether the polyol pathway enzyme aldose reductase mediates diabetes

159 Sorbitol dehydrogenase (SDH) is a polyol pathway enzyme that catalyzes conversion of sorbi

160 irms that 3-FG is metabolized to 3-FF by the polyol pathway enzymes.

161 These findings suggest that increased polyol pathway flux in diabetic animals leads to the act

162 Polyol pathway flux in spinal oligodendrocytes provides

163 The impact of exaggerated polyol pathway flux on ciliary neurotrophic factor (CNTF

164 trolled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and

165 dose reductase inhibitors can prevent excess polyol pathway flux, and hence these agents may prevent

166 volved in the pathogenesis of complications: polyol pathway flux, increased formation of AGEs (advanc

167 Activation of the polyol pathway has been linked to the development of sec

168 the increased metabolism of glucose via the polyol pathway has received considerable attention.

169 These observations suggest that the polyol pathway hyperactivity induced by HG contributes t

170 ases, polyol formation, and flux through the polyol pathway in cultured dog retinal capillary cells w

171 ications for how to evaluate the role of the polyol pathway in diabetic retinopathy.

172 The role of the polyol pathway in the pathogenesis of diabetic retinopat

173 ed for 3 months at a dose that inhibited the polyol pathway in the retina of diabetic rats to a simil

174 as associated with significant inhibition of polyol pathway intermediates in both lens and sciatic ne

175 es showed a dramatic increase in glucose and polyol pathway intermediates in diabetes, a striking upr

176 depletion, and enhanced the accumulation of polyol pathway intermediates without worsening myo-inosi

177 The polyol pathway is a metabolic route able to convert gluc

178 ry stress is the distinct signature that the polyol pathway leaves on retinal vessels.

179 These data suggest that polyol pathway metabolites and AGE can stimulate rat vas

180 ficant effect on either energy metabolism or polyol pathway of normal nerves.

181 activation of Janus kinase 2 (JAK2), and the polyol pathway play important parts in the hyperprolifer

182 diabetic rat if documented inhibition of the polyol pathway prevents a sequence of retinal vascular a

183 The data confirm that flux through the polyol pathway primarily results in sorbitol accumulatio

184 blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions h

185 easing evidence to link abnormalities in the polyol pathway to the pathogenesis of diabetic neuropath

186 by gas chromatography, and flux through the polyol pathway was investigated by 19F nuclear magnetic

187 in the development of DR, namely, increased polyol pathway, activation of protein kinase C (PKC), in

188 e genes, blocks NF-kappaB, and represses the polyol pathway, AGEs production, and hyperlipidemia.

189 glucose uptake, nerve energy metabolism, the polyol pathway, and protein kinase C (PKC) activity in E

190 of aldose reductase, the first enzyme of the polyol pathway, is a key response to ischemia and that i

191 study investigated the relation between the polyol pathway, PKC-beta, ROS, JAK2, and Ang II in the d

192 e reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the pathogenesis of

193 f 3-deoxyglucosone, at least in part via the polyol pathway, provides an amplification loop to sustai

194 ehydrogenase (SDH) in the second step of the polyol pathway, under conditions of high glucose flux.

195 the pentose phosphate pathway (PPP) and the polyol pathway, while also regulating ion channel functi

196 nder hyperglycemic conditions through the AR polyol pathway.

197 n preventing diabetes-induced changes in the polyol pathway.

198 n the calculated flux of glucose through the polyol pathway.

199 exerted by phosphofructokinase on the PP and polyol pathways revealed that the extent of glycolytic f

200 The polyol phosphate subunits of these glycopolymers are dec

201 eatures are adapted for recognition of small polyol phosphates, and not nucleotide substrates.

202 anowires (AgNWs) were prepared by a modified polyol process and were incubated in three cell culture

203 The formation of AuCuSn(2) using a modified polyol process occurs through a multistep pathway that w

204 y manipulating the reduction kinetics of the polyol process.

205 to similarities in their major carbohydrate/polyol profiles.

206 of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and me

207 Protonated polyols react by consecutive derivatization reactions, w

208 particles (NPs) were prepared using standard polyol reduction chemistry in ethylene glycol (EG) with

209 We report a facile route based on polyol reduction for the synthesis of Pd RBPs with purit

210 ave been extensively synthesized by a simple polyol reduction method using different copper salts, i.

211 B self-assembles in lipid membranes with the polyol region lining a channel interior that funnels to

212 The epitope for the polyol-responsive mAb NT73, which reacts with Escherichi

213 Polyol-responsive monoclonal antibodies (mAbs) are usefu

214 We use a previously described polyol-responsive monoclonal antibody to investigate the

215 elective and stereospecific oxidation of the polyol (S,S)-1,2,3,4-tetrahydroxybutane [(S,S)-threitol]

216 simple, reagentless, and flexible format for polyol screening that does not require aqueous alkaline

217 The acyclic polyol sorbitol is a primary photosynthetic product and

218 The polyol (sorbitol) pathway of glucose metabolism is activ

219 The accumulation of two cryoprotective polyols, sorbitol and threitol, is integral to the extra

220 ect due to increased hydrogen bonding of the polyol species to the bilayer headgroups.

221 d a result of complex formation with di- and polyols, specific binding.

222 suitable for selective reactions of complex polyol structures.

223 achieve various group transfer reactions on polyol substrates with high enantio- or regioselectivity

224 electivity for the glycosylations of complex polyols such as 6-deoxyerythronolide B and oleandomycin-

225 Although accumulation of polyols such as xylitol and sorbitol is associated with

226 Polyhydroxylated compounds (polyols) such as sugars, sugar alcohols and sugar acids

227 an iterative strategy for the preparation of polyols, such as the fully differentiated L-ribo-tetrol

228 Reduced protection by polyols suggested that glycerol had specific functions f

229 The one-step modified polyol synthesis in air directly generates water-soluble

230 n the assumed values, which are based on the polyol synthesis reactions.

231 ol (EG)--the solvent most commonly used in a polyol synthesis--with diethylene glycol (DEG).

232 ng rate of metal precursor ions in a one-pot polyol synthesis.

233 ic simplification of differentiated diol and polyol targets.

234 -reacting only with xylitol (4.9%) among all polyols tested.

235 tress, cells retained more of the six-carbon polyols than glycerol.

236 thesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacr

237 a series of structurally novel sesterterpene polyols, the mangicols A-G (4-10).

238 Based on docking of polyols to homology models of transporters, we propose t

239 The ability of various sugars and polyols to inhibit the fiber assembly and to destabilize

240 al reduction of silyl-protected C6O6-derived polyols to produce a diverse set of oxygen-functionalize

241 pentose phosphate (PP), glycogenolysis, and polyols to translate the glucose metabolome of the heart

242 The mutant was shown to be defective in polyol transport by GlpF.

243 tically and functionally distinct from known polyol transporters.

244 and triblock ethylene oxide/propylene oxide polyols using LC/CR/MS.

245 nvironment, specifically oligosaccharide and polyol utilization, arsenic resistance and lantibiotic p

246 The candidin polyol was further elaborated to a protected candidin ag

247 Retinal polyol was reduced by 95% in all ARI-treated groups and

248 e simplest representative of biomass-derived polyols, was studied via density functional theory (DFT)

249 echanism of regulation of MIOX expression by polyols, we have cloned the human MIOX gene locus of 10

250 Acidity constants of a series of polyols were also computed, and the combination of hydro

251 Aldose reductase activity and polyols were below our limits of detection, 0.5 nmol/min

252 w MW fractions of the degraded and unreacted polyols were collected and analyzed by MALDI.

253 We found that the effects of sugars and polyols were highly specific with respect to small struc

254 We conclude from this that polyols were present on the early Earth and therefore at

255 moselective oxidation of unprotected vicinal polyols with [(neocuproine)Pd(OAc)]2(OTf)2 (1) (neocupro

256 ivity, and phosphorylates several sugars and polyols with low catalytic efficiency.

257 high intracellular concentration of retained polyols would be less protective.