ライフサイエンスコーパス: prephenate

1 catalyzes the rearrangement of chorismate to prephenate.

2 he pericyclic rearrangement of chorismate to prephenate.

3 nd catalyzes the conversion of chorismate to prephenate.

4 ntramolecular rearrangement of chorismate to prephenate.

5 -type bifunctional enzyme displaying Asp and prephenate aminotransferase activities (PAT).

6 itated discovery of the tomato gene encoding prephenate aminotransferase, which converts prephenate t

7 We present here the first identification of prephenate aminotransferases (PATs) in seven arogenate-c

8 lly informed biochemical characterization of prephenate aminotransferases (PPA-ATs) that belong to cl

9 easurable catalytic activity, yet bound both prephenate and a competitive inhibitor (S-DNBA) comparab

10 This is because both prephenate and arogenate have been reported to undergo d

11 nd ADT homologs indeed efficiently converted prephenate and arogenate into arogenate and Phe, respect

12 Feeding with shikimate also led to prephenate and phenylpyruvate accumulation and a partial

13 indicate that the PDH domain, in which NAD, prephenate and tyrosine binding sites were present, was

14 n specific recognition of dicarboxylic keto (prephenate) and amino (aspartate) acid substrates.

15 ic analyses showed an unprecedented role for prephenate as the carboxyl donor and the involvement of

16 Prephenate binding results in the tighter association be

17 ne binding to the regulatory site as well as prephenate binding to the dehydratase domain, both throu

18 al structure of the full-length protein with prephenate bound and the accompanying small angle x-ray

19 the enolpyruvyl side chain, and the other to prephenate by a facile Claisen rearrangement.

20 The isomerization of chorismate to prephenate by chorismate mutase in the biosynthetic path

21 tant roles in the catalysis of chorismate to prephenate by chorismate mutase.

22 the mechanism of catalysis of chorismate --> prephenate by the EcCM enzyme are discussed.

23 BacA is an unusual prephenate decarboxylase that avoids the typical aromati

24 contains distinct chorismate mutase (CM) and prephenate dehydratase (PDT) domains as well as a regula

25 two catalytic domains (chorismate mutase and prephenate dehydratase activities) as well as one R-doma

26 n fragment (residues 101-386) containing the prephenate dehydratase and regulatory domains, and (c) R

27 A specific prephenate dehydratase protein (PD1) was discovered to h

28 P-protein, a bifunctional chorismate mutase/prephenate dehydratase that is feedback inhibited by Phe

29 the biosynthetic enzymes chorismate mutase, prephenate dehydratase, and prephenate dehydrogenase in

30 inotransferase, a bidomain chorismate mutase/prephenate dehydratase, imidazole acetol-phosphate amino

31 oute in which arogenate dehydratase (ADT) or prephenate dehydratase, respectively, plays a key role.

32 in of the Escherichia coli chorismate mutase-prephenate dehydratase.

33 mer that exhibits chorismate mutase (CM) and prephenate dehydrogenase (PDH) activities, both of which

34 orismate mutase, prephenate dehydratase, and prephenate dehydrogenase in cell extracts, so the inhibi

35 While Phe is synthesized from prephenate exclusively via a phenylpyruvate intermediate

36 Chorismate mutase converts chorismate into prephenate for aromatic amino acid biosynthesis.

37 PchB also produces prephenate from chorismate, most likely due to structura

38 r the Claisen rearrangement of chorismate to prephenate has been investigated by application of the c

39 f the Claisen rearrangement of chorismate to prephenate have been examined in water and methanol.

40 r the Claisen rearrangement of chorismate to prephenate in six different environments: water, wild-ty

41 ant PAT enzymes exhibit high activity toward prephenate, indicating that the corresponding genes enco

42 ferase is required for the transamination of prephenate into arogenate, but the identity of the genes

43 with the reactant chorismate or the product prephenate, no water molecule remained near the oxygen o

44 lues of 1140, 490, and 620 M(-1) S(-1), with prephenate not serving as a substrate unless excess reco

45 via the action of either arogenate (ADT) or prephenate (PDT) dehydratases; however, neither enzyme(s

46 that the relative rate of the chorismate --> prephenate reaction is overwhelmingly dependent on the e

47 the important features of the chorismate --> prephenate reaction using molecular dynamics (MD) and th

48 enate versus 38, 240, and 16 M(-1) S(-1) for prephenate, respectively.

49 uggest that, along with ADT, a gene encoding prephenate-specific PPA-AT was transferred from a Chloro

50 For the full-length protein, prephenate, the product of the CM reaction, acts as an a

51 cilysin antibiotic pathway, BacABGF, convert prephenate to a tetrahydrotyrosine (H(4)Tyr) diastereome

52 prephenate aminotransferase, which converts prephenate to arogenate.

53 rous phenolic compounds, is synthesized from prephenate via an arogenate and/or phenylpyruvate route

54 acid anticapsin from the primary metabolite prephenate, we have overproduced, purified, and characte

55 0), more efficiently utilized arogenate than prephenate, whereas the remaining three, ADT3 (At2g27820