ライフサイエンスコーパス: presymptomatic

1 ients studied, including 3 patients who were presymptomatic.

2 tein biochemistry in hippocampal tissue from presymptomatic 3xTg-AD and NonTg mice, we show that bloc

3 nels of hippocampal CA1 pyramidal neurons in presymptomatic 3xTg-AD mice.

4 ecal ligation and excision were performed on presymptomatic 5- to 11-month-old triple-transgenic Alzh

5 ovide an ongoing opportunity to characterize presymptomatic abnormalities that predict progression to

6 subtle amounts or changes of Abeta burden in presymptomatic AD and during therapy.

7 gnitude of cognitive decline on each test in presymptomatic AD compared with normal aging.

8 en the increased RyR calcium release seen in presymptomatic AD mice and aberrant NO signaling which a

9 homeostasis and network depression at early (presymptomatic) AD stages.

10 Presymptomatic ADAD mutation carriers showed significant

11 DED binding was highest in presymptomatic ADAD mutation carriers.

12 pression using shRNA in the dentate gyrus of presymptomatic adolescent hAPP mice was sufficient to pr

13 s of mutant (G93A) SOD1 transgenic mice at a presymptomatic age, which was similarly induced by in vi

14 tive allosteric modulator (PAM) beginning at presymptomatic ages improves motor and synaptic deficits

15 ings demonstrate that 3xTg-AD CA1 neurons at presymptomatic ages operate under an aberrant, yet seemi

16 ng in vitro patch-clamp electrophysiology at presymptomatic ages P8-P12.

17 Strikingly, in two presymptomatic ALS mouse strains transgenic for mutant h

18 d across a spectrum of cognitive measures in presymptomatic Alzheimer disease (AD) within a community

19 he first time, they include the diagnosis of presymptomatic Alzheimer disease, recognizing that the d

20 Astrocyte activation may occur in presymptomatic Alzheimer's disease (AD) because reactive

21 e should expect to see additional studies of presymptomatic Alzheimer's disease to join the ongoing p

22 that axonal injury may be an early event in presymptomatic Alzheimer's disease, causing an initial f

23 responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.

24 and will soon be tested in individuals with presymptomatic Alzheimer's disease.

25 tilized the facial nerve axotomy model and a presymptomatic amyotrophic lateral sclerosis (ALS) mouse

26 g data from 27 HCHWA-D mutation carriers (12 presymptomatic and 15 symptomatic) and 33 healthy contro

27 g to DNA in postmortem brain tissues of both presymptomatic and affected HD patients.

28 ld impact the current capability to diagnose presymptomatic and asymptomatic EBOV infections.

29 ification, and this approach can misdiagnose presymptomatic and asymptomatic individuals.

30 enzymes of glutamine/glutamate metabolism in presymptomatic and early symptomatic NPC1-deficient cere

31 and axonopathy would thus be the hallmark of presymptomatic and early-stage Parkinson disease, follow

32 (1)H-MRS profiles from the putamen of presymptomatic and manifest patients reflect heterogenei

33 tron emission tomography imaging profiles of presymptomatic and mildly affected (mini-mental state ex

34 al assessments; 10 were symptomatic, 10 were presymptomatic and on average 5.6 years younger than the

35 Intriguingly, in the striatum of presymptomatic and pathological grade 1 Huntington disea

36 These data demonstrate that presymptomatic and progressive neurodegeneration in SCA1

37 8)F-fluorodeoxyglucose (FDG) respectively in presymptomatic and symptomatic ADAD participants (n = 21

38 we examined brain volume differences between presymptomatic and symptomatic FAD mutation carriers and

39 In this case-control study, we included presymptomatic and symptomatic HCHWA-D mutation carriers

40 ether haemodynamic measures are decreased in presymptomatic and symptomatic HCHWA-D mutation carriers

41 uch antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients.

42 Data from presymptomatic and symptomatic individuals were compared

43 , was reduced in a niche-specific pattern in presymptomatic and symptomatic mice, with the SVZa havin

44 e essential features of NSC/NPCs remained in presymptomatic and symptomatic mice.

45 inal transit of radio-opaque pellets through presymptomatic and symptomatic PrP-SCA7-92Q mice and non

46 s in these subcortical structures during the presymptomatic and symptomatic stages of familial Alzhei

47 of the substantia nigra (SN) from wild-type, presymptomatic, and symptomatic Mecp2(+/-) mice.

48 spinal cord V(max) values were observed with presymptomatic animals compared with controls.

49 s were not present in brain homogenates from presymptomatic animals early in the disease course, prio

50 tage but downregulate postsynaptic Chrna2 in presymptomatic animals.

51 n hippocampus CA1 and dentate gyrus of young presymptomatic APPPS1 mice (1 to 3 months) as compared t

52 Measurements were conducted at presymptomatic [approximately postnatal day 50 (approxim

53 , non-invasive imaging (including studies of presymptomatic, at-risk cases) and genetically modified

54 least the next 40 weeks, a range over which presymptomatic BACHD mice become symptomatic.

55 ese pathogenic autoantibodies could serve as presymptomatic biomarkers and therapeutic targets, there

56 ate stages, and major progress in validating presymptomatic biomarkers now makes secondary prevention

57 [730] vs 2119 [619] kcal/day; P < .01), and presymptomatic body mass index (calculated as weight in

58 Determining risk factors for such presymptomatic brain changes may assist in identifying c

59 low levels of proviral DNA were detected in presymptomatic brain samples.

60 Low creatine was common in the presymptomatic but not in the manifest group.

61 abnormal on all affected individuals and one presymptomatic carrier.

62 Network analysis of the presymptomatic carriers and the gene-negative control su

63 ver, we noted no changes in rCBF and flux in presymptomatic carriers compared with controls.

64 Presymptomatic carriers demonstrated cognitive dysfuncti

65 these results indicate that brain atrophy in presymptomatic carriers of common frontotemporal dementi

66 otentiation-like plasticity were impaired in presymptomatic carriers, compared to healthy controls, m

67 terval intracortical inhibition, compared to presymptomatic carriers, was found.

68 A full understanding of these presymptomatic cellular properties may lead to more effe

69 nd hydrocortisone sodium succinate [HSS]) as presymptomatic central nervous system (CNS) treatment.

70 These presymptomatic changes in hippocampal physiology in FAD

71 ty during treadmill running aiming to detect presymptomatic changes in motor patterning.

72 Having picked up presymptomatic changes in the hemisphere opposite the un

73 FAD) provide a model in which early and even presymptomatic changes of the disease may be identified.

74 are also being used to identify the earliest presymptomatic changes.

75 nsplantation provides modest benefit in both presymptomatic children and the murine model (Twitcher),

76 d a powerful imaging biomarker for the early presymptomatic classification and prediction of Alzheime

77 Sample sizes to power presymptomatic clinical trials based on rate of atrophy

78 al (clinical dementia rating <1, n = 20) and presymptomatic (clinical dementia rating = 0, n = 15) st

79 s of astrocytic and microglial activation in presymptomatic Cln3(-/-) mice at 5 months of age, many m

80 It appears that ITT improves presymptomatic CNS treatment but does not improve overal

81 stack mosaics, we characterized the earliest presymptomatic cortical LVPN morphologic and electrophys

82 EMMPRIN levels on splenic lymphocytes at the presymptomatic (day 7) phase, and prevented the developm

83 These presymptomatic defects may contribute to HD pathology.

84 Presymptomatic delivery of scAAV9-SMN prevented SMA symp

85 While early, presymptomatic detection and chelation with conventional

86 Recent work using techniques for presymptomatic detection of disease in cognitively norma

87 velopment of an accurate diagnostic test for presymptomatic detection of individuals at risk is an ur

88 ve prenatal testing also may enable accurate presymptomatic detection of maternal tumors and treatmen

89 is to improve early detection of disease and presymptomatic detection of neuronal dysfunction.

90 We show that plasma DNA profiling allows for presymptomatic detection of tumors in pregnant women und

91 of bioinformatics tools for the purposes of presymptomatic diabetes risk prediction in the general p

92 Advancement in presymptomatic diagnosis and screening programs will be

93 g disease-causing genetic variation will aid presymptomatic diagnosis and treatment of such disorders

94 y progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-mod

95 However, presymptomatic diagnosis is hampered by imperfect genoty

96 A means of presymptomatic diagnosis is urgently needed.

97 creening is warranted because it may lead to presymptomatic diagnosis of a cardiomyopathy that could

98 AA1 gene will enhance our ability to achieve presymptomatic diagnosis of aortic aneurysms and will de

99 Rapid presymptomatic diagnosis of Bacillus anthracis at early

100 Proteomic biomarkers enable an early, presymptomatic diagnosis of disease, which makes them im

101 ification of the TAAD2 gene will improve the presymptomatic diagnosis of individuals with this life-t

102 a noninvasive test is not available for the presymptomatic diagnosis of prion disease, and thus the

103 ntegrated public health program, can achieve presymptomatic diagnosis of SCID and other disorders wit

104 stages in its natural history (i.e., early, presymptomatic diagnosis), undertaking such efforts in t

105 emergence will provide new opportunities for presymptomatic diagnosis.

106 uld help to define biomarkers that can stage presymptomatic disease and track disease progression, wh

107 r neurochemical levels are altered by early, presymptomatic disease and whether they gauge disease pr

108 ated accumulation of infectious particles in presymptomatic disease is preceded by a progressive fall

109 We discovered that in presymptomatic disease microglial cells overexpress anti

110 iomarkers will help diagnose symptomatic and presymptomatic disease or provide surrogate end-points t

111 e localized morphological variation of early presymptomatic disease progression.

112 ovides a unique model for studying the early presymptomatic disease stages.

113 nowledge has allowed molecular diagnosis and presymptomatic DNA-based testing to become possible.

114 er of dendritic spines and axonal boutons in presymptomatic EAE mice.

115 of response to infection that correlate with presymptomatic, early, and late symptomatic stages of in

116 e possibility of using PET as a quantitative presymptomatic endophenotype to help evaluate the indivi

117 connections to muscle is among the earliest presymptomatic events.

118 rson with a serious genetic condition who is presymptomatic faces little or no difficulty in obtainin

119 Presymptomatic FAD individuals show widespread MRglc red

120 in the white matter in preclinical and even presymptomatic FAD mutation carriers, particularly in th

121 Amyloid imaging studies of presymptomatic familial Alzheimer's disease have reveale

122 gton's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness.

123 NF-L appear as early pathological changes in presymptomatic G93A mutant SOD1 transgenic mice.

124 On the other hand, presymptomatic G93A transgenic mice and mice expressing

125 we investigated microglial activation in HD presymptomatic gene carriers (PGCs), its relationship wi

126 .5 Tesla, T) on 27 right-handed patients (17 presymptomatic gene carriers and 10 manifest patients of

127 ple of subjects (n = 707) who have undergone presymptomatic gene testing.

128 f health insurers either asking for or using presymptomatic genetic test results in their underwritin

129 symptomatic group compared with those of the presymptomatic group (P < 0.005).

130 44% in symptomatic HD patients and by 35% in presymptomatic HD carriers.

131 reased density of oligodendrocytes among the presymptomatic HD gene carriers (mean cells/field: carri

132 Eighteen presymptomatic HD gene carriers, 13 early-stage HD patie

133 ore, mitochondria from brain synaptosomes of presymptomatic HD model mice and from mutant Htt-express

134 ency of motion, was a sensitive indicator of presymptomatic HD progression.

135 of 8 biomarkers that can identify 80% of the presymptomatic HD sheep as transgenic, with 90% confiden

136 Ten other amino acids decreased in presymptomatic HD sheep, including branched chain amino

137 ly reduced in both groups of symptomatic and presymptomatic HD subjects and was below the normal rang

138 the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifi

139 performed metabolic profiling of plasma from presymptomatic HD transgenic and control sheep.

140 t LTP is impaired in hippocampal slices from presymptomatic Hdh(Q92) and Hdh(Q111) knock-in mice, des

141 In contrast, in the initially presymptomatic hemisphere, putamen metabolic activity in

142 al hemisphere, focusing specifically on the "presymptomatic" hemisphere--ipsilateral to the initially

143 hippocampal, but not cortical, neurons from presymptomatic homozygous mutant mice carrying 150Q hunt

144 del of HD and could provide insight into the presymptomatic human disease.

145 Motor sequence learning is abnormal in presymptomatic Huntington's disease (p-HD).

146 Presymptomatic Huntington's disease patients often exhib

147 Presymptomatic immaturity in neonatal T-cell function is

148 afted into the lumbar spinal ventral horn in presymptomatic immunosuppressed SOD1(G93A) rats and to a

149 group of healthy, young, cognitively-intact presymptomatic individuals (average age 33.7 years) who

150 ther such biomarkers can be used to identify presymptomatic individuals (probably yes), provide a mea

151 Studies in presymptomatic individuals at risk for developing Huntin

152 this group was able to distinguish controls, presymptomatic individuals carrying the HD mutation, and

153 kers of Alzheimer's disease (AD) by studying presymptomatic individuals from families with known earl

154 ner, providing a unique opportunity to study presymptomatic individuals who can be predicted to devel

155 ward it may be relevant to clinically follow presymptomatic individuals who carry a C9orf72 repeat ex

156 Presymptomatic individuals with the Huntingtin (HTT) CAG

157 Progressive atrophy was revealed in presymptomatic individuals, with posterior cingulate and

158 rtex and striatum and highest in striatum of presymptomatic individuals.

159 CPAP oxygen signal increased risk of NEC in presymptomatic infants.

160 We assess how presymptomatic infection affects predictability of infec

161 However, despite extensive cryptic (i.e., presymptomatic) infection and frequent long-range transm

162 mation of the proportion of asymptomatic and presymptomatic infections is achievable by contact traci

163 Others maintain that early, presymptomatic intervention would be a more informative

164 Attention is increasingly focused on presymptomatic intervention, because Abeta mismetabolism

165 must move from post-symptomatic treatment to presymptomatic intervention.

166 provide ideas for antecedent biomarkers and presymptomatic interventions in PD.

167 (EAE) mouse model of MS, we have shown that presymptomatic lesions can be quantified using VCAM-MPIO

168 Presymptomatic lupus-prone MRL(lpr/lpr) mice exhibited a

169 ants from the GENFI study were included: 108 presymptomatic MAPT, GRN, and C9orf72 mutation carriers

170 ntly decreased in the occipital lobe in both presymptomatic (mean BOLD change 1.1% [SD 0.5], mean dif

171 LTP were not affected in slices from younger presymptomatic Mecp2 KO mice.

172 fects, indicating that statin use may unmask presymptomatic metabolic myopathies.

173 viral delivery of GDNF into the striatum of presymptomatic mice ameliorates behavioral deficits on t

174 ately 5 times larger in motor terminals from presymptomatic mice expressing mutations of human supero

175 In spinal motoneurones cultured from presymptomatic mice expressing the glycine to alanine mu

176 g and capture (STC) were impaired already in presymptomatic mice.

177 8 per patient) at different clinical stages (presymptomatic, mild cognitive impairment, or clinical A

178 an modulate alpha-synuclein aggregation in a presymptomatic mouse model of Gaucher-related synucleino

179 perimposed the facial nerve axotomy model on presymptomatic mSOD1 mice and investigated gene expressi

180 Behavioral tests were performed by using presymptomatic mSOD1 mice.

181 Presymptomatic mSOD1(G93A) mouse facial MN (FMN) are mor

182 dentified clear axonal transport deficits in presymptomatic mutant mice.

183 nts (P = 0.04 and 0.05, respectively) and in presymptomatic mutation carriers (P = 0.04 and 0.01, res

184 tter (P = 0.045) were decreased in the eight presymptomatic mutation carriers compared to seven non-c

185 d a cohort of 11 symptomatic individuals, 19 presymptomatic mutation carriers, and 20 asymptomatic no

186 uals of 3 large SCA17 pedigrees, including 4 presymptomatic mutation carriers, underwent cranial 3-di

187 and parietal lobe, in all SCA17 patients and presymptomatic mutation carriers.

188 screening of families identified many (often presymptomatic) mutation-positive subjects.

189 tic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n =

190 of hUCB cells into the cerebral ventricle of presymptomatic Naglu mice had a beneficial effect, proba

191 s in 27/29 (93.1%) samples and in 6/12 (50%) presymptomatic NHPs.

192 Transplantation at a presymptomatic or early symptomatic stage of juvenile ML

193 plexes occur in late stages of HD but not in presymptomatic or early-stage HD patients.

194 There was no change in behaviorally presymptomatic or symptomatic animals.

195 ly widely available and offers a window into presymptomatic organ dysfunction.

196 These findings suggest that presymptomatic oxidative stress yields abnormal adult br

197 mice, unlike transgenic SOD1(G93A) mice with presymptomatic p75(NTR) induction and death-signalling.

198 ge of symptom onset, allows investigation of presymptomatic pathological processes that can identify

199 ients) and 2 gene-positive DRPLA patients (1 presymptomatic patient) were studied.

200 th the possible exception of low creatine in presymptomatic patients (1)H-MRS spectra are not suggest

201 Two presymptomatic patients showed normal spectra but all ot

202 Twelve gene-positive HP patients (4 presymptomatic patients) and 2 gene-positive DRPLA patie

203 lower in the dominant hemisphere of only the presymptomatic patients.

204 isease (ILBD), which is thought to represent presymptomatic PD.

205 DAT radioligands, it may be able to identify presymptomatic PD.

206 the neurochemical mechanisms underlying this presymptomatic period are still unclear.

207 ase pathogenesis that defines the extensive, presymptomatic period for many prion strains.

208 A long preclinical and subsequent presymptomatic period pose a challenge for recognition,

209 ions for use early in disease and during the presymptomatic period.

210 ined Mecp2(-/y) and wild-type (WT) mice from presymptomatic periods to end-stage disease.

211 ion of the antisense oligonucleotides in the presymptomatic phase efficiently suppressed the mutant g

212 ers infected with scrapie during most of the presymptomatic phase of the disease.

213 ing patients susceptible to arrhythmias in a presymptomatic phase, and thus implementing preventive t

214 abetic, both of which can be detected in the presymptomatic phase.

215 mmation, myelin, and neuron markers from the presymptomatic phase.

216 d their associated biomarkers in the mild or presymptomatic phases of Alzheimer's disease are likely

217 disease (AD) research moves to intervene in presymptomatic phases of the disease, we must develop ou

218 naffected organs of CBA/Pdss2(kd/kd) mice at presymptomatic, phenotypic-onset, and end-stages of the

219 sected from SMN-deficient SMA mouse model at presymptomatic postnatal day 1 (P1), before detectable M

220 Compared to non-carriers, presymptomatic presenilin 1 mutation carriers exhibited

221 at increased amyloid load may be detected in presymptomatic presenilin 1 mutation carriers with (11)C

222 Despite identical behavioral performance, presymptomatic PS1 mutation carriers exhibited increased

223 ined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers t

224 ting neural stem/progenitor lineage cells in presymptomatic Pten-deficient mutant brains supports the

225 We report here that motor presymptomatic R6/1 HD mice show a severe impairment of

226 endogenous SOD1 in the spinal cord of young presymptomatic rats to 16-fold in end-stage animals.

227 stimulation has convincingly demonstrated a presymptomatic reduction or absence of short interval in

228 on-based results support recommendations for presymptomatic screening of relatives of cardiomyopathy

229 Recommendations for presymptomatic screening of relatives of cardiomyopathy

230 bed in muscle and spinal cord was normal in presymptomatic SMA mice (postnatal day 1), but failed to

231 Axotomized presymptomatic SOD1 FMNs displayed a dynamic pro-surviva

232 propose that the increased susceptibility of presymptomatic SOD1 FMNs to axotomy-induced cell death a

233 and axotomized facial motor nuclei of WT and presymptomatic SOD1 mice for mRNA expression pattern ana

234 Presymptomatic SOD1 mice had a significant decrease in F

235 axotomy-induced gene expression response of presymptomatic SOD1 neuropil was compared with WT.

236 ted in the peripheral blood transcriptome of presymptomatic SOD1(G93A) animals using custom-designed

237 METHODS/PRINCIPAL FINDINGS: Presymptomatic SOD1(G93A) rats (60-65 days old) received

238 n of mutant SOD1 in only the motor cortex of presymptomatic SOD1(G93A) rats through targeted delivery

239 in the spinal cord of these mice as early as presymptomatic stage (70 days of age) and not in other c

240 ysfunction and neurodegeneration even in the presymptomatic stage and may serve as markers for diseas

241 with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional

242 Identification of at-risk individuals at the presymptomatic stage has become a major research interes

243 Detection and treatment at an early presymptomatic stage may have contributed to the favorab

244 in older adults who are unlikely to be in a presymptomatic stage of AD.

245 We observed a normal NMJ organization at a presymptomatic stage of ALS (120 d), but PSC detection o

246 Individuals in the presymptomatic stage of Alzheimer disease (AD) are incre

247 cies in the SMA mouse model occur during the presymptomatic stage of disease, suggesting a role in in

248 ve/reactive brain mechanisms attributed to a presymptomatic stage of obstructive sleep apnea.

249 the transcripts that are up-regulated in the presymptomatic stage of SOD1(G93A) mice.

250 e of neurodegeneration in SCA17, even in the presymptomatic stage of the disease.

251 l level of task performance, even during the presymptomatic stage of the disease.

252 lial Alzheimer's disease progresses from the presymptomatic stage through to diagnosis.

253 heimer's disease who were followed up from a presymptomatic stage through to moderately severe dement

254 ly disrupted in R6/2 mice at 9 weeks of age (presymptomatic stage).

255 tation carriers over non-carriers during the presymptomatic stage, suggesting these symptoms result w

256 amus and bilateral caudate were evident at a presymptomatic stage, together with increased fractional

257 eded to inform design of trials aimed at the presymptomatic stage.

258 TAU(P301L), transgenic mice were used at the presymptomatic stage.

259 ulate and temporoparietal cortical losses at presymptomatic stage.

260 lecular processes, and diagnose disease at a presymptomatic stage.

261 med expPABPN1 carriers at a symptomatic or a presymptomatic stage.

262 mpal interneurons occurred mostly during the presymptomatic stage.

263 y to treat individuals in the "preclinical" (presymptomatic) stage.

264 we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats wit

265 of subtle myelin disruption during the early presymptomatic stages of AD and may help to validate new

266 variation at the APP locus in the earliest, presymptomatic stages of AD.

267 -dependent trajectory of cortical atrophy in presymptomatic stages of AD.

268 a peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the te

269 associated with faster cognitive decline in presymptomatic stages of disease progression.

270 igated its influence on cognitive decline in presymptomatic stages of disease progression.

271 y performance relative to noncarriers in the presymptomatic stages of disease progression.

272 rom 15 untreated individuals who died in the presymptomatic stages of infection from non-HIV causes.

273 ondrial stress was detected during the early presymptomatic stages of leaf senescence, which was acco

274 and epigenetic changes in the cerebellum at presymptomatic stages of NPC disease represent previousl

275 We found that at the presymptomatic stages of the disease, copper-induced cha

276 nCL1 expression was found to be increased at presymptomatic stages of the disease.

277 tamatergic corticostriatal synapses at early presymptomatic stages that have been postulated to set t

278 e onset of AD given that we observed them in presymptomatic subjects and that six of the validated ge

279 d AD patients or via secondary prevention in presymptomatic subjects bearing amyloid plaques.

280 ) on grey matter volume in a large cohort of presymptomatic subjects bearing frontotemporal dementia-

281 In addition, presymptomatic subjects carrying pathogenic PSEN1 gene m

282 tomatic patients diagnosed with sporadic AD, presymptomatic subjects carrying pathogenic PSEN1 mutati

283 s similar to those of controls, whereas late presymptomatic subjects showed altered expression that r

284 In addition, early presymptomatic subjects showed gene expression profiles

285 sfunction in frontal executive systems in 10 presymptomatic subjects with known mutation carrier stat

286 ower grey matter volume (P = 0.002), even in presymptomatic subjects.

287 es and then recorded sleep/wake behaviour at presymptomatic, symptomatic and late stages of the disea

288 or AD, which suggests that NGRN may reflect presymptomatic synaptic dysfunction or loss.

289 of PKCzeta levels in cord blood T cells as a presymptomatic test to predict allergy risk in children,

290 g, and has formed the basis for prenatal and presymptomatic testing and preimplantation genetic diagn

291 Proteomic analysis of a vulnerable organ, presymptomatic testis, showed a preferential accumulatio

292 crucial determinants in the transition from presymptomatic to symptomatic prion disease.

293 Presymptomatic total daily energy intake in patients, re

294 Re-evaluation of presymptomatic transgenic mice expressing A53T human alp

295 ion profiling of spinal cord astrocytes from presymptomatic transgenic mice expressing mutant superox

296 The benefits of the early identification and presymptomatic treatment of these disorders are now reco

297 g such syndromes and providing timely (often presymptomatic) treatment to families in which such synd

298 on at large to optimally identify those with presymptomatic type 1 diabetes, and introducing safe and

299 Presymptomatic valve operation was not associated with l

300 that this effect is dramatically enhanced in presymptomatic YAC128 HD and BACHD relative to wild-type