ライフサイエンスコーパス: polyomavirus

1 linked to a contributory virus (Merkel cell polyomavirus).

2 c acid, is the major attachment receptor for polyomavirus.

3 virus (MWPyV) is a recently identified human polyomavirus.

4 uce MCC in mice using oncoproteins from this polyomavirus.

5 Merkel cell carcinoma virus, which is also a polyomavirus.

6 ent of trichodysplasia spinulosa caused by a polyomavirus.

7 nty-one percent were seropositive for the JC polyomavirus.

8 sequencing of nucleic acid revealed a novel polyomavirus.

9 amily profile or the presence of Merkel cell polyomavirus.

10 r frequently associated with the Merkel cell polyomavirus.

11 cancers associated with a recently described polyomavirus.

12 CD8 T cell response to infection with mouse polyomavirus.

13 the rearrangements typical for reactivating polyomaviruses.

14 ion of Fe/S coordination in the sTs of other polyomaviruses.

15 ural history of the more recently discovered polyomaviruses.

16 uses, including two papillomaviruses and two polyomaviruses.

17 ds sialylated glycan receptors in many other polyomaviruses.

18 ommon ancestor of a large clade of mammalian polyomaviruses.

19 noviruses (AdV), papillomaviruses (HPV), and polyomaviruses.

20 elated overall to human and nonhuman primate polyomaviruses.

21 nt of the recently reported MWPyV and HPyV10 polyomaviruses.

22 Human polyomavirus 6 (HPyV6) and HPyV7 are commonly found on h

23 Human polyomavirus 6 (HPyV6) is most often detected at the ski

24 rus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HPyV7, HPyV9, and Trichodysplasi

25 Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently disco

26 re included herpesviruses, papillomaviruses, polyomaviruses, adenoviruses and anelloviruses.

27 In this Gem, we will discuss two viruses, polyomavirus and cytomegalovirus, in which cell culture

28 VP1 is the major coat protein of murine polyomavirus and forms virus-like particles (VLPs) in vi

29 thway for cytosolic entry varied between the polyomaviruses and between different cell types, namely,

30 ructures of closely related animal and human polyomaviruses and examine their strategies for engaging

31 patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood.

32 ersely associated with the seroprevalence of polyomaviruses and herpesviruses.

33 This pore is conserved across polyomaviruses and suggests either that these viruses ha

34 tical evidence in favor of an association of polyomaviruses and their hosts over millions of years.

35 V9, and Trichodysplasia spinulosa-associated polyomavirus) and examined factors associated with MCPyV

36 almonella spp., Campylobacter jejuni, bovine polyomavirus, and bovine rotavirus A were present most f

37 Mammalian polyomaviruses are characterized by establishing persist

38 Polyomaviruses are nonenveloped viruses with capsids com

39 Polyomaviruses are opportunistic pathogens that are asso

40 viruses and explain the rarity of some novel polyomavirus-associated diseases.

41 nfiltrates in renal biopsy specimens with BK polyomavirus-associated nephropathy (BKPyVAN) and specim

42 Polyomavirus-associated nephropathy (PVAN) after BK viru

43 tomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pat

44 Polyomavirus-associated nephropathy (PVAN) occurs in a s

45 o a specific diagnosis), infections, such as polyomavirus-associated nephropathy, calcineurin inhibit

46 m a pediatric kidney transplant patient with polyomavirus-associated nephropathy.

47 .9, and 9.7 months for viruria, viremia, and polyomavirus-associated nephropathy.

48 sustained viremia, and 17 (7%) biopsy-proven polyomavirus-associated nephropathy.

49 factors that underlie the pathophysiology of polyomavirus-associated nephropathy.

50 imental data on unperturbed adenoviruses and polyomaviruses, at the same time providing insight into

51 ear if desensitization increases the risk of polyomavirus BK (BKV) viremia.

52 ear if desensitization increases the risk of polyomavirus BK (BKV) viremia.

53 Reactivation of the polyomavirus BK has been associated with de novo antibod

54 onstrating "decoy" cells, and/or significant polyomavirus BK viremia.

55 ented: elucidating the transmission route of polyomaviruses BK and JC and estimating the basic reprod

56 BK polyomavirus (BKPyV) affects mostly kidney and bone marr

57 BK polyomavirus (BKPyV) frequently reactivates in kidney tr

58 t APOBEC3B is specifically upregulated by BK polyomavirus (BKPyV) infection in primary kidney cells a

59 BK polyomavirus (BKPyV) is a widespread human pathogen that

60 BK polyomavirus (BKPyV) is the most common viral pathogen a

61 is study, we investigated the role of the BK polyomavirus (BKPyV) miRNA in regulating virus replicati

62 BK polyomavirus (BKPyV) reactivation is associated with sev

63 Here, we demonstrate the detection of BK Polyomavirus (BKPyV), an emerging indicator of microbiol

64 d immunoglobulin G seroreactivity against 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, HPyV6

65 irus (CMV), Epstein-Barr virus (EBV), and BK polyomavirus (BKV) at transplant was a risk factor for p

66 BK polyomavirus (BKV) causes significant urinary tract path

67 BK polyomavirus (BKV) establishes persistent, low-level, an

68 uppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropathy

69 Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney tr

70 The pathogenesis of BK polyomavirus (BKV) infection and associated nephropathy

71 BK polyomavirus (BKV) infection remains a significant cause

72 BK polyomavirus (BKV) is an emerging pathogen in immunocomp

73 BK polyomavirus (BKV)-associated nephropathy is a threat to

74 Middle T antigen (MT), the oncogene of polyomavirus, can drive tumor formation in a variety of

75 Nephropathy associated with BK polyomavirus causes kidney allograft dysfunction and fai

76 affects the quantity and quality of the anti-polyomavirus CD8 T cell response and its differentiation

77 e 1; hepatitis E virus; bocavirus; KI and WU polyomaviruses; coronaviruses HKU1 and NL63; influenza,

78 No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; ho

79 Merkel cell polyomavirus could contribute to the origin of this derm

80 ly related to the middle T antigen of murine polyomavirus despite almost no sequence similarity.

81 Polyomaviruses encode a large T Ag (LT), a multifunction

82 Other polyomavirus-encoded large T antigens also increase the

83 these mutants will provide new insight into polyomavirus entry, pathogenesis, and evolution.

84 omaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-a

85 d 58.9% of eyebrow hair specimens) among all polyomaviruses examined.

86 y, and, ultimately, pathogenicity within the polyomavirus family and highlight the need for structure

87 hylogenetic relationships within the growing polyomavirus family and perhaps also for other viruses.

88 DNA tumor viruses, including members of the polyomavirus family, often result in tumor formation in

89 This was also hypothesized for polyomaviruses (family Polyomaviridae), a group comprisi

90 The number of polyomaviruses found in the human body continues to grow

91 evidence that, consistent with this idea, BK polyomavirus genomes are depleted of APOBEC3B-preferred

92 Whereas mouse polyomavirus has been studied in a fair amount of detail

93 Murine polyomavirus has repeatedly provided insights into tumor

94 Polyomavirus-Haufen counts showed excellent correlation

95 Polyomavirus-Haufen were counted in 40 urine samples fro

96 Several new polyomaviruses have been discovered in the last decade,

97 Polyomaviruses have repeating sequences at their origins

98 Both the papillomaviruses and the polyomaviruses have served as tools for understanding pa

99 Polyomaviruses have shown the importance of phosphotyros

100 titative PCR to test for cytomegalovirus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus,

101 avirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HPyV7, HPyV9

102 ors and a novel mechanism of stability for a polyomavirus in cancer.

103 hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis a

104 rare skin cancer associated with Merkel cell polyomavirus in most cases.

105 zation of the noncoding control region of JC polyomavirus in vivo, mainly in CSF and blood.

106 n of large tumor T antigens (TAg) encoded by polyomaviruses in mammalian cells results in increased t

107 The natural cycle of polyomaviruses in mammals is to persist in the host with

108 vides insight into how DDRs are activated by polyomaviruses in primary cells with intact cell cycle c

109 viously undefined protein encoded by several polyomaviruses including MCPyV, but also provides insigh

110 Eleven new human polyomaviruses, including the skin viruses HPyV6 and HPy

111 ory of these viruses and the evolution of JC polyomavirus-induced progressive multifocal leukoencepha

112 BDCA-1(+) mDCs localized in proximity to the polyomavirus-infected tubular epithelial cells.

113 Although both polyomavirus infection and T cell-mediated rejection (TC

114 P2.139-specific CD8 T cell response to mouse polyomavirus infection depends on CD4 T cell help and CD

115 is known about the initial host response to polyomavirus infection.

116 of herpes simplex, Epstein-Barr virus or BK polyomavirus infections.

117 Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ultraviolet-radiation-induc

118 Merkel cell polyomavirus is a newly discovered human cancer virus th

119 e and rare event, the oncogenic potential of polyomavirus is primarily evaluated in laboratory animal

120 BK polyomavirus is ubiquitous, with a seropositivity rate o

121 tides found in the origins of replication of polyomaviruses is discussed.

122 acid-containing glycan receptors in related polyomaviruses is obstructed, and VP1 of HPyV6 and HPyV7

123 en, as well as large T antigens from related polyomaviruses, is alone capable of upregulating APOBEC3

124 the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in hu

125 the presence of this pore is conserved among polyomaviruses, its functional role in infection or asse

126 document a unique DNA recombination between polyomavirus JC (JC virus [JCV]) and Epstein-Barr virus

127 ting disease caused by the human neurotropic polyomavirus JC (JCV) and is found almost exclusively in

128 elinating disease of the brain caused by the polyomavirus JC (JCV), has evolved tremendously.

129 Isolates of the human polyomavirus JC virus from patients with the frequently

130 the white matter of the brain caused by the polyomavirus JC virus, which typically occurs only in im

131 Classic human polyomaviruses (JC and BK viruses) become pathogenic whe

132 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human po

133 The human JC polyomavirus (JCPyV) causes the rapidly progressing demy

134 The human JC polyomavirus (JCPyV) establishes an asymptomatic, persis

135 a fatal disease caused by reactivation of JC polyomavirus (JCPyV) in immunosuppressed individuals and

136 JC polyomavirus (JCPyV) infection of immunocompromised indi

137 JC polyomavirus (JCPyV) is reactivated in approximately 20%

138 nally, endocytosis-dependent infection by JC polyomavirus (JCPyV) was reduced in human cells with dec

139 rebral manifestations are associated with JC polyomavirus (JCPyV) which are diagnosed by detection of

140 the receptor-binding properties of human JC polyomavirus (JCPyV), a virus that resides in the kidney

141 arget and neutralize its etiologic agent, JC polyomavirus (JCPyV).

142 from infection of oligodendrocytes by the JC polyomavirus (JCPyV).

143 The human polyomavirus, JCPyV, is the causative agent of progressi

144 life-threatening infections caused by human polyomaviruses JCV and BKV.

145 tients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like r

146 The relationship between latent JC polyomavirus (JCV) infection and progressive multifocal

147 of the central nervous system (CNS) with JC polyomavirus (JCV) usually occur as a result of immunoco

148 s from lytic infection of the glia by the JC polyomavirus (JCV); JCV granule cell neuronopathy is cau

149 d persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyo

150 Combined, these results demonstrate that polyomaviruses lacking miRNAs can arise infrequently and

151 A-mediated viral gene autoregulation in some polyomavirus life cycles.

152 erkel cell carcinoma (MCC) is an aggressive, polyomavirus-linked skin cancer.

153 iated with clinical presentation: intrarenal polyomavirus load levels and Banff interstitial fibrosis

154 f DNA translocation by papillomavirus E1 and polyomavirus LTag hexameric helicases involves consecuti

155 ic infection of oligodendrocytes by human JC polyomavirus may result in the development of progressiv

156 CD8 T cell responses to infections by human polyomaviruses may be influenced by VP1 mutations involv

157 PyV-6 DNA load and VP1 protein suggests that polyomaviruses may contribute to the epithelial prolifer

158 ve to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomavirus subtype 17

159 rcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical significance of tu

160 Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (

161 Merkel cell polyomavirus (MCPyV) causes the majority of cases of Mer

162 Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases du

163 MCCs frequently contain Merkel cell polyomavirus (MCPyV) DNA and express viral transforming

164 In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clonal integratio

165 Merkel cell polyomavirus (MCPyV) expressing viral T antigens is a co

166 ng evidence indicates a role for Merkel cell polyomavirus (MCPyV) in the development of Merkel cell c

167 Merkel cell polyomavirus (MCPyV) is frequently associated with Merke

168 yV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage.

169 Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in

170 Merkel cell polyomavirus (MCPyV) plays an important role in Merkel c

171 ns, copy number alterations, and Merkel cell polyomavirus (MCPyV) sequence were analyzed and compared

172 l integration of a polyomavirus, Merkel cell polyomavirus (MCPyV), and MCC tumor cells express putati

173 The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives the dev

174 Merkel cell polyomavirus (MCPyV), identified in the majority of MCCs

175 me (ALTO) in the early region of Merkel cell polyomavirus (MCPyV), the causative agent of most Merkel

176 ure to ultraviolet light and the Merkel-cell polyomavirus (MCPyV).

177 ed in the last decade, including Merkel cell polyomavirus (MCPyV).

178 incidence, prevalence, and persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus,

179 Merkel cell polyomavirus (MCV) causes an aggressive human skin cance

180 Merkel cell polyomavirus (MCV) causes an aggressive skin cancer afte

181 Clonal integration of Merkel cell polyomavirus (MCV) DNA into the host genome has been obs

182 Merkel cell polyomavirus (MCV) infection and DNA integration into th

183 Merkel cell polyomavirus (MCV) is a newly discovered human cancer vi

184 Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces cent

185 skin cancer associated with the Merkel cell polyomavirus (MCV).

186 and tractable model for a novel mechanism of polyomavirus-mediated oncogenesis.

187 ntly associated with clonal integration of a polyomavirus, Merkel cell polyomavirus (MCPyV), and MCC

188 aneous tumor system with mice expressing the polyomavirus middle T (PyMT) oncogene under control of t

189 The polyomavirus middle T antigen (PyMT) oncogene activates

190 In addition, mammary gland tumors induced by polyomavirus middle T antigen in JNK2(-/-) mice were mor

191 r cells derived from mice transgenic for the polyomavirus middle T oncogene to ionizing radiation res

192 RT-deficient mice displayed marked delays in polyomavirus middle T oncogene-induced (PyMT-induced) ma

193 tors in the mouse mammary tumor virus (MMTV)-polyomavirus middle T oncoprotein (PyMT) mouse model of

194 ased mammary tumorigenesis in ovariectomized polyomavirus middle T-antigen mice.

195 k Institute set out to determine whether the polyomavirus middle T-transforming protein had a similar

196 of breast cancer, including the widely used polyomavirus middle-T antigen (PyVmT) model, which provi

197 rovide evidence for a unique function of the polyomavirus miRNA that may have important implications

198 The function of the polyomavirus miRNA was investigated in archetype BKPyV,

199 Using mouse polyomavirus (MPyV) infection, we previously showed that

200 Mouse polyomavirus (MPyV) is a ubiquitous persistent natural m

201 Using a mouse polyomavirus (MPyV) kidney transplant model, we investig

202 Malawi polyomavirus (MWPyV) is a recently identified human poly

203 vergent polyomavirus, provisionally named MX polyomavirus (MXPyV), in stool samples from children.

204 Polyomavirus-negative matched patients (n = 943) were de

205 Polyomavirus nephropathy (PVAN) is a common cause of kid

206 Polyomavirus nephropathy (PVN) is a common viral infecti

207 alitative highly predictive urinary test for polyomavirus nephropathy (PVN) is the PV-Haufen test.

208 ated with hemorrhagic cystitis and also with polyomavirus nephropathy (PVN).

209 finitive PVN from the Banff Working Group on Polyomavirus Nephropathy, comprising nine transplant cen

210 novo or recurrent glomerular pathologies and polyomavirus nephropathy.

211 New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that m

212 ding for middle T antigen (MT) is the murine polyomavirus oncogene most responsible for tumor formati

213 Middle T antigen (MT) is the primary polyomavirus oncogene responsible for tumor formation.

214 MCPyV), and MCC tumor cells express putative polyomavirus oncoprotein small T antigen (sTAg) and trun

215 mavirus sequence repeats in complex with the polyomavirus origin-binding domain reveals that only thr

216 Polyomavirus origins of replication contain multiple occ

217 viruses, herpesviruses, papillomaviruses and polyomaviruses) over time were observed in individuals w

218 ttempted to reveal the composition of the JC polyomavirus population (the quasispecies, i.e., the who

219 For the first time, the JC polyomavirus population contained in different body comp

220 Polyomavirus-positive patients (n = 943) were defined as

221 ach, we identified a novel, highly divergent polyomavirus, provisionally named MX polyomavirus (MXPyV

222 Polyomaviruses (PV) have been historically associated wi

223 ) mice are susceptible to tumor induction by polyomavirus (Py), while C57BR/cdJ (BR) mice are resista

224 The nonenveloped simian polyomavirus (PyV) simian virus 40 (SV40) hijacks the en

225 The nonenveloped polyomavirus (PyV) simian virus 40 (SV40) traffics from

226 Nine polyomavirus (PyV) species are known to productively inf

227 rovide some simian virus 40 (SV40) or murine polyomavirus (PyV) ST functions.

228 ng these infections can be studied in murine polyomavirus (PyV)-infected mice as a model.

229 Polyomaviruses (PyV) are potentially tumorigenic in huma

230 It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged w

231 Polyomavirus (PyVs) are small DNA pathogens that contain

232 Polyomaviruses (PyVs) are a group of emerging pathogens

233 Polyomaviruses (PyVs) are small DNA viruses, long known

234 Polyomaviruses (PyVs) cause devastating human diseases,

235 Several different polyomaviruses (PyVs) encode microRNAs (miRNAs) that reg

236 Other tumor-associated polyomaviruses (PyVs), including simian virus 40 (SV40),

237 Raccoon polyomavirus (RacPyV) is associated with 100% of neurogl

238 Recently, raccoon polyomavirus (RacPyV) was identified in neuroglial tumor

239 Unlike other oncogenic polyomaviruses, RacPyV was episomal, not integrated, in

240 Seroprevalence of polyomaviruses ranged from 38.5% to 99.8% in cord blood

241 The effect of polyomavirus reactivation (BK viremia or JC viruria) on

242 study (n=40) to explore associations between polyomavirus reactivation and immune responses to the se

243 Furthermore, these results indicate that polyomavirus reactivation associates with immune respons

244 Polyomavirus reactivation can cause significant morbidit

245 ore prevalent during year 1 in subjects with polyomavirus reactivation than in those without reactiva

246 conserved VP1 proteins from closely related polyomaviruses recognize different oligosaccharides.

247 titative histologic assessment of intrarenal polyomavirus replication/load levels.

248 crystal structure of the four central murine polyomavirus sequence repeats in complex with the polyom

249 how that miRNAs from related variants of the polyomavirus simian vacuolating virus 40 (SV40) have dif

250 In the case of the nonenveloped polyomavirus simian virus 40 (SV40), the virus penetrate

251 comparing the cytosolic entry of the related polyomavirus simian virus 40 (SV40), we found that depen

252 usage affect tropism, we studied the primate polyomavirus simian virus 40 (SV40), which uses the gang

253 revealed by a viral oncoprotein, Merkel cell polyomavirus small T (MCV sT).

254 Murine polyomavirus small t antigen (PyST) regulates cell cycle

255 We recently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major eff

256 Polyomavirus small t antigen is a viral oncogene that co

257 t cell transformation induced by Merkel cell polyomavirus small T antigen viral oncoprotein.

258 xamined whether some of the functions of the polyomavirus small T antigens (ST) are shared by the E6

259 mavirus E7 has the same effect as the murine polyomavirus small T protein.

260 presence of a tenth apparently human-tropic polyomavirus species, which we name HPyV10.

261 yomavirus, we show that brain-resident mouse polyomavirus-specific CD8 T cells, unlike memory cells i

262 Animal polyomavirus sT oncoproteins have been found to cause ex

263 not based on PD-L1 expression or Merkel cell polyomavirus status.

264 ace morphology from those of all other known polyomavirus structures.

265 for the transforming properties of nonhuman polyomaviruses, such as simian virus 40 (SV40), but is n

266 Here we probe polyomavirus SV40 endoplasmic reticulum (ER)-to-cytosol

267 model is described that predicts patterns of polyomavirus SV40 infections and associated cancers in h

268 Here we probe how the non-enveloped polyomavirus SV40 penetrates the endoplasmic reticulum (

269 tosol membrane transport of the nonenveloped polyomavirus SV40, a decisive infection step, a cytosoli

270 bserved for the beta-herpesvirus CMV and the polyomaviruses SV40 and SA12.

271 These studies uncover the action of polyomavirus T antigens on cellular CBP/p300 and suggest

272 Like all polyomavirus T antigens, PyST functions largely via its

273 Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothel

274 question by focusing on a single lineage of polyomaviruses that infect both humans and their closest

275 In murine polyomavirus, the central region of the origin contains

276 In contrast to better-studied polyomaviruses, the routes of infection, cell tropism, a

277 cell carcinoma (MCC), making MCPyV the first polyomavirus to be clearly associated with human cancer.

278 MCPyV is the first polyomavirus to be clearly associated with human cancer.

279 rt the complete genome sequence of the first polyomavirus to be isolated from a horse.

280 in complex, a tumor suppressor in some other polyomavirus transformation models, but was strictly dep

281 en (MT), the principal oncoprotein of murine polyomavirus, transforms by association with cellular pr

282 we show that manifestations of the causative polyomavirus (TSPyV) occur during primary infection of t

283 witnessed the discovery of eleven new human polyomaviruses, two of which cause unusual and rare canc

284 Any polyomavirus urinary shedding was more frequent in liver

285 arison with other structurally characterized polyomavirus VP1 proteins enhances our understanding of

286 In polyomaviruses, VP1 commonly determines antigenicity as

287 ere found with the expression of recombinant polyomavirus Vp1s and human papillomavirus L1s in COS-7

288 Merkel cell polyomavirus was detected in 32 of 38 specimens (84%).

289 JC polyomavirus was detected in the CSF at the time of pres

290 JC polyomavirus was detected within the graft's collecting

291 In that same year a second human polyomavirus was discovered in the urine of a kidney tra

292 In 1971, the first human polyomavirus was isolated from the brain of a patient wh

293 A polyomavirus was isolated from the eyes of horses, and t

294 JC polyomavirus was not detected in pretransplant serum, ho

295 A human polyomavirus was recently discovered in Merkel cell carc

296 Using mouse polyomavirus, we demonstrate that a single amino acid di

297 Using mouse polyomavirus, we show that brain-resident mouse polyomav

298 lutionary divergence and diverse sampling of polyomaviruses, we propose evolutionary transitions that

299 We review what is currently known about JC polyomavirus, what is suspected, and what remains to be

300 (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPy