ライフサイエンスコーパス: prepubertal

1 ur)) and Cftr(+/+) littermate controls at 6 (prepubertal), 10 (pubertal), and 14 (young adult) weeks

2 kidney, thymus, heart, spleen, liver, or in prepubertal 14day old rat testis.

3 /or sexual abuse and 11 without a history of prepubertal abuse-and 14 healthy nonabused female volunt

4 bsolute BMR/RMR and TDEE in pubertal than in prepubertal adolescents.

5 Prepubertal African American (AA) youth compared with th

6 Subjects were 61 prepubertal African-American and Caucasian children.

7 , this disorder is now diagnosed even in the prepubertal age group.

8 in an aggressive MPN with death at a murine prepubertal age of 20 to 35 days (equivalent to an early

9 Changes were predominantly present at prepubertal ages (postnatal days 20 and 30).

10 enzymes (ApaI, BsmI, and TaqI) in 100 normal prepubertal American girls of Mexican descent.

11 the density of femoral and vertebral bone in prepubertal American girls of Mexican descent.

12 icrog/kg) and how these effects vary between prepubertal and adult conspecifics.

13 Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and a

14 Sexually nai;ve prepubertal and adult male hamsters were exposed to cott

15 cross the rostro-caudal extent of the HDB in prepubertal and adult male rats and to determine whether

16 rations of leptotene/zygotene spermatocytes, prepubertal and adult pachytene spermatocytes, as well a

17 myocytes isolated from the apex and base of prepubertal and adult rabbit hearts.

18 c buds from the urogenital sinus, during the prepubertal and androgen-driven proliferative expansion

19 the need for child informants in research on prepubertal and early adolescent bipolar disorder in chi

20 actor (BDNF) Val66 allele in children with a prepubertal and early adolescent bipolar disorder phenot

21 The prepubertal and early adolescent bipolar disorder phenot

22 s of recovery and relapse in children with a prepubertal and early adolescent bipolar disorder phenot

23 for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenot

24 The definition of the prepubertal and early adolescent bipolar disorder phenot

25 imilarity between the characteristics of the prepubertal and early adolescent bipolar disorder phenot

26 xhibit increased anxiety-like behaviors over prepubertal and early adult development, show significan

27 A key question is whether a prepubertal and early-adolescent bipolar I disorder phen

28 pants with KS had received TRT, and all were prepubertal and had nonmosaic 47,XXY karyotypes.

29 nduced luteinizing hormone (LH) secretion in prepubertal and peripubertal females.

30 medial amygdala was significantly smaller in prepubertal and photoinhibited males compared to photost

31 levels of reproductive behavior exhibited by prepubertal and photoinhibited males would be correlated

32 the deficits in sexual behavior exhibited by prepubertal and photoinhibited males.

33 As ERalpha levels are elevated during the prepubertal and postmenopausal stages, these may represe

34 te a long-lasting activation in neurons from prepubertal and postpubertal mice of both sexes.

35 Data were dichotomized into prepubertal and pubertal groups and compared through the

36 ew DXA SM prediction model was developed for prepubertal and pubertal subjects (Tanner stage </=4) ag

37 In children they often present as prepubertal and/or peripubertal gynecomastia.

38 RBM is a nuclear protein expressed in fetal, prepubertal, and adult male germ cells.

39 rm of the human prolactin receptor in fetal, prepubertal, and adult prostate.

40 ange, < 0.5-31 mug/dL), most boys (86%) were prepubertal, and mean +/- SD height and BMI z-scores wer

41 in epithelial cells of the fetal, neonatal, prepubertal, and normal adult prostate.

42 d for the epithelial cells from the uteri of prepubertal animals treated with PMSG, cells previously

43 of their dopamine afferents in adult but not prepubertal animals with a neonatal lesion.

44 ation on LHRH and/or gonadotropin release in prepubertal animals, nothing is known about the receptor

45 of gonadotropin secretion similar to that of prepubertal animals.

46 ptic activity differs between hemispheres in prepubertal animals.

47 sults are affirmed, the early recognition of prepubertal bipolar disorder will be important, so that

48 hydroxyvitamin D [25(OH)D] concentrations in prepubertal black and white girls (n = 83) living in nor

49 atric pelvis, including ambiguous genitalia, prepubertal bleeding, primary amenorrhea, pelvic mass, a

50 of which show opposing correlations between prepubertal BMI and male puberty.

51 idemiological correlations between increased prepubertal body mass and earlier pubertal timing in gir

52 Gynecomastia in a prepubertal boy is rare and should prompt an immediate e

53 analyzed retrospectively in 24 testes in 12 prepubertal boys (mean age, 4 years) and 49 testes in 25

54 ith IGF-1 was stronger for mid-pubertal than prepubertal boys (p = 0.04).

55 airflow values are present by spirometry for prepubertal boys than for age-matched girls; however, gr

56 ted possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had norm

57 d thicknesses to predict body fat in African prepubertal boys, controlling for chronologic age, was t

58 For prepubertal boys, testicular biopsy cryopreservation is

59 re significantly greater in pubertal than in prepubertal boys.

60 The decrease is partially reversed by prepubertal but not postpubertal gonadectomy.

61 t the presence of severe hyperinsulinemia in prepubertal carriers of the proline-467-leucine (P467L)

62 IUGR and increase IGF bioavailability during prepubertal catch-up growth.

63 Prepubertal children >or=5 y of age with IE were eligibl

64 Forty-two prepubertal children (20 girls and 22 boys) aged 4-10 y

65 Forty-four prepubertal children (22 AA and 22 AW) with comparable b

66 blind, placebo-controlled trial of CLA in 62 prepubertal children aged 6-10 y who were overweight or

67 Immune function was measured in 472 prepubertal children aged 6.5-9.5 y from 28 villages in

68 d serotonergic function has been observed in prepubertal children and adults with an acute episode of

69 hildren with SCD had significantly lower FM (prepubertal children and pubertal males only) and FFM (a

70 erg equations to predict body fat in African prepubertal children and to compare the results with bod

71 ge fat to body mass index (BMI; in kg/m2) in prepubertal children are programmed during intrauterine

72 nding of the regulation of energy balance in prepubertal children by using the doubly labeled water m

73 cid amplification tests (NAATs), to evaluate prepubertal children for N. gonorrhoeae or C. trachomati

74 ulinemia is a risk factor for weight gain in prepubertal children in the Pima Indian population-a pop

75 gth to the suggestion that percentage fat in prepubertal children is programmed in utero (independent

76 ects of vitamin D supplementation in healthy prepubertal children on physiologic outcomes have not be

77 d with the use of inhaled glucocorticoids in prepubertal children persisted as a reduction in adult h

78 s report prevalence rates ranging from 1% in prepubertal children to 4% in adolescents.

79 uscle cell culture model derived from normal prepubertal children to investigate the effects of insul

80 erefore, need to be considered clinically in prepubertal children with active JRA.

81 Thirty-four prepubertal children with ADHD and chronic multiple tic

82 for evaluating systemic exposure to ICSs in prepubertal children with asthma.

83 Eighteen prepubertal children with JRA and growth retardation rec

84 an be used to determine testicular status in prepubertal children with nonpalpable gonads, thus diffe

85 Prepubertal children with SCD fail to compensate for the

86 Prepubertal children with SCD-SS may have zinc deficienc

87 The most pronounced effect was seen in prepubertal children with SDS of 0.28 (95% CI, 0.14-0.41

88 ese subjects, the identification of affected prepubertal children within one of the original families

89 menopausal and postmenopausal females), age (prepubertal children), and the presence of hypoxia are t

90 Prepubertal children, pubertal males, and pubertal femal

91 Specific infections in prepubertal children, such as Neisseria gonorrhoeae or C

92 gative effect on bone mineralization even in prepubertal children, which can be demonstrated despite

93 ut the appropriateness of this threshold for prepubertal children.

94 e for predicting body fat in 9-y-old African prepubertal children.

95 safety and efficacy of bariatric surgery in prepubertal children.

96 ical growth and serum zinc concentrations of prepubertal children.

97 determine if similar relationships exist in prepubertal children.

98 n autoimmune blistering disease occurring in prepubertal children.

99 years after transplantation, particularly in prepubertal children.

100 a temporary reduction in growth velocity in prepubertal children.

101 the form of the cranial base differs between prepubertal Class I and Class III subjects.

102 ed and control animals at juvenile (day 20), prepubertal (day 30), postpubertal (day 56), and adult (

103 ductive tracts were excised on days 5 or 10 (prepubertal), day 30 (pubertal), day 90 (young adult), o

104 gene; its expression is induced later during prepubertal development (between days 23 and 30 post par

105 To examine SC function during fetal and prepubertal development we generated two transgenic mous

106 ion differentially, and predominantly during prepubertal development.

107 ence of cognitive function, primarily during prepubertal development.SIGNIFICANCE STATEMENT Parvalbum

108 , significantly more of the subjects who had prepubertal diagnoses of major depressive disorder (N=24

109 Subjects who had prepubertal diagnoses of major depressive disorder also

110 subjects and included 72 subjects who had a prepubertal diagnosis of major depressive disorder and 2

111 (Eda) as a unique regulator of embryonic and prepubertal ductal morphogenesis.

112 dissociated from brain slices prepared from prepubertal female GnRH-EGFP mice.

113 Ca,L) were not significant in adult male and prepubertal female hearts.

114 Normal prepubertal female mice injected with leptin grew at a s

115 Consistent with this, treatment of prepubertal female mice with the mitotic germ-cell toxic

116 were implanted into the mammary fat pads of prepubertal female mice.

117 hat 17 beta-estradiol (E2) administration to prepubertal female rats leads to acquisition of the abil

118 mone-releasing hormone (LHRH) secretion from prepubertal female rats.

119 ubset of GnRH neurons in the hypothalamus of prepubertal female rats.

120 tic and environmental risk factors among 182 prepubertal female, 237 prepubertal male, 314 pubertal f

121 of the mammary glands approximated that of a prepubertal female.

122 es in the BL: in acute slices from juvenile (prepubertal) female rats, wash-in of letrozole virtually

123 Behavioral hyporesponsiveness in prepubertal females may be due, in part, to deficiencies

124 Estrogen treatment of prepubertal fish elicited increases in tac3a, kiss1, kis

125 es of an NMDA antagonist cause an adult or a prepubertal form of neurodegeneration, depending on the

126 tudies in mammary whole mounts revealed that prepubertal genistein exposure resulted in fewer termina

127 few years, large advances have been made in prepubertal germ cell storage aimed at subsequent transp

128 on, notably for self-renewal genes, in these prepubertal germline cells between two species that dive

129 ns raise the suspicion for sexual abuse in a prepubertal girl, but the findings do not independently

130 usted energy intake tended to be lower among prepubertal girls (905 +/- 140 kcal) than among females

131 um 25(OH)D concentration was assessed in 168 prepubertal girls aged 4-8 y living in the southeastern

132 We studied 19 prepubertal girls aged 6.0-10.1 y with a mean weight-for

133 reater degree of subclinical air trapping in prepubertal girls because residual volumes are not detec

134 lial resemblance of body composition between prepubertal girls of normal weight and body fatness and

135 The body composition of prepubertal girls of normal weight and body fatness is s

136 nce in EE between normal-weight, multiethnic prepubertal girls predisposed to obesity and those not p

137 al trauma from sexual abuse, the majority of prepubertal girls will not have a hymenal transection (s

138 In addition, nine formerly prepubertal girls with normal gonadal function became pr

139 red in normal-weight-for-height, multiethnic prepubertal girls with or without a familial predisposit

140 d physical fitness on weight and fat gain in prepubertal girls with or without a predisposition to ob

141 Intestinal carriage of Escherichia coli in prepubertal girls without a history of urinary tract inf

142 cluded were poor-quality studies; studies of prepubertal girls, men, women without the potential for

143 lly diverse population groups, as well as in prepubertal girls, young adult and postmenopausal women,

144 xual abuse as the cause of genital trauma in prepubertal girls.

145 itamin D [25(OH)D] and bone were examined in prepubertal girls.

146 cantly lower among pubertal girls than among prepubertal girls.

147 These findings were strongest in prepubertal girls.

148 rine growth retardation (IUGR) and increased prepubertal growth rate in female lambs.

149 play of progesterone-facilitated lordosis in prepubertal guinea pigs following MPOA lesions is due to

150 igh systemic estrogen levels, short stature, prepubertal gynecomastia and testicular failure in males

151 Most cases of male prepubertal gynecomastia are classified as idiopathic.

152 o lavender and tea tree oils probably caused prepubertal gynecomastia in these boys.

153 ional dimensions were studied in 31 pairs of prepubertal healthy white girls and boys 5-10 years of a

154 ggests birth weight is a better predictor of prepubertal height than is self-reported midparental hei

155 B, Bcl6b) were more highly expressed in both prepubertal human spermatogonia and mouse gonocytes than

156 Essentially pure populations of prepubertal human spermatogonia and mouse gonocytes were

157 arche, a key endocrine event associated with prepubertal increases in the adrenal production of andro

158 onstrated that in a mildly to moderately ill prepubertal JRA population that had never been exposed t

159 We also show that female prepubertal Kiss1 neurons are under higher inhibitory in

160 tly at T2, T3, and T4, but decreases to near prepubertal levels at T5; and 3) while insulin resistanc

161 onset of puberty (T2), but returned to near prepubertal levels by the end of puberty (T5).

162 al laser microscopy revealed that subsets of prepubertal LHRH neurons are endowed with alpha 1, alpha

163 e NO, hence generating cGMP and resulting in prepubertal LHRH release.

164 notype of peritubular myoid cells (PTMCs) in prepubertal life; (2) to maintain the ALC progenitor pop

165 nal study, the mean age of the children with prepubertal major depressive disorder was 10.3 years (SD

166 ound in the one other adult outcome study of prepubertal major depressive disorder.

167 ear to be of physiologic significance, since prepubertal male mice (age 5 wk) displayed accelerated b

168 reased avoidance in both sexes of adults and prepubertal male partners.

169 ell patch-clamp recordings were performed on prepubertal male rat hypothalamic slices, where TIDA neu

170 SF) samples from 49 free-ranging, 2-year-old prepubertal male rhesus monkeys.

171 sk factors among 182 prepubertal female, 237 prepubertal male, 314 pubertal female, and 171 pubertal

172 Half of the prepubertal males (P7-P14) received 200 micrograms of te

173 testosterone (500 microg/kg) pretreatment in prepubertal males administered LPS restored the expressi

174 display of reproductive behavior in adults, prepubertal males do not engage in these same behaviors.

175 POA DOPAC concentrations did not increase in prepubertal males exposed to pheromone.

176 Even a 2.5-fold higher load of LPS in prepubertal males failed to produce aversive odor cues,

177 We also found that prepubertal males have a larger anterior subdivision of

178 d that, specifically in the left hemisphere, prepubertal males have approximately 80% more excitatory

179 at the left MeApd is significantly larger in prepubertal males than females.

180 o puberty may contribute to the inability of prepubertal males to display reproductive behavior.

181 per se did not influence odor properties of prepubertal males, indicating that estrogen receptors ma

182 Because estradiol induced PR in prepubertal males, these data also suggest that ERa is f

183 nd if so, whether this response is absent in prepubertal males, which do not mate.

184 hen they were exposed to odor of LPS-treated prepubertal males.

185 activated behavior in postpubertal, but not prepubertal, males.

186 nical presentations and biologic behavior of prepubertal melanoma are discussed.

187 This is the largest known study of prepubertal melanoma patients.

188 1% (128 of 142) had diagnosed no more than 2 prepubertal melanomas in the past 5 years.

189 An additional two formerly prepubertal men had partners who became pregnant.

190 In cultured ovarian explants from prepubertal mice containing preantral follicles, treatme

191 Prepubertal mice overexpressing adiponectin from adipose

192 rn3 mRNA were high in the arcuate nucleus of prepubertal mice, decreased immediately before puberty,

193 gradient analyses of testes from 21-day-old prepubertal mice, which contain early round spermatids a

194 ]hexane-4,6-dicarboxylate) in adult, but not prepubertal, mice born to stressed mothers during pregna

195 s is effective in increasing LHRH release in prepubertal monkeys.

196 eurons was lower in postpubertal relative to prepubertal monkeys.

197 essential for early folliculogenesis in the prepubertal mouse ovary.

198 Northern analyses of prepubertal mouse testes revealed that the time course o

199 In contrast, DNA from prepubertal mouse testis and from purified spermatocytes

200 There is also evidence that prepubertal neglect in children causes abnormal metaboli

201 findings are indicative of a characteristic prepubertal neuroanatomical phenotype that may be associ

202 lated C-peptide-modeled insulin secretion in prepubertal normal-weight AA versus C peers during a 2-h

203 BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers.

204 ibodies only to clustered AChRs had frequent prepubertal onset (62.5% [median age, 6 years; age range

205 17-year-old boy with severe gynecomastia of prepubertal onset and hypogonadotropic hypogonadism caus

206 Gynecomastia of prepubertal onset may result from increased estrogen owi

207 eafness, constant vestibular dysfunction and prepubertal onset of retinitis pigmentosa.

208 ects with bipolar disorder presenting with a prepubertal onset was significantly higher in the later

209 rbidity in clinically referred children with prepubertal-onset MDD and anxiety, but continuity and sp

210 selecting clinically referred children with prepubertal-onset MDD for inclusion in genetic studies u

211 The clinical outcome of children with prepubertal-onset MDD in adulthood includes a high risk

212 Children with prepubertal-onset MDD with a recurrence of MDD during fo

213 Prepubertal onsets were uncommon, but high-risk offsprin

214 Donor testis cells isolated from prepubertal or adult mice and frozen from 4 to 156 days

215 NMDA failed to stimulate GnRH/LH release in prepubertal or gonadally intact mutant male mice.

216 ature, pregnant, and postweaning, but not in prepubertal or lactating mammary glands.

217 muscle and stromal cells taken from uteri of prepubertal or PMSG-treated rats (shown previously to ex

218 Prepubertal ovariectomy of Wnt-1 TG mice also extended t

219 In contrast, prepubertal ovariectomy, which arrested mammary epitheli

220 aging, pathology, and clinical management of prepubertal paratesticular and testicular tumours.

221 Prepubertal participants (n = 12) had lower average BMI

222 n the budesonide group occurred primarily in prepubertal participants.

223 Prepubertal patients appeared to have the greatest benef

224 Records of 1,326 postpubertal and 196 prepubertal patients currently more than 12 years of age

225 Among 57 patients who had an SLNB, prepubertal patients had a higher percentage of sentinel

226 85 and 131 percent, respectively, in the six prepubertal patients.

227 Growth improved in 3/3 growth-delayed prepubertal patients.

228 The data also highlight the prepubertal period as a sensitive time for redox-related

229 t injections of genistein in rats during the prepubertal period resulted in a 50% reduction of chemic

230 the face of abnormal hormonal stimuli in the prepubertal period.

231 were immunodetectable in oocytes during the prepubertal period.

232 case history, eliminated the possibility of prepubertal periodontitis and suggested a diagnosis of s

233 This condition was previously classified as prepubertal periodontitis, a disease diagnosis that focu

234 ed to acute and repeated footshock stress at prepubertal, peripubteral, and adult ages.

235 jor depressive disorder-21 with a history of prepubertal physical and/or sexual abuse and 11 without

236 In ovariectomized prepubertal PR-A transgenic mice, end buds with unusual

237 cantly reduced after AP-1 blockade in adult, prepubertal, pubertal, and hormone-stimulated mammary gl

238 ion under a constitutive active WAPCre(c) in prepubertal/pubertal mice, but not under MMTVCre in adul

239 In prepubertal rabbits (and children), the arrhythmia pheno

240 fore, we cultured testicular germ cells from prepubertal rabbits in the presence of GDNF and FGF2 and

241 In prepubertal rabbits, peak I(Ca,L) at the base was 22% hi

242 ommon to all organs, including the adult and prepubertal rat testis.

243 ABP(II) expression] was also observed if the prepubertal rat was treated with estrogen before cell co

244 s that double-labeled with NMDA-R1 was 2% in prepubertal rats and 3% in pubertal rats; this increased

245 evels of retinoic acid than did the uteri of prepubertal rats treated with the control vehicle.

246 ine surface epithelial cells by treatment of prepubertal rats with pregnant mare serum gonadotropin (

247 The MeApd is also sexually dimorphic in prepubertal rats.

248 e expression of aversive odor in LPS-treated prepubertal rats.

249 lantations into the testes of 18 adult and 5 prepubertal recipient macaques that were rendered infert

250 n the ejaculated sperm of 9/12 adult and 3/5 prepubertal recipients after they reached maturity.

251 renal (HPA) axis function of male and female prepubertal rhesus monkeys.

252 te an essential role of UPF2-mediated NMD in prepubertal SC development and male fertility.

253 Higher prepubertal serum HCB and betaHCH concentrations were as

254 rocytes as wild-type males at this age, this prepubertal sexual dimorphism is independent of ARs.

255 Collectively, our findings indicate that prepubertal skin is colonized by diverse fungi, whereas

256 aches in vivo to show that during the first, prepubertal, spermatogenic cycle (i) RALDH-dependent syn

257 ed in conscious female rhesus monkeys at the prepubertal stage using a push-pull perfusion method.

258 etarded with reduced ductal branching in the prepubertal stages, and fewer Cap cells in the terminal

259 pathological lesions more rapidly than their prepubertal standard-diet counterparts.

260 with inactivity (e.g., at age 50 years) were prepubertal stature (5% lower odds per 1-standard deviat

261 .41); P = 0.06), and significantly better in prepubertal subjects (0.50 (0.16, 0.84); P = 0.004).

262 in trabecular vBMD z scores were greater in prepubertal subjects.

263 occipital pole that was most significant in prepubertal subjects.

264 eria: presence of OCD and/or a tic disorder, prepubertal symptom onset, episodic course of symptom se

265 een for pubertal (Tanner stages 2-4) but not prepubertal (Tanner stage 1) white children over the ran

266 All patients were prepubertal (Tanner stage I or II) and had never taken c

267 is tightly regulated in fetal, neonatal, and prepubertal testes and adult ovaries and is well conserv

268 Color Doppler US depicted flow in 20 prepubertal testes and in all 49 postpubertal testes.

269 Power Doppler US depicted flow in 22 of 24 prepubertal testes and in all 49 postpubertal testes.

270 ng substance, produced constitutively by the prepubertal testes, promotes involution of the mullerian

271 essels, but flow cannot be identified in all prepubertal testes.

272 Prepubertal testicular and paratesticular tumours are a

273 During prepubertal testicular development, Pem expression was d

274 depletion of both SCs and germ cells during prepubertal testicular development.

275 SCR transcripts were undetectable in the prepubertal testis but were readily identified in sperma

276 ly from SC, germ cell or PTMC support in the prepubertal testis.

277 We further showed that in prepubertal Tg glands, signaling was mediated by formati

278 ctivated the PI3K/Akt pathway in glands from prepubertal Tg mice, resulting in increased cyclin D1 ex

279 gestation, at birth, approximately 5 months (prepubertal, the catch-up growth period), and approximat

280 Mammary glands from prepubertal transgenic mice had significantly increased

281 oduced by cultured epithelial cells from the prepubertal uteri [shown previously to be negative for C

282 Normal-weight, prepubertal white (n = 52), African American (n = 30), a

283 In the prepubertal years, exercise results in periosteal gains,

284 In conclusion, AA and C prepubertal youth both demonstrated a decline in beta-ce