ライフサイエンスコーパス: posttranslational modification

1 distinct nucleotide states or with different posttranslational modifications).

2 be modified by SUMOylation, a ubiquitin-like posttranslational modification.

3 ITM3 is activated by palmitoylation, a lipid posttranslational modification.

4 with increased binding to HLA-DQ8trans upon posttranslational modification.

5 inity changes that occur upon stress-related posttranslational modification.

6 bout how DAG kinase activity is regulated by posttranslational modification.

7 , promoting allostery, or allowing efficient posttranslational modification.

8 alter Runx1 transcriptional function through posttranslational modification.

9 ion, the most widespread and complex form of posttranslational modification.

10 omal peptide synthesis followed by extensive posttranslational modification.

11 secondary metabolites that undergo extensive posttranslational modification.

12 line, the product of the most abundant human posttranslational modification.

13 er biological investigations of this central posttranslational modification.

14 tion of type I collagen and causes excessive posttranslational modifications.

15 es oscillates by regulated expression and/or posttranslational modifications.

16 actions by transcriptional reprogramming and posttranslational modifications.

17 ly nucleation factors, tubulin isoforms, and posttranslational modifications.

18 network of protein-protein interactions and posttranslational modifications.

19 mporally and spatially controlled by tubulin posttranslational modifications.

20 Its functions are regulated tightly by posttranslational modifications.

21 otein can undergo a diverse array of co- and posttranslational modifications.

22 keleton and mediate phenotypic responses via posttranslational modifications.

23 sponse to Ag is largely regulated by protein posttranslational modifications.

24 rchestrated process involving a multitude of posttranslational modifications.

25 protein-protein interactions, as well as by posttranslational modifications.

26 SF1 at S303/307, previously known repressive posttranslational modifications.

27 hat the BMV CP contains a complex pattern of posttranslational modifications.

28 which CpG methylation is linked with histone posttranslational modifications.

29 heir roles and how these may be modulated by posttranslational modifications.

30 polymers inside of cells that are subject to posttranslational modifications.

31 th various BH3-only proteins such as through posttranslational modifications.

32 and are marked with active enhancer histone posttranslational modifications.

33 nnel synthesis, membrane trafficking, and/or posttranslational modifications.

34 lular effectors and act in tandem with other posttranslational modifications.

35 microtubule-associated proteins, and tubulin posttranslational modifications.

36 in interactions, proteolytic activities, and posttranslational modifications.

37 otential regulation of ZBP1 function through posttranslational modifications.

38 ecursor peptide, TbtA, by a complex array of posttranslational modifications.

39 Lysine acetylation is a widespread posttranslational modification affecting many biological

40 ubstrates is an important disease-associated posttranslational modification, although few inhibitors

41 Like other, more well-studied posttranslational modifications, AMPylation is predicted

42 Posttranslational modification analysis of affinity-isol

43 Histone posttranslational modification analysis showed that the

44 evidence for a graded response to a tubulin posttranslational modification and a biochemical link be

45 ntegrity by responding to DNA damage through posttranslational modification and coordinating the down

46 irst case, to our knowledge, of both ex situ posttranslational modification and pharmacological repro

47 es associated with this poorly characterized posttranslational modification and provides a unique ins

48 ctivity by simultaneously repressing Fat via posttranslational modification and recruiting Dachs to t

49 The comparisons reported here of the posttranslational modifications and activities of p53 po

50 placed in recent years on roles for histone posttranslational modifications and chromatin-remodeling

51 n mechanics, including congenital mutations, posttranslational modifications and ligand binding, and

52 environmental cues, acquiring distinguishing posttranslational modifications and performing discrete

53 nucleotide sugars to drive processes such as posttranslational modifications and polysaccharide biosy

54 acellular domains, providing clues as to how posttranslational modifications and receptor function in

55 htly controlled through cyclin interactions, posttranslational modifications, and binding of inhibito

56 , it modulates huntingtin's function through posttranslational modifications, and it controls the sel

57 activity of sirtuins toward additional lysyl posttranslational modifications, and show that sirtuins

58 he reprogramming of DNA methylation, histone posttranslational modifications, and small noncoding RNA

59 nert C-terminal domain (CTD) of TOP2 and its posttranslational modification are critical to this chec

60 Posttranslational modifications are central to the spati

61 Posttranslational modifications are covalent changes mad

62 Furthermore, we show that posttranslational modifications are enriched at key loca

63 because tools and techniques to detect these posttranslational modifications are scarce.

64 ear to change due to H2O2 treatment, nor did posttranslational modifications, as measured by two-dime

65 Protein glycation is an age-dependent posttranslational modification associated with several n

66 itope in T1D and suggest there may be common posttranslational modifications at the C terminus of the

67 teins (IDPs) are known to undergo a range of posttranslational modifications, but by what mechanism d

68 most studied and best characterized histone posttranslational modifications, but it is not known if

69 Protein lysine posttranslational modification by an increasing number o

70 mechanism in which the leader peptide guides posttranslational modification by positioning the cross-

71 I (IFN-I) response has been shown to rely on posttranslational modification by ubiquitin (Ub) and Ub-

72 rsulfide donor for protein persulfidation, a posttranslational modification by which H2S is postulate

73 he process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have

74 Posttranslational modifications by small ubiquitin-like

75 torial tubulin code written in two different posttranslational modifications can arise through the ac

76 Posttranslational modifications can have profound effect

77 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification catalyzed by poly(ADP-rib

78 S-acylation is a major posttranslational modification, catalyzed by the zinc fi

79 the molluscan hormone and are unique in that posttranslational modifications characteristic of conoto

80 Timing of this posttranslational modification coincides with the ATM-me

81 ated with an abnormal composition of histone posttranslational modifications compared with mIC1.

82 Changes in protein by posttranslational modifications comprise an important me

83 Posttranslational modifications control microtubule beha

84 Posttranslational modifications control the functional a

85 -kappaB protein p65 on Ser-536 and that this posttranslational modification controls its nuclear loca

86 These posttranslational modifications create functionally dist

87 residues of the C-terminal tail generates a posttranslational modification-dependent PDZ/14-3-3 inte

88 Ubiquitin can be subjected to further posttranslational modifications (e.g., phosphorylation a

89 Thus, posttranslational modifications enable dynamic but tight

90 t that global quantitative rate analysis for posttranslational modification enzymes in complex milieu

91 (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associa

92 N-linked glycosylation is a common posttranslational modification found on viral glycoprote

93 Known posttranslational modifications function at the outer su

94 ntain repeated sequence motifs and extensive posttranslational modifications (glycosylation), and the

95 oproteins formed by the most complex form of posttranslational modification, glycosylation.

96 While posttranslational modification has been demonstrated to

97 y characterize despite the fact that several posttranslational modifications have already been identi

98 Histone posttranslational modifications have been associated wit

99 ional membrane transport system and a unique posttranslational modification-hypusination-that is beli

100 demonstrate that acetylation is a widespread posttranslational modification impacting proteins encode

101 Here, we introduce palmitoylation as a novel posttranslational modification in CLL, which might impac

102 Moreover, we identified the same posttranslational modification in eEF1A from Schizosacch

103 Maximal activity of EF-P requires a posttranslational modification in Escherichia coli, Pseu

104 Arginine methylation is a common posttranslational modification in eukaryotes catalyzed b

105 irions, suggesting a difference in G-protein posttranslational modification in the two cell lines.

106 osphorylation site, but the function of this posttranslational modification in the virus life cycle r

107 the mechanistic details of the role of this posttranslational modification in the virus life cycle r

108 charomyces cerevisiae eEF1A, we identified a posttranslational modification in which the alpha amino

109 Pupylation is a posttranslational modification in which the prokaryotic

110 ot have a major effect on the pattern of p53 posttranslational modifications in adenovirus-infected c

111 ed primarily in bacteria and is regulated by posttranslational modifications in eukaryotes, and both

112 or the detection of protein interactions and posttranslational modifications in microscopy and flow c

113 our findings suggest a stimulatory role for posttranslational modifications in PB accumulation and r

114 disease through the ability of Be to induce posttranslational modifications in preexisting HLA-DP2-p

115 three-step approach for installing authentic posttranslational modifications in recombinant proteins.

116 of the Golgi, which is required for accurate posttranslational modifications in the Golgi.

117 ion between alternative splicing and histone posttranslational modifications in the nucleus accumbens

118 data therefore support an important role of posttranslational modifications in the structural polymo

119 ified structure include somatic mutation and posttranslational modifications (including citrullinatio

120 mental details of how peptidases accommodate posttranslational modifications, including glycosylation

121 Tau is subject to various posttranslational modifications, including phosphorylati

122 damage response components is fine-tuned by posttranslational modifications, including ubiquitinatio

123 t in increased myocardial S-nitrosylation, a posttranslational modification increasingly implicated i

124 Histones and their posttranslational modifications influence the regulation

125 is a novel glutamylation substrate, and this posttranslational modification is critical for its funct

126 egulation, the molecular basis governing its posttranslational modification is enigmatic.

127 and, as is compatible with a crucial role in posttranslational modification, its N-terminal glycine i

128 nts the most prolific and well-characterized posttranslational modification known.

129 On a genome-wide scale, some of the histone posttranslational modification landscapes show significa

130 etter characterization of Drd3 signaling and posttranslational modifications, like palmitoylation, ma

131 rategy for counteracting and repurposing the posttranslational modification machineries of the host b

132 will be useful for projects aimed at histone posttranslational modification mapping in chromatin extr

133 Glutamylation, the most prevalent tubulin posttranslational modification, marks stable microtubule

134 tes of protein pyrophosphorylation, a unique posttranslational modification mediated by the PP-InsPs.

135 ecific sites and quantitative levels of this posttranslational modification modulate cellular pathway

136 d is vital to understand how these important posttranslational modifications modulate biological func

137 We propose that these posttranslational modifications modulate microbial virul

138 r for protein glycosylation, the most common posttranslational modification modulating the stability

139 Recently, we have determined that posttranslational modification (neddylation) of Cullin-4

140 emical reactions referred to as nonenzymatic posttranslational modifications (NEPTMs), such as glycox

141 dified by this glutaminylation and that this posttranslational modification occurs at all stages of y

142 Our studies show that redox-mediated posttranslational modification of brain proteins link Ab

143 ponsive transcriptional cascades through the posttranslational modification of CES and redundantly ac

144 Our results point to posttranslational modification of chromatin-bridging pro

145 s identify barttin palmitoylation as a novel posttranslational modification of CLC-K/barttin chloride

146 ermediate filaments and proteins involved in posttranslational modification of collagen.

147 S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH

148 ion (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an

149 in B. subtilis, a previously uncharacterized posttranslational modification of EF-P can modulate the

150 equirement for spermidine for the downstream posttranslational modification of eIF5A by its enzymatic

151 sm that controls the activation of ER by the posttranslational modification of epigenetic regulators,

152 his proteostatic mechanism, dependent on the posttranslational modification of GRP78, allows cells to

153 Taken together, our findings reveal a novel posttranslational modification of HBx by HDM2 which regu

154 asses of viral proteases observed to reverse posttranslational modification of host proteins by ubiqu

155 hese results expand our understanding of the posttranslational modification of KLF4 and of its role i

156 oated beads, indicating that charge-shifting posttranslational modification of Nap1 contributes to H1

157 Even though the ubiquitin-like posttranslational modification of neddylation, that conj

158 methylation is an important and much-studied posttranslational modification of nuclear and cytosolic

159 O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic prot

160 O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc a

161 Posttranslational modification of proteins by small ubiq

162 Posttranslational modification of proteins by small ubiq

163 Posttranslational modification of proteins by ubiquitin

164 Posttranslational modification of proteins expands their

165 Because the posttranslational modification of proteins via S-nitrosy

166 Palmitoylation is the posttranslational modification of proteins with a 16-car

167 ms involving nitric oxide (NO) synthesis and posttranslational modification of proteins.

168 transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thio

169 esis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, an

170 Posttranslational modification of ribosomally synthesize

171 Our findings indicate that posttranslational modification of SR proteins underlies

172 k of processes that generate ssDNA, and that posttranslational modification of ssNucs may generate no

173 Here, we studied the posttranslational modification of such channels by palmi

174 s essential for surface exposure of PorU and posttranslational modification of T9SS cargo proteins.

175 We propose that posttranslational modification of TCP14/15 by SPY inhibi

176 h was associated with transcriptional and/or posttranslational modification of the central cell-cycle

177 In all cells, IL-6 treatment results in posttranslational modification of the proapoptotic prote

178 is insufficient to stabilize opening; thus, posttranslational modification of the protein may be req

179 ins, resulting in a widespread, irreversible posttranslational modification of the protein's structur

180 ription of the POR and CHLP genes but to the posttranslational modification of their protein products

181 O-fucosylation is a common posttranslational modification of thrombospondin type 1

182 al therapies to target it, is to examine the posttranslational modification of viral proteins and its

183 in-related modifier (SUMO)ylation as a novel posttranslational modification of WASp, impairment of wh

184 mall-molecule inhibitors targeting essential posttranslational modification of Wnt reduced tumour gro

185 is-unsaturated fatty acyl group, a necessary posttranslational modification of Wnts, by multiple FZD

186 arizes the progress in the research field of posttranslational modifications of chloroplast proteins

187 cular the cerebellum, nor the effects of any posttranslational modifications of FOXP2 in the brain an

188 elevance of these findings and the potential posttranslational modifications of HDAC1 remained elusiv

189 Posttranslational modifications of histone proteins repr

190 m may include more than 100 residue-specific posttranslational modifications of histones forming the

191 Posttranslational modifications of LARP6 and how they af

192 ns of the core histones constitute sites for posttranslational modifications of major epigenetic impa

193 Phosphorylation and other posttranslational modifications of MeCP2 have been descr

194 but have since diverged to control distinct posttranslational modifications of NCAM1.

195 thers indicates that, in addition to various posttranslational modifications of NF-kappaB that have b

196 n induce either proapoptotic or prosenescent posttranslational modifications of p53.

197 on of the POSH scaffold complex and distinct posttranslational modifications of POSH.

198 FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in t

199 roteomic approaches to understand changes in posttranslational modifications of proteins that may exp

200 n ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regul

201 These posttranslational modifications of RyR1 were mediated by

202 improved mitochondrial function and reduced posttranslational modifications of RyR2 macromolecular c

203 Posttranslational modifications of self-proteins play a

204 note "stressorins." We highlight the role of posttranslational modifications of stressorins as key re

205 main enzymes catalyze adenylylation or other posttranslational modifications of target proteins to co

206 LPS induces posttranslational modifications of TDP-43; in particular

207 Posttranslational modifications of the N2B element are t

208 unctional constraints, we dissected here the posttranslational modifications of the nuclear basket pr

209 strate that SC fate is dependent on opposing posttranslational modifications of the Pax7 protein.

210 s capable of hijacking Rab1 function through posttranslational modifications of the switch II region.

211 if the positive charge and susceptibility to posttranslational modifications of these lysines contrib

212 this trafficking is synchronized by dynamic posttranslational modifications of USP20 that, in turn,

213 omodulin N-terminal domain are O-sulfated, a posttranslational modification often involved in protein

214 eir cell surface, and MS analysis revealed a posttranslational modification on cysteine 328 (C328) by

215 functionally identified a novel Her4-induced posttranslational modification on MDMX at Ser-314, a put

216 PRMT-1) cooperate to orchestrate a series of posttranslational modifications on the IF-anchoring prot

217 f neurodegenerative diseases, the effects of posttranslational modifications on the molecular propert

218 This study highlights the influence of posttranslational modifications on viral protein functio

219 teogenic amino acids, which may then require posttranslational modification or the recruitment of coe

220 h epitopes on glycoproteins may be formed by posttranslational modifications or neoepitopes resulting

221 SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the co

222 The posttranslational modification pathway leading to lipopr

223 alidate a quantitative assay for detecting a posttranslational modification (phosphorylation at resid

224 Dysfunction of protein posttranslational modification plays critical roles in t

225 ncrease in their catalytic production of the posttranslational modification poly(ADP-ribose) (PAR) to

226 Proteins may undergo a type of posttranslational modification - polyglutamylation, wher

227 Poly(ADP-ribose) (PAR) is a posttranslational modification predominantly synthesized

228 with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and

229 findings indicate that regulation of GPS2 by posttranslational modifications provides an effective st

230 asthma-related phenotypes through oxidative posttranslational modification (PTM) of proteins in asth

231 ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that co

232 hat cellular exposure to *NO changes histone posttranslational modifications (PTM) by directly inhibi

233 the individual nuclei using histone type- or posttranslational modification- (PTM-) specific antibodi

234 Posttranslational modifications (PTMs) affecting E2 func

235 dependent conformational cycle influenced by posttranslational modifications (PTMs) and assisted by a

236 ampal neurons, Abeta acutely induces tubulin posttranslational modifications (PTMs) and stabilizes dy

237 Posttranslational modifications (PTMs) are key contribut

238 genetic marks, including DNA methylation and posttranslational modifications (PTMs) in histones, are

239 aging method to measure histones and histone posttranslational modifications (PTMs) in single cells.

240 Posttranslational modifications (PTMs) of tubulin specif

241 Posttranslational modifications (PTMs) regulate protein

242 Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM c

243 Protein posttranslational modifications (PTMs), including acetyl

244 genesis revealed specific and well-conserved posttranslational modifications (PTMs), including O-myco

245 Mapping posttranslational modifications (PTMs), which diversely

246 CoA, can modify proteins, leading to protein posttranslational modifications (PTMs).

247 to target RUNX1 is through modulation of its posttranslational modifications (PTMs).

248 brane organization of CD82, through specific posttranslational modifications, regulates N-cadherin cl

249 Protein ADP-ribosylation is a covalent posttranslational modification regulating cellular prote

250 Signals and posttranslational modifications regulating the decapping

251 t MC159 inhibited NEMO polyubiquitination, a posttranslational modification required for IKK and down

252 d biochemical analyses, this work shows that posttranslational modifications, specifically, phosphory

253 Mutations and posttranslational modifications stabilize high-energy in

254 inding sites represent hot spots for defined posttranslational modifications such as lysine acetylati

255 However, the role of other posttranslational modifications, such as deacetylation/a

256 Collagens are subjected to extensive posttranslational modifications, such as lysine hydroxyl

257 postulate that epsilon ligation is a genuine posttranslational modification, suggesting that the prot

258 conserved waters also correspond to sites of posttranslational modifications, suggesting that the con

259 at eEF1A glutaminylation is a yeast-specific posttranslational modification that appears to influence

260 ous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram

261 Disulfide bonds are a common posttranslational modification that contributes to the f

262 ly reduced SUMOylation of S100A4, a critical posttranslational modification that directs its traffick

263 ADP-ribosylation is a posttranslational modification that exists in monomeric

264 Arginine methylation is a common posttranslational modification that has been shown to re

265 Palmitoylation is a reversible, posttranslational modification that helps target protein

266 Arginine methylation is a posttranslational modification that impacts wide-ranging

267 ein tyrosine sulfation (PTS) is a widespread posttranslational modification that induces intercellula

268 AMPylation is an emerging posttranslational modification that involves the additio

269 lucosepane is a structurally complex protein posttranslational modification that is believed to exist

270 S-palmitoylation is a dynamic posttranslational modification that is important for tra

271 independently of its gamma-carboxylation, a posttranslational modification that is known to hamper O

272 s, referred to as polysialylation, is a rare posttranslational modification that is mainly known to c

273 Protein acetylation is a prevalent posttranslational modification that is regulated by dive

274 GlcNAcase (OGA), has emerged as an important posttranslational modification that may factor in multip

275 SUMO is a key posttranslational modification that modulates the functi

276 Lysine acetylation is a key posttranslational modification that regulates diverse pr

277 Linear ubiquitination is a key posttranslational modification that regulates immune sig

278 Ubiquitination is a posttranslational modification that regulates many cellu

279 Ubiquitination, the crucial posttranslational modification that regulates the eukary

280 UT decreased PP2A activity through posttranslational modification that was accompanied by a

281 ese mechanisms of activation, as well as the posttranslational modifications that affect this process

282 phylquinone (CTQ) cofactor that is formed by posttranslational modifications that are catalyzed by a

283 N-terminal histone tails are subject to many posttranslational modifications that are recognized by a

284 id-binding domain that undergoes a number of posttranslational modifications that can modulate htt to

285 ns (IDRs) of proteins are often the sites of posttranslational modifications that control cell-signal

286 muli relies on the generation of cascades of posttranslational modifications that promote protein-pro

287 ccelerates diprolyl synthesis and requires a posttranslational modification to maintain proteostasis.

288 activity of multiple proteins via oxidative posttranslational modifications to fine-tune guard cell

289 Posttranslational modifications to the intracellular dom

290 e the activity of various target proteins by posttranslational modification, typically AMPylation.

291 The importance of this posttranslational modification was revealed when mutagen

292 While investigating the function of this posttranslational modification, we serendipitously disco

293 Ubiquitination is a key posttranslational modification, which affects numerous b

294 s, histones are subject to a large number of posttranslational modifications whose sequential or comb

295 Protein AMPylation is a conserved posttranslational modification with emerging roles in en

296 Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical com

297 Posttranslational modification with ubiquitin chains con

298 Posttranslational modifications with small ubiquitin-lik

299 inding depended on an orchestrated series of posttranslational modifications within Aire's caspase ac

300 Therefore, MCa is potentially subjected to posttranslational modifications within recipient cells.