ライフサイエンスコーパス: potential target

1 specific substrates among a diverse array of potential targets.

2 resultant data to screen for uncharacterized potential targets.

3 ociated with ARGONAUTE proteins and have few potential targets.

4 mutant lung adenocarcinomas and pinpoint new potential targets.

5 ealed inducible and noninducible pathways as potential targets.

6 injection of noise in the prioritization of potential targets.

7 is have yet to be preclinically evaluated as potential targets.

8 n preclinical translational science point to potential targets across multiple organ systems for earl

9 findings suggest that miR-128-3p might be a potential target against both metastasis and chemoresist

10 STAT3-mutant PTCL xenografts, delineating a potential targeted agent-based therapeutic option for th

11 ning deficits in mood disorders as well as a potential target - altering an individual's mood or task

12 Moreover, we unveiled Ang-2 as a potential target and suitable response biomarker for N6L

13 These findings point to potential targets and pathways that may be central to as

14 Our experiments may identify potential targets and strategies for sensitizing pancrea

15 SS has allowed for the identification of new potential targets and the development of novel biology-d

16 and compared with expression profiles of its potential targets associated with lipid traits.

17 e and substrate specificity owing to several potential target bonds within the reactive-center loop a

18 tumor-associated Ag should be considered as potential targets, but tumor reduction should always be

19 pes of ARGONAUTE proteins and that they have potential target candidate genes.

20 ccine delivery, the skin is viewed as a high potential target, due to the abundance of immune cells t

21 sues, and developed an algorithm to identify potential targets expressed in leukemia stem cells, but

22 acting on the GABA-polarity switch offers a potential target for 22q11.2 DS therapeutic intervention

23 erest in neurodegenerative diseases and as a potential target for AD therapies.

24 Our results demonstrate that CXCR7 is a potential target for adjuvant therapy in combination wit

25 This P450 is also a potential target for Alzheimer disease because it can be

26 le-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates.

27 n the majority of human cancers, and it is a potential target for anticancer therapy.

28 yofibroblasts, suggesting that MSLN may be a potential target for antifibrotic therapy.

29 h systemic infections, and TacL represents a potential target for antimicrobial drug development.

30 nuclease, therefore, should be explored as a potential target for antiviral development against human

31 n, and it suggests that the SLII domain is a potential target for antiviral therapy.

32 plex or the retrograde pathway can provide a potential target for antiviral therapy.

33 The TMD surface we defined is a potential target for auxiliary subunit-specific compound

34 l regulator of MRE11 and identify cIAP2 as a potential target for biomarker discovery or chemoradiati

35 e the brain over time, this paper provides a potential target for blocking the progression of CVD.

36 get for atherosclerosis, is therefore also a potential target for cancer immunotherapy.

37 tumor growth in bone, pointing to CXCL5 as a potential target for cancer therapeutics.

38 Mps1 has emerged as a potential target for cancer therapy, and a variety of co

39 As Ror1 has been implicated to be a potential target for cancer therapy, we selected this pr

40 Our results suggest that lipin-1 is a potential target for cancer therapy.

41 on neutrophil migration, suggesting a2V as a potential target for cancer therapy.

42 and GABAB receptors have been proposed as a potential target for clinical treatment of alcoholism.

43 g suggests that the secondary resistome is a potential target for developing antimicrobial "helper" d

44 NA and energy generation, it may represent a potential target for developing new antifungals.

45 of EMT, indicating IL-17-MMP7-EMT axis as a potential target for developing new strategies in the pr

46 e distinct compared with human, suggesting a potential target for development of parasite-specific in

47 e in breast cancer development and provide a potential target for diagnosis and therapeutic treatment

48 d prolongs lifespan, pointing to DNAJB6 as a potential target for disease therapy and tool for unrave

49 provides a platform to explore LdTyrRS as a potential target for drug development.

50 The integrin-IL-1beta interaction is a potential target for drug discovery.

51 mours separase is overexpressed, making it a potential target for drug discovery.

52 se studies provide evidence that the AR is a potential target for drug therapy to treat conditions as

53 MCs) in DVT initiation and validate MCs as a potential target for DVT prevention.

54 survival factor for these cells, making it a potential target for EOMA therapeutics.

55 Menaquinone (MK) biosynthesis pathway is a potential target for evaluating antimicrobials in gram-p

56 ation in clinical trials and may represent a potential target for future PAH drug development.

57 toimmunity during pregnancy and represents a potential target for future therapy.

58 Another potential target for gene editing are DNA viruses that c

59 ivity, suggesting that SP110b may serve as a potential target for host-directed therapy aimed at mani

60 tudy identifies calpain exteriorization as a potential target for immune modulation.

61 many tumors and is, therefore, considered a potential target for immunotherapy.

62 in endometrial carcinogenesis and could be a potential target for improving EC treatment strategies.

63 ms that control blood pressure and provide a potential target for individualized antihypertensive the

64 ment during latency and, therefore, may be a potential target for intervention strategies.

65 y is a potent modulator of nociception and a potential target for interventions to alleviate chronic

66 on events, daily eating pattern offers a new potential target for lifestyle intervention to reduce CV

67 ession, and FAK signaling pathway could be a potential target for liver fibrosis.

68 cytometric screening to identify ICAM-1 as a potential target for metastatic melanoma (MM).

69 perties via its metabolic activity, and as a potential target for modulating barrier function in endo

70 We propose SK channels as a potential target for modulating SAN rate, and for treati

71 FKBP5 is accordingly a potential target for more extensive studies of the impac

72 in promoting cell death and is emerging as a potential target for neurological diseases.

73 Our results identify Cdc25A as a potential target for neuroprotectant strategy for the tr

74 SOCE may therefore serve as a potential target for new bronchodilators to reduce airwa

75 g infection and identifies this pathway as a potential target for novel immune-based treatments of ch

76 Here we identify N17 as a potential target for novel therapeutic intervention usin

77 y for NE clearance, which thus constitutes a potential target for obesity treatment.

78 naling pathways and has been implicated as a potential target for oncology and diabetes/obesity.

79 e traits of osteosarcoma cells and provide a potential target for osteosarcoma therapy.

80 for mutant channels, highlighting KCNC1 as a potential target for precision therapeutics.

81 ts with Chagas heart disease, which may be a potential target for preventing progression of inflammat

82 al identity in PanIN initiation and may be a potential target for prevention of PDA initiation.

83 highlight inhibition of NRG3 signaling as a potential target for psychiatric treatment development.

84 ion- and motivation-related projection and a potential target for relapse prevention.

85 Modulation of cis-UCA may be a potential target for skin diseases associated with IgE-m

86 The linker-binding site on the SBD is a potential target for small molecule modulators of the Hs

87 The disease is a potential target for stem cell therapy but success is li

88 key virulence factor in Campylobacter and a potential target for the control of this zoonotic pathog

89 Our findings suggest a potential target for the control of vessel restenosis.

90 nase C epsilon (PKCepsilon) is emerging as a potential target for the development of pharmacotherapie

91 ults show that the uPA/uPAR/LRP1 system is a potential target for the development of therapeutic stra

92 rophy treatment, but also identify PHD3 as a potential target for the development of therapies for mu

93 nserved Vif-Pr55(Gag) interaction provides a potential target for the future development of antiviral

94 usceptibility gene for CAD, which provides a potential target for the prevention and treatment of CAD

95 se microvascular dysfunction might provide a potential target for the prevention and treatment of dep

96 he MMP-2-alphaIIbbeta3-PAR1 interaction as a potential target for the prevention of arterial thrombos

97 ting that glucocorticoid receptor might be a potential target for the therapy of Leydig cell tumors.

98 verses dendritic spine density, suggesting a potential target for the treatment of addiction in chron

99 g, identifying this histone demethylase as a potential target for the treatment of anxiety and depres

100 The transcription factor STAT3 is a potential target for the treatment of castration-resista

101 inflammation in wound repair and identify a potential target for the treatment of chronic inflammati

102 rom microglia, in the NAc represents a novel potential target for the treatment of cocaine relapse.

103 Thus BMP signaling is a new and powerful potential target for the treatment of depression.

104 ction and has therefore been identified as a potential target for the treatment of immunological diso

105 A1 neurons and that HCN channels represent a potential target for the treatment of major depressive d

106 This system represents a potential target for the treatment of metabolic diseases

107 A4 or GPR120) has appeared as an interesting potential target for the treatment of metabolic disorder

108 new blood vasculature, angiogenesis offers a potential target for the treatment of obesity-associated

109 he pathogenesis of GSDIa, and identify a new potential target for the treatment of this disease.

110 ncover a new critical regulatory region as a potential target for therapeutic genome editing for hemo

111 onses to stress and may therefore serve as a potential target for therapeutic intervention for stress

112 pivotal role in demyelination, making them a potential target for therapeutic intervention, and that

113 CMV coinfection, which represents a potential target for therapeutic intervention, was stron

114 somatosensory signal integration and offer a potential target for therapeutic intervention.

115 and Parkinson's disease, and is considered a potential target for therapeutic intervention.

116 l transplant dysfunction, US28 may provide a potential target for therapeutic intervention.

117 athology via TNTs, revealing astrocytes as a potential target for therapeutic intervention.

118 mediate in disease pathogenesis, making it a potential target for therapeutic intervention.

119 g of treated HIV may represent an attractive potential target for therapeutic intervention.

120 These findings indicate that SIRT2 will be a potential target for therapeutic interventions in aging-

121 r effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in condit

122 mic injuries, highlighting mitochondria as a potential target for therapeutic interventions.

123 neuropathology and indicate that DUSP1 is a potential target for therapeutic interventions.

124 e propose that shedding of PrP(c) could be a potential target for therapeutics to limit the cognitive

125 a ligand-specific fashion and constitutes a potential target for therapies.

126 targeting T-bet-expressing B cells may be a potential target for therapy for autoimmune diseases.

127 Our study indicates that miR-96 might be a potential target for therapy of pediatric SE.

128 RM/spermidine axis in TAMs might represent a potential target for therapy.

129 o TAM, and its regulatory pathway could be a potential target for therapy.

130 VHL is a potential target for treating anemia and ischemic diseas

131 ceptor-mediated Abeta BBB clearance may be a potential target for treatment and prevention of Abeta b

132 r in the pathophysiology of depression and a potential target for treatment development.

133 acid receptor 2 (FFA2/GPR43) is considered a potential target for treatment of metabolic and inflamma

134 d inflammation and insulin resistance and as potential target for treatment of T2DM.

135 free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes.

136 1 or GPR40) is established as an interesting potential target for treatment of type 2 diabetes.

137 This functionally conserved epitope is a potential target for vaccines against P. falciparum.

138 e studies to understand their regulation and potential targeting for novel antifungal therapies.

139 key regulators of allergic inflammation and potential targets for anti-inflammatory therapy.

140 vation events in schistosomes, and represent potential targets for anti-schistosome therapy aimed at

141 nism of action for their effects, suggesting potential targets for anti-ZIKV therapeutic intervention

142 trix metalloproteinase and ADAM families, as potential targets for anticoronavirus therapy.

143 Since sncRNAs have been suggested to be potential targets for antiviral therapies, identificatio

144 containing proteins have been identified as potential targets for blocking proliferation in a variet

145 cently been studied as cancer biomarkers and potential targets for cancer therapy.

146 asis of tumor cells and have been considered potential targets for cancer therapy.

147 reproduction in C. lectularius, and could be potential targets for control in this notorious pest.

148 We identify several potential targets for developing novel control measures

149 ecent advances in the field, focusing on the potential targets for development of neuroprotective dru

150 gest that the pathophysiology of AS and thus potential targets for drug development may be different

151 l processes and therefore are proposed to be potential targets for drug development.

152 and may facilitate the identification of new potential targets for drug discovery.

153 and cancer, PI-converting enzymes represent potential targets for drug-based therapies.

154 Thus, PvRBPs appear as potential targets for efficacious P. vivax neutralizatio

155 f active and passive symplastic loading, and potential targets for engineering improved rates of expo

156 Flexible sites are potential targets for engineering the stability of enzym

157 es with key epigenetic enzymes, representing potential targets for epigenetic therapy.

158 ly viable diberyllium complex, which provide potential targets for experimental realization.

159 nflammation on viral outcomes and identified potential targets for future studies.

160 ages and the underlying mechanisms represent potential targets for host-directed therapies.

161 g Administration initiatives, and identifies potential targets for improvement.

162 velopmental signalling pathways representing potential targets for improving the efficiency of the cu

163 Evidence indicates alpha3(V) chains as potential targets for inhibiting tumour growth and as ma

164 c role of miR-125b in monocytes and identify potential targets for interfering with excessive inflamm

165 s directions for future research to identify potential targets for intervention in the treatment of f

166 ification of at-risk individuals and reveals potential targets for intervention or symptom prevention

167 w a defined minimum value, and it identifies potential targets for intervention to prevent the evolut

168 or human endothelial cells (ECs) and provide potential targets for intervention.

169 ve impairment in the older population and as potential targets for interventions.

170 Potential targets for LRAs are host factors, and the pot

171 specific serine residues in the molecule as potential targets for neuroprotection.SIGNIFICANCE STATE

172 he SUMO pathway and NaV1.2 are identified as potential targets for neuroprotective interventions.

173 To identify potential targets for new therapeutics, we screened inse

174 al of this study is to determine if Ryrs are potential targets for nGD treatment.

175 To identify potential targets for novel control approaches, we have

176 characterizing genes of unknown function and potential targets for novel small molecule inhibitors.

177 s pabA and the pyrimidine salvage pathway as potential targets for novel therapeutics and suggests a

178 Based on recent findings, we pinpoint potential targets for novel therapies to slow down the p

179 Here, to identify potential targets for personalized treatment, we perform

180 n the enterohepatic circulation has revealed potential targets for pharmacological therapies of chole

181 ensive genomic landscape of ESCC and provide potential targets for precision treatment and prevention

182 to normal hemostasis, they can be considered potential targets for prevention of DVT in humans.

183 number and quality of eating occasions, are potential targets for primary prevention strategies with

184 l homeostasis and host switching and reveals potential targets for rational design of new interventio

185 ata implicate astroglial calcium pathways as potential targets for stroke therapy.

186 entially regulated genes highlights numerous potential targets for the design of novel therapeutics.

187 All are potential targets for the development of new antibiotics

188 anding heme homeostasis in trematodes and as potential targets for the development of new flukicides.

189 and highlight striatal signaling pathways as potential targets for the development of novel treatment

190 Thus, both CSF1 and DAP12 are potential targets for the pharmacotherapy of neuropathic

191 t study points to these receptor subtypes as potential targets for the symptomatic treatment of parki

192 oth controllers of microglial physiology and potential targets for therapeutic intervention in CNS di

193 -GBP interactions are significant to provide potential targets for therapeutic intervention of many d

194 hat unveils new markers of poor outcomes and potential targets for therapeutic intervention.

195 y manifestations of WAS, thereby identifying potential targets for therapeutic intervention.

196 s that provide insight into pathogenesis and potential targets for therapeutic intervention.

197 co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention.

198 s affecting Gaq family members, and identify potential targets for therapeutic intervention.

199 wound healing and identifies a repertoire of potential targets for therapeutic manipulation.

200 These three isoforms thus represent potential targets for therapeutic RNA interference (RNAi

201 o NAcC, and their regulation by dopamine, as potential targets for therapeutics designed to treat coc

202 results identify RIAM and its regulators as potential targets for therapies of T cell-mediated autoi

203 ase and fructose bisphosphatase in tumors as potential targets for therapy.

204 that high MPL-expressing CML stem cells are potential targets for therapy.

205 e been used to identify patient clusters and potential targets for therapy.

206 Motif analysis of potential targets for these kinases revealed that the ac

207 o the mechanisms of protein reabsorption and potential targets for treating diabetic proteinuria.

208 oninfectious human disease, and identify new potential targets for treatment of a major cause of blin

209 autoimmune diseases and melanoma, and offer potential targets for treatment.

210 Thus, PPIP5Ks are potential targets for tumor therapy.

211 arget genes is identified that comprise 3509 potential targets from 13 high-throughput studies, and 3

212 ied in CKD GWASs, indicating that MANBA is a potential target gene for CKD.

213 ding to a fourfold increase in the number of potential target genes for autoimmune and cardiovascular

214 rlap and Bayesian methods, we identified new potential target genes for CKD.

215 -375, which were further analyzed for their potential target genes in angiogenic, hypoxic, and immun

216 o construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma.

217 interactions between risk regions and their potential target genes including CAPG at 2p11.2, C2orf43

218 es of the up-regulated miRNAs identified 121 potential target genes involved in inflammatory and canc

219 y relationship between the lncRNAs and their potential target genes using the 'cis' and 'trans' model

220 ated in MDV-induced lymphoma, and one of its potential target genes, B-cell chronic lymphocytic /lymp

221 Many potential targets have been identified but the physiolog

222 een completely established, although several potential targets have been identified.

223 However, searches for these potential targets have not yet been conducted, particula

224 immunoglobulin-like adhesion molecules, as a potential target in epithelial cancers.

225 ich suggests calcineurin-NFAT signaling as a potential target in preventing PCa.

226 dy identifies a new host factor, TRIM6, as a potential target in the development of antiviral drugs a

227 eneity and plasticity, and suggest SOX1 as a potential target in the GSC population in glioblastoma.

228 he K-Ras pathway, and identify PKCdelta as a potential target in this tumor population.

229 1, suggesting that PLCepsilon1 is a specific potential target in treating conditions involving migrat

230 Therefore, cathepsin K may represent a potential target in treating diabetes-associated cardiac

231 forms may be evaluated in future studies as potential targets in a glycopeptide biomarker panel to f

232 Nucleic acids have been widely recognized as potential targets in drug discovery and aptamer selectio

233 We aimed to explore miRNA expression and potential targets in the female fat body of Ae. aegypti,

234 d suggest HS and its biosynthetic enzymes as potential targets in the treatment of MM.

235 tment of viral respiratory tract infections, potential targets include the causative pathogens themse

236 This pathway contains a number of potential targets, including some that have been identif

237 ng a weighted average of motor plans for the potential targets, it could also arise from planning a s

238 abases or biological networks can expand the potential target list.

239 r leukemic long-term culture initiating cell potential, targeting mitochondrial transfer could repres

240 giogenesis in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration a

241 ylated alanine-rich C kinase substrate) as a potential target molecule for kidney cancer.

242 g screening was performed through identified potential targets namely, AKR1B10, NR3C1, PTGS2, and HER

243 nst the signal-regulatory protein CD47 and a potential target of anti-cancer immunotherapy.

244 lthy humans and render the oxytocin system a potential target of antidiabetic treatment.

245 ediction analysis revealed that ZNF423 was a potential target of bta-miR-23a.

246 To explore PauA2 as a potential target of drug development, suppressors of the

247 Alpha-gal is a potential target of IgE-mediated reactivity to equine an

248 ed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a sym

249 ascade suggested cytochrome c oxidase as the potential target of IPE class of molecules, whereas char

250 ylcytosine methyltransferase DNMT1 is also a potential target of miR-342, we inhibited miR-342 in MCF

251 dylation in synapse formation, and reveals a potential target of therapeutic intervention for relevan

252 Herein, we exploited the potential targeting of TF for positron emission tomograp

253 proteins as regulators of pathogenicity and potential targets of antimicrobial therapy.

254 llowed identification and expansion of novel potential targets of both DNA binding proteins and sRNA

255 r defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development

256 s or the proteasome) have been identified as potential targets of DTCs in the brain, the molecular me

257 Target prediction algorithms identified potential targets of miR-146b.

258 and SlVHA-A1, which in turn are revealed as potential targets of SlCBL10.

259 ed or viral-infected cells, the function and potential targets of tRFs are not known.

260 To identify a potential target (or targets) for reducing TIM-3 express

261 iew of these results, we suggest MOSPD2 as a potential target protein for treating diseases in which

262 Furthermore, the potential targets provided by the epigenome for the deve

263 Identification of ZPR1 and HoxA5 as potential targets provides a paradigm for developing str

264 ative dimerization designating Sprouty2 as a potential target reliant on Sox2/Pax6 cooperativity in s

265 he interaction between the transposase and a potential target site, which may be how other DNA bindin

266 om extending sprouts, suggesting sampling of potential target sites, and lowered Flt1 levels reduced

267 adaptability of fusicoccin, predicting more potential targets than so far anticipated.

268 data suggest that Src kinase may represent a potential target that could interrupt the enzymatic acti

269 Thus from an abundance of potential targets, the dragonfly selects a stereotyped s

270 ervation that when reaching towards multiple potential targets, the initial movement is directed towa

271 hogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal d

272 pproach can rapidly optimize the efficacy of potential targeted therapies on bone metastatic prostate

273 al role in the initiation of BOS process and potential targeted therapies.

274 uppression of leptin expression, and suggest potential targeted therapies.

275 athways that confer poor prognosis and guide potential targeted therapy.

276 ne TrkA expression in MCC as a rationale for potential targeted therapy.

277 SCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in t

278 hich makes the ubiquitin-proteasome system a potential target to enhance the efficacy of Dox therapy.

279 emogenesis, and highlight this receptor as a potential target to eradicate primitive LSCs in AML.

280 determine the aging transcriptome provides a potential target to extend healthy cellular lifespan.

281 controlling CD8(+) T-cell function and is a potential target to improve cytotoxic T-cell activity.Gr

282 This work also identifies Shp-1 as a potential target to improve the cytotoxic effector funct

283 ting to tumor dissemination and represents a potential target to inhibit metastasis.

284 ced by cigarette smoke and highlight another potential target to modulate COPD.

285 ism of action of SGs and identify TRPM5 as a potential target to prevent and treat type 2 diabetes.

286 in imparting gemcitabine resistance and as a potential target to restore PDAC chemoresponse.

287 GPCRs; thus, Gpr126 represents an attractive potential target to stimulate repair in myelin disease o

288 Thus, Syn-2 may serve as a potential target to treat diabetes.

289 progression and suggest integrin beta3 as a potential target to treat HE.

290 otease that has emerged in recent years as a potential target to treat or prevent pathological thromb

291 adult NSCs and identify alpha-SYN and DA as potential targets to ameliorate neurogenic defects in th

292 inding to Akt may help in the development of potential targets to control the pathophysiological proc

293 nate immune responses and identifies them as potential targets to dampen inflammatory tissue damage i

294 Their proteomic study defines potential targets to evaluate for improved diagnostic te

295 f-of-concept evidence that inflammasomes are potential targets to limit the pathological consequences

296 res for patient stratification and uncover a potential targeted treatment approach for MYC-driven SCL

297 d phenotypic spectrum and the exploration of potential targeted treatment options.

298 diseases and cardiomyopathy and may underlie potential target treatments for such conditions.

299 ach to either a single target or towards two potential targets while grasping an object.

300 utic target in cancer, but the full range of potential targets within the pathway has been underexplo