ライフサイエンスコーパス: potential drug target

1 lism of microbial human pathogens, PPDK is a potential drug target.

2 multi-drug efflux we suggest that CsrA is a potential drug target.

3 iral maturation and has been identified as a potential drug target.

4 facing pathogen, Citrobacter rodentium, as a potential drug target.

5 nd will enable therapeutic targeting of this potential drug target.

6 an essential step in virus replication and a potential drug target.

7 an essential mediator in SIRS and, hence, a potential drug target.

8 thogens and its absence in humans make UGM a potential drug target.

9 as been identified as a virulence factor and potential drug target.

10 ilities for the utilization of center N as a potential drug target.

11 purine nucleoside phosphorylase (PfPNP) is a potential drug target.

12 upregulated in numerous cancers making it a potential drug target.

13 g, validating the Vif-APOBEC3 interface as a potential drug target.

14 viral precursor polyprotein and therefore a potential drug target.

15 cific inhibition of LysRS1 indicates it is a potential drug target.

16 l aid in identifying new inhibitors for this potential drug target.

17 f-splicing reaction and thus is a model of a potential drug target.

18 the organism and thus identify CaMnn9p as a potential drug target.

19 l effects of anandamide, and may represent a potential drug target.

20 1 as an essential gene, validating CRK1 as a potential drug target.

21 ription factor within the top GO term, and a potential drug target.

22 sion injury, and suggest that Plexin C1 is a potential drug target.

23 and INPP4B alterations, supporting IGF2 as a potential drug target.

24 arasitic nematode Haemonchus contortus, as a potential drug target.

25 patch on the NTD of TbBILBO1 is therefore a potential drug target.

26 ese humans, strengthening its prospects as a potential drug target.

27 en considered essential and is proposed as a potential drug target.

28 neration of PD pathogenesis, making LRRK2, a potential drug target.

29 insights about molecular pathophysiology and potential drug targets.

30 s, KDM4 proteins present themselves as novel potential drug targets.

31 important biological pathways, rhomboids are potential drug targets.

32 s may represent a promising reservoir of new potential drug targets.

33 the process of fibril extension and provide potential drug targets.

34 te the highly conserved trypanosomal PDEs as potential drug targets.

35 ase family C (GT-C) members, which represent potential drug targets.

36 have been implicated in pathogenesis and are potential drug targets.

37 site and, consequently, can be considered as potential drug targets.

38 ences in their properties and to predict new potential drug targets.

39 uld be particularly valuable for identifying potential drug targets.

40 o the identification of many more kinases as potential drug targets.

41 es of trypanosomatid ribosome assembly offer potential drug targets.

42 ole in signal transduction and are therefore potential drug targets.

43 a phosphorylation of CDK1 and are considered potential drug targets.

44 ion of KS tumor markers for diagnosis and as potential drug targets.

45 aid in drug discovery and identification of potential drug targets.

46 vealing structure-function relationships and potential drug targets.

47 known as falcipains, are hemoglobinases and potential drug targets.

48 polyglutamine pathology, and in identifying potential drug targets.

49 cate dimerization interfaces of oncogenes as potential drug targets.

50 lciparum suggests that they might be used as potential drug targets.

51 ive method for identifying malarial genes as potential drug targets.

52 seful in identifying novel disease genes and potential drug targets.

53 gs, their side effects, withdrawn drugs, and potential drug targets.

54 oteomics to identify novel BCR effectors and potential drug targets.

55 survival in Mtb, commending both proteins as potential drug targets.

56 nteracting proteins, that may thus represent potential drug targets.

57 dium lipid synthesis enzymes are emerging as potential drug targets.

58 e siRNA gene knockout studies and identified potential drug targets.

59 genesis of ALS and merit further analysis as potential drug targets.

60 rpin RNA (shRNA) library to screen for novel potential drug targets.

61 isms underpinning these diseases and suggest potential drug targets.

62 milies or posttranslational modifications as potential drug targets.

63 om the host, these kinases are considered as potential drug targets.

64 genomes could identify key intermediates as potential drug targets.

65 n of gene function and the identification of potential drug targets, a process often known as target

66 dentify malignancy-associated biomarkers and potential drug targets, a signature proteome.

67 se-1,6-bisphosphatase has been proposed as a potential drug target against Leishmania parasites that

68 bECT is therefore genetically validated as a potential drug target against the African trypanosome.

69 ssential pyruvate transporter and provides a potential drug target against the mammalian life cycle s

70 d genes encoding proteins that represent new potential drug targets against hookworms.

71 ggest that macrophage PAR1 and calpain 1 are potential drug targets against leishmaniasis.

72 In silico screening identified numerous new potential drug targets against trichuriasis.

73 ites in their vicinity are anticipated to be potential drug targets aimed at inhibiting viral infecti

74 of attention from both the perspective of a potential drug target and a catalyst for the development

75 Thus, Ldp27 can be explored as a potential drug target and parasites devoid of the p27 ge

76 abotropic glutamate receptor 4 (mGluR4) as a potential drug target and predicted that selective activ

77 ing site in cysteine protease cathepsin B, a potential drug target and prognostic marker for tumor me

78 synthesis, identifying HMG-CoA synthase as a potential drug target and suggesting that identification

79 , can provide pathogenic insights as well as potential drug targets and biomarkers for T2D and other

80 wnstream genes valuable candidates for being potential drug targets and exploratory biomarkers.

81 ovided an opportunity to expand the range of potential drug targets and have facilitated a fundamenta

82 Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind

83 y also allow the efficient identification of potential drug targets and markers for monitoring the co

84 lved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their prot

85 nd previously unconsidered cellular genes as potential drug targets and to provide insight into basic

86 teins play important roles in cancer and are potential drug targets and tumor markers.

87 ied 562 NF-kappaB/RelA modulators, which are potential drug targets, and clarified mechanisms of achi

88 ul for study of gene functions, discovery of potential drug targets, and gene therapy applications.

89 rapid acceleration in the identification of potential drug targets, and in high-throughput screens f

90 They represent excellent potential drug targets, and it is likely that additional

91 sequences of uncoupling V-ATPases in vivo as potential drug targets are discussed.

92 ed significantly, its underlying biology and potential drug targets are still unexplored.

93 FtsZ is a potential drug target, as illustrated by the small-molec

94 te cancer above Gleason grade 3, ERbeta is a potential drug target at the initial stage of the diseas

95 The LT superfamily is a potential drug target because it is active in essential

96 eins have received considerable attention as potential drug targets because of their ability to modul

97 Topoisomerases are valuable as potential drug targets because they have indispensable f

98 of the menaquinone (Vitamin K2) pathway are potential drug targets because they lack human homologs.

99 spases have been intensively investigated as potential drug targets, both in academic and industrial

100 lective of biological predisposition and are potential drug targets) brought to the fore APOE and IL6

101 g number of proteins are being identified as potential drug targets but are difficult to obtain in a

102 iology, both enzymes have been identified as potential drug targets, but few useful inhibitors have b

103 proteases are increasingly being explored as potential drug targets, but their potent and specific in

104 dentify genes or pathways for new and unique potential drug targets, determine premorbid diagnosis, p

105 p90 ribosomal S6 family of kinases (RSK) are potential drug targets, due to their involvement in canc

106 ressentiality can help choose an enzyme as a potential drug target, especially because the index is n

107 s of metabolism can be useful in identifying potential drug targets, especially in unicellular organi

108 and processing in AD, suggesting Golgi as a potential drug target for AD treatment.

109 inant of tumor angiogenesis and, hence, as a potential drug target for adjuvant therapy of solid tumo

110 ls and zebrafish, MAP2K5 kinase emerged as a potential drug target for ALS therapy.

111 ique sensor of noxious stimuli and, hence, a potential drug target for analgesics.

112 as a host factor for HCV infection and as a potential drug target for antiviral therapy.

113 ocking ADAM8 function, highlighting ADAM8 as potential drug target for asthma therapy.

114 nd myelomonocytic fate and suggests Glut1 as potential drug target for atherosclerosis.

115 ions allows critical evaluation of Plk1 as a potential drug target for cancer therapy.

116 ulator of neurovasculature development and a potential drug target for cerebrovascular diseases.

117 radation of these client proteins makes it a potential drug target for certain forms of cancer.

118 of this, it has received much attention as a potential drug target for controlling diseases such as r

119 this study supports the notion that sT is a potential drug target for dampening MCPyV infection.

120 The GIVD cPLA2 (cPLA2delta) is a potential drug target for developing a selective therape

121 a critical regulator of the Hh pathway and a potential drug target for Hh-driven cancers.

122 These data suggest a new potential drug target for human C. difficile treatment a

123 f PI3K signaling, and is also discussed as a potential drug target for immunomodulation and the treat

124 bitor of both inflammation and cancer, and a potential drug target for inflammatory and neoplastic di

125 , suggesting that the JAK/STAT1 pathway is a potential drug target for inhibiting HMGB1 release.

126 mmalian parasitization and thus represents a potential drug target for leishmaniasis.

127 ion in cancerous tissues and is considered a potential drug target for liver and lung cancer.

128 acid homeostasis, has recently emerged as a potential drug target for liver disease.

129 et of Hh signaling regulation, and reveals a potential drug target for modulating Hh signaling activi

130 Parasite lactate dehydrogenase (pLDH) is a potential drug target for new antimalarials owing to par

131 arrest and apoptosis, so it is considered a potential drug target for oncology.

132 the enzyme in cuticle production makes it a potential drug target for parasitic nematodes.

133 absorption and macrophage iron release, is a potential drug target for patients with iron overload sy

134 that the AMP site of FBPase may represent a potential drug target for reducing the excessive glucose

135 The NorA efflux pump is a potential drug target for reversal of resistance to sele

136 atening disease, and supports COUP-TFII as a potential drug target for the intervention of metastatic

137 o uroporphyrinogen III and serves as a novel potential drug target for the pharmaceutical industry.

138 receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Par

139 This identifies Star-PAP as a potential drug target for the treatment of HPV-positive

140 rrent inhibition by nifedipine, CaV1.1e is a potential drug target for the treatment of myotonic dyst

141 (GOAT), is receiving increased interest as a potential drug target for the treatment of obesity, diab

142 The adenosine A(2A) receptor (A(2A) R) is a potential drug target for the treatment of Parkinson's d

143 The H3R has attracted interest as a potential drug target for the treatment of several impor

144 tor of insulin receptor (IR) signaling and a potential drug target for the treatment of type 2 diabet

145 tative allosteric activator site, which is a potential drug target for the treatment of type 2 diabet

146 These data define PTPMT1 as a potential drug target for the treatment of type II diabe

147 from inflammatory arthritis, making iRHOM2 a potential drug target for this condition.

148 ing of assembly, which is an as yet untapped potential drug target for this important class of pathog

149 PCR, GPR161, as an important regulator and a potential drug target for TNBC.

150 he hepatic RAR-FGF21 pathway may represent a potential drug target for treating metabolic disorders.

151 esses and has generated recent interest as a potential drug target for treating neurodegenerative dis

152 A potential drug target for treatment of Chagas disease, s

153 years, ASBT has attracted much interest as a potential drug target for treatment of hypercholesterola

154 In humans, it is a potential drug target for treatment of primary hyperoxal

155 ymes in this pathway, only HisG represents a potential drug target for tuberculosis.

156 -induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations

157 protein-coupled receptors, is emerging as a potential drug target for various disorders, including c

158 AH2-omega-3 epoxide-Srcin1 axis presents new potential drug targets for allergic diseases.

159 tion of genes, and for the identification of potential drug targets for antimicrobial treatment.

160 imply that these responses are attractive as potential drug targets for blocking the evolution of pat

161 Tankyrases constitute potential drug targets for cancer and myelin-degrading d

162 Glutamate receptors are important potential drug targets for cognitive enhancement and the

163 ate central nervous system and are important potential drug targets for cognitive enhancement and the

164 essential roles in viral propagation and are potential drug targets for curbing herpesvirus infection

165 nd present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

166 Histone deacetylases are potential drug targets for diseases caused by protozoan

167 This study establishes the PLKs as potential drug targets for influenza and contributes to

168 -transduction regulators and have emerged as potential drug targets for inhibitor design.

169 st that the extracellular domains of APP are potential drug targets for interfering with beta-secreta

170 These proteases may constitute potential drug targets for intervention against malaria

171 Because Hsp70s are emerging as potential drug targets for many diseases, fully mapping

172 Since many of these enzymes represent potential drug targets for metabolic diseases, efforts w

173 actinobacteria and highlights a new class of potential drug targets for mycobacterial diseases.

174 atory subunits KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they

175 Thus, these modulatory subunits could be potential drug targets for neuropathic pain.SIGNIFICANCE

176 ght into the role of ASIC1a and CP-AMPARs as potential drug targets for neuroprotection.

177 Our results suggest that LIMKs are potential drug targets for NF2 and tumors associated wit

178 genomics and proteomics are identifying many potential drug targets for novel therapeutic proteins, a

179 these reasons, cyclophilins have emerged as potential drug targets for several diseases.

180 of blood pressure regulation and highlights potential drug targets for the prevention or treatment o

181 portant regulators of liver repopulation and potential drug targets for the promotion of liver repopu

182 verse cognitive functions and they represent potential drug targets for the treatment of a number of

183 , and miR-326 and miR-9 may be considered as potential drug targets for the treatment of disorders in

184 These proteins are potential drug targets for the treatment of muscle atrop

185 te axon death genes, thereby providing novel potential drug targets for therapeutic intervention to p

186 rious pathways affected, as well as provided potential drug targets for therapeutics.

187 tioxidant small molecules such as NtBuHA are potential drug targets for thioesterase deficiency disea

188 ical pathways that may provide insights into potential drug targets for treatment or prevention of CV

189 xpression profiles and the identification of potential drug targets from biologically active compound

190 Elucidation of new biomarkers and potential drug targets from high-throughput profiling da

191 We identified 20 potential drug target genes in two genomewide-corrected

192 es in these parasites, and a number of novel potential drug targets have been identified.

193 ns that HBc makes prior to capsid formation (potential drug targets) have proved refractory to struct

194 entifies Vaccinia-related kinase (VRK1) as a potential drug target in a tumour-specific mitotic netwo

195 Our findings indicate that PTGER4 is a potential drug target in AI-resistant cancers.

196 ide 3-kinase beta (PI3Kbeta) is considered a potential drug target in arterial thrombosis, which is a

197 ptor 2, the androgen receptor (AR) is also a potential drug target in breast cancer treatment.

198 diagnostic/prognostic value and can act as a potential drug target in cervical cancer.

199 ling partner for Bcr-Abl and may represent a potential drug target in CML.

200 ges of L. donovani and authenticate ASL as a potential drug target in Leishmania.

201 c glutamate receptor subtype 5 (mGluR5) is a potential drug target in neurological and psychiatric di

202 these results indicate that CRL4(CDT2) is a potential drug target in ovarian cancers and that MLN492

203 yme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which ca

204 tumor cells to IR, implicating gadd45a as a potential drug target in radiotherapy management.

205 enzyme porphobilinogen synthase (PBGS) is a potential drug target in several human pathogens.

206 yl diphosphate biosynthetic pathway and is a potential drug target in some pathogenic bacteria.

207 -2 in these keratinocytes and may serve as a potential drug target in the chemoprevention of skin can

208 Our observations suggest that SR-A may be a potential drug target in the prevention of metastatic ca

209 tion for the hypothesis that toxopain-1 is a potential drug target in Toxoplasma gondii and also prov

210 power-grid network and the identification of potential drug targets in a signalling network of human

211 and identify myeloid-specific Src kinases as potential drug targets in CML.

212 identify NAD(P)(H)-binding proteins that are potential drug targets in Mycobacterium tuberculosis and

213 These bifunctional proteins are potential drug targets in several human pathogens (e.g.

214 they could represent driver alterations and potential drug targets in subgroups of SCLC patients.

215 to solve structures of proteins that may be potential drug targets, in order to support drug discove

216 We identify new potential drug targets, including some on which existing

217 factorization (DNILMF) algorithm to predict potential drug-target interactions (DTI).

218 nal contact points of the ligand, to predict potential drug-target interactions with remarkable accur

219 amidase, a metal-dependent amidase that is a potential drug target involved in the mycothiol detoxifi

220 Evaluation of the BRPF family as a potential drug target is at an early stage although ther

221 One potential drug target is isocitrate dehydrogenase 1 (IDH

222 PqsBC, a potential drug target, is unique for its heterodimeric a

223 of inhibiting these enzymes and as leads for potential drugs targeting JNKs.

224 erstanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to fur

225 Methods to accurately predict potential drug target mutations in response to early-sta

226 are available to treat CoV infections; thus, potential drug targets need to be identified and charact

227 n stress response and cell survival and is a potential drug target of activators and inhibitors.

228 Accordingly, any potential drug targeting of this gene product must be st

229 the toxic Abeta peptides may also provide a potential drug target or targetable pathway for interven

230 al of five different RNA constructs: four as potential drug targets plus one control RNA construct.

231 To identify virulence factors and potential drug targets, random transposon (Tn) mutants d

232 olubility screen and detailed results for 41 potential drug target recombinant proteins from infectio

233 ity of remote memory and identifies AC1 as a potential drug target site to improve long-term remote m

234 PCR) C-X-C chemokine receptor 3 (CXCR3) is a potential drug target that mediates signaling involved i

235 As the list includes a number of known and potential drug targets, the identification of NTP bindin

236 if activity toward both A3F and A3G and is a potential drug target to inhibit Vif activity and block

237 altered, making serine 14 phosphorylation a potential drug target to interfere with TRPC6 channel ac

238 nel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related s

239 found in human, suggesting that they may be potential drug targets to block encystation.

240 ed in a myriad of contexts, from identifying potential drug targets to predicting the spread of epide

241 ther pathways localized in the apicoplast as potential drug targets to prevent malaria infection.

242 e of our society, and thus identification of potential drug targets to reduce age-associated disease

243 athways in GAS species narrows the choice of potential drug targets to the two indispensable downstre

244 ets of insulin signaling that could serve as potential drug targets to treat type 2 diabetes.

245 ation of disease states and the selection of potential drug targets, to patient selection and the con

246 Finally, by analyzing potential drug targets, we provide a genomics-based rati

247 bolic functions of P. gingivalis and suggest potential drug targets, we study systematically how the

248 evidence about the association of known and potential drug targets with diseases.

249 roperties of a wide range of established and potential drug targets, with in-depth information for a

250 rotein and messenger RNA levels, and suggest potential drug targets within the kinase-substrate netwo

251 se antibiotics, prompting a re-evaluation of potential drug targets within the pathway.

252 lopment of small-molecule agonists acting at potential drug targets within this physiologically impor